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Agraphia: definition, clinical contexts, neurobiological profiles and clinical treatments

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Review Article | DOI: https://doi.org/10.31579/2578-8868/134

Agraphia: definition, clinical contexts, neurobiological profiles and clinical treatments

  • Giulio Perrotta 1*

1 Psychologist sp.ing in psychotherapy with a strategic approach, Forensic Criminologist expert in sectarian cults, esoteric and security profiles, Jurist sp.ed SSPL, Essayist

*Corresponding Author: Giulio Perrotta, Psychologist sp.ing in psychotherapy with a strategic approach, Forensic Criminologist expert in sectarian cults, esoteric and security profiles, Jurist sp.ed SSPL, Essayist

Citation: Perrotta G., (2020) Agraphia: definition, clinical contexts, neurobiological profiles and clinical treatments. J. Neuroscience and Neurological Surgery. 6(4); DOI:10.31579/2578-8868/134

Copyright: © 2020 Giulio Perrotta, This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Received: 17 August 2020 | Accepted: 31 August 2020 | Published: 07 September 2020

Keywords: neurobiological; neuropsychological disorder; psychotherapy

Abstract

Starting from the general concept of Agraphia, the present work focuses on the clinical, neurobiological, and functional aspects of the morbid condition, suggesting a multidimensional treatment between physiotherapy, psychotherapy, and rehabilitation exercises for lost skills.

Contents of the manuscript:

L'agraphia is an acquired neurological and neuropsychological disorder [1] that causes a loss in the ability to communicate through writing and is often associated with another neuropsychological disorder, in the area of the mechanisms involved in the form of writing (whether they are linked to language and motor deficits), such as alexia, aphasia, dysarthria, agnosia, and apraxia. [2] In summary, agraphia consists in the difficulty in producing a previously learned and known written language, with damage to various related cognitive processes, such as language processing, spelling, visual perception, visual orientation for graphic symbols, motor planning and motor control of writing). [3] 

In 1553, within Thomas Wilson's book, entitled "Arte of Rhetorique", there is a trace of the first description of acquired agraphia, but only in the second half of the 19th century, the loss of the ability to produce the known written language and previously learned finally receives adequate clinical attention. In this period the idea arises that certain cortical lesions of the brain can involve a dissociation between written and spoken language, as well as altering both reading and writing skills, such as the studies of Broca and Wernicke. [12-13]

During the 1850s, Armand Trousseau and John Hughlings Jackson maintained the opinion that the same linguistic deficit occurs both in writing, both in speech and in reading, while in 1856 Louis-Victor Marcé argued the opposite: written and spoken language are independent of each other. He discovers that in many patients with language disorders, there is an impairment of both spoken language and writing. In these same patients, however, the recovery of an adequate written and spoken linguistic production does not always take place in parallel, suggesting that these two modes of expression are independent. [12-13]

Louis-Victor Marcé comes to believe that the ability to write not only involves the control of motor skills, but also the memory of signs and their meaning. Even Benedikt in 1865 comes to suggest that the areas of the brain that control writing and spoken language may have different anatomical locations, coining for the first time the clinical term, then followed in 1867 by William Ogle who laid the foundations for the first classifications nosographic, distinguishing the different dissociation models that can be found between written and spoken language. He showed that some patients with writing deficits were perfectly capable of copying the written letters, but they struggled or found it completely impossible to organize those same letters to form words of complete meaning. Ogle knew that aphasia and agraphia often occur together, but he also stressed that the deficit of the two different types of language (spoken and written) could vary in type and severity. Ogle himself distinguished between two different types of agraphia: in subjects suffering from mnemonic agraphy the written letters appeared well-formed, but often used incorrectly or completely randomly, and the words could indifferently take the place of each other; in patients with atraphic agraphia, on the other hand, the letters appeared poorly formed, intelligible and sometimes completely unrecognizable. Although Ogle's observations contributed significantly to scientific progress towards understanding writing disorders, there was still no documented case of pure agraphia. [12-13]

In 1884, Albert Pitres, strongly influenced by the modular approach to the memory of Théodule-Armand Ribot, made an important discovery by contributing to the publication of the first report of a case of pure agraphy. Pitres' reading and writing models consisted of three main components: visual (the memory for the letters and how the letters form syllables and words), auditory (the memory for the sounds represented by each letter), and motor (motor-graphic memory for letters). Based on this three-dimensional model, Pitres proposed his classification of the agraphia: a) agraphia from blindness for words: inability to copy a model, but the individual can write spontaneously and under dictation; b) agraphia from deafness for words: the inability to write under dictation, but the subject can copy a model and write spontaneously; c) motor agraphia: no ability to write, but the individual has no language deficit. [12-13]

The agraphia [1], today, is classified according to two precise forms:

  1. "central" ("aphasic"), which includes the lexical form, the phonological form, the deep form and the semantic writing;
  2. "peripheral" ("non-aphasic"), which includes the allographic, apraxic, motor, hemianoptic, and afferent forms.

"Central agraphia" [4-7] occurs when there is a deficit of spoken language and a deficit of the various motor and visualization skills involved in writing, distinguished in fluent and not fluent. In the "agraphia with fluent aphasia" (for example receptive aphasia) they normally write well-formed letters, but are unable to write significant words; those who have "agraphia with non-fluent aphasia", do not have an impairment of the spoken language and can write short sentences, but their writing is difficult to read, requires great physical effort, lacks correct syntax and often characterized by poor spelling (e.g. expressive or modifying aphasia):

  1. the "deep Agraphia" affects the phonological ability and the spelling memory of individuals and is often the result of an injury involving the left parietal region (supramarginal or insula convolution). The subjects do not remember what the words look like even if they are spelled correctly, nor do they have any idea what sound determines the correct spelling. Individuals usually rely on their damaged spelling memory for writing, which results in frequent errors, usually semantic. Individuals have more difficulty with abstract concepts and uncommon words. Reading and spoken language is also often compromised. Deep agraphia involves damage to the same areas of the brain (as happens with lexical agraphy), which is associated with some damage to the perisylvian linguistic areas as well. Major and massive damage to the left hemisphere can result in a global agraphia.
  2. the "global agraphia" instead also damages the spelling memory of a subject, even if to a greater extent than the deep writing. In global agraphia, spelling knowledge is lost to such an extent that the individual can only write a few significant words, or he cannot write any words. Reading and spoken language are significantly impaired.
  3. "Gerstmann's syndrome agraphia" is the loss of value of written language production associated with the following structural symptoms: difficulty in discriminating between one's fingers, difficulty in distinguishing the right from the left, difficulty in making calculations. All four of these symptoms result from lesions of a nerve pathway. Gerstmann syndrome can also be associated with alexia and mild aphasia and is caused by a dominant parietal lobe lesion (usually the left one), normally an angular convolution injury.
  4. the "lexical and structural agraphia" is caused by damage to the spelling memory; affected individuals cannot view the spelling of a word, even if they retain the ability to pronounce it. This altered spelling memory can result in the loss or degradation of knowledge or simply the inability to access it efficiently. There is a regularity effect associated with lexical letter-writing as individuals are less likely to spell words correctly without regular and predictable spelling. Also, the ability to write a word tends to be less compromised for commonly used words. People also have difficulties with homophonic terms. The linguistic competence in terms of grammar and writing of the sentence tends to be preserved. Lexical agraphia is associated with damage to the left angular convolution and/or posterior temporal cortex. The damage is typically posterior and less than in the Perisylvian language areas.
  5. "phonological agraphia" is the opposite of lexical writing because the ability to pronounce words is compromised, but the spelling memory of words can be completely intact. Often it is associated with a lexical effect as there is a difference in the ability to write words with meaning compared to words that are devoid of them. Individuals with this form of agraphia depend on their spelling memory. Moreover, for these subjects, it is often difficult to access more abstract words, without a strong semantic representation (for example, they find it much more difficult to make explicit prepositions than names that represent an object). This type of agraphia is linked to damage in the areas of the brain involved in the phonological processing capacity (the sound of words), in particular the linguistic areas around the Silvian fissure, such as the Broca area, the Wernicke area, and the supramarginal convolution.
  6. the "pure agraphia" finally consists in the loss of value of the written language production, without any other linguistic or cognitive disturbance.

"Peripheral agraphia" [3-4, 8-9] occurs when there is damage to the various motor and visualization skills that are necessarily involved in the writing activity:

  1. "apraxic agraphia" is the loss of value of written language production associated with a disorder of the motor system. This type of disorder results in the tiring and slow formation of distorted, incomplete and/or inaccurate letters and words. Although the letters and words that are written by these subjects are often so poorly formed that they are almost illegible, the ability to spell out loud is often preserved. This pathological form is caused specifically by a loss of motor planning specialized in letter formation and not by a dysfunction affecting the writing hand. It can present with or without ideomotor apraxia, but other neurological conditions are often associated, such as paralysis, Huntington's chorea, Parkinson's disease (micrograph), and dystonia (writer's cramp). Apraxic ataphia with ideomotor apraxia is usually caused by damage to the upper parietal lobe (in which the skills and graphomotor planning are stored) or the premotor cortex (where the planning is converted into motor commands). Also, some individuals with cerebellar lesions (more typically associated with non-apraxic motor dysfunction) may develop apraxic agraphia. Apraxic ataphia without ideomotor apraxia can be caused by damage to one of the parietal lobes, the dominant frontal lobe, or to the dominant thalamus.
  2. "hysterical agraphia" ​​is the loss of value of written language production caused by a conversion disorder.
  3. "reiterative agraphia" is found in individuals who repeat letters, words or sentences, in the production of written language, an abnormal number of times. Preservation, paragraph, and ultrasound itself (understood as an eco-phenomenon of automatic imitative action, without an explicit awareness) are examples of reiterative agraphy.
  4. “visuospatial agraphia” is the loss of value of written linguistic production defined by a tendency to neglect a portion (often an entire side) of the page, oblique lines upwards or downwards, leaving an abnormal spacing between letters, syllables and words. The orientation and correct sequence of writing also appear to be compromised. It is often associated with a lack of attention to the left hemispace, difficulties in the construction or assembly of objects, as well as other spatial difficulties. Visuospatial agraphia generally is associated with a pathology of the right hemisphere. Damage to the right frontal region of the brain can cause multiple types of motor deficits, while damage to the posterior part of the right hemisphere mainly leads to spatial defects in writing.

Etiologically, agraphia is the consequence of a series of morbid neurological (vascular, infectious, traumatic lesions, dementia) or systemic (autoimmune and tumor) conditions that neurobiologically interfere in whole or in part with twelve brain areas associated with writing [20-27]:

  1. the upper left frontal area, consisting of the middle frontal convolution (1) and the upper frontal sulcus (2), the upper left parietal area (3), composed of the lower parietal lobule, the upper parietal lobule and the intraparietal sulcus and finally from the primary motor cortex and the somatosensory cortex (4).
  2. the associative areas: the right anterior cerebellum (5), the left posterior nucleus of the thalamus (6), the lower left frontal convolution (7), the right posterior cerebellum (8), the upper right frontal cortex (9), the right lower parietal lobule (10), the left fusiform convolution (11) and the left putamen (12).

The specific type of agraphia, resulting from trauma and consequent brain injury, will, therefore, depend on which area of ​​the brain is damaged.

Very often then it is observed the writing in association with Alzheimer's disease. Writing disorders can be an early manifestation of Alzheimer's disease. The first indicative sign of involvement of the writing ability is the selective syntactic simplification of the handwriting of these patients. These patients begin to write with fewer descriptions, less detail, and complexity. Other indicators may also emerge, such as some grammatical errors. As Alzheimer's disease develops, different types of agraphia may emerge and develop. In the initial stages of the disorder, the subjects affected by it show signs of allographic agraphia and apraxic agraphy. The allographic ethic in subjects with Alzheimer's dementia is represented by the tendency to mix uppercase and lowercase in words. Egyptian Ataxia is represented by the tendency of patients to build poor, poorly constructed, or frankly illegible letters or a continuous repetition of the same traits of the letters. As the disease progresses, the severity of the writing process also progresses. Patients begin to manifest spatial agraphia, that is, the inability to write on a straight horizontal line, with the tendency to leave unnecessary spaces between letters and words. A connection between Alzheimer's disease and agraphia is the role of memory in normal writing skills. Those who can spell normally have access to a lexical spelling system that is based on a whole word: when it works correctly, it allows you to recall the spelling of a complete word, not of single letters or sounds. This system also uses an internal memory archive, where the spelling of hundreds of words is kept. This system is called a graphemic elaborate lexicon and is aptly named about the graphemic buffer, which represents the short-term memory ring for many of the functions involved in writing. When the spelling system cannot be used, for example because we are dealing with unknown words, non-words, or words whose spelling is not recognized, some people can use the phonological process called "sub-lexical spelling system". The latter system is used to probe a word and be able to write it. In individuals with Alzheimer's disease, the memory stores that are used for everyday writing are lost as the disease progresses. [14]

From a rehabilitative point of view, agraphia cannot be treated directly, but individuals affected by it can be rehabilitated to regain some of their previous writing skills: in the absence of neurological symptoms of another nature, such as amnesia [15], epilepsies [16] or dementia [14, 17-18], the techniques of memorization of keywords, the use of technology for word processing, manual writing, artistic and abstract drawing and physiotherapy are extremely functional, combining a targeted psychological therapy for cognitive-behavioral or strategic support [19].

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Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia