AUCTORES
Globalize your Research
Research Article
*Corresponding Author: Gökhan Doğukan Akarsu, Department of Pharmacy Services, Yozgat Bozok University, School of Health Services, Turkey.
Citation: Citation: Gökhan D. Akarsu, (2024), The Effect of Α-Bisabolol on Alzheimer Disease, J. Neuroscience and Neurological Surgery, 14(6); DOI:10.31579/2578-8868/334
Copyright: Copyrights: ©, 2024, Gökhan Doğukan Akarsu. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Received: 26 July 2024 | Accepted: 14 August 2024 | Published: 26 August 2024
Keywords: alzheimer; aβ; α-bisabolol; treatment
Alzheimer's disease is a condition that causes permanent effects due to damage in memory cells, leading to the inability to meet basic life needs and eventually resulting in loss of life. The increasing lifespan of individuals, particularly in advanced and developing cells, has raised the risk of developing this disease among people aged 65 and older. α-Bisabolol is a molecule derived from the essential oil of hemp. It is found in various plants, such as chamomile, similar to its presence in hemp. Due to its molecular structure, α-Bisabolol is considered to have strong effects against Alzheimer's disease. In this systematic review, clinical animal and cell line studies investigating α-Bisabolol for Alzheimer's disease have been examined. Given that α-Bisabolol is a newly discovered compound and there is a lack of sufficient clinical and experimental studies, there are still uncertainties. With further research in the future, the effects of α-Bisabolol on Alzheimer's disease can be determined conclusively.
Alzheimer's disease is a debilitating condition that results in permanent effects due to damage to memory cells, ultimately leading to the inability to meet basic life needs and, in some cases, loss of life (1). The increasing lifespan of individuals, particularly in advanced and developing cells, has raised the risk of developing this disease among people aged 65 and older.
Alzheimer's disease begins with the formation of amyloid plaques and neurofibrillary tangles between brain cells (2). The increasing plaques and tangles lead to a gradual decline in communication between cells. Consequently, the diminishing level of information and skills can provide insights into the progression of the disease.
Casdellani et al. (2020) described the cognitive and functional impairments that develop in Alzheimer's patients, including memory decline, difficulties in understanding and perceiving routine everyday questions, decreased responsiveness, loss of skills such as dressing, and deficiencies in tasks like bathing or shopping (3). Furthermore, the U.S. Department of Health and Human Services (HHS) has provided various information about Alzheimer's, emphasizing the importance of not confusing it with dementia and Parkinson's disease.
The treatment options for Alzheimer's disease currently remain uncertain. Existing clinical treatments aim to reduce the formation of amyloid plaques. The drugs developed for this purpose aim to slow down the progression of the disease, but the extent of their effectiveness is still a subject of debate.
Numerous studies are being conducted to develop therapeutic agents based on newly obtained information.
Mintun et al. (2021) reported that Donanemab halted the formation of amyloid plaques after 12 months of treatment (4). Bouter et al. (2015) found that Solanezumab, Crenezumab, and Bapineuzumab react with amyloid plaques and dissolve amyloid β (Aβ), allowing it to pass from neuronal cells into the plasma (5). McDade et al. (2022) reported that Lecanemab reduced amyloid plaques and slowed down clinical deterioration (6). Jun et al. (2023) demonstrated that a carbamate JNK3 inhibitor restored cognitive functions to their previous state in a transgenic mouse model (7).
Most of the current research aims to prevent the production or reduce the formation of amyloid plaques. However, the exact causes of the disease's onset are not fully understood.
Therefore, research continues to explore different molecules that could potentially prevent the disease. Particularly, molecules that can be naturally supplemented through daily diet would be beneficial for protecting against neurocognitive disorders in advanced age.
α-Bisabolol is a molecule derived from the essential oil of hemp. It is found in various plants, including hemp and chamomile (8). Due to its molecular structure, α-Bisabolol is believed to have effects against Alzheimer's disease.
In our study, we aimed to systematically evaluate the clinical, animal, and cell line studies that investigate the effects of α-Bisabolol on Alzheimer's disease.
Type of Research
This study is a systematic review prepared according to the PRISMA checklist and Cochrane guideline (9, 10).
Research Strategy
We aimed to evaluate the effect of α-bisabolol in Alzheimer's disease. It has been evaluated that α-bisabolol affects Alzheimer's by preventing the formation of amyloid plaque, by dissolving the formed plaques or by acting in another mechanism. Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest databases were made by searching English articles published between January 2000 and June 2024. The abstracts of 173 studies published between January 2000 and June 2024 for the words α-bisabolol and Alzheimer's disease were systematically reviewed, and then 6 studies suitable for the purpose of the study constituted the sample of the study.
Although the entire research was done by a single researcher, full-text review and data abstraction were done in duplicate.
When the articles were scanned, only clinical, experimental animal models and cell line studies showing the effect of α-bisabolol were included.
The effect of other therapeutic agents on Alzheimer's disease or other diseases in which bisabolol acts are not included.
Inclusion criteria
•Full text accessible,
•In the field of Alzheimer,
•About α-bisabolol,
•Studies published in the Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest database center between January 2000 since June 2024 were included.
In this study, PICOS;
Limitation of the study
The compilations that were not included in the Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest databases and were not saved in the system could not be accessed. Investigating the effects of α-bisabolol treatment on Alzheimer's disease, accessing the same reviews with different keywords, and the small number of accessed articles are the limitations of the study. Effects of other molecules for Alzheimer's disease are not included.
Ethical aspect of research
Ethical permission was not obtained because reviews were open to access were used in this systematic review. Reviews were selected by the researchers considering the PRISMA checklist.
Analysis of data
The data were evaluated using the data summary form prepared by the researchers. The data summary form includes the article name, authors, year, aim and results of the study. Data summary forms were evaluated independently by the researchers and filled with consensus.
Using the search strategy, PRISMA checklist and Cochrane guideline, 173 articles were identified in the Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest databases data. Duplicate studies were weeded out. Only 6 (3.4%) of the articles were related to Alzheimer's disease and α-Bisabolol. Other studies include the efficacy of α-Bisabolol in different diseases (8%), different molecules trying to treat Alzheimer's disease (69%), full text not available (12%), presence of disease other than Alzheimer's disease (4.6%), and α-Bisabolol. It was not included because it was used in other different molecules. (Figure 1).
Figure 1. Prisma flow chart
| Article Name | Year and Author | Aim | Results | |
α-Bisabolol Protect Mice Of Neuronal Loss And Cognitive Deficitis İn Sporadic Alzheimer's Disease Animal Model İnduced By Streptozotocin
| 2019;Jéssica Rabelo Bezerr | Evaluation of the effect of α-Bisabolol in an animal model of sporadic Alzheimer's disease induced by streptozotocin. | It was reported that α-bisabolol treatment significantly improved impairments in working memory, avoidance memory, recognition memory and spatial memory, and did not affect motor activity. It has been stated that α-bisabolol treatment is not sufficient to reduce the increase in nitrite concentration in the prefrontal cortex and hippocampus, but significantly reduces the increase in malondialdehyde (MDA) concentration in the prefrontal cortex, prevents neuronal damage and the decrease in synaptophysin expression in the hippocampus, and increases synaptophysin [removed]11). | |
| Amyloid-β induced neuropathological actions are suppressed by Padina gymnospora (Phaeophyceae) and its active constituent α-bisabolol in Neuro2a cells and transgenic Caenorhabditis elegans Alzheimer's model | 2019; Balakrishnan Shanmuganathan, Sethuraman Sathya, Boopathi Balasubramaniam, Krishnaswamy Balamurugan, Kasi Pandima Devi | Evaluation of the neuroprotective efficacy of α-bisabolol against neurotoxicity induced by Aβ25-35 in N2a cells. | It reverses the change in intracellular protein and lipid oxidation induced by Aβ25-35, inhibits cholinesterase and β-secretase activity in Neuro2a cells, decreases the production of intracellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) in Neuro2a cells, Bax and caspase- It has been stated that apoptotic proteins such as 3 reduce the expression level. In addition, it has been reported that it has a neuroprotective effect against proteotoxicity induced by Aβ, and inhibits Aβ synthesis by reducing life span, macromolecular damage and AD-related ace-1, hsp-4 and Aβ gene [removed]12). | |
Deciphering the anti-apoptotic potential of α-bisabolol loaded solid lipid nanoparticles against Aβ induced neurotoxicity in Neuro-2a cells
| 2020; Sethuraman Satha,Balakrishnan Shanmuganathan, Kasi Pandima Devi | Evaluation of the protective efficacy of α-bisabolol-loaded particles against Alzheimer's against neurotoxicity induced by Aβ25-35 in N2a cells. | According to the results of in vitro studies, it has been reported that α-bisabolol prevents macromolecular damage and oxidative stress by scavenging reactive oxygen and nitrogen species, exhibits cholinergic activity, inhibits β-secretase enzyme and apoptosis-mediated cell death(13). | |
| α-Bisabolol loaded solid lipid nanoparticles attenuates Aβ aggregation and protects Neuro-2a cells from Aβ induced neurotoxicity | 2018; Sethuraman Sathya, Balakrishnan Shanmuganathan, Ganeshan Manirathinam, Kandasamy Ruckmani, Kasi Pandima Devi | Evaluation of the neuroprotective effect of α-bisabolol loaded solid nanoparticles in N2a cells | It has been reported that solid nanoparticles loaded with α-Bisabolol inhibit AChE and have antioxidant potential, protect N2a cells from Aβ-induced neurotoxicity, and inhibit Aβ aggregation(14). | |
| α-bisabolol β-D-fucopyranoside inhibits β-amyloid (Aβ)25–35 induced oxidative stress in Neuro-2a cells via antioxidant approaches | 2022; Mahalingam Jeyakumar, Sethuraman Sathya, Soniya Gandhi, Prabhakararao Tharra, Murali Aarthy, Devasahayam Jaya Balan, Chandramohan Kiruthig, Beeraiah Baire, Sanjeev Kumar Singh, Kasi Pandima Devi | Evaluation of the protective efficacy of α-bisabolol against neurotoxicity induced by Aβ25-35 in N2a cells. | It has been reported that α-bisabolol inhibits caspase 3 production, increases anti-apoptotic protein expression, and protects it from Aβ 25-35 peptide-induced toxicity(15). | |
| Anti-amyloidogenic and anti-apoptotic effect of α-bisabolol against Aβ induced neurotoxicity in PC12 cells | 2018; Balakrishnan Shanmuganathan, Venkatesan Suryanarayanan, Sethuraman Sathya, Muralidharan Narenkumar, Sanjeev Kumar Singh, Kandasamy Ruckmani, Kasi Pandima Devi | Investigation of anti-amyloidogenic and anti-apoptotic properties of α-bisabolol against Aβ25-35-induced neurotoxicity | It has been reported that α-bisabolol has the ability to rescue PC12 cells from Aβ-induced neurotoxicity and chromosomal damage(16). | |
Table 1. Studies using α-Bisabolol in Alzheimer's disease research.
Studies in which α-Bisabolol was used in Alzheimer's disease studies are given in the table below (table 1). Bezerra (2019) evaluated the cognitive functions of α-Bisabolol on mice in his research. while other studies evaluated the effect of α-Bisabolol in cell line studies. No studies were found in which α-Bisabolol was evaluated clinically. The fact that α-Bisabolol is newly discovered and not enough research has been done on it limits our research. For this reason, the data obtained from the current studies are given below.
Studies using α-Bisabolol in Alzheimer's disease studies are given in table 1 (table 1).
Bezerra (2019) evaluated the cognitive functions of α-Bisabolol in mice in his research. In her research, Bezerra injected streptozotocin intracerebroventricularly to rats. She stated that the reason for using streptozotocin is that it causes deterioration in insulin signaling pathways, increase in oxidative stress parameters, neuroinflammation and neurogenesis dysfunctions. In her study, which aimed to examine the effects of α-bisabolol on these negative effects of streptozotocin, she reported that treatment with α-bisabolol did not cause a significant change in blood glukoz, significantly improved the deficits in working memory, aversive memory, recognition memory and spatial memory, and did not change locomotor activity. In addition, she reported that after the treatment protocol with α-bisabolol, it could not stop the increase in nitrite concentration in the prefrontal cortex and hippocampus, affected the dose-dependent increase in MDA concentration in the prefrontal cortex, and prevented neuronal damage in the hippocampus by increasing the expression of synaptophysin.
Shanmuganathan (2019) in his research evaluated the neuroprotective efficacy of α-bisabolol against neurotoxicity induced by Aβ25-35 in N2a cells. It showed that α-bisabolol tried to correct the differences in intracellular protein and lipid oxidation induced by Aβ25-35, and stopped cholinesterase and β-secretase activity. Reactive oxygen and nitrogen species increase in Alzheimer's disease. Shanmuganathan reported that one of the most important effects of α-bisabolol is the reduction of intracellular reactive oxygen species and reactive nitrogen species production. In other words, it can be described as one of the most important findings showing that it can be effective against Alzheimer's disease.
In their study, Sathya et al. (2020) injected Aβ25-35 into N2a cells and investigated whether α-bisabolol loaded solid lipid nanoparticles given to N2a cells could prevent the aggregation of Aβ25-35 and enhance neuronal damage repair. The research results indicated that it significantly suppressed the production of free radicals such as reactive oxygen species and nitrogen species, and it also increased the reactive oxygen species-mediated macromolecular damage and loss of mitochondrial membrane potential caused by toxic Aβ peptide. The study reported a reduction in β-secretase, caspase-3, and cholinesterase activities. Decreased expression of Bax and increased expression of Bcl-2 protein were observed, indicating that α-bisabolol loaded solid lipid nanoparticles protected against Aβ-induced apoptosis.
Sathya et al. (2018) injected Aβ25-35 into N2a cells and evaluated the neuronal protective effect of solid lipid nanoparticles loaded with α-bisabol. They reported that α-Bisabolol significantly inhibited Acetylcholinesterase, protected N2a cells from Aβ-induced neurotoxicity, and inhibited Aβ aggregation.
Jeyakumar et al. (2022), Aβ25-35 mediated neuronal damage was caused in N2a cells. The neuroprotective effect was evaluated by infusing the cells with solid nanoparticles loaded with α-bisabolol. Solid nanoparticles loaded with α-bisabolol have been reported to reduce the formation of lipid peroxides, protein carbonyls, and nitric oxides in N2a cells. It has also been reported to inhibit acetylcholinesterase. It has been reported that solid nanoparticles loaded with α-bisabolol significantly inhibit caspase 3 production in N2a cells, increase anti-apoptotic protein expression, and protect Neuro-2a cell from β-amyloid (Aβ) 25-35 peptide-induced toxicity.
Shanmuganathan et al. (2018) evaluated the effectiveness of α-bisabolol against Aβ 25–35-induced neurotoxicity in PC12 cells. According to the results of the research, it was reported that there was a decrease in the fluorescence intensity used in the detection of Aβ. It was stated that α-bisabolol breaks down mature fibrils and prevents oligomer formation.
α-Bisabolol is a molecule that can be derived from various plants, including hemp and chamomile. Its chemical structure consists of 15 carbon, 26 hydrogen, and 1 oxygen atoms. α-Bisabolol has been evaluated for its effects on Alzheimer's disease in cell culture and animal studies. Alzheimer's disease is a progressive condition characterized by permanent cognitive impairments, and currently, there is no definitive cure for it. The available treatments aim to improve the patient's impaired quality of life or slow down the progression of the disease, but it still remains one of the most significant age-related diseases. Therefore, it remains a priority among research endeavors.
One of the fundamental characteristics that allow scientists to find faster responses to diseases is the application of newly discovered molecules in various disease models, including cell culture, animal studies, and clinical trials. In our study, we aimed to compile and systematically report the efficacy evaluations of α-Bisabolol in therapeutic approaches to Alzheimer's disease modeling.
Bezerra (2019) evaluated the effects of α-Bisabolol in an Alzheimer's disease animal model induced by streptozotocin. Streptozotocin, also used by Salkovic-Petrisic et al. (2013) and Chen et al. (2014), is a commonly used model in Alzheimer's disease research (17, 18). There are also other Alzheimer's models induced by chronic exposure to AlCl3 and D-galactose (1, 19). Bezerra (2019) reported that α-Bisabolol treatment significantly improved impairments in working memory, avoidance memory, recognition memory, and spatial memory, without affecting motor activity. The study indicated that α-Bisabolol treatment did not sufficiently prevent the increase in nitrite concentration in the prefrontal cortex and hippocampus. However, it significantly reduced the increase in malondialdehyde (MDA) concentration in the prefrontal cortex, prevented neuronal damage and the decrease in synaptophysin expression in the hippocampus, and increased synaptophysin [removed]11). Although it did not prevent the increase in nitrite as required, the reduction in MDA expression and improvement in memory impairments suggest that long-term α-Bisabolol exposure could yield better results.
Shanmuganathan et al. (2019) attempted to induce cellular damage in N2a neuronal cell line using Aβ25-35 and treated the induced damage with α-Bisabolol and acetone extract of Padina gymnospora. The study reported that the treatment reversed the changes in intracellular protein and lipid oxidation induced by Aβ25-35, inhibited cholinesterase and β-secretase activity in N2a cells, reduced the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), decreased the expression of apoptotic proteins such as Bax and caspase-3, and exhibited neuroprotective effects against Aβ-induced proteotoxicity. The study also found that α-Bisabolol extended lifespan, reduced macromolecular damage, and lowered the expression of ACE-1, HSP-4, and Aβ genes associated with Alzheimer's disease, thereby inhibiting Aβ synthesis (12).
Sathya et al. (2020) and Sathya et al. (2018) reported that α-Bisabolol cleared ROS and RNS, inhibited β-secretase enzyme and apoptotic cell death, inhibited AChE, protected N2a cells from Aβ-induced neurotoxicity, and inhibited Aβ aggregation (13, 14).
Jeyakumar et al. (2022) reported that α-Bisabolol inhibited caspase-3 production, increased the expression of anti-apoptotic proteins, and protected against Aβ25-35 peptide-induced toxicity (15).
Shanmuganathan et al. (2018) demonstrated that α-Bisabolol had the ability to rescue PC12 cells from Aβ-induced neurotoxicity and chromosomal damage (16).
Although Bezerra (2019) did not report a reduction in RNS levels with α-Bisabolol, Shanmuganathan et al. (2019) demonstrated this effect in their cell study. It is possible that the visible effect is due to the presence of Padina gymnospora extract. The reduction in ROS and RNS levels may contribute to the alleviation of apoptotic effects by decreasing the expression of Bax and caspase-3. MacLachlan et al. (2022) reported an increase in ACE-1 activity in the early stages of Alzheimer's disease (20), while Pereira et al. (2019) found an increase in HSP-4 in Alzheimer's disease. With these perspectives, it can be stated that α-Bisabolol may assist in the treatment of Alzheimer's disease.
In this study, we examined the research conducted on α-Bisabolol's effects on Alzheimer's disease, and it was observed that α-Bisabolol eliminated the factors involved in the onset and progression of Alzheimer's disease in the early stages. α-Bisabolol's ability to reduce ROS, RNS, Bax, caspase-3, ACE-1, and HSP-4 expression may contribute to its effects on the disease. However, as α-Bisabolol is a newly discovered molecule and has been investigated in only one animal study using an Alzheimer's disease model, and with limited cell line studies, its safe use cannot be fully assured. Moreover, the absence of studies specifically investigating the toxic effects of α-Bisabolol in Alzheimer's disease further complicates the decision-making process. Further research with a larger number of studies in the future is necessary for a reevaluation of α-Bisabolol's effects.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
