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Research Article | DOI: https://doi.org/10.31579/2637-8914/333
Department for Chemistry of Bioactive Nitrogen-Containing Heterocyclic Compounds, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
*Corresponding Author: Tsygankova Victoria Anatolyivna, Dr. Biol. Sci., Principal researcher, Senior Staff Scientist, Ukraine. E-mail: [email protected].
Citation: Tsygankova V.A, Andrusevich Ya.V., Vasylenko N.M., Kopich V.M., Solomyannyi R.M, et al., (2025), Novel Pyrimidine Derivatives as Regulators of Barley Growth and Photosynthesis During the Vegetation Period, J. Nutrition and Food Processing, 8(7); DOI: 10.31579/2637-8914/333
Copyright: © 2025, Tsygankova V.A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 13 August 2025 | Accepted: 21 August 2025 | Published: 29 August 2025
Keywords: Hordeum vulgare L.; IAA; Methyur; Kamethur; pyrimidine derivatives; plant growth regulators
A comparative analysis of the regulatory effect of the plant hormone auxin IAA (1H-indol-3-yl) acetic acid and novel synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur) and other pyrimidine derivatives, at a concentration of 10-7M, on the growth and photosynthesis ofspring barley (Hordeum vulgare L.) variety Salome during the vegetation period was carried out. Morphological traits such as shoot and root length (mm) and biochemical indicators such as content of chlorophylls a, b and carotenoids (mg/g fresh weight) of 4-week-old barley plants were studied. A screening of the most active synthetic azaheterocyclic compounds, pyrimidine derivatives that demonstrated auxin-like and cytokinin-like activity on the growth and photosynthesis of barley plants was conducted. The correlation between the chemical structure and the species specificity of the regulatory effect of synthetic azaheterocyclic compounds, pyrimidine derivatives, on plant growth and photosynthesis is discussed. A conclusion was made regarding the prospects of using most of the active synthetic azaheterocyclic compounds, pyrimidine derivatives, as new regulators of barley growth and photosynthesis.
Barley (Hordeum vulgare L.) is one of the globally significant cereal crops in the world after wheat, rice, and maize [1, 2]. The annual world barley harvest is over 159 million tons, grown on approximately 51 million hectares [2]. Europe is the largest producer of barley in the world accounting for around 40% of the total production [3]. Its widespread cultivation and versatility make it a key crop for human food and livestock feed, as well as a crucial ingredient in the malting and brewing industries [2, 3, 4]. Barley is rich in nutrients such as complex carbohydrates (mainly starch), proteins, dietary fiber (mainly ß-glucan), sugar, fat, minerals (particularly calcium, phosphorus), vitamins (particularly vitamin E), ash, and antioxidant polyphenols [4]. Given the physiological benefits and nutritional properties of barley and its processed products, consumers and producers are exploring new emerging opportunities for the incorporation of barley into the human diet. Barley grain can be used as whole-grain, pearled, raw-grain flour, and roasted-grain flour in the manufacturing of breakfast cereals, stews, soups, noodles and pasta, as a coffee substitute and in porridges, sauces, bread (flatbread and leavened bread), muffins, cakes, cookies and biscuits, as well as in the production of malt for brewing [4, 5].
Barley cultivation is sensitive to both temperature and the physical, chemical and biological properties of the soil [3, 6, 7]. Barley grows more effectively in temperate climate zones with moderate temperatures between 15 and 20°C; high temperatures, especially during the grain filling period, can significantly reduce yields [3, 6]. The decrease in barley grain yield is largely due to its adaptation to warming, which leads to an acceleration of metabolic processes and a reducing in the accumulation of storage compounds with a decrease in the final concentration of starch due to elevated temperatures [3]. Otherwise, climate warming increases the protein concentration in barley grain, providing higher nutritional value, but for malting barley this can be seen as an adverse effect, since low to moderate protein concentrations in the grain are preferred [3]. While barley grows best on well-drained, fertile loams, it can be cultivated on a variety of soil types, including lighter and even saline or sodic soils [6, 7]. This makes it a versatile crop for various agricultural settings. Barley requires fertile soils, especially those with good loam or light clay content. The soil organic matter (SOM), soil physical properties and availability of nutrients to which barley is sensitive play a major role in barley plant growth response and grain yield [8]. Proper nutrient management, especially preventing nutrient deficiencies, is important to maximize tillering and yield in barley. Catch crops, including legume species like peas, cowpeas, soybeans, faba beans, hairy vetch and non-legume species such as ryegrass, winter rye,red clover, and forage radish are valuable in crop rotations, especially with cereals like barley, because they improve soil health by fixing atmospheric nitrogen and increasing organic matter. These crops, when properly managed, can enhance the soil's nitrogen-supplying power and boost its organic matter reserves, and they also help suppress weeds, prevent erosion, and improve soil structure [9 - 12].
Modern barley growing technologies are based on the use of phytohormones auxins, cytokinins, gibberellic acid, synthetic plant growth regulators, and microbial biostimulants, which can accelerate the development of barley roots and shoots during the vegetative phase, increase barley yield, and improve crop quality [13 – 17]. However, the development of new effective barley growth regulators is a very urgent problem for agriculture. A new promising approach is the creation of environmentally friendly plant growth regulators based on synthetic low-molecular-weight azaheterocyclic compounds, which can be used as auxin-like and cytokinin-like substances that regulate plant growth [18 - 20]. Among these synthetic azaheterocyclic compounds, pyrimidine derivatives play a significant role in agriculture, mainly as plant growth regulators that enhance plant growth and photosynthesis during the vegetation period [21 - 30], increase crop yield [31 - 34], and enhance plant resistance to abiotic stresses such as heat and drought, as well as to toxic trace elements [35 - 37]. Additionally, some pyrimidine derivatives are widely used as herbicides, pesticides, fungicides, and bactericides [38 - 47]. Pyrimidine derivatives represent a potentially safer and more environmentally friendly alternative to some traditional agrochemicals. The use of environmentally friendly plant growth regulators based on synthetic azaheterocyclic compounds, pyrimidine derivatives in low non-toxic concentrations from 10-5M to 10-9M allows reducing the consumption rate of pesticides and fungicides toxic to human and animal health [48 - 51], which has a significant economic effect for agriculture and contributes to solving environmental problems.
Considering the importance of the above aspects, the aim of this work is to develop new plant growth regulators based on novel synthetic azaheterocyclic compounds, pyrimidine derivatives, to improve growth and enhance photosynthesis of spring barley (Hordeum vulgare L.) variety Salome during the vegetation period.
Study of morphological traits of barley plants.
The seeds of spring barley (Hordeum vulgare L.) variety Salome were sterilized with 1 % KMnO4 solution for 10 min, then treated with 96 % ethanol solution for 1 min, after which they were washed three times with sterile distilled water. After this procedure, seeds were placed in the plastic cuvettes (each containing 15-20 seeds) on the perlite moistened with distilled water (control sample) or water solutions of auxin IAA (1H-indol-3-yl)acetic acid or synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), or pyrimidine derivatives (compounds № 1–15) at a concentration of 10-7M (experimental samples).
The chemical name and structure of auxin IAA and all synthetic compounds studied are illustrated in Table 1. Auxin IAA (1H-indol-3-yl) acetic acid was manufactured by Sigma-Aldrich, USA; synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur) and new pyrimidine derivatives (compounds № 1–15) were synthesized at the Department for Chemistry of Bioactive Nitrogen-Containing Heterocyclic Compounds, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine.
Table 1: Chemical structure, name and relative molecular weight of IAA (1H-indol-3-yl) acetic acid, synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives (compounds № 1–15).
Seed germination took place in a thermostat in the dark at a temperature of 20-22 °C for 48 hours. After that, the germinated seedlings were placed in a climatic chamber, in which the plants were grown for 4 weeks under a light/dark regime of 16/8 h, a temperature of 20-22 °C, a light intensity of 3000 lux, and an air humidity of 60-80 %.
Morphological traits, such as average shoot and root length (mm) of experimental plants, were determined according to the methodical manual [52] and compared with the morphological traits of control plants and expressed as %.
Study of photosynthetic pigments in barley plants.
The photosynthetic pigments such as chlorophylls a and b, as well as carotenoids (mg/g fresh weight) in plant leaves were analyzed according to methodological recommendations [53, 54]. To perform the extraction of photosynthetic pigments, we homogenized a sample (500 mg) of plant leaves in the porcelain mortar in a cooled at the temperature 10 °С 96 % ethanol at the ratio of 1:10 (weight:volume) with addition of 0.1-0.2 g CaCO3 (to neutralize the plant acids). The 1 ml of obtained homogenate was centrifuged at 8000 g in a refrigerated centrifuge K24D (MLW, Engelsdorf, Germany) during 5 min at the temperature 4 °С. The obtained precipitate was washed three times, with 1 ml 96 % ethanol and centrifuged at above mentioned conditions. After this procedure, the optical density of chlorophyll a, chlorophyll b and carotenoid in the obtained extract was measured using spectrophotometer Specord M-40 (Carl Zeiss, Germany).
The content of chlorophylls a, b, and carotenoids in plant leaves was calculated in accordance with formula [53, 54]:
Cchl a = 13.36×A664.2 – 5.19×A648.6,
Cchl b = 27.43×A648.6 – 8.12A×664.2,
Cchl (a + b) = 5.24×A664.2 + 22.24×A648.6,
Ccar = (1000×A470 – 2.13×Cchl a – 97.64×Cchlb)/209,
Where, Cchl – concentration of chlorophylls (µg/ml), Cchl a – concentration of chlorophyll a (µg/ml), Cchl b – concentration of chlorophyll b (µg/ml), Ccar – concentration of carotenoids (µg/ml), А – absorbance value at a proper wavelength in nm.
The chlorophyll and carotenoids content per 1 g of fresh weight of extracted from plant leaves was calculated by the following formula (separately for chlorophyll a, chlorophyll b and carotenoids): A1=(C×V)/(1000×a1),
where A1 – content of chlorophyll a, chlorophyll b, or carotenoids (mg/g fresh weight), C - concentration of pigments (µg/ml), V - volume of extract (ml), a1 - sample of leaves (g).
The content of photosynthetic pigments determined in the leaves of experimental plants in relation to control plants was expressed as %.
Statistical data analysis
Each experiment was performed three times. Statistical processing of the experimental data was carried out using Student’s t-test with a significance level of P≤0.05; mean values ± standard deviation (± SD) [55].
Regulatory effect of pyrimidine derivatives on barley growth
As is known, phytohormones auxins and cytokinins play an important role in the growth and development of roots, shoots, leaves, fruits and seeds in the vegetative and reproductive phases of plants, enhance photosynthetic processes and prevent the destruction of photosynthetic pigments such as chlorophylls and carotenoids in plant leaves, increase the yield of agricultural crops, and also protect plant from biotic and abiotic stresses that significantly limit crop yields [56 - 63]. Therefore, screening of new synthetic compounds capable of exhibiting regulatory effects similar to these plant hormones is a priority area for modern agriculture.
As evidenced by the results of our previous studies, synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), as well as other representatives of pyrimidine derivatives, exhibit an auxin- and cytokinin-like effects on the formation and growth of roots and shoots and the synthesis of photosynthetic pigments, such as chlorophylls a, b, and carotenoids, in spring barley (Hordeum vulgare L.) of two varieties: Avatar and Acordine during the vegetation period [23, 26]. The new synthetic azaheterocyclic compounds, pyrimidine derivatives, presented in the Table 1, were previously studied on the growth and photosynthesis of winter wheat (Triticum aestivum L.) variety Taira during the vegetation period [30]. It has been shown that the regulatory activity of these compounds used at a concentration of 10-6M is similar to or higher than the regulatory activity of auxin IAA or derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), used at a similar concentration of 10-6M.
Therefore, an important aspect of the present work is the study of the species specificity of the regulatory effect of synthetic azaheterocyclic compounds, pyrimidine derivatives, presented in the Table 1, on the growth of spring barley (Hordeum vulgare L.) variety Salome during the vegetation period in a physiologically active concentration of 10-7M. The results obtained showed the auxin and cytokinin-like effects of the studied synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives, on the formation and growth of roots and shoots in barley plants during the vegetation period (Figure 1).
Figure 1: The regulatory effect of auxin IAA, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), as well as the most physiologically active pyrimidine derivatives № 2, 3, 4, 5, 9, 10, 13, 14, 15 at a concentration of 10-7M on the growth of roots and shoots of 4-week-old spring barley (Hordeum vulgare L.) variety Salome, compared to control (С) plants.
Morphological traits, such as average shoot and root length (mm) of barley plants treated with synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), as well as pyrimidine derivatives, exceeded the morphological traits of control barley plants, and were similar to or higher than the morphological traits of barley plants treated with auxin IAA.
Auxin IAA, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), as well as the most physiologically active pyrimidine derivatives № 2, 3, 5, 6, 7, 8, 14 revealed the highest regulatory effect on the parameters of average shoot length (mm), which increased: by 8.95% - under the effect of IAA, by 6.89% - under the effect of Methyur, by 11.74% - under the effect of Kamethyur, by 6.3–12.42% - under the effect of pyrimidine derivatives № 2, 3, 5, 6, 7, 8, 14, compared to similar parameters of control plants (Figure 2).
Pyrimidine derivatives № 1, 4, 9, 10, 11, 12, 13, 15 showed a lower regulatory effect on the parameters of average shoot length (mm), which increased by 1.55–4.67%, compared to similar parameters of control plants (Figure 2).
Figure 2: The regulatory effect of auxin IAA, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 1-15 at a concentration of 10-7M on the average shoot length (mm) of 4-week-old spring barley (Hordeum vulgare L.) variety Salome, compared to control plants.
Derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), as well as the most physiologically active pyrimidine derivatives № 2, 3, 4, 5, 8, 9, 10, 12, 13, 14, 15 revealed the highest regulatory effect on the parameters of average root length (mm), which increased: by 195.48% - under the effect of Methyur, by 168.74% - under the effect of Kamethyur, by 88.1–203.65% - under the effect of pyrimidine derivatives № 2, 3, 4, 5, 8, 9, 10, 12, 13, 14, 15, compared to similar parameters of control plants (Figure 3).
Auxin IAA, pyrimidine derivatives № 1, 6, 7, 11 showed a lower regulatory effect on the parameters of average root length (mm), which increased: by 88.21% - under the effect of IAA, by 56.98–73.41% - under the effect of pyrimidine derivatives № 1, 6, 7, 11, compared to similar parameters of control plants (Figure 3).
Figure 3: The regulatory effect of auxin IAA, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 1-15 at a concentration of 10-7M on the average root length (mm) of 4-week-old spring barley (Hordeum vulgare L.) variety Salome, compared to control plants.
Summarizing the obtained data, it should be noted that the highest auxin- and cytokinin-like regulatory effects on the growth of shoots and roots on the barley plants [56 - 60] was exerted by synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 2–10, 12–15. The plant growth regulatory effect of these synthetic compounds, applied at a concentration of 10-7M, was similar to or higher than the plant growth regulatory effect of the auxin IAA, applied at a similar concentration. Obviously, this fact can be explained by the auxin-like and cytokinin-like regulatory effects [56 - 60] of these synthetic compounds on the processes of elongation, proliferation and differentiation of plant cells, which are the main processes of seed germination, growth and development of shoots and roots of barley plants.
Regulatory effect of pyrimidine derivatives on barley photosynthesis
An important aspect of the present work is the study of the regulatory effect of synthetic azaheterocyclic compounds, pyrimidine derivatives, presented in the Table 1, on the photosynthesis of spring barley (Hordeum vulgare L.) variety Salome during the vegetation period in a physiologically active concentration of 10-7M. The results obtained showed a cytokinin-like effect of the studied synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives, on the photosynthesis of barley plants during the vegetation period.
A comparative study of the regulatory effect of auxin IAA (1H-indol-3-yl)acetic acid, synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 1–15 in a concentration of 10-7M on the photosynthetic parameters of spring barley (Hordeum vulgare L.) variety Salome was carried out. Photosynthetic parameters such as content of chlorophylls a, b, a+b and carotenoids (mg/g fresh weight), measured in the leaves of barley plants 4 weeks after seed germination, were compared with those of control barley plants.
The highest regulatory effect on the content of chlorophylls and carotenoids in barley leaves is exerted by a derivative of potassium salt of 6-methyl-2-mercapto-4-hydroxypyrimidine (Kamethur) and pyrimidine derivatives № 1, 2, 3, 4, 5, 9, 10, 13, under the effect of which the content of chlorophyll a increases: by 37.4% - under the effect of Kamethur, by 16.51–42.34 % - under the effect of pyrimidine derivatives № 1, 2, 3, 4, 5, 9, 10, 13; the content of chlorophyll b increases: by 38.35% - under the effect of Kamethur, by 7.6–38.35% - under the effect of pyrimidine derivatives № 1, 3, 9, 13; the content of chlorophylls a+b increases: by 37.67% - under the effect of Kamethur, by 14.23–41.1% - under the effect of pyrimidine derivatives № 1, 2, 3, 4, 5, 9, 10, 13; the content of carotenoids increases: by 22.59% - under the effect of Kamethur, by 22.26–70.67% - under the effect of pyrimidine derivatives № 1, 2, 3, 4, 5, 9, 10, 13, compared to similar parameters of control plants (Figure 4).
Figure 4. The regulatory effect of auxin IAA, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 1-15 at a concentration of 10-7M on the concentration of chlorophylls a, b, a+b and carotenoids (µg/ml) in the leaves of 4-week-old spring barley (Hordeum vulgare L.) variety Salome, compared to control plants.
The lower regulatory effect on the content of chlorophylls and carotenoids in barley leaves is exerted by auxin IAA, a derivative of sodium salt of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur) and pyrimidine derivatives № 6, 7, 8, 11, 12, 14, 15, under the effect of which the content of chlorophyll a increases: by 5.59% - under the effect of auxin IAA, by 9.66 % - under the effect of Methyur, by 2.63–17.19% - under the effect of pyrimidine derivatives № 6, 7, 8, 11, 12, 14, 15; the content of chlorophyll b increases: by 9.12% - under the effect of Methyur; the content of chlorophylls a+b increases: by 1.39% - under the effect of auxin IAA, by 9.5% - under the effect of Methyur, by 1.3–8.21% - under the effect of pyrimidine derivatives № 6, 7, 8, 11, 12, 14, 15; the content of carotenoids increases: by 11.9 % - under the effect of auxin IAA, by 12.23–39.26% - under the effect of pyrimidine derivatives № 6, 7, 8, 11, 12, 14, 15, compared to similar parameters of control plants (Figure 4).
Thus, the results obtained confirmed the regulatory effect of synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 1-15, similar to the effect of phytohormones cytokinins on enhancing the synthesis and preventing the destruction of photosynthetic pigments such as chlorophylls and carotenoids in leaves of barley plants, which play a key role in photosynthesis and ensuring plant productivity and photoprotection [61 – 66].
Analyzing the relationship between the chemical structure and selectivity of regulatory effect of synthetic compounds, pyrimidine derivatives №1-15, on barley growth and photosynthesis, it can be assumed that their effect, similar to or exceeding the effect of the auxin IAA or derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), is associated with the presence of substituents in the chemical structure of these compounds (Table 1).
The synthetic compounds, pyrimidine derivatives № 2, 3, 4, 5, 8, 9, 10, 12, 13, 14, 15, showed the highest regulatory effect on barley growth and photosynthesis, these compounds contain: compound №2 contains benzenesulfonyl group in position 5, phenyl group in position 3, propyl group in position 1 of the 1H-pyrimidine-2,4-dione ring; compound №3 contains tolylsulfonyl group in position 5, propyl group in position 1, phenyl group in position 3 of the 1H-pyrimidine-2,4-dione ring; compound №4 contains allyl substituent in position 1, phenylsulfonyl group in position 5, phenyl group in position 3 of the 1H-pyrimidine-2,4-dione ring; compound №5 contains benzenesulfonyl group in position 5, phenyl group in position 3, butyl group in position 1 of the 1H-pyrimidine-2,4-dione ring; compound №8 contains phenylsulfonyl group in position 5, 2,3‑dihydroxypropyl group in position 1, phenyl group in position 3 of the 1H-pyrimidine-2,4-dione ring; compound №9 contains benzenesulfonyl group in position 5, phenyl group in position 3, tetrahydrofuran-2-ylmethane group in position 1 of the 1H-pyrimidine-2,4-dione ring; compound №10 contains para-tolylsulfonyl group in position 5, phenyl group in position 1, tetrahydrofuran-2-ylmethyl group in position 1 of the 1H-pyrimidine-2,4-dione ring; №12 contains a benzenesulfonyl group in position 5, an ethyl group in position 3 of the 2-thioxo-2,3-dihydro-1H-pyrimidin-4-one ring; compound №13 contains an allyl substituent in position 3, a phenylsulfonyl group in position 5 of the 2-thioxo-2,3-dihydro-1H-pyrimidin-4-one ring; compound №14 contains a phenyl group in position 3, a benzenesulfonyl group in position 5 of the 2-thioxo-2,3-dihydro-1H-pyrimidin-4-one ring; compound № 15 contains a phenyl group in position 6, a cyano group in position 5 of the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine ring.
At the same time, the synthetic compounds, pyrimidine derivatives № 1, 6, 7, 11, showed the lower regulatory effect on barley growth and photosynthesis, these compounds contain:compound №1 contains methylsulfonyl group in position 5, propyl group in position 1, phenyl group in position 3 of the 1H-pyrimidine-2,4-dione ring; compound №6 contains benzenesulfonyl group in position 5, phenyl group in position 3, 3-hydroxypropyl group in position 1 of the 1H-pyrimidine-2,4-dione ring; compound №7 contains para-tolylsulfonyl group in position 5, phenyl group in position 1, 3-hydroxypropyl group in position 1 of the 1H-pyrimidine-2,4-dione ring; compound №11 contains phenylsulfonyl group in position 5, 4-chlorobenzoic acid ethyl ester residue in position 3, 4-chlorophenyl group in position 1 of the 2,4-dioxo-3,4-dihydro-2H-pyrimidine ring.
The results obtained in this work correlate with the data of our previously published study [30], which indicate that synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 1-15, exhibit auxin- and cytokinin-like regulatory effects on the growth of shoots and roots, as well as on photosynthesis in wheat plants. The most physiologically active synthetic compounds, pyrimidine derivatives № 1, 3, 4, 5, 6, 8, 9, 10, 11, 15, which stimulate wheat growth and increase photosynthesis, were selected and proposed for use in agricultural practice as new plant growth regulators.
Comparing the results of this work with our previously published work [30], we can conclude that synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 3, 4, 5, 8, 9, 10, 15, exhibit auxin- and cytokinin-like regulatory effects on the growth and photosynthesis of both wheat and barley plant species. At the same time, synthetic azaheterocyclic compounds, pyrimidine derivatives № 1, 2, 6, 7, 11, 12, 13, 14, exhibit selectivity in their auxin- and cytokinin-like regulatory effects on the growth and photosynthesis of wheat or barley plant species. It is possible that there is a difference in the intracellular signaling pathways of these compounds in wheat and barley cells by analogy with nature or synthetic auxins and cytokinins through auxin or cytokinin signaling pathways or by modulating the activity of key enzymes involved in the biosynthesis, transport, metabolism, conjugation and oxidation of endogenous auxins and cytokinins in plant cells [67 - 85].
Thus, in this work, the most physiologically active synthetic azaheterocyclic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), and pyrimidine derivatives № 2, 3, 4, 5, 8, 9, 10, 12, 13, 14, 15, which stimulate barley growth and enhance photosynthesis during the vegetation period, were selected and proposed for use in agricultural practice as new plant growth regulators. The use of environmentally friendly plant growth regulators based on synthetic compounds, derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur), as well as pyrimidine derivatives № 2, 3, 4, 5, 8, 9, 10, 12, 13, 14, 15 in low, non-toxic to human health and the environment concentration of 10-7M allows to improve seed germination, the formation and growth of shoots, roots of barley plants, to enhance photosynthetic processes in plant leaves. Due to the physiological effects of these synthetic compounds, they can be used in the agricultural industry as new auxin-like and cytokinin-like substances that regulate the growth of barley plants, which has a significant economic effect on agriculture and helps to solve environmental problems.
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Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
