AUCTORES
Globalize your Research
Chat with us
Research Article | DOI: https://doi.org/10.31579/2637-8914/261
Institute of Viticulture and Oenology, Eszterházy Károly Catholic University, HU-3300 Eger, Leányka street 12., Hungary.
*Corresponding Author: Zsuzsanna Bene, (2024), Impact of climate change on the (poly)phenol composition of botrytization in the Tokaj wine region, J. Nutrition and Food Processing, 7(11); DOI:10.31579/2637-8914/261
Citation: Zsuzsanna Bene, (2024), Impact of climate change on the (poly)phenol composition of botrytization in the Tokaj wine region, J. Nutrition and Food Processing, 7(11); DOI:10.31579/2637-8914/261
Copyright: © 2024, Zsuzsanna Bene. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 23 August 2024 | Accepted: 02 September 2024 | Published: 16 September 2024
Keywords: botrytization; noble rot; phenolic acids; polyphenol; tokaj
Tokaj wine region is famous for its aszú wines, which are made of noble rotted raw materials. There is also a continuous change in the life activity of Botrytis cinerea as a result of climate change, which not only alters the rate of acidification but also its characteristic biochemical processes. Increasing sugar content is associated with a fructose excess, an increase in succinic acid, fumaric acid, citric acid, a change in the composition of phenolic compounds and an increase in phenolic acid content. This study examines the polyphenol content measured in the last 4 vintages and presents the typical phenolic acid composition.
Changes in the phenological cycles of plants, changes in the microclimate of regions with terroir that determines the organoleptic characteristics of wines, and an increase in the potential for severe weather events each year are just some of the effects of climate change (Bonnefoy et al., 2010). In regions where specific climatic conditions are very important for the development of berry necrosis, climate change can disrupt the microclimate, leading to drier or wetter seasons, which can affect the botrytis process (Agenis-Nevers, 2006).
The historical Tokaj region in northeast Hungary is an UNESCO World Heritage region since 2002 owning 5.500 ha vineyards. Produced from „noble rotted” grapes, Tokaji Aszú is known as one of the oldest botrytized wines all over the world (Magyar, 2011). Special microclimatic conditions (due to Bodrog and Tisza rivers, Indian summer), soil circumstances (clay, loess on volcanic bedrock) and grape-varieties (Furmint, Hárslevelű) of Tokaj-region offer favourable parameters to the formation of noble rot caused by Botrytis cinerea (Bene, 2004). The special metabolic activity of Botrytis results in noble rot grape called “aszú” berries. The grapes undergo complex chemical modifications as the joint result of the enzymatic activity of Botrytis and the physical process of concentration.
Sugar: The sugar content of the berry increases very significantly as a result of evaporation, resulting in an average must sugar content of 300 - 350 g/l (Donèche, 1989). The breakdown of polysaccharides and pectic substances increases the amount of other hexoses (rhamnose, galactose, mannose), pentoses (arabinose, xylose) and galacturonic acid (Dittrich&Grossmann, 2011; Magyar, 2011).
Polyols: three main polyols are responsible for the increased viscosity and "body" of wines with botrytis: butanediol, glycerol and sorbitol (Moreno&Peinado, 2012). Must from healthy grapes contains only traces of glycerol, but must from grapes with noble rot usually contains more than 5 g/l of glycerol (Dittrich&Sponholz, 1975). As the glycerol content continues to increase during fermentation, the glycerol content of wines made from raisined grapes is generally above 10 g/l, but often exceeds 20-30 g/l in Tokaj aszú (Magyar, 2011).
Acid composition: the activity of B. cinerea increases the amount of citric and succinic acids in the must, resulting in a particular acid composition in the wine. Tartaric acid, expressed in g/l, decreases by 55% in botrytised must and malic acid increases by 45%. Thus, the total acidity of around 8 g/l expressed as tartaric acid is almost unchanged compared with must from healthy grapes (Ribéreau-Gayon, 1982). Botrytis also produces certain acids (pectolytic, cellulose complex, protease and phospholipase) which were not originally present in the berry (gluconic, glucuronic, galactaric) (Ribéreau-Gayon et al., 2000). An increase in galacturonic acid content has also been observed in grapes infected by Botrytis (Dittrich&Sponholz, 1985, Doneche, 1993). Ketone acids (pyrosulfonic acid, 2-ketoglutaric acid) are present in increased concentrations as a result of noble rot (Bene, 2004).
Polysaccharides: the two main polysaccharides secreted by B. cinerea have different solubility in alcoholic solution (König et al., 2017). The first is a fairly soluble heteropolysaccharide consisting of 60% mannose, 30% galactose, 5% glucose, 5% rhamnose and a protein moiety. The other is botrytis glucan, a high molecular weight glucose polymer linked by β-D-position glycosidic bonds, less soluble in alcoholic solution and with a high impairment of filterability (Bene, 2004).
Free amino acids: The amount of free amino acids depends to a large extent on the vinification technology. In general, proline and arginine predominate, with very similar proportions of proline and arginine (30 and 28% respectively) in Tokaj specialities (Csomós, 2003).
Biogenic amines: The concentration of biogenic amines (tyramine, agmatine, phenylethylamine) and other amines (primary aliphatic amines: i-butylamine, 2-methylbutylamine) increases during the aszú production (Csomós, 2003; Kiss&Sass-Kiss, 2005).
Anti-inflammatory molecules: Kalló et al., 2020 isolated about 20 anti-inflammatory compounds in aszú wines: rhododendrin, caftaric acid, ethyl caffeate, chlorogenic acid, ethyl gallate, feraric acid, quercetin and taxifolin (phenolic compounds), asperlin, phenylalanine, bestatin, dodecanoic acid, histinidol, linamarin are among the most typical compounds.
Aroma compounds: Aroma compounds and other constituents: significant roles are played by furfural, benzaldehyde, a phenylacetaldehyde and benzaldehyde cyanohydrin (other name: prunasin-bitter almond flavour), as well as the so-called mushroom alcohol (1-octen-3-ol). Sotolon (3-Hydroxy-4,5-dimethylfuran-2(5H)- furanone) 3-hydroxy-4,5-dimethyl-2 (5H) furanone) produced by Botrytis cinerea is one of the most important components that gives the distinctive “Aszú” aroma (caramel flavour) (Ribéreau-Gayon et al., 2000). Botrytis increases the quantity of polyphenol oxidases that increase the tendency of the wine to browning, while polysaccharides (β-glucan) synthesis causes poor filterability of wines.
Polyphenols and phenolic acids: The effects of polyphenols on sensory properties have attracted increasing attention in recent times. Several studies (Costa et al., 2014; Shah et al., 2022; Rouxinol et al., 2023) have investigated the effects of increased temperature, UV radiation and drought on polyphenol content due to climate change. Costa et al., 2014 carried out studies in three different Portuguese regions (Alentejo, Douro and Dão) and found that high temperatures generally reduce berry weight, titratable acidity, total phenolic content, increase pH and potential alcohol. Shah et al., 2022 found that high temperatures impair phenolic biosynthesis pathways and therefore reduce their accumulation, while lower temperatures favour their production. High UV radiation can cause degradation of phenolic compounds. Water balance is also an important factor, as even a slight water deficit during the verasion period causes elevated levels. Rouxinol et el., 2023 examined red wines from Portugal (Alentejo) in two different vintages and the results show that polyphenol compounds vary from vintage to vintage. The reduction in berry size can cause results higher contents of polyphenolic compounds related to grape quality.
Achieving a level below the 200 mg/l threshold in the Tokaj wine region is a major challenge but certainly an aspiration for discerning winemakers. Previous research (Bene et al., 2023) has not demonstrated that an increase in polyphenol content can be detected as a result of climate change, but efforts to reduce polyphenol content are having an impact, with more and more samples achieving below 200 mg/l, especially for the Furmint grape variety.
Phenolic acids are an important group of non-flavonoid compounds present in grapes and wines that have attracted increasing interest over the past decade for their potential health benefits (e.g. antioxidant, antibacterial, antiviral, anticancer, anti-inflammatory and vasodilatory effects). Phenolic acids are predominantly composed of two subgroups: hydroxycinnamic acids (HCA) of the C6-C3 and C6-C1 types and hydroxybenzoic acids (HBA) (Monagas et al., 2005). HCA compounds constitute the major polyphenol content of white wines. Cinnamic acid derivatives without condensed skeleton (p-coumaric acid, ferulic acid, caftaric acid) are mostly present in the form of esters with tartaric acid (cutaric acid, ferulic acid, caftaric acid), of which caftaric acid (caffeyl tartrate) in particular is a preferred substrate for polyphenol oxidase enzymes in grapes. During the fermentation process, a partial hydrolysis of the esters takes place, the rate of which depends on pH and the presence of specific enzymes, free HCAs may be released and partially esterified with ethanol to form HCA ethyl esters. HCAs and their derivatives have antimicrobial properties, in particular against lactic acid bacteria and yeasts (e.g. Brettanomyces bruxellensis, Dekkera spp.) responsible for wine spoilage (Harris et al., 2010), increase cell membrane permeability in wine (Campos et al., 2009).
During botrytization, the three main hydroxy acids : p-coumaric acid, caftaric acid and ferulic acid accumulate in the berries (Blanco-Ulate et al., 2015; Kalló et al., 2020).
2.1 Aszú wine samples
The aszú base wine samples come from the same 4 wineries in each vintage: Dereszla Winery (DE), Tokaj Disznókő Co. (D), Royal Tokaji Wine Estate Co. (R) and Tokaj-Hétszőlő Organic Vineyards (H). The cooperation with these wineries has been carried out over several years of research work. These wineries use similar production processes for aszú wine making (Table 1) and focus strictly on the first class category in terms of the quality of the aszú grapes (Figure 1). It is very important to emphasize paying great attention to the fact that the grapes are not only sun-dried but that their character is determined by the activity of Botrytis.
| Aszú berry grape variety | Furmint, Hárslevelű |
| Base wine type | in an active state of fermentation |
| Aszú berries harvesting and storage practices | per berry in the field, short term storage |
| Maceration time | 16 hours |
| Use of specified yeast | yes |
| Use of cooling | yes, controlled fermentation |
| Fermentation temperature and duration | 16-18oC, 20 days |
| Use of nutritients | yes |
| Fermentation vessel type | stainless steel tank |
| Stop for fermentation | cooling and suphuring |
| Technology | Maceration with fermenting must without berry crushed |
| Press duration | 8-10 hours |
| Press type | Bucher pneumatic |
| Raking to barrel | after fermentation |
| Press bar | under 2 bars |
| Treatment | sulphuring with 50 mg/l free SO2 content |
Table 1: Technology used for aszú wine making
Figure 1: Botrytized bunch (Source: Bene, 2022)
The state of the aszú base wine samples is the so-called raw aszú state in the technology (Figure 2.), which means the state after fermentation and subsequent stopping, when they have not yet been barrel-aged and no wine technological intervention other than sulphurisation has taken place.
Figure 2. Aszú making process (Source: https://www.bor.hu)
2.2 Wine profiling
Examination of chemical composition was carried out with analysis (NMR - Nuclear Magnetic Resonance) in Diagnosticum Zrt. laboratory, Szerencs. H NMR Technique (Godelmann et al.,2013): 1H NMR (proton nuclear magnetic resonance) spectra acquisitions were performed on a 400 MHz spectrometer (Bruker Avance) and a magnet Bruker Ascend TM 400 MHz equipment with 2H "lock" channel and z gradient at a frequency of 400.13 MHz and 26.85 °C. The data analysis is performed at Bruker BioSpin GmbH (Rheinstetten, Germany) according to testing method AA-72-02-06 (Wine-Profiling 4.0.4), released on 06-Nov-2020 (DIN EN ISO/IEC 17025:2018 Accreditation Certificate D-PL-19229-01-00 of Bruker BioSpin GmbH).
2.3 Measurement of total phenols
Total polyphenol: Colorimetric Folin-Ciocalteu method by chromogenic complex according to REF984346 published by Thermo Fisher Gallery method and procedures (TSF, 2020). Method is performed at 37 °C, using 700 nm filter and calibrated with gallic acid standard. Polyphenols react in basic environment with Folin-Ciocalteau reagent optimized and modified. The chromogenic complex is proportional to the concentration of polyphenols in the sample, measured at 700 nm wavelength.
Orange Data Mining Toolbox (Demšar et al., 2013) 3.37.0 software was used for statistical analysis (ANOVA - Box Plot).
The measured values are shown in Table 2.
Table 2. Measured values in 2020, 2021, 2022 and 2023 vintages
The NMR instrument allows the analysis of 56 parameters, the compounds selected for the analysis of the crude ash are those that are indicators of botrytis activity according to the literature, so the following are used as a basis for comparison: sugar content, citric acid, gluconic acid, galacturonic acid, succinic acid, glycerol, phenolic acids (caftaric acid, shikimic acid, trigonelline). In all cases, the citric acid exceeds 200 mg/l, higher than that measured in normal sweet wines. For gluconic acid, it can be concluded that it is not higher than in normal sweet wines for each sample, this series of tests also confirms that this parameter is not an indicator of botrytis activity. Galacturonic acid exceeds 200 mg/l in all samples, indicating botrytis activity, as reported in the literature. Succinic acid reaches a maximum of 300 mg/l in normal sweet wines, and exceeds this value in all vintages and in all wineries in the wines tested. Glycerol levels were higher than in normal sweet white wines in all samples, exceeding 20 g/l in 4 samples (1DE20, 2H20, 3D20, 4R20).
Of the phenolic acids tested, caftaric acid shows higher values in the samples tested compared to normal sweet white wines.
The total polyphenol content is in the range of 400-500 mg/l, with 2 samples having higher values (12R22, 15D23), but not reaching 800 mg/l (Figure 3.). Botrytised raw material use increases the total polyphenol content, but not significantly and to a level that can be reduced by different derivations during maturation. The values do not vary with the vintage and the growing area (wineries), so there is no evidence that climate change is associated with increased polyphenol content.
Figure 3. Measured values in the case of total polyphenol content
Based on the statistical analysis carried out, differences are shown in Table 3.
| Parameters/ Sample | p-value grouped by vintage | levels of significance | p-value grouped by winery | levels of significance |
| Alc.(v/v%) | 0.083 | - | 0.747 | - |
| Sugar /g/l) | 0.376 | - | 0.022 | * |
| Citric acid (mg/l) | 0.008 | ** | 0.817 | - |
| Gluconic acid (mg/l) | 0.040 | * | 0.893 | - |
| Galacturonic acid (mg/l) | 0.053 | - | 0.377 | - |
| Succinic acid (g/l) | 0.043 | * | 0.523 | - |
| Glycerol (g/l) | 0.002 | ** | 0.752 | - |
| Caftaric acid | 0.266 | - | 0.047 | * |
| Shikimic acid (mg/l) | 0.508 | - | 0.254 | - |
| Trigonelline (mg/l) | 0.143 | - | 0.114 | - |
Table 3. Results of statistical analysis (Analysis of variance, levels of significance: - (ns); * (P<0>
In terms of vintage, citric acid, gluconic acid, succinic acid and glycerol have the largest effect. With respect to place of production (winery), sugar and caftaric acid show significant differences.
Caftaric acid can also undergo hydrolysis in the presence of the enzyme pectinase, releasing caffeic and tartaric acids, but its involvement in certain oxidation processes is more significant. The first step in such reactions is the breakdown by polyphenol oxidase into caftaric acid ortho-quinone and water (Cheynier, 1988). If reduced glutathione (GSH) is present in the must, it is the first to react with the caftaric acid ortho-
quinone to form 2-glutathionyl caftaric acid (grape reaction product, GRP) (Salgues, 1986). GRP is colourless - its appearance does not indicate browning - and does not react with polyphenol oxidase. Its formation may therefore have the advantage of partially distracting caftaric acid ortho-quinone from reactions with other compounds leading to browning and from polyphenol oxidases (Singleton et al., 1985). However, the enzyme laccase from Botrytis cinerea, unlike polyphenol oxidase, reacts with GRP. Since caffeic acid and GRP are present in white wines in varying amounts, they can also have an effect on the taste of the wine, giving a bitter taste sensation. Based on the literature (Gawel et al., 2013), this taste is not observed at levels below 60 mg/l. In none of the samples tested did it exceed 40 mg/l, but significant differences between wineries can be detected (Figure 4.).
Figure 4. Statistic examination in caftaric acid composition grouped by vineyard (winery) and vintage
Importantly, it should be noted that when examining the impact of climate change, it is not possible to draw conclusions 4 years into the future. Data must be systematically collected year by year and knowledge must be systematically built up. As observed in the examined vintages, there is no evidence of an increase in polyphenol content due to climate change (400-500 mg/l). The most important phenolic acid is the caftaric acid and in none of the samples tested exceeded 40 mg/l but significant differences can be found between wineries. The glycerol content is not affected by climate change, the deviation from normal sweet wines is typical of all vintages (10-30 g/l) and is not dependent on the production area. Particular attention should be paid to the compounds citric acid, succinic acid, galacturonic acid, caftaric acid, shikimic acid, trigonelline and their quantitative ratios should be studied in relation to the different seasons, as they can be important indicators of botrytis activity. In the case of Tokaj aszú wines, the increased amount of succinic acid is noteworthy.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
