Research Article | DOI: https://doi.org/10.31579/2690-8794/331
1 Department of Internal Medicine I, Cancer Research, Medical University of Vienna, Vienna, Austria.
2 Department of Internal Medicine II, Division of Pulmonary Medicine, Medical University of Vienna, Medical School, Vienna, Austria.
3 Pulmonary Cell Research, Department Biomedicine, University Hospital Basel, Switzerland.
4 Ordensklinikum Linz Elisabethinen, Dept. Pneumology, Linz, Austria.
† In Memoriam
*Corresponding Author: Wilhelm Mosgoeller. MD, Medical University of Vienna, Borschkegasse 8a A-1090 Vienna, Austria.
Citation: Wilhelm Mosgoeller, Ventzislav Petkov, Bernhard Burian, Michael Roth, Christopher Lambers, et al, (2026), Chronic Obstructive Pulmonary Disease: Effective treatment with Vasoactive Intestinal Peptide (VIP), Clinical Medical Reviews and Reports, 8(8); DOI:10.31579/2690-8794/331
Copyright: © 2026, Wilhelm Mosgoeller. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 29 June 2026 | Accepted: 20 July 2026 | Published: 18 August 2026
Keywords: COPD; chronic inflammation; lung biopsy; vasoactive intestinal peptide
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and chronic inflammation including the increased expression of Interleukin 8 (IL-8) and tumor necrosis factor (TNF, previously known as tumor necrosis factor alpha). We describe a novel physiological role of the Vasoactive Intestinal Peptide (VIP) and its therapeutical potential in COPD. Our rationale is based on a deficiency of VIP in the serum of COPD patients.
Objectives: The aim of this study was to evaluate a new therapy of COPD.
Methods: Molecular biological and immunochemical methods were used to characterize the action of VIP at the cellular level. A double-blind, placebo-controlled, randomized study was undertaken to evaluate the potential clinical role of VIP in COPD.
Measurements and Main Results: VIP treatment downregulates the expression of IL-8 and TNF that coincides with the inhibition of transcription factors AP-1, Stat3 and NF-κB. VIP treatment improves lung function and prognostic parameters of COPD. In a clinical study with 34 COPD patients, forced expiratory volume in 1s significantly improved with VIP by 0.107l and vital capacity by 0.155l compared with placebo (P<0.01).
According to the short 36-item questionnaire and to St. George’s respiratory questionnaire, the improvement in quality of life was greater with VIP (4.08; -5.25) than with placebo (0.20; 1.72). Similarly, exercise capacity increased by 24.1 m (P<0.05) in the VIP group as compared to placebo (-8.6m) using the six minutes walking test.
Conclusions: This study is the first to show the immunoregulatory effect of VIP in COPD patients, and supports the notion of inhaled VIP as an attractive future therapy to dampen exaggerated immune responses in chronic lung disorders. Our data provide “proof of concept” for further investigation of VIP and its potential role in COPD.
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, causing 3.4 million deaths in 2023, approximately 6% of all global deaths. COPD is the overall term for a group of chronic conditions that are associated with the obstruction of lungs' airways, usually referring to the following disorders: Chronic bronchitis, Bronchiectasis and Emphysema. The most common symptoms of COPD include shortness of breath, chronic coughing, chest tightness, greater effort to breathe, increased mucus production and frequent clearing of the throat.
The mainstay medication consists of anticholinergic and beta-adrenergic bronchodilators. Addition of corticosteroid therapy may enhance bronchodilator responses and reduce exacerbations. An important feature of COPD is the ongoing chronic inflammatory process in the airways as indicated by the current GOLD (Global Initiative for Chronic Obstructive Lung Disease) definition. Neutrophil granulocytes, macrophages, and T-cells are involved in the cellular mechanisms of inflammation in COPD and are associated with an increased release of pro- and anti-inflammatory mediators such as e.g. IL-8 and TNF, a protease-antiprotease imbalance, oxidative stress, viral infections, and a genetic predisposition (e.g. Alpha-1 Antitrypsin Deficiency) [8, 13, 14, 23, 26, 30, 34, 35, 36, 39, 40, 42, 43, 45, 46].
We were looking for a drug that provides the combined potential advantages of lowering inflammation of the lung tissues, lowering pulmonary arterial pressure, reducing bronchoconstriction, improving blood circulation to the heart and lung, enhancing healing of bronchial epithelial cells, and improving the cardiovascular deficiencies in COPD.
Vasoactive Intestinal Peptide (VIP) is an abundant biologically active peptide endogenous in humans as well as in other mammalian species. It is produced by neurons in the peripheral and central nervous system, by endocrine cells, T-lymphocytes, and B-lymphocytes. This natural peptide is one of the signal molecules of the neuroendocrine-immune network comprising vasodilating, anti-proliferative, anti-inflammatory, and immune-regulatory features. Its predominant biological activity is performed in the lungs, and a vast body of experimental, pharmacological as well as clinical evidence suggests VIP to be an attractive candidate for the treatment of COPD [3, 9, 11, 12, 16, 18, 53, 54].
VIP’s biological effects are mediated through the drug’s pharmacological activity on VPAC1, VPAC2, and PAC-1 receptors (7-membrane-spanning G-protein coupled receptors) at the transcriptional level via modulation of NF-κB, AP-1, Stat3, and cAMP responsive element (CRE)-binding, or ets-2 complexes in target cells [5, 12, 50]. The presence of VPAC receptors has been shown on airway epithelial cells, on macrophages surrounding capillaries and in the subintima of pulmonary arteries and veins [5, 50]. Stimulation of VPAC receptors activates pathways which have been shown to mediate the action of prostacyclins, nitric oxide, and phosphodiestrase inhibitors [19, 52].
We and others [21], noted that in patients with the lowest VIP serum levels, a more rapid formation of COPD was observed. The smallest values of VIP and the greatest changes in cardiopulmonary parameters were found in the cohort of COPD-patients with concomitant hypertension [21].
As a preferred route of administration, mouth inhalation was chosen. Previously we showed that after intravenous administration VIP is rapidly distributed to the lungs, where it gets completely metabolized into biologically inactive parts by neutral endopeptidase, mast cell tryptase and mast cell chymase [37]. In general, inhaled drugs intended for lungs act quickly, minimize undesired negative side effects, avoid the hepatic first-pass metabolism, and act locally. As the size variability among adult lungs is smaller than the overall body size variability, the dosing reliability is also improved when inhaling.
We and others have shown that inhaled VIP decreases pulmonary artery pressure and pulmonary vascular resistance in patients with pulmonary hypertension, and exerts immunoregulatory and anti-inflammatory effects in sarcoidosis [37, 59, 60]. However, the exact mode of action of VIP is not yet completely understood.
After producing cigarette smoke-induced COPD in a mouse model, and after treatment of those mice with VIP, the levels of antioxidant-related factors (malondialdehyde (MDA) and superoxide dismutase (SOD), fibrotic factors (hydroxyproline (HP) and TGF-β), pro-inflammatory cytokines (TNF, IL-1β, and IL-6), and inflammation were diminished and controlled by VIP. The anti-inflammatory, anti-fibrotic, and anti-oxidant properties of VIP may be effective therapy in COPD [6].
Furthermore, the anti-inflammatory properties of IK312532 respirable powder (RP) - a stabilized VIP derivative - were characterized in an asthma/COPD-like animal model. Marked inflammatory events in the lung were observed after OVA-RP challenge in rats as evidenced by significant increase of inflammatory biomarkers such as eosinophil peroxidase (EPO), myeloperoxidase (MPO) and lactate dehydrogenase (LDH). However, intratracheal administration of IK312532-RP led to significant attenuation of plasma EPO, MPO and LDH activities, as well as significant reduction of recruited inflammatory cells in bronchoalveolar lavage fluid, especially macrophages and eosinophils. Thus, inhalable powder formulation of IK312532 exerts its anti-inflammatory activity by suppressing granulocyte recruitment to the lung and epithelial hyperplasia, followed by the reduction of cytotoxic peroxidases [29].
Alveolar macrophages (AM) are key players in the pathogenesis of COPD and contribute to the severity and progression of the disease. AM from COPD patients show a strong VPAC1 expression which exceeds VPAC2 expression. A similar receptor expression pattern was also observed in lipopolysaccharide (LPS)-activated monocyte-derived macrophages (MDM) from healthy volunteers and COPD patients. VIP has been shown to down-regulate IL-8 secretion significantly in MDM after LPS stimulation. The response to VIP was similar in MDM from COPD patients and healthy volunteers. Our previous results indicate that VPAC1 up-regulation in macrophages is a common mechanism in response to acute and chronic pro-inflammatory stimuli. Although VPAC1 up-regulation is dominant, both receptor subtypes are necessary for optimal anti-inflammatory signaling. The high VPAC1 expression in AM may reflect the chronic pro-inflammatory environment found in the lung of COPD patients. Treatment with VIP may help to decrease the chronic inflammation in the lung of COPD patients [4].
In view of what is known about VIP we correlated the serum concentration of VIP with the disease state of COPD and examined some of its effects on the transcription and expression of two essential cytokines in COPD both in vitro and in vivo. Moreover, we identified the essential therapeutic role of VIP in COPD patients in a small double-blind placebo controlled clinical trial.
VIP serum concentration
VIP was determined by radioimmunoassay (123I-VIP RIA) in healthy controls n=48, COPD patients (GOLD II) n=12, COPD (GOLD III) n=16, COPD (GOLD IV) n=14 [37].
Cell isolation and characterization
We cultured lung fibroblasts and bronchial smooth muscle cells (BSMC). All primary cell lines were isolated from resected lung biopsies of COPD patients undergoing therapeutic surgery for other reasons, after agreement of the local ethical committee and written informed consent of the patients. Human lung fibroblasts were isolated from bronchial biopsies and cultured as described earlier [48].
BSMC were isolated and grown from resected bronchi of the above patients as previously described, and BSMC were characterized by positive immuno-staining for a-smooth muscle actin and calponin [20].
Cell treatment
Sub-confluent (80%) cell cultures were serum deprived for 24 hours in medium without serum. The cells were then pre-incubated for 30 minutes with VIP (10-6 M - 10-12 M) and then stimulated with the respective growth medium with VIP added at various concentrations.
Total RNA extraction and RT-PCR and Real-Time RCR-analysis mRNA was obtained from biopsy by TRIZOL using standard protocols and was directly transcribed into c-DNA using a reverse transcription kit (Advantage RT-for-PCR Kit) according to instructions of the manufacturer and was stored at minus 80°C until analysis.
Relative mRNA expression was determined by the ACT method as previously described [25]. The ACT numbers indicate the difference in amplification cycles between target and housekeeping (18s) gene.
Immunoblotting
Nuclear/cytosolic proteins were prepared with NE-PER kit according to the manufacturer protocol. Protein extracts were then size- fractionated by SDS-PAGE electrophoresis and transferred onto nitrocellulose membranes as described previously [41] and protein transfer was confirmed by Ponceau staining.
Electrophoretic mobility shift assay
Nuclear protein extracts were prepared after 30 min by NE-PER extraction kit and the protein content was determined by Bradford assay. The oligonucleotide was labeled using [Y33P]-dATP (3,000 Ci/mmol) and a T4 polynucleotide kinase. Samples were size fractionated by electrophoresis in a non-denaturing 4% polyacrylamide gel [41].
Cytokine enzyme linked immuno sorbent assay (ELISA)
Cytokines (IL-8 and TNF) were quantified in cell culture medium samples collected at below indicated time points form the same cell culture vessel for each cell line. Commercially available ELISA for IL-8, and TNF were used following the instructions of the manufacturer.
Immunohistochemistry for IL-8 and TNF
Rehydrated paraffin sections were stained for IL-8 and TNF according to the procedures as described previously [37].
This parallel-group, double-blind, placebo-controlled, randomized, monocenter study was undertaken at the Medical University of Vienna, Austria. The clinical study was clared by the positive ethics approval from the Ethics Committee of the Medical University of Vienna, reference number 168/2003 and announced by the ClinicalTrials.gov ID NCT00464932.
The randomization sequence was generated by Rancode in a blinded manner; no person involved in data analysis had knowledge of the randomization sequence. Treatment was assigned by the investigators with sequential study numbers according to a block randomization list in ratios of 1:1 (VIP:placebo). VIP was synthetically manufactured. It was applied by a 10-minute inhalation (50 μg VIP diluted in 3 ml of 0.9% NaCl solution), four-times daily, using a mesh nebulizer providing an average mass median aerodynamic diameter (MMAD) VIP particle size of 3 μm to allow for a deep-lung deposition of the drug.
The trial substance was an “add-on” treatment; concomitant respiratory medications allowed throughout the study were short- and long-acting ß-mimetics, long-acting anticholinergics, inhaled corticosteroids and theophyllines at a constant daily dose. Patients could receive a course of oral corticosteroids for treatment of exacerbations during the treatment phase.
The primary outcome variables were exercise capacity measured using the six-minute walking test (6MWT), Borg dyspnea score and health-related quality of life (HRQL) indicators measured by means of the short 36-item questionnaire (SF-36) developed for medical outcomes studies and St. George’s respiratory questionnaire (SGRQ). Findings were calculated as the change from base-line to the exit.
Secondary outcome measures were change from base-line in post-bronchodilator FEV1, post-bronchodilator inspiratory vital capacity (IVC) and number of COPD exacerbations. We recorded adverse events as part of the safety assessment using standard International Conference on Harmonisation Guidelines for Good Clinical Practice (ICH-GCP). Pulmonary function tests were done at rest before treatment onset (base-line), and at week 12 of the treatment period as recommended by the American Thoracic Society [44].
All patients were recruited from an outpatient setting. Inclusion criteria were: history of COPD >12 months, as defined by Global Initiative for chronic Obstructive Lung Disease (GOLD) [35], 40 years or older; current smoker or ex-smoker with a smoking history of >10 pack-years; post-bronchodilator FEVi of 20-80% of predicted value; post-bronchodilator IVC ratio >70%; reversibility of FEV1 of Less-than sign12 % and/or Less-than sign200 ml after 400 pg inhaled salbutamol; and stable clinical disease status with no change in COPD treatment during the last 4 weeks. Patients were excluded from study enrolment if they were diagnosed with asthma or other relevant lung diseases (e.g. lung cancer, bronchiectasis); if they had a recent exacerbation that required a course of systemic corticosteroids, emergency room treatment, or hospital admission within 4 weeks before the randomization. Patients were also excluded from study enrolment if they had a respiratory tract infection within 4 weeks before the randomization or known alpha-1-antitrypsin deficiency. The study was approved by the local ethical committee and each patient gave informed consent to participate in the trial and investigations according to institutional guidelines and to the Helsinki principles.
After completion of the case report forms, data capture was done with the double entry technique. Thereafter, the data were analyzed descriptively using the SPSS (IBM Statistics V.8) software package.
For analysis of the recruitment allocation, we compared means and standard deviation of relevant parameters (see table 1) of the patient groups.
Data analysis was done with SPSS, Version 12. Baseline demographic, lung function variables, quality of life are presented as means ± SD. Variables measured at baseline and during VIP inhalation in the same patients were compared by Wilcoxon signed rank test (two-sided) for paired data. P values below 0.05 were considered statistically significant.
VIP serum levels were compared between the groups by means of the Students T-test, and by the Wilcoxon signed rank test when the data did not allow for computing the mean and standard deviations.
We determined the serum concentration of VIP in humans by radioimmunoassay. As shown in Figure 1, patients with COPD show significantly reduced levels of VIP as compared to controls whereby the VIP levels correlated inversely with disease stage.
Figure 1: VIP serum concentration as determined by RIA of healthy controls and COPD patients. Healthy controls n=48, COPD (GOLD II) n=12, COPD (GOLD III) n=16, COPD (GOLD IV) n=14.
BSMC and fibroblasts obtained from COPD patients were stimulated with fetal calf serum (5%) following, the release of TNF and IL-8 was determined. Serum induced a significant release of both cytokines (Figure 2). This effect was counterbalanced by VIP as a function of concentration (IC50, TNF 8.5 x 10-9 M and that for IL-8 2.6 x 10-9 M).
BSMC (n = 8) TNF
Bronchial smooth muscle cells did not produce significant levels of TNF within 24 hours.
Figure 2: Inhibitory effect of VIP on 5?S-stimulated IL-8 and TNF secretion by human lung BSMC and fibroblasts (A) IL-8 in BSMC (B) in fibroblasts (C) TNF in fibroblasts** indicates p Less-than sign 0.001, * indicates p Less-than sign 0.05 student’s paired t-test compared to 5?S. Bars represent the mean ± S.E.M. of three independent experiments performed in four individual primary human BSMC lines or fibroblasts. BSMC did not secrete TNF under the described cell culture conditions within 24 hours.
Bronchial biopsies were used for examining the mRNA transcription and protein expression of the cytokines before and following the inhalation of VIP. The biopsies were taken from 6 patients at baseline and after 3 months of VIP inhalation (50 μg, 4 x daily). Compared to 3 healthy controls RT-PCR results of biopsies obtained from COPD patients showed a increased transcription of IL-8 and TNF before therapy at baseline. In contrast, as depicted in Figure 3, the transcription of both genes was down-regulated in the tissue samples from COPD patients following treatment with VIP.
Figure 3: Transcription of IL-8 and TNF genes in bronchial biopsies before and after inhalation of VIP in COPD in vivo. Quantitative analysis of gene expression of IL-8 (A) and TNF (B) in human lungs. Total RNA was isolated from lung biopsies collected from patients before and after 3 months VIP treatment and from control subjects; mRNA levels of 18s were used for normalization. Data are expressed as mean±SD (n=6). P Less-than sign 0.01 in treated versus untreated patients.
The expression of the two genes in biopsies of lung tissue by immuno-histochemistry demonstrated a similar pattern. While before the inhalation of VIP the expression of the two genes was more pronounced in tissue sections of COPD patients, following treatment the signal declined (Figure 4).
Figure 4: Expression of IL-8 and TNF in bronchial biopsies before and after inhalation of VIP in COPD. Immunohistochemical staining of IL-8 (A and B) and TNF (C and D) in lung tissue from COPD patients before (A and C) and after (B and D) 3 months VIP therapy. Bar ~ 200µm.
TNF activated the DNA binding of the three transcription factors AP-1, Stat3 and NF-κB with individual kinetics as assessed by DNA mobility shift assay, and which was confirmed by the transfer of the respective proteins from the cytosol into the nucleus by immuno-blot analysis (Figure 5). When pre-incubated with VIP (10-6 M - 10-12 M) for 30 minutes, the DNA binding of AP-1 and Stat3 was significantly reduced in a dose-dependent manner (Figure 5A, 5.C) while that of NF-κB was only marginally reduced (Figure 5E). A similar reducing effect of VIP was observed on the protein translocation of the respective transcription factors as shown for AP-1 in figure 5B, for Stat3 in figure 5D and for NF-κB in figure 5F. Equal protein loading was confirmed by α-tubulin (loading).
Figure 5: The effect of VIP on TNF induced transcription factor activity in primary BSMC and fibroblasts. A) A representative EMSA of the dose-dependent inhibition of TNF stimulated AP-1 to DNA binding by increasing concentrations of VIP. Similar results were obtained in two additional cell lines. B) A representative immuno-blot of the kinetic of TNF activated AP-1 translocation from the cytosol (cyt) into the nucleus (nuc) and its inhibition by VIP. Similar results were obtained in a second cell line. C) a representative EMSA of the dose- dependent inhibition of TNF stimulated Stat3 to DNA binding by increasing concentrations of VIP. Similar results were obtained in two additional cell lines. D) A representative immuno- blot of the kinetic of TNF activated Stat3 nuclear translocation and its inhibition by VIP. Similar results were obtained in a second cell line. E) a representative EMSA of the effect of VIP on TNF stimulated NF-κB to DNA binding. Similar results were obtained in two additional cell lines. F) A representative immuno-blot of the effect of VIP on TNF activated NF-κB nuclear translocation. Similar results were obtained in a second cell line.
VIP is released through inflammatory processes as evidenced by the finding that the serum VIP levels were significantly higher in COPD patients with acute exacerbations compared to stable COPD [27].
We found an inverse relationship between the serum concentration of VIP and the progression of COPD. VIP inhibited the release of IL-8 and TNF in parallel with the inhibition of transcription and expression of the two genes and downregulated the transcription factors AP-1 Stat3 and NF-κB. The inhalation of VIP resulted in a significant improvement of lung function parameters of COPD patients (GOLD l-IV), a better quality of life and exercise capacity and in lesser exacerbations without relevant side effects. How can the efficacy of VIP in COPD be interpreted?
Firstly, an inverse relationship between the level of expression of VIP receptor proteins and of the level of circulating VIP was previously observed in pulmonary arterial hypertension [37]. Similarly, VIP serum levels in COPD patients were significantly decreased versus normal subjects suggesting a lack of VIP contributing to the pathogenesis of COPD. Elevated levels of several pro-inflammatory cytokines and other mediators have been demonstrated in the lungs of patients with COPD [8,17]. For example, IL-8, adhesion molecule (ICAM-1), and TNF are present in inducted sputum [22], and their levels increased further during exacerbation [51]. The levels of TNF, IL-8 and metalloproteinase-9 (MMP-9) are elevated in bronchoalveolar lavage fluid from chronic smokers compared to non-smokers [24]. Blood levels of TNF, as well as of the soluble receptors for these cytokines, are two to three times higher in subjects with COPD than in the non-COPD population. Importantly, these levels correlate directly with the severity of airflow impairment [47, 13]. A recently performed study on gene expression profiles using serial analysis of gene expression and microarray analysis in lung biopsies of GOLD II smokers revealed a significantly increased expression of a number of genes encoding transcription factors or related proteins [31, 32]. Analogously, measurements of IL-8 and TNF mRNAs in bronchial biopsies of the COPD patients of our trial using real-time PCR demonstrated lower transcription after VIP treatment. Among its various immuno-modulatory properties, VIP was reported to down-regulate the biosynthesis of CXC- and CC-chemokines such as IL-8, ICAM-1, MMP-9, and TNF [11, 49]. Moreover, VIP inhibits the binding and activation of the transcription factor NF-κB to corresponding promoter sequences of genes encoding mediators of inflammation, such as early growth factors 2/3 [11]. Another transcription factor which has been implicated in COPD is Stat3 [15, 38] and the observation that VIP inhibits TNF induced Stat3 activation in cells, as shown in this study, isolated from COPD patients indicates that VIP has a broad anti-inflammatory action. In mouse as well as in human fibroblasts cigarette smoke, the prevalent cause of COPD, activated AP-1 which was involved in the regulation of redox system-dependent pro-inflammatory factors such as heme oxygenase [2, 24]. Furthermore, it was suggested that the inhibition of NF-κB and AP-1 could circumvent steroid insensitivity in chronic inflammatory diseases [1]. Since steroids are not very efficient in the therapy of COPD the inhibition of NF-κB and AP-1 would explain the significant clinical improvement in COPD which we report here.
The molecular basis for the observed reduction of acute exacerbations following VIP treatment is unclear. Although various immuno-modulatory properties may be involved, experimental evidence suggests that VIP promotes Th-2 type and reduces inflammatory Th-1 type responses [10] that may lead to reduced susceptibility against infections.
Secondly, the fact that none of the patients included in this study exhibited pulmonary hypertension excludes the known vasodilatory effect of VIP as relevant effective mechanism. VIP has been shown to stimulate the dilatation of bronchial rings in vitro (Greenberg et al. 1987). Moreover, VIP inhalation resulted in increased FEV1 in asthmatics [33]. Similarly, in our trial the daily dose of 200 pg VIP significantly increased post-bronchodilator FEVi and that of IVC throughout the 12-week treatment period (P<0>
Thirdly, chronic inflammation is generally regarded as a central mechanism in the pathogenesis of COPD [17]. Analogously, VIP has been shown to inhibit the inflammatory processes associated with COPD, and bronchial biopsy specimens of COPD patients (GOLD 0) exhibited increased expression of VPAC1 and VPAC2 receptors [28]. Furthermore, mitochondrial dysfunction and the effects of severely reduced availability of the protein deacetylase sirtuin-1 (SIRT1) are evident in COPD patients. The reduced SIRT1 expression within cells is a result of severe oxidative stress. The effects of VIP in pneumoplegic solution were tested in isolated rat lungs. Rat lungs were isolated, flushed and stored for 24 hours in presence or absence of VIP in the restoration solution. Electron microscopy showed that lungs stored in VIP-containing solutions had significantly more normal shaped mitochondria, less mitochondrial edema, less distortion of mitochondrial cristae, thinner basal lamina, and less aggregation of nuclear chromatin than control solutions.
Treatment with VIP also reduced histopathological severity of colitis and cell death markers in a murine model, leading to partial recovery of inhibited mitochondrial respiratory complexes, altered mitochondrial membrane potential and lowered ATP generation.
Mice lacking VIP (VIP-KO mice) gene develop right ventricular hypertrophy, thickened pulmonary artery, perivascular inflammatory cell infiltrates in the lung, and exhibit airway hyperresponsiveness to the cholinergic agonist methacholine. Treatment of these mice with exogenous VIP attenuates both, the vascular remodeling and right ventricular remodeling. [55, 56, 57, 58, 61, 62, 63, 64].
The fact that the treatment of COPD is limited to only few therapeutic options indicates the need for research and product development of additional alternatives. The unique ability of VIP to improve cardiopulmonary circulation and lung function in COPD, and quality of life, and 6 MWD without relevant side effects suggests that it may become a new therapeutic option. Future studies on VIP and VIP analogues are therefore necessary to reveal its full potential for clinical use.
Our study is the first to report that the inhalation of VIP has clear immunoregulatory effects in COPD patients. VIP inhalation might be an attractive, new immunoregulatory treatment strategy without systemic immunosuppression and negative side effects. Inhaled VIP can act alone, or in combination with any other approved COPD treatment option, with excellent safety profile. Further multicentric controlled studies are needed to evaluate the clinical efficiency of this new treatment option in COPD.
Author’s Contributions
Wilhelm Mosgoeller, preclinical project design, histology, immunhistochemistry, Ventzislav Petkov, clinical study conceptualization, principal clinical investigator Bernhard Burian, patient recruitment and investigation, clinical study rollout Michael Roth, in vitro molecular laboratory studies, immunoblotting Christopher Lambers, in vitro cell isolation, sample administration Lutz-Henning Block, data review, manuscript writing, senior PI, Claudia Vonbank, clinical patient investigation and data administration
We are indebted to all participating physicians of the Department of Pulmonary Medicine of the Medical University of Vienna to their help in realizing this study.
Registration number for the clinical study:
ClinicalTrials.gov Identifier: NCT00464932
Scientific Knowledge on the Subject:
Molecular and clinical effects of the neuropeptide VIP in COPD.
What This Study Adds to the Field:
A new aspect of the role of Vasoactive Intestinal Peptide (VIP) in Chronic Obstructive Pulmonary Disease (COPD) and its therapeutical potential, when inhaled.
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International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
