Obesity and Metabolic Disorders: GLP-1–Based Therapeutics, Cardiometabolic Outcomes, and Clinical Management

Special Issue Information

Dear Colleagues,

Obesity and metabolic disorders have emerged as major global health challenges, contributing substantially to type 2 diabetes, cardiovascular disease, fatty liver disease, chronic kidney disease, and increased overall mortality. The complex interplay between adipose tissue dysfunction, insulin resistance, systemic inflammation, and neurohormonal imbalance underlies the progressive nature of these conditions.

In recent years, glucagon-like peptide-1 (GLP-1)–based therapies have revolutionized the management of obesity and related metabolic disorders. Beyond glycemic control, GLP-1 receptor agonists and dual incretin-based agents have demonstrated significant benefits in weight reduction, cardiovascular risk mitigation, and improvement in metabolic parameters. These advances signal a paradigm shift toward integrated cardiometabolic care that targets both metabolic dysfunction and long-term clinical outcomes.

Despite these therapeutic breakthroughs, challenges remain in optimizing individualized treatment strategies, improving long-term adherence, addressing disparities in access to care, and understanding the broader mechanistic pathways through which incretin-based therapies exert systemic effects.

This Special Issue of Endocrinology and Disorders aims to provide a comprehensive overview of current research and clinical advances in obesity and metabolic diseases, with particular emphasis on:

• Mechanisms of metabolic dysfunction and adipose tissue biology 
• GLP-1 receptor agonists and emerging incretin-based therapies 
• Cardiometabolic and renal outcomes 
• Clinical management strategies and guideline-directed therapy 
• Personalized and precision medicine approaches 
• Real-world evidence and long-term safety data 

We welcome original research articles, systematic reviews, meta-analyses, clinical studies, and translational research contributions that advance understanding and management of obesity and metabolic disorders.

We look forward to your valuable contributions to this timely and impactful Special Issue.

Raul A Bastarrachea
Guest Editor
Endocrinology and Disorders

Manuscript Submission Information

Manuscripts should be submitted through the journal’s online submission system available on the Endocrinology and Disorders website. All submissions will undergo editorial screening followed by a rigorous peer-review process.

We invite:

• Original Research Articles 
• Review Articles 
• Clinical Studies 
• Short Communications 
• Case Reports (if within journal scope) 

Submitted manuscripts must not be previously published or under consideration elsewhere. Authors are encouraged to follow the journal’s Instructions for Authors to ensure proper formatting and compliance with editorial standards.

Accepted articles will be published online promptly and indexed according to journal policies.

For inquiries regarding suitability of topics or planned submissions, authors may contact the Editorial Office.

Benefits

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Publishing in a Special Issue provides valuable advantages for authors by strengthening the reach, impact, and recognition of their research within the global scientific community.

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Accepted manuscripts are published online promptly and added to the Special Issue collection on a rolling basis, ensuring immediate availability and sustained accessibility for the research community.