Cancer Therapies and Immune-Related Adverse Events: Mechanisms, Clinical Manifestations, and Management Strategies
Deadline for manuscript submissions:
07 Oct 2026 | Viewed by
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Special Issue Information
Dear Colleagues,
Recent advances in oncology—particularly immune checkpoint inhibitors, adoptive cell therapies, monoclonal antibodies, and targeted molecular agents—have significantly improved survival outcomes across multiple malignancies. However, these therapeutic breakthroughs are frequently accompanied by immune-related adverse events (irAEs), which can affect nearly every organ system and present complex diagnostic and management challenges.
Immune-related toxicities may involve the skin, gastrointestinal tract, endocrine glands, lungs, liver, heart, and nervous system. Their pathophysiology is often linked to dysregulated immune activation, loss of self-tolerance, and inflammatory cascades triggered by cancer immunotherapies. Early recognition and appropriate management of these complications are critical to maintaining treatment efficacy while minimizing morbidity and mortality.
Despite growing clinical experience, significant gaps remain in understanding predictive biomarkers, mechanistic pathways, optimal management strategies, and long-term outcomes associated with immune-related adverse events.
This Special Issue aims to provide a comprehensive overview of the mechanisms underlying immune-related toxicities, their diverse clinical manifestations, and evolving therapeutic strategies for prevention and management. We welcome high-quality submissions addressing, but not limited to:
- Mechanisms of immune-related adverse events
- Toxicities associated with immune checkpoint inhibitors
- CAR-T cell therapy–related complications
- Organ-specific irAEs (cardiac, pulmonary, endocrine, neurologic, hepatic, dermatologic)
- Biomarkers for prediction and risk stratification
- Management algorithms and immunosuppressive strategies
- Long-term outcomes and survivorship considerations
- Multidisciplinary approaches in oncology care
Through this Special Issue, we aim to bring together oncologists, immunologists, internists, and clinical researchers to advance understanding and improve the safe delivery of modern cancer therapies.
We invite original research articles, systematic reviews, meta-analyses, clinical studies, and comprehensive review articles.
Guest Editor
Sabzali Javadov
Manuscript Submission Information
Manuscripts should be submitted through the journal’s online submission system at:
https://auctoresonline.org/journals/clinical-medical-reviews-and-reports
All submissions will undergo initial editorial assessment followed by a rigorous peer-review process. Accepted papers will be published online promptly and grouped within the Special Issue collection.
We welcome original research articles, review articles, case reports, and short communications. Authors planning to submit may send a proposed title and abstract (approximately 200–250 words) to the Editorial Office for preliminary consideration.
Submitted manuscripts must be original, not previously published, and not under consideration elsewhere. Authors should prepare manuscripts according to the journal’s Instructions for Authors.
We look forward to your valuable contributions to this important and rapidly evolving field.
Keywords
- Cancer Therapies; Immunotherapy; Immune Checkpoint Inhibitors; Immune-Related Adverse Events (irAEs); CAR-T Cell Therapy; Targeted Therapy; Monoclonal Antibodies
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