Clinical Research and Trials in Diabetes and Its Complications: Real-World Evidence, Renal and Cardiovascular Outcomes, and Therapeutic Strategies
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Special Issue Information
Dear Colleagues,
Diabetes mellitus is a rapidly growing global health challenge, characterized by complex metabolic dysregulation and a high burden of microvascular and macrovascular complications. Despite major advances in pharmacological and technological management, diabetes continues to be a leading cause of chronic kidney disease, cardiovascular morbidity, neuropathy, and premature mortality worldwide.
In recent years, clinical research and trials have played a pivotal role in transforming diabetes care, particularly through the integration of real-world evidence and large-scale outcome studies. Contemporary investigations are increasingly focused on understanding the long-term renal and cardiovascular outcomes associated with novel antidiabetic therapies, including SGLT2 inhibitors, GLP-1 receptor agonists, and emerging combination strategies. These studies also highlight the importance of individualized treatment approaches, glycemic variability, and cardiometabolic risk reduction.
A critical area of ongoing research is the intersection between diabetes and its complications, particularly diabetic kidney disease and atherosclerotic cardiovascular disease. Mechanistic and clinical studies continue to explore pathways such as inflammation, oxidative stress, endothelial dysfunction, and metabolic signaling, which contribute to disease progression. Furthermore, real-world data are providing valuable insights into treatment effectiveness, safety profiles, and healthcare outcomes beyond controlled clinical trial settings.
Building on the success of previous initiatives in this field, this Special Issue aims to further advance knowledge in clinical research and trials related to diabetes and its complications. We welcome original research articles, systematic reviews, meta-analyses, and clinical trial reports that address translational and clinical aspects of diabetes care, with a focus on improving patient outcomes and guiding future therapeutic strategies.
We particularly encourage submissions that explore:
- Real-world evidence in diabetes management
- Renal outcomes and diabetic kidney disease progression
- Cardiovascular risk reduction strategies
- Novel antidiabetic therapies and combination treatments
- Biomarkers and predictive tools for complications
- Long-term safety and effectiveness of interventions
We invite researchers and clinicians to contribute high-quality manuscripts that will help shape the future of diabetes research and clinical practice.
Guest Editor
Kastanis Grigorios
Manuscript Submission Information
Manuscripts should be submitted online through the journal submission system by registering and logging into the website. Once registered, authors may access the submission portal directly. Submissions are accepted until the stated deadline. All manuscripts that pass initial editorial screening will undergo a rigorous peer-review process.
Accepted articles will be published continuously upon acceptance and will be listed collectively on the Special Issue webpage. We welcome original research articles, comprehensive reviews, and short communications. Authors intending to submit planned papers may send a title and abstract (approximately 250 words) to the Editorial Office for preliminary evaluation.
Submitted manuscripts must be original, not previously published, and not under consideration elsewhere (except conference proceedings). All submissions are subject to a single-blind peer-review process. Detailed author guidelines are available on the Instructions for Authors page.
We encourage authors to ensure clear scientific writing and proper formatting prior to submission. Language editing services may be used to improve manuscript quality if needed.
We look forward to your valuable contributions to this Special Issue.
Keywords
- Clinical research; clinical trials; diabetes mellitus; diabetic complications; real-world evidence; renal outcomes; cardiovascular outcomes; diabetic nephropathy
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