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Review Article | DOI: https://doi.org/10.31579/2637-8914/313
1B. Sc Students, Department of Nutrition and Dietetics, School of Allied Health Science, Sharda University, Greater Noida 201310, U.P, India.
2Assistant Professor, Department of Nutrition and Dietetics, School of Allied Health Science, Sharda University, Greater Noida 201310, U.P, India
*Corresponding Author: Neelesh Kumar Maurya, Assistant Professor, Department of Nutrition and Dietetics, School of Allied Health Science, Sharda University, Greater Noida 201310, U.P, India
Citation: Diana G. Nino., Nani Yaza., Neelesh K. Maurya, (2025), Dietary Strategies for Irritable Bowel Syndrome: An Evidence-Based Review of Current and Emerging Interventions, J. Nutrition and Food Processing, 8(6); DOI:10.31579/2637-8914/313
Copyright: © 2025, Neelesh Kumar Maurya. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 15 April 2025 | Accepted: 23 April 2025 | Published: 01 May 2025
Keywords: irritable bowel syndrome; diet; low fodmap; probiotics; gut-brain axis; microbiota; personalized nutrition
Irritable Bowel Syndrome (IBS) is a chronic, functional gastrointestinal disorder that affects approximately 10–15% of the global population and imposes a significant burden on healthcare systems and patients’ quality of life. Characterized by abdominal pain and altered bowel habits in the absence of structural abnormalities, IBS is now increasingly recognized as a multifactorial condition involving gut-brain axis dysregulation, motility disturbances, visceral hypersensitivity, microbial dysbiosis, and immune activation. Among the most modifiable and impactful contributors to symptom generation is diet. This review explores the evolving understanding of dietary influences on IBS pathophysiology and presents a comprehensive summary of evidence-based nutritional interventions. Traditional and emerging dietary strategies—including low FODMAP, gluten-free, fiber-modulated, and lactose/fructose-restricted diets—are assessed for their clinical efficacy and mechanistic insights. Functional food approaches, such as the use of probiotics, prebiotics, peppermint oil, polyphenols, and low-histamine diets, are also discussed for their therapeutic potential. The review further addresses the integration of personalized nutrition, highlighting the controversial role of food sensitivity testing and the promise of nutrigenomics. It also underscores the importance of combining dietary therapy with lifestyle factors like stress management, physical activity, and cognitive-behavioral support. Clinical guidelines from leading global organizations are reviewed to guide evidence-based practice. In summary, dietary management in IBS is no longer one-size-fits-all but must be individualized, evidence-driven, and holistic. Future research should prioritize long-term outcomes, microbiome-targeted therapies, and precision nutrition
Understanding Irritable Bowel Syndrome: Definition, Impact, and Dietary Relevance
Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain or discomfort associated with altered bowel habits in the absence of identifiable structural pathology. IBS is clinically subtyped into four categories based on predominant stool patterns: IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), mixed-type (IBS-M), and unsub typed (IBS-U) when bowel habits do not meet criteria for the other subtypes (Mearin et al., 2016). Globally, IBS affects approximately 11.2% of the population, with regional variations ranging from 7% in South Asia to 21% in South America (Oka et al., 2020). This widespread prevalence translates into a significant socioeconomic burden, with IBS patients showing higher rates of work absenteeism, decreased productivity, and increased healthcare utilization. For example, in the United States alone, IBS is estimated to cost over $20 billion annually in direct and indirect expenses (Peery et al., 2012). The pathophysiology of IBS is multifactorial, involving altered gut-brain axis communication, visceral hypersensitivity, dysbiosis, low-grade inflammation, and psychological comorbidities such as anxiety and depression (Ford et al., 2020). Diet has emerged as a critical modifiable factor in IBS management, influencing symptom severity and gut microbiota composition. Up to 84% of IBS patients report symptom exacerbation after meals, particularly following consumption of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) (Halmos et al., 2014). Consequently, dietary strategies, especially low-FODMAP diets, are increasingly recommended in clinical practice to alleviate IBS symptoms. The aim of this review is to explore the role of diet in the pathogenesis and management of IBS, examining current scientific evidence and highlighting emerging nutritional therapies.
The thyroid gland, a butterfly-shaped endocrine organ located at the base of the neck, plays a central role in regulating metabolic processes, growth, and development. Its optimal function is vital for physiological homeostasis, and disruptions can lead to significant clinical conditions.
2.1 Thyroid Gland Function and Hormone Regulation
The thyroid gland synthesizes two main hormones: thyroxine (T4) and triiodothyronine (T3), both of which are critical regulators of metabolism. The secretion of these hormones is tightly regulated by the hypothalamic-pituitary-thyroid (HPT) axis. Thyrotropin-releasing hormone (TRH) from the hypothalamus stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH), which in turn prompts the thyroid gland to produce T3 and T4 (Brent, 2012).
Approximately 80% of the hormone released by the thyroid is T4, which is later converted to the more active T3 in peripheral tissues. Feedback inhibition from circulating T3 and T4 levels helps maintain hormonal balance. Disruption in this axis, whether at the level of the hypothalamus, pituitary, or thyroid, can result in hypo- or hyperthyroidism (Yen, 2001).
2.2 Impact of Lifestyle Factors on Endocrine Function
Stress and the HPA Axis: Chronic stress activates the hypothalamic-pituitary-adrenal (HPA) axis, elevating cortisol levels, which can suppress TSH secretion and hinder peripheral conversion of T4 to T3. Long-term stress is associated with altered thyroid hormone levels and may precipitate autoimmune thyroid conditions (Peters et al., 2017).
Sleep and Circadian Rhythm: Disrupted circadian rhythms can influence the pulsatile release of TSH. Studies show that night-shift workers exhibit altered thyroid profiles, often displaying elevated TSH and reduced T3 levels (Srinivasan et al., 2019).
Physical Activity and Metabolism: Moderate exercise enhances thyroid function, promoting T3 production and metabolic efficiency. Conversely, excessive exercise or energy restriction can lower T3 levels, mimicking hypothyroidism (Hackney et al., 2012).
| Lifestyle Factor | Mechanism of Influence | Outcome on Thyroid Hormones |
| Chronic Stress | Increased cortisol suppresses TSH | Lower T3, potential for hypothyroidism |
| Sleep Disruption | Alters TSH secretion patterns | Elevated TSH, reduced T3 |
| Exercise | Moderate enhances T3; excess reduces it | Variable T3 levels |
Table 1: Lifestyle Factors Influencing Thyroid Function
2.3 Overview of Common Thyroid Disorders
Hypothyroidism: Characterized by insufficient thyroid hormone production, it can result from iodine deficiency, autoimmune destruction (Hashimoto’s thyroiditis), or post-surgical causes. Symptoms include fatigue, weight gain, cold intolerance, and depression. Hashimoto’s is the most common cause in developed nations and is marked by elevated TSH and low free T4, along with thyroid peroxidase (TPO) antibodies (Vanderpump, 2011).
Hyperthyroidism: Excess thyroid hormone production leads to symptoms like weight loss, anxiety, tachycardia, and heat intolerance. Graves’ disease is the predominant autoimmune etiology, identifiable by TSH receptor antibodies (TRAb), suppressed TSH, and elevated T3 and T4 (Smith & Hegedüs, 2016).
Thyroid Nodules and Cancer: Nodules are prevalent, detected in up to 50% of the population via ultrasound. Most are benign, but a small fraction may harbor malignancy. Papillary thyroid carcinoma is the most common form, with excellent prognosis when detected early (Haugen et al., 2016).
| Disorder | Key Features | Diagnostic Markers |
| Hypothyroidism | Fatigue, weight gain, cold sensitivity | ↑ TSH, ↓ T4, ↑ TPO antibodies |
| Hyperthyroidism | Weight loss, anxiety, heat intolerance | ↓ TSH, ↑ T3/T4, ↑ TRAb |
| Thyroid Nodules/Cancer | Palpable mass, voice changes, dysphagia | Ultrasound, FNA, ↑ Thyroglobulin |
Table 2: Common Thyroid Disorders at a Glance
The gastrointestinal symptoms of irritable bowel syndrome (IBS)—such as bloating, abdominal pain, diarrhea, and constipation—are frequently associated with specific dietary triggers. Patients often report a strong relationship between food intake and symptom exacerbation, with up to 84% noting that certain foods provoke symptoms (Böhn et al., 2013).
3.1 High-FODMAP Foods FODMAPs (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) are short-chain carbohydrates poorly absorbed in the small intestine. They undergo rapid fermentation by colonic bacteria, producing gas and drawing water into the gut, leading to distension and discomfort (Halmos et al., 2015).
3.2 Fatty Foods Dietary fats delay gastric emptying and enhance colonic contractions, particularly in IBS-D patients. High-fat meals exacerbate symptoms like bloating and urgency due to hypersensitivity of the gastrointestinal tract (Simrén et al., 2007).
3.3 Gluten and Wheat Sensitivity Many IBS patients without celiac disease report symptom improvement on a gluten-free diet. Non-celiac gluten sensitivity may involve immune activation or altered gut permeability. However, recent
studies suggest that fructus in wheat may be the true culprits rather than gluten itself (Biesiekierski et al., 2013).
3.4 Caffeine and Alcohol Caffeine stimulates gastric acid and colonic motility, aggravating diarrhea in sensitive individuals. Alcohol, particularly beer and wine, can irritate the gut lining and disturb motility, especially in combination with other triggers (Rao et al., 2014).
3.5 Spicy Foods Capsaicin, the active component in spicy foods, activates TRPV1 receptors involved in pain transmission. Frequent intake may increase visceral hypersensitivity and exacerbate abdominal discomfort (Yazdanpanah et al., 2021).
3.6 Artificial Sweeteners Polyols such as sorbitol, mannitol, and xylitol are poorly absorbed and fermented in the colon, contributing to bloating, flatulence, and diarrhea. These are especially problematic in sugar-free gums and diet beverages (Tuck et al., 2014).
3.7 Fiber Type and Quantity Fiber have a dual role. Soluble fiber (e.g., psyllium) improves stool consistency and reduces symptoms. In contrast, insoluble fiber (e.g., wheat bran) may worsen bloating and discomfort due to increased mechanical irritation (Moayyedi et al., 2014).
| Dietary Component | Mechanism of Action | Symptom Pattern | Reference |
| High-FODMAP foods | Fermentation and osmotic effects | Bloating, diarrhea, pain | Halmos et al., 2015 |
| Fatty foods | Increased gut motility | Urgency, bloating | Simrén et al., 2007 |
| Gluten/Wheat | Immune activation, gut permeability | Discomfort, bloating | Biesiekierski et al., 2013 |
| Caffeine and alcohol | Motility stimulation, mucosal irritation | Diarrhea, urgency | Rao et al., 2014 |
| Spicy foods | TRPV1 receptor activation | Pain, burning | Yazdanpanah et al., 2021 |
| Artificial sweeteners | Poor absorption, fermentation | Bloating, gas, diarrhea | Tuck et al., 2014 |
| Insoluble fiber | Mechanical irritation | Bloating, discomfort | Moayyedi et al., 2014 |
Table 3: Common Dietary Triggers in IBS
4.1 Low FODMAP Diet 4.1.1 Mechanism of Action
This diet reduces intake of poorly absorbed fermentable carbohydrates, thereby minimizing luminal distension and associated symptoms.
4.1.2 Phases
4.1.3 Clinical Evidence and Efficacy A randomized controlled trial by Staudacher et al. (2017) showed that 76% of patients reported symptom relief with a low-FODMAP diet.
4.1.4 Limitations and Risks Potential risks include reduced prebiotic fiber intake and altered gut microbiota composition. Dietitian supervision is recommended. 4.2 Gluten-Free Diet 4.2.1 Non-Celiac Gluten Sensitivity (NCGS) Some IBS patients show gluten-responsive symptoms despite negative celiac tests.
4.2.2 Efficacy Biesiekierski et al. (2013) found symptom improvement in up to 50% of IBS patients on a gluten-free diet, though fructans may be responsible for symptoms in many cases.
4.2.3 Controversies Distinguishing between gluten sensitivity and FODMAP intolerance is challenging due to overlapping content in wheat-containing foods.
4.3 Fiber Modulation
4.3.1 Soluble Fiber Psyllium has been shown to improve symptoms in IBS-C and IBS-M. Moayyedi et al. (2014) observed a significant reduction in global IBS symptoms with psyllium supplementation.
4.3.2 Insoluble Fiber Wheat bran may worsen symptoms due to its roughage effect and limited fermentability.
4.3.3 Guidelines ACG recommends soluble fiber as first-line treatment, while insoluble fiber is generally discouraged.
4.4 Lactose and Fructose Restriction
4.4.1 Prevalence of Intolerance Lactose and fructose malabsorption are reported in 20–40% of IBS patients (Misselwitz et al., 2013).
4.4.2 Diagnostic Strategies Hydrogen breath testing aids diagnosis, followed by individualized dietary restriction.
| Intervention | Response Rate | Key Findings | Reference |
| Low FODMAP Diet | ~76% | Significant symptom relief | Staudacher et al., 2017 |
| Gluten-Free Diet | 30–50% | Useful in NCGS patients | Biesiekierski et al., 2013 |
| Psyllium (Soluble Fiber) | ~50% | Improves stool form and consistency | Moayyedi et al., 2014 |
| Lactose/Fructose Restr. | 20–40% | Effective with confirmed intolerance | Misselwitz et al., 2013 |
Table 4: Efficacy of Dietary Interventions in IBS
A growing body of evidence supports novel dietary strategies for managing IBS beyond the traditional low-FODMAP and fiber-modulated diets. These include probiotics, prebiotics, peppermint oil, polyphenols, and low-histamine diets—all of which offer potential in reducing symptoms by targeting the microbiome, inflammation, gut motility, or visceral sensitivity.
5.1 Probiotics and Prebiotics
5.1.1 Specific Strains Clinical trials suggest that specific strains of Bifidobacterium and Lactobacillus offer symptom relief in IBS patients. Bifidobacterium infantis 35624 and Lactobacillus plantarum 299v are among the most studied, with evidence showing improvement in bloating, pain, and stool regularity (Whorwell et al., 2006; Nobaek et al., 2000).
5.1.2 Mechanisms and Clinical Trials Probiotics modulate intestinal barrier function, produce short-chain fatty acids, reduce mucosal inflammation, and alter the gut-brain axis. A meta-analysis reported that multi-strain probiotics reduced global IBS symptoms in 21–75% of participants across studies (Ford et al., 2018). Prebiotics like galacto-oligosaccharides (GOS) promote beneficial microbial growth but may initially cause bloating. Emerging synbiotics—combinations of pro- and prebiotics—are under evaluation for synergistic effects (Wilson et al., 2020).
5.2 Peppermint Oil
5.2.1 Antispasmodic Properties Peppermint oil contains menthol, a calcium channel blocker that reduces smooth muscle contraction in the gastrointestinal tract. This makes it a potent natural antispasmodic.
5.2.2 Clinical Efficacy and Dosage Multiple randomized controlled trials confirm its efficacy. A pooled analysis showed that enteric-coated peppermint oil capsules significantly reduced IBS symptoms in 44–79% of patients (Cash et al., 2016). Typical dosage is 180–225 mg, taken up to three times daily before meals.
5.3 Polyphenols and Anti-Inflammatory Diets
5.3.1 Role in Gut Barrier Integrity Polyphenols such as curcumin (turmeric), epigallocatechin gallate (EGCG, green tea), and anthocyanins (berries) improve mucosal barrier integrity, reduce oxidative stress, and modulate gut microbial composition (Cardona et al., 2013).
5.3.2 Sources and Dietary Patterns Anti-inflammatory diets rich in plant polyphenols show promise. For example, the Mediterranean diet, abundant in polyphenol-rich foods, has been associated with reduced IBS severity scores (Papada et al., 2018).
5.4 Low-Histamine Diet and Mast Cell Modulation
5.4.1 Emerging Evidence Some IBS patients exhibit mast cell activation and elevated histamine levels in gut mucosa. Histamine-rich foods (e.g., fermented foods, alcohol, aged cheese) may worsen symptoms (Theoharides et al., 2015). 5.4.2 Practical Implications Low-histamine diets may benefit a subset of IBS sufferers. However, more clinical trials are needed. A trial by Schnedl et al. (2021) reported significant symptom reduction in patients adhering to low-histamine protocols for four weeks.
| Strategy | Active Component | Reported Benefit | References |
| Probiotics | Bifidobacterium, Lactobacillus | Pain, bloating, stool form | Whorwell et al., 2006; Ford, 2018 |
| Prebiotics | GOS, FOS | Microbiota modulation | Wilson et al., 2020 |
| Peppermint Oil | Menthol | Antispasmodic, pain relief | Cash et al., 2016 |
| Polyphenols | Curcumin, EGCG, anthocyanins | Anti-inflammatory | Cardona et al., 2013 |
| Low-Histamine Diet | Reduced histamine load | Reduced urgency, pain | Schnedl et al., 2021 |
Table 5: Functional Foods and IBS - Evidence Overview
Emerging tools like nutrigenomics allow a more tailored dietary approach. Genetic polymorphisms (e.g., in the FUT2 gene affecting microbiota) may predict dietary responsiveness. Although promising, these methods are still under validation (Mills et al., 2019). Food sensitivity tests (e.g., IgG, MRT) remain controversial due to limited reproducibility and lack of robust evidence. Despite this, some patients report subjective improvements with IgG-guided elimination diets (Atkinson et al., 2004). Personalized elimination diets, guided by symptom diaries and professional support, remain the gold standard. Registered dietitians play a key role in ensuring nutritional adequacy and helping patients navigate complex dietary regimens.
7. Lifestyle Integration with Diet
Managing IBS requires a holistic approach. Chronic stress influences gut function via the HPA axis and vagal tone. CBT and gut-directed hypnotherapy can improve IBS outcomes by modifying cognitive and emotional responses to symptoms (Laird et al., 2016). Physical activity improves gut motility and reduces stress-related symptom flare-ups. Regular aerobic exercise has shown to improve symptoms in 60% of patients in RCTs (Johannesson et al., 2015). Sleep quality correlates with symptom severity. Sleep deprivation can worsen pain perception and gut inflammation (Jarrett et al., 2008). Sleep hygiene practices form a supportive pillar in IBS care.
8. Clinical Guidelines and Consensus Statements
| Organization | Dietary Strategy Endorsed | Notable Notes |
| ACG (2021) | Low-FODMAP, probiotics, peppermint oil | Avoid restrictive diets long-term |
| NICE (2017) | Food diaries, fiber, low-FODMAP | Personalized support recommended |
| WGO | Evidence-based local diets | Culturally adaptable dietary plans |
| Rome IV | Individualized management | Emphasizes gut-brain axis and diet linkage |
Table 6: Clinical Recommendations by Key Organizations
The landscape of dietary management in irritable bowel syndrome (IBS) has shifted from generalized advice to highly individualized, scientifically supported interventions. Key findings from the literature reveal that diet plays a pivotal role not only in symptom modulation but also in influencing the core pathophysiological mechanisms of IBS, including microbial composition, immune activation, motility, and visceral sensitivity. The low FODMAP diet currently holds the strongest evidence base, with substantial clinical benefits for a majority of patients. However, it is not without its limitations, particularly concerning long-term sustainability and potential effects on gut microbiota diversity. Other dietary approaches, such as gluten-free and fiber-modulated diets, show benefit in selected individuals. Additionally, the use of probiotics, peppermint oil, polyphenols, and low-histamine diets highlights the expanding frontier of functional food-based therapy in IBS management. Personalized nutrition, supported by symptom tracking and guided by dietitians, remains the cornerstone of sustainable outcomes. While tools such as food sensitivity testing and nutrigenomic profiling offer future promise, their clinical utility is still evolving. Moreover, the integration of dietary strategies with lifestyle modifications—especially stress reduction, improved sleep, and psychological support—emphasizes the need for a multidisciplinary model of care. Clinical guidelines from major gastrointestinal organizations increasingly endorse dietary therapies as a core component of IBS management. Moving forward, robust clinical trials, long-term safety assessments, and microbiome-based diagnostics will be essential in refining therapeutic strategies. Ultimately, a personalized, evidence-informed, and patient-centered approach remains the optimal pathway for effective and compassionate IBS care.
Funding: None
Conflict of interest: None
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Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
