Negative Appendectomy Rate and Its Correlation with Use of Radiology; a Clinical Audit of Our Department

Introduction; Appendectomy is the most common surgical emergency and negative appendectomy is a one of recognized consequence of appendectomy. Recently an increased use of radiology is seen in diagnosing appendicitis and it has significantly decreased the rate of negative appendectomy. Every effort should be made to establish an exact diagnosis. If, however, this is impossible and a suspicion of appendicitis exists, exploration is mandatory. It is far better to subject a moderate number of patients to a theoretically unnecessary operation than to let one patient suffer perforation. Aim; Recently we have seen an increased use of radiology in our department for diagnosing appendicitis. The idea of conducting this audit was to calculate our negative appendectomy rate by correlating it with use of radiology and to compare it with international figures and to set up guide lines for use of radiology in diagnosing appendicitis on basis of results of our audit . Methods; Records of all patients who underwent appendectomy in Dubai Hospital, UAE from jan 2018 to jan 2019 were retrospectively analyzed using electronic record system. Clinical diagnosis and radiological findings were compared with histopathology as gold standard for negative appendectomy rate. The sensitivity and specificity of different radiological procedures was calculated as well. Results; Total 165 patients underwent appendectomy in specified duration. Over all negative appendectomy rate was 17 % with male being 9.7 % and female rate 31% . CTSCAN was found to be 100% specific and 91.4 % sensitive in diagnosing appendicitis while clinical diagnosis was accurate in 88.5 % cases.


Introduction
Appendicitis is the most common cause of an acute surgical abdomen, with an estimated lifetime prevalence of 7-8 %. Despite advances in diagnosis and treatment, it is still associated with significant morbidity (10 %) and mortality (1-5 %) (1). This rapidly progressing inflammatory process requires prompt removal of the appendix to prevent lifethreatening complications such as ruptured appendix and peritonitis and hence accurate and quick diagnosis is important. Traditionally the diagnosis of acute appendicitis is based on clinical features and physical examination .Over the past two decades, the use of dedicated preoperative ultrasonography (US) and computed tomography (CT) techniques for the evaluation of patients clinically suspected of acute appendicitis has led to improved diagnostic accuracy (1) Negative appendectomy rate, a recognized consequence of appendectomy varies between 6% to 40% in the literature. The suggested acceptable rate of negative appendectomy is 20%.
This rate is considered acceptable to avoid missing cases of appendicitis and possible sequela of appendicitis such as perforation, peritonitis, access formation and sepsis, and also to avoid prolonged hospital stay and financial consequences (1).
However, it can further be reduced by utilizing combined clinical assessment with diagnostic modalities.
We did a retrospective audit for negative appendectomy rate of general surgery department Dubai Hospital, UAE for a duration of one year by correlating the clinical diagnosis of appendicitis with histopathology being gold standard. We also correlated histopathological diagnosis with radiological diagnosis and hence calculated specificity and sensitivity of different radiological procedures in diagnosing appendicitis. Medical records of all the patients were reviewed retrospectively using electronic medical records used in our hospital from jan 2018 to jan 2019.

Data Analysis:
All analysis will be conducted by using the Statistical package for social sciences (SPSS) version 24. p Value is used for changes in quantitative viable for significant changes and numbers and percentage are used for descriptive variables.

Results
Total 165 appendectomies were performed between Jan 2018 till Jan 2019.
Mean age was 23 years.
For sex data; 1. Negative appendectomy rate in male patients was 9.7% while in female patients it was 31 %.

Discussion
Several recent papers have cited a declining negative appendectomy rate( NAR) , including several large database studies and meta analyses with NARs as low as 6-8% and single institution studies with NARs as low as 1.7-7%, coinciding with the increased use of computed tomography (CT) and laparoscopy i . While CT is often credited with lowering the NAR, a definitive causal relationship has not been established and lingering questions about proper usage remain. Routine CT is unnecessary for male patients with clinical diagnosis of appendicitis. Mild appendicitis may resolve without surgery and CT may contribute to unnecessary surgery (2).
.Over the past two decades, the use of dedicated pre-operative ultrasonography (US) and computed tomography (CT) techniques for the evaluation of patients clinically suspected of acute appendicitis has led to improved diagnostic accuracy ii . In light of this, in 2010 the Dutch College of Surgeons introduced a guideline entitled ''diagnostics and treatment in acute appendicitis'' with recommendations concerning pre-operative imaging in the diagnosis and treatment of acute appendicitis. The guideline states that in every patient with clinically suspected acute appendicitis an ultrasonography or CT scan is advised to confirm diagnosis before surgery (3).
When compared with patients with appendicitis, negative appendectomy was associated with a significantly longer length of stay ( Our audit showed an overall negative appendectomy rate of 17 % while it is 9.7% in male and 31% in female patients. Imaging was used over all in 68.4% cases while 31.55 % cases had clinical diagnosis. CT SCAN was done in 63% cases while ultrasound was done in only 5.4 % cases.
Moreover our audit showed that the type of CT SCAN used was not consistent and following types of different CT scans were used CT kub 20/93 , 21.5% CT kub followed by ct with contrast 9/93 , 5.4% CT scan abdomen plain 12/93,7.2% CT scan abdomen with iv contrast 49/93,52.6% CT scan abdomen with iv and oral contrast 9/93,9.6% Our results show that Ct scan abdomen has 100% specificity in diagnosing appendicitis while sensitivity of Ct scan is 91.4 % at the same time clinical diagnosis alone without help of imaging diagnosed 88% cases of appendicitis.
We used imaging in all female patients and male patients above 40 years. Imaging was also used in patients where history was not clear or history was 3 days or more to rule out appendicular mass.
Clinical diagnosis was made on basis of history and Alvarado score.
The results on basis of this audit cannot be generalized as the number of patients are very small and there was no consistent guidelines for use of imaging (Ct scan /ultrasound abdomen) further more even the Ct scan abdomen was not done with one protocol some patients have plain some had with contrast so the results are biased The suggestion is as follows;

CT scan is better than us in diagnosing appendicitis.
Use of us should be restricted where CT scan is a contraindication as sensitivity and specificity is low and should be combined with clinical diagnosis.

Clinical diagnosis should be combined with use of CT scan whenever indicated as follows;
a. All female patients. Clinical and laboratory parameters not matching.
Complicated cases.
Also we agreed with our radiology department to go for ct scan abdomen with oral and IV contrast if needed for diagnosis of acute appendicitis, although nowadays FACT is used to diagnose but as for our institute most of radiologist agreed that in thin patients non contrast ct scan is not help full and can give false information.
Also as far as histopathology is concerned most of our colleagues said that it should be double checked with 2 histopathologist but keeping in mind the frequent cases of appendicitis coming to emergency and as a volume overload it is difficult to implement that outside research area.
On the basis of results of this audit local guide lines for us of CT SCAN abdomen are made for our department saying that appendicitis should be a clinical diagnosis and where there is doubt about the diagnosis ( conditions described above ) radiology help should be taken .Moreover all female patients should have radiology prior to subjecting any patient for appendectomy . Whenever CT SCAN is needed it should be done with both IV and oral contrast (although many people will not agree for it especially with advent of FACT, but we will be able to give an opinion after re-audit). Based on these implementation of these guidelines the department will recon duct the audit after 2 years and results will be evaluated again. Furthermore, another prospective research study can be conducted to look for sensitivity and specificity of CT SCAN in diagnosing acute appendicitis and results can be implemented then.