AUCTORES
Globalize your Research
Case Report
*Corresponding Author: Jaya Pandey, Department of Chemistry, Amity University, Lucknow, U.P. India
Citation: Pandey J. , Murthy S. , Dubey R. and D.K. Awasthi (2021) Study of Properties and Applications Nicotine Alkaloids. Clinical Cancer and Oncology Research 1(2) DOI: 10.31579/CCOR-2021/007
Copyright: © 2021, Jaya Pandey, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 06 June 2021 | Accepted: 12 July 2021 | Published: 17 July 2021
Keywords: nicotine alkaloids, beta-endorphin, dopamine, norepinephrine, serotonin, and acth
Nicotine = Nicotine may be a plant alkaloid, found within the tobacco plant, and addictive focal sensory system (CNS) energizer that causes either ganglionic incitement in low portions or ganglionic blockage in high dosages. Nicotine goes about as an agonist at the nicotinic cholinergic receptors within the autonomic ganglia, at neuromuscular intersections, and within the medulla and therefore the mind. Nicotine's CNS-animating exercises could be intervened through the arrival of a couple of synapses, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. Subsequently, fringe vasoconstriction, tachycardia, and raised pulse could be seen with nicotine admission. This specialist may likewise animate the chemoreceptor trigger zone, subsequently instigating queasiness and spewing.
(S)- Nicotine may be a 3-(1-methylpyrrolidin-2-yl) pyridine during which the chiral focus has S-setup. The normally happening and most dynamic enantiomer of nicotine, disengaged from common tobacco. it's a neighborhood as a phytogenic bug spray, a teratogenic specialist, a neurotoxin, an anxiolytic medication, a nicotinic acetylcholine receptor agonist, a biomarker, an immunomodulator, a mitogen, a fringe sensory system drug, a psychotropic medication, a plant metabolite and a xenobiotic. It’s a form base of a (S)- nicotinium(1+). It’s an enantiomer of a (R) - nicotine.
Nicotine, a natural compound that's the central alkaloid of tobacco. (An alkaloid is one among a gathering of nitrogenous natural mixtures that have stamped physiological consequences for people.) Nicotine happens during the tobacco plant and particularly within the leaves. The compound comprises around 5% of the plant by weight. Both the tobacco plant (Nicotiana tabacum) and therefore the compound are named for Jean Nicot, a French envoy to Portugal, who sent tobacco seeds to Paris in 1550.
Nicotine is economically acquired from tobacco scraps and is employed as a bug spray and as a veterinary vermifuge. Nitric corrosive or other oxidizing specialists convert it to nicotinic corrosive, or niacin, which is employed as a food supplement.
Nicotine is additionally called 3-(1-methyl-2-pyrrolidinyl) pyridine consistent with the IUPACa nomenclature. It’s a bicyclic compound with a pyridine cycle and a pyrrolidine cycle. The molecule possesses an asymetric carbon then exists in two enantiomeric compounds. In nature, nicotine only exists within the S shape, which is levogyre.
Nicotine is additionally called 3-(1-methyl-2-pyrrolidinyl) pyridine consistent with the IUPACa nomenclature. It’s a bicyclic compound with a pyridine cycle and a pyrrolidine cycle. The molecule possesses an asymetric carbon then exists in two enantiomeric compounds. In nature, nicotine only exists within the S shape, which is levogyre.
Total enantioselective synthesis of (R)-nicotine
Nicotine is additionally called 3-(1-methyl-2-pyrrolidinyl) pyridine consistent with the IUPACa nomenclature. It’s a bicyclic compound with a pyridine cycle and a pyrrolidine cycle. The molecule possesses an asymetric carbon then exists in two enantiomeric compounds. In nature, nicotine only exists within the S shape, which is levogyre.
Retrosynthetic analysis
Synthesis
a - The first step is the allylation of pyridinecarboxaldehyde 1 with 2, 2 equivalents of B-allyldiisopinocampheylborane in Et2O at -100°C. The (S)-homoallylicalcool 2 is obtained in 86% yield with an enantiomeric excess of 94%.
b - The chiral azide 3 is obtained from alcohol 2 using the Thompson procedure with a 90% yield and without racemisation. DBU (1, 2 equivalents), (PhO) 2P(O)-N3 (1,2 equivalents), Toluene
c- Intramolecular hydroboration-cycloalkylation of the azido-olefin 3
2,2 equivalents of B(C6H11)2H in THF. This step proceeds by the hydroboration of the double bond of 3 followed by the formation of a boron-nitrogen bond between the azide and the trialkylborane.
Finally, ring closure occurs by migration of the borane methylene group to nitrogen-1 with concomitant loss of nitrogen.
d- Alkylation of (R)-Nornicotine 4 in (R)-Nicotine.
(i) EtOCOCl (1,2 equiv.), Et3N (1,3 equiv.), Et2O
(ii) LiAlH4 (1, 2 equiv.), THF, 0°C
Nicotine is exceptionally addictive, except if utilized in lethargic delivery forms. Animal exploration proposes that MAO inhibitors present in tobacco smoke may upgrade nicotine's addictive properties. A traditional cigarette yields around 2 mg of consumed nicotine. The assessed lower portion limit for deadly results is 500–1,000 mg of ingested nicotine for a grown-up (6.5–13 mg/kg). Nicotine fixation includes drug-supported conduct, enthusiastic use, and backslide following abstinence. Nicotine reliance includes resistance, sensitization, actual reliance, and mental dependence. Nicotine reliance causes distress. Nicotine withdrawal side effects incorporate discouraged disposition, stress, tension, touchiness, trouble focusing, and rest disturbances. Mild nicotine withdrawal indications are quantifiable in unhindered smokers, who experience typical mind-sets even as their blood nicotine levels top, with each cigarette. On stopping, withdrawal manifestations deteriorate pointedly, at that time continuously improve to a standard state.
Medical
The essential remedial utilization of nicotine is getting nicotine reliance kill smoking and therefore the harm it does to wellbeing. Controlled degrees of nicotine are given to patients through gums, dermal patches, capsules, inhalers, or nasal showers to wean them off their reliance.
Nicotine on Parkinson's disease
Epidemiological examinations show that smoking is said with a lower frequency of Parkinson's illness (PD). This finding is critical on the grounds that it could give hints about remedial procedures to security against this crippling development issue. Smoke contains various synthetic compounds that would be in charge of the clear defensive impact. Here, employment for nicotine is assumed of, in light of the very fact that this compound invigorates mind dopaminergic frameworks and provides some suggestive advantage in PD. Nicotine likewise features a neuroprotective activity. Putative factors and flagging pathways engaged with the activities of nicotine are talked about. A comprehension of the sub-atomic reason for the decreased event of PD in tobacco clients is pivotal for the advancement of intercession techniques to diminish or stop infection movement.
Nicotine as antioxidant and potential protective agents against in vitro oxidative haemolysis
The limit of 11 nicotine alkaloids to decrease oxidative pressure was explored. to offer a design action connections examination, new nicotine subsidiaries with a substituent brought into the pyrrolidine ring were incorporated and researched alongside nicotine and its known analogs. All recently orchestrated mixtures were described by 1H, 13C NMR and EI-MS procedure. The cancer prevention agent properties of nicotine, its known analogs and recently created subsidiaries, were assessed by different cell reinforcement tests such 1,1-diphenyl-2-picryl-hydrazyl free revolutionary (DPPH•) searching, ferrous particles (Fe2+) chelating movement and absolute decreasing capacity assurance by Fe3+ → Fe2+ change measure. The defensive impacts of all mixtures tried against 2, 2′-azobis(2-methylpropionamidine) dihydrochloride (AAPH) and tert-butyl hydroperoxide (t-BuOOH)- incited oxidative haemolysis and morphological injury of human erythrocytes, were assessed in vitro. The outcomes showed that nicotine alkaloids displayed different antiradical viability and cell reinforcement movement during a design and some subordinate way. Furthermore, the limit of nicotine alkaloids to shield erythrocytes from AAPH-and t-BuOOH-prompted oxidative haemolysis, was reliant on its brooding time with cells. Our discoveries showed that synthetic and organic examinations directed all the while can give complete information concerning the cell reinforcement capability of nicotine alkaloids. This information are often useful in better understanding the properties of nicotine alkaloids under oxidative pressure conditions.
Pesticide
Nicotine has been utilized as an insect spray since in any event the 1690s, as tobacco extracts (albeit different parts of tobacco likewise appear to possess pesticide effects). Nicotine pesticides haven't been monetarily accessible within the US since 2014, and hand crafted pesticides are prohibited on natural crops and not suggested for small gardeners. Nicotine pesticides are restricted within the EU since 2009. Foods are imported from nations during which nicotine pesticides are permitted, like China, however food varieties might not surpass most extreme nicotine levels. Neonicotinoids, which are gotten from and basically like nicotine, are broadly utilized as farming and veterinary pesticides starting at 2016.
Adverse Effect of Nicotine
Nicotine is delegated a poison. However, at dosages utilized by buyers, it presents on the brink of nothing if any peril to the user. A 2018 Cochrane Collaboration audit records 9 fundamental unfriendly occasions identified with nicotine substitution treatment: migraine, wooziness/light‐headedness, sickness/spewing, gastro‐intestinal indications, rest/dream issues, non‐ischemic palpitations and chest torment, skin responses, oral/nasal responses and hiccups. Many of those were likewise basic within the fake treatment bunch without nicotine. The palpitations and chest torment were considered "uncommon" and there was no proof of an expanded number of genuine cardiovascular issues contrasted with the fake treatment bunch, even in individuals with found out heart condition. The essential results from nicotine openness are recorded within the table underneath. Genuine unfriendly occasions due to the use of nicotine substitution treatment are very rare. At low sums, it's a mild pain relieving effect. At adequately high dosages, nicotine may cause queasiness, heaving, loose bowels, salivation, bradyarrhythmia, and maybe seizures, hypoventilation, and spending.
Sleep
Nicotine is exceptionally addictive. Its addictiveness relies upon how it's administered. Animal exploration proposes that MAO inhibitors in tobacco smoke may improve its addictiveness. Nicotine reliance includes parts of both mental reliance and actual reliance, since stopping of stretched use has been seemed to create both filled with feeling (e.g., uneasiness, crabbiness, wanting, anhedonia) and physical (gentle engine dysfunctions like quake) withdrawal symptoms.
Nicotine has been seemed to create birth absconds in some creature species, yet not others; therefore, it's viewed as a possible teratogen in humans. In creature considers that caused birth surrenders, analysts found that nicotine adversely influences fetal psychological state and pregnancy outcomes; the negative consequences for early psychological state are related with irregularities in mind digestion and synapse framework function. Nicotine crosses the placenta and is found within the bosom milk of moms who smoke even as moms who inhale detached smoke.
Nicotine openness in utero is responsible for a couple of complexities of pregnancy and birth: pregnant ladies who smoke are at more serious danger for both premature delivery and stillbirth and newborn children presented to nicotine in utero will generally have lower birth weights.[109] Some proof proposes that in utero nicotine openness impacts the event of specific conditions sometime down the road, including type 2 diabetes, corpulence, hypertension, neurobehavioral surrenders, respiratory brokenness, and infertility.
Cancer
The rundown of cancer growths purportedly related to nicotine is extending and as of now incorporates little cell and non-little cell lung carcinomas, even as head and neck, gastric, pancreatic, gallbladder, liver, colon, bosom, cervical, bladder and kidney diseases. The mutagenic and tumor-advancing exercises of nicotine may result from its capacity to harm the genome, disturb cell metabolic cycles, and encourage development and spreading of changed cells. The nicotinic acetylcholine receptors (nAChRs), which are enacted by nicotine, can initiate a couple of flagging pathways which will have tumorigenic impacts, and these receptors could possibly be focused for disease treatment or anticipation. there's additionally developing proof that the remarkable hereditary cosmetics of a private , for instance , polymorphisms in qualities encoding nAChR subunits, may impact the weakness of that person to the pathobiological impacts of nicotine. The arising information about the cancer-causing instruments of nicotine activity need to be considered during the assessment of guidelines on nicotine item assembling, appropriation and promoting.
Nicotine in different form
Cigarettes: The measure of nicotine contained during a single cigarette varies. Just alittle amount of the nicotine is inhaled since an outsized portion of it pops as side-stream smoke within the normal smoker. Nicotine poisonousness from smoking is further limited because the consequences of inhaled nicotine happen quickly (in practically no time), restricting further intake. Nicotine poisonousness can happen through the ingestion of cigarettes or butts, commonly eaten by small kids, during which case an outsized measure of nicotine are often absorbed.
Chewing tobacco: Chewing tobacco is additionally called smokeless tobacco, or "plunge." The nicotine is absorbed through the oral surface. The nicotine content are often just about as high as that of "low nicotine cigarettes." Chewing tobacco is related to a really high danger of cancers within the mouth and throat.
Nicotine gum: Nicotine gums are used as an aide to smoking cessation. Gum contains a limited quantity of nicotine and raises the nicotine concentration within the body slower than cigarette smoking. Excess use of the gum is restricted by adverse effects.
Nicotine patches: These patches contain an outsized measure of nicotine to allow the medication to be delivered consistently for an extended time a day. On the off chance that the fix is bitten and ingested, nicotine may leak and severe poisonousness may happen.
E-cigarettes: this is often a battery-powered device that vaporizes fluid nicotine, sometimes called "e-fluid" or "e-juice." The nicotine in these preparations is usually profoundly concentrated, and could be mixed with a seasoning agent like blueberry, chewing gum, or vanilla. The containers range from the dimensions of an eye-drop bottle to a gallon container, and sometimes have designs that are appealing to a child, resulting in concerns that children are going to be poisoned by these things. Moreover, there are concerns that the straightforwardness and straightforward accessibility of those items could be a pathway to nicotine dependence for non-smokers. Its role in smoking cessation is currently unclear however likely might be beneficial.
Toxicity of Nicotine
Today nicotine is a smaller amount generally utilized in horticultural insect sprays, which was a fundamental wellspring of harming. Later instances of harming ordinarily give off an impact of being as Green Tobacco Sickness, inadvertent ingestion of tobacco or tobacco items, or ingestion of nicotine-containing plants. People that gather or develop tobacco may encounter Green Tobacco Sickness (GTS), a kind of nicotine harming caused by dermal openness to wet tobacco leaves. This happens most typically in youthful, unpracticed tobacco gatherers who don't devour tobacco. People are often presented to nicotine within the work environment by breathing it in, skin retention, gulping it, or eye to eye connection. The Occupational Safety and Health Administration (OSHA) has set as far as possible (passable openness limit) for nicotine openness within the work environment as 0.5 mg/m3 skin openness over a 8-hour workday. The US National Institute for Occupational Safety and Health (NIOSH) has set a suggested openness limit (REL) of 0.5 mg/m3 skin openness over an 8-hour workday. At natural degrees of 5 mg/m3, nicotine is promptly risky to life and wellbeing.
Fluid nicotine and smokeless tobacco items are the most sources of nicotine harming. This is often on the grounds that the nicotine is cleaner. Additionally, you'll feel that these sorts of items are safer than tobacco smoke and afterward burn-through a greater amount of them.
Biosynthesis
The biosynthetic pathway of nicotine includes a coupling response between the 2 cyclic constructions that involve nicotine. Metabolic investigations show that the pyridine ring of nicotine is gotten from niacin (nicotinic corrosive) while the pyrrolidine is gotten from N-methyl-Δ1-pyrrollidium cation. Biosynthesis of the 2 segment structures continues by means of two free amalgamations, the NAD pathway for niacin and therefore the tropane pathway for N-methyl-Δ1-pyrrollidium cation.
The NAD pathway within the class Nicotiana starts with the oxidation of aspartic corrosive into α-imino succinate by aspartate oxidase (AO). This is often trailed by a buildup with glyceraldehyde-3-phosphate and a cyclization catalyzed by quinolinate synthase (QS) to offer quinolinic corrosive. Quinolinic corrosive at that time responds with phosphoriboxyl pyrophosphate catalyzed by quinolinic corrosive phosphoribosyl transferase (QPT) to shape niacin mononucleotide (NaMN). The response currently continues through the NAD rescue cycle to deliver niacin by means of the change of nicotinamide by the compound nicotinamidase.
The N-methyl-Δ1-pyrrollidium cation utilized within the union of nicotine may be a middle of the road within the amalgamation of tropane-determined alkaloids. Biosynthesis starts with decarboxylation of ornithine by ornithine decarboxylase (ODC) to deliver putrescine. Putrescine is then changed over into N-methyl putrescine by means of methylation by SAM catalyzed by putrescine N-methyltransferase (PMT). N-methylputrescine then goes through deamination into 4-methylaminobutanal by the N-methylputrescine oxidase (MPO) catalyst, 4-methylaminobutanal then suddenly cyclize into N-methyl-Δ1-pyrrollidium cation.
The last advance within the amalgamation of nicotine is that the coupling between N-methyl-Δ1-pyrrollidium cation and niacin. Despite the very fact that reviews close some sort of coupling between the 2 part structures, the positive interaction and system stays unsure. The present concurred hypothesis includes the transformation of niacin into 2,5-dihydropyridine through 3,6-dihydronicotinic corrosive. The 2, 5-dihydropyridine transitional would then respond with N-methyl-Δ1-pyrrollidium cation to border enantiomerically unadulterated (−) - nicotine.
Nicotine is that the boss addictive fixing within the tobacco utilized in cigarettes, stogies, and snuff. In its psychoactive impacts, nicotine may be a one among a sort substance with a biphasic impact; when breathed briefly puffs it's an energizer impact, yet when smoked in profound hauls it can have a sedating impact. This is often the rationale smoking can feel empowering at certain occasions and may appear to obstruct upsetting upgrades at others. Nicotine is additionally an addictive medication, however, and smokers naturally show a solid inclination to backslide after having effectively quit smoking for a period. At the purpose when ingested in bigger portions, nicotine may be a profoundly poisonous toxic substance that causes spewing and sickness, migraines, stomach torments, and, in serious cases, seizures, loss of motion, and demise.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
