Multi-Omics Biomarkers in Human Diseases: From Molecular Discovery to Clinical Diagnosis and Prediction of Clinical Outcomes

Special Issue Information

Dear Colleagues,

Advances in multi-omics technologies—including genomics, proteomics, transcriptomics, and metabolomics—are transforming our understanding of complex human diseases and enabling the discovery of next-generation biomarkers for early diagnosis and prognosis. Among these, cytokines and immune-related proteins play a central role in mediating inflammation, disease progression, and therapeutic response.

Non-communicable or “civilization diseases,” such as cancer and neurodegenerative disorders, represent a major global health burden, accounting for over 80% of premature mortality. With the continued ageing of the population, the incidence of central nervous system disorders and malignancies is rapidly increasing, highlighting the urgent need for early detection strategies and predictive biomarkers.

This Special Issue focuses on the integration of multi-omics biomarker discovery with clinical applications, emphasizing cytokine profiling and molecular signatures that can identify disease risk in asymptomatic individuals, often years before clinical onset. The incorporation of such biomarkers into clinical practice has the potential to improve diagnostic accuracy, disease stratification, and personalized treatment decisions, ultimately enhancing patient outcomes.

Aim and Scope

This Special Issue aims to provide a comprehensive platform for exploring:

• The role of multi-omics biomarkers in human diseases 
• Integration of molecular discovery with clinical diagnostics 
• Cytokines as key mediators in disease mechanisms and progression 
• Development of predictive and prognostic models for clinical outcomes 
• Advances in precision medicine and personalized therapeutics 

We invite original research articles, systematic reviews, meta-analyses, and short communications that contribute to this rapidly evolving field.

Topics of Interest Include (but are not limited to):

• Multi-omics approaches to biomarker discovery and validation 
• Cytokines as prognostic and predictive biomarkers 
• Cytokines as novel tumor markers in oncology 
• Multi-omics insights into neurodegeneration and neuroinflammation 
• Immune profiling and cytokines in infectious diseases (including COVID-19)
• Biomarker-driven clinical diagnosis and outcome prediction 
• Cytokine-targeted therapeutic strategies and immunotherapy 
• Systems biology and integrated omics analysis in disease research 

Guest Editor
Ian James Martins 

Manuscript Submission Information

Authors are invited to submit their manuscripts through the online submission system of Auctores Publishing LLC via the journal website.

All submissions will undergo a rigorous peer-review process to ensure scientific quality and integrity. Accepted articles will be published on a continuous basis and featured within this Special Issue.

Submission Guidelines

• Manuscripts must be original and not under consideration elsewhere 
• Accepted article types: 
  • Original Research Articles 
  • Review Articles 
  • Short Communications 
• Authors may optionally submit a proposed title and abstract (~250 words) for editorial evaluation 

Author Instructions

Detailed guidelines are available on the journal’s Instructions for Authors page. Authors should ensure:

• Clear scientific writing and structure 
• Proper formatting and referencing 
• High-quality English (editing recommended if necessary) 

Publication Policy

• Open Access model 
• Rapid peer-review and editorial decision 
• Immediate online publication upon acceptance 

Final Note

We warmly encourage researchers, clinicians, and scientists to contribute their latest work and help advance the field of multi-omics biomarkers and translational medicine, bridging the gap between molecular discovery and clinical impact.

Benefits

Benefits of Publishing in a Special Issue

• Enhanced Content Navigation:
  Special Issues organize articles around focused themes, enabling readers and researchers to efficiently explore relevant topics within broad-scope journals.
• Increased Visibility and Citations:
  Articles published in Special Issues benefit from higher discoverability, leading to improved readership, academic impact, and citation potential.
• Stronger Research Collaboration:
  Special Issues bring together experts from similar domains, encouraging networking, knowledge exchange, and collaborative research opportunities.
• Wider Promotion and Outreach:
  Published articles receive additional exposure through the journal’s digital platforms, email campaigns, and social media channels, enhancing global visibility.
• Opportunities for Extended Publication:
  High-impact Special Issues may be considered for compilation into edited volumes or thematic collections, increasing long-term accessibility and recognition.

Learn More

For detailed information on Special Issue policies and submission guidelines, please visit the journal website:
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