Cardiometabolic and Cardiorenal Diseases: Pathophysiology, Clinical Management, and Cardiovascular Outcomes

Special Issue Information

Dear Colleagues,

Cardiometabolic and cardiorenal diseases represent an interconnected spectrum of disorders that significantly contribute to global morbidity and mortality. Conditions such as diabetes mellitus, obesity, hypertension, chronic kidney disease, and heart failure frequently coexist and interact through complex pathophysiological pathways, amplifying cardiovascular risk and accelerating disease progression.

Growing evidence highlights the intricate relationships between metabolic dysfunction, systemic inflammation, neurohormonal activation, endothelial injury, and organ cross-talk between the heart, kidneys, and vasculature. These mechanisms form the basis of the cardiometabolic and cardiorenal continuum, underscoring the need for integrated and multidisciplinary management strategies.

Recent therapeutic advances—including SGLT2 inhibitors, GLP-1 receptor agonists, mineralocorticoid receptor antagonists, and novel anti-inflammatory approaches—have demonstrated substantial cardiovascular and renal benefits. However, optimizing patient selection, risk stratification, and long-term outcomes remains an evolving challenge in clinical practice.

This Special Issue aims to provide a comprehensive overview of the pathophysiology, clinical progression, and management of cardiometabolic and cardiorenal diseases, with particular emphasis on improving cardiovascular outcomes. We welcome high-quality submissions addressing, but not limited to:

• Mechanisms underlying cardiometabolic and cardiorenal interactions 
• Diabetes, obesity, and hypertension in cardiovascular disease 
• Chronic kidney disease and cardiovascular risk 
• Cardiorenal syndrome and heart failure 
• Biomarkers and risk prediction models 
• Pharmacological and device-based therapeutic strategies 
• Preventive cardiology and lifestyle interventions 
• Multidisciplinary and integrated care approaches 
• Long-term cardiovascular and renal outcomes 

Through this Special Issue, we aim to bring together cardiologists, nephrologists, endocrinologists, and clinical researchers to advance understanding and improve patient-centered care in this rapidly expanding field.

We invite original research articles, systematic reviews, meta-analyses, clinical investigations, and comprehensive review articles.

Guest Editor

Dr. Samer Ellahham

Manuscript Submission Information

Manuscripts should be submitted through the journal’s online submission system at:
https://auctoresonline.org/journals/cardiology-research-and-reports

All submissions will undergo initial editorial assessment followed by a rigorous peer-review process. Accepted papers will be published online promptly and grouped within the Special Issue collection.

We welcome original research articles, review articles, case reports, and short communications. Authors planning to submit may send a proposed title and abstract (approximately 200–250 words) to the Editorial Office for preliminary consideration.

Submitted manuscripts must be original and not under consideration elsewhere. Authors should prepare manuscripts according to the journal’s Instructions for Authors.

We look forward to your valuable contributions to this important area of cardiovascular medicine.

Benefits

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