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*Corresponding Author: Saeed Shoja Shafti, Full Professor of Psychiatry University of Social Welfare and Rehabilitation Sciences (USWR) Razi Psychiatric Hospital Tehran – Iran.
Citation: Saeed Shoja Shafti, Alireza Memarie, Masomeh Rezaie, Behjat Rahimi. Severe Mental Disorder and Comorbid Medical Ailments: A Pilot Enquiry in Aged Schizophrenic Patients. J Clinical Research and Reports, 5(3); DOI:10.31579/2690-1919/083
Copyright: © 2020 Saeed Shoja Shafti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Received: 28 July 2020 | Accepted: 29 August 2020 | Published: 10 September 2020
Keywords: schizophrenia; psychiatric disorders; medical comorbidity; elderly mental patients; senior group of people; chronic patients
Introduction: Comorbidity between mental disorders and physical illnesses is the rule rather than the exception. Approaches to study the impact of comorbidity become challenging also due to lack of consensus about how to define and measure the concept of comorbidity. The aim of the present study was to evaluate the clinical profile of medical comorbidity among a group of local chronic elderly schizophrenic patients to see their prevalence and physiognomies.
Methods: while geriatric section of Razi psychiatric hospital had been selected as the field of investigation, all elderly schizophrenic patients, who have been hospitalized there for lifelong, had been selected as accessible sample and surveyed with respect to recorded checkups and comorbid medical diagnoses. Psychiatric diagnosis was in essence based on ‘Diagnostic and Statistical Manual of Mental Disorders’, 5th edition (DSM-5) and medical diagnosis was principally based on ‘International Classification of Diseases’, 10th edition.
Results: Assessment had been performed on 168 aged schizophrenic patients (≥65 years old), including 101 men and 67 women. According to results, 89% (n=151) of elderly patients had some kind of registered non-psychiatric co-morbidity, which was meaningfully higher than frequency of comorbidity among senior group of local residents. Amongst recorded co-morbidities falls, hypertension and osteoarthritis were the most prevalent comorbidities with a frequency around 48.8%, 44.6% and 39.2%, respectively. Hypertension, renal disease and malnutrition were significantly more prevalent among male patients (p<0.0000, p<0.0045 and p< 0.0018, in turn) and hyponaremia, aspiration/asphyxiation and seizure were meaningfully more prevalent among female patients (p<0.0075, p<0.0000 and p<0.0009, one-to-one). As stated by the findings and in comparison with the senior group of local people while diabetes, renal diseases and malnutrition were significantly more frequent, coronary artery disease, gastrointestinal disorder and osteoarthritis were significantly less frequent among the present sample of elderly schizophrenic patients.
Conclusion: While in comparison with senior group of local people the rate of medical co-morbidities, particularly diabetes, renal diseases and malnutrition, were significantly higher in chronic elderly schizophrenic patients, a significant difference, as well, was palpable regarding the interrelated items between male and female patients, which demands further methodical and gender-based studies to define proper care and interventions for this vulnerable group of patients.
Perhaps, comorbidity between mental disorders and physical sicknesses is the rule rather than the exception (1). It is estimated that although 25% of adult population have mental health illness, 68% of them suffer from comorbid medical disease (2). While readmission rates in psychiatric patients are high and we still lack understanding its likely predictors, physical co-morbidity could be one of important risk factors for psychiatric readmission (2). On the other hand, while the term ‘comorbidity’ is well-acknowledged in research and clinical settings, the idea remains complicated and methodological approaches are different (3). So, there is now no agreement about the definition of comorbidity, which can be defined in several different methods (3). In general, the term comorbidity has three meanings: a) Indicating a medical sickness in a patient existing concurrently but independently with another condition; b) Representing a medical disease in a patient that causes, is caused by, or is otherwise related to another ailment in the same patient; c) Indicative of two or more medical sicknesses in a patient that exist at the same time, regardless of their causative association (4). In an inclusive trial of integrating different aspects of comorbidity, authors have combined different constructs and measures associated with the core concept of comorbidity. Hence, in this respect, four major distinctions were made according to the nature of the health condition, the relative importance of the co-occurring conditions, and the chronology of the conditions: comorbidity, multimorbidity, morbidity burden and patient’s complexity (5, 6). On the other hand, there is growing interest among physicians and scholars in the impact of comorbidity on a range of outcomes, such as mortality, health-related quality of life, patient's functioning, and health care utilization (7). For instance, physical comorbidities, basic demographic data, and clinical variables have shown to much better foretell mortality than the risk of readmission (8). Also, in patients with comorbidities, along with the higher risk of dying, a poorer functional status, quality of life, and a greater use of health services has been recounted (8). These conclusions led to the inference that among patients with comorbidity, the focus of health care should not only be on one particular ailment, but, besides, on the pathology in other organs and on indicators for quality of care, such as complications of management, readmissions, treatment plans and compliance to generally accepted clinical recommendations (9, 10). Earlier studies on patients with serious mental ailment such as long-lasting schizophrenia, bipolar disorder, or protracted recurrent depression, have revealed that these patients have higher mortality rates than persons without serious mental disorder (11). This variance is partially explained as being produced by increases in comorbid medical disorders in the mentally ill, frequently chronic diseases such as diabetes (12) and cardiovascular disease (13). Alternatively, though there is an assumption that patients with serious mental sickness experience a shortened life expectancy due to increased mortality and few of these patients would survive until old age (14), there is now evidence that the numbers of these old mentally ill survivors is increasing (15, 16). As stated by a study, patients with serious mental disorder had significantly higher rates of medical emergency room visits and meaningfully longer lengths of medical hospitalizations than did the primary care control group (17), and for depressed aged persons with at least one chronic medical ailment, improvements in clinical management and harmonization of medical and mental health amenities could moderate the rate of utilization of services (18). Furthermore, as said by another study on senior persons, readmission was most likely among persons with a primary diagnosis of schizophrenia, followed by bipolar disorder, depression, and substance abuse (19). Likewise, comorbid severe mental illness in patients with diabetes is individually linked with greater risk of early medical or surgical re-hospitalization (20). Besides, while health-risk behaviors (e.g., smoking, poor diet, and sedentary lifestyle) contribute to these poor outcomes, treatment with second generation antipsychotic drugs as well has been associated with poorer glycemic control among patients with diabetes (21). Alternatively, patients with serious mental conditions appear to under-utilize primary care services (22) and consequently increase the risk of medical hospitalizations due to possibly avoidable complications (23). Additionally, these patients may be at heightened risk of in-hospital adverse events, too, such as nosocomial infections and postoperative complications (24). Nevertheless, another study had found no increased risk due to these comorbidities (25). The aim of the present evaluation was to appraise the prevalence and physiognomies of medical comorbidities among a group of native elderly schizophrenic patients.
Razi psychiatric hospital in south of capital city of Tehran, as one of the largest and oldest public psychiatric hospitals in the Middle East, which has been established formally in 1917 and with a capacity around 1375 active beds, had been selected as the field of study in the present retrospective assessment. So, amongst its separate existent sections, chronic geriatric section of hospital with a capacity around 220 beds (110 for male and female aged patients, separately) had been designated as the specific field of investigation. Thus, for assessment, all chronic elderly schizophrenic patients (≥65 years old), as accessible sample, had been nominated and estimated with respect to registered checkups and comorbid medical conditions. Psychiatric diagnosis was principally based on ‘Diagnostic and Statistical Manual of Mental Disorders’, 5th edition (DSM-5) (26) and medical diagnosis was principally based on ‘International Statistical Classification of Diseases and Related Health Problems’, 10thRevision (27).
Statistical analysis:
Descriptive statistics including means, standard deviations, and ranges for continuous variables and quantity or percent in each category for categorical variables were calculated for all characteristics. T-tests for continuous data and chi-square tests for categorical data were used to compare the necessary variables between genders or groups. Statistical significance, as well, had been defined as p value ≤0.05. MedCalc Statistical Software version 15.2 was used as statistical software tool for analysis.
According to the findings, the current assessment of elderly schizophrenic patients had been performed on one hundred and sixty-eight patients, including one hundred and one males and sixty-seven females, who had been hospitalized in the chronic section of the hospital for long-life. Mean age (±SD) of the patients were around 69.12 ± 8.93 and 74.69 ± 6.54 for male and female patients, respectively, which was significantly shorter for male patients [t = -4.383, p < 0.00, CI 95% = -8.08, -3.06]. As said by results, nearly 89% (n=151) of aged patients had some kind of registered non-psychiatric co-morbidity, usually between one to four problems, that required specific care by a primary care physician or specialist, and so had received related standard cares, visits and treatments, on a regular basis (Table 1).
Co-morbidity | Number | Percentage |
Falls | 82 | 48.8 |
Hypertension | 75 | 44.6 |
Osteoarthritis | 51 | 30.3 |
Malnutrition | 64 | 30 |
Aspiration / Asphyxiation | 49 | 29.1 |
Prostate enlargement | 28 | 27.7 |
Diabetes | 39 | 23.2 |
Seizure | 34 | 20.2 |
Renal disease | 33 | 19.6 |
Bed sore | 30 | 17.8 |
Hyponatremia | 27 | 16 |
Coronary artery disease | 25 | 14.8 |
Gastrointestinal disorder | 14 | 8.3 |
Cataract | 14 | 8.3 |
Hypothyroid | 13 | 7.7 |
Chronic obstructive pulmonary disease | 13 | 7.7 |
Liver disease | 13 | 7.7 |
Anemia | 9 | 5.3 |
Congestive heart failure | 7 | 4.1 |
Cancer | 7 | 4.1 |
Stroke | 5 | 2.9 |
Hyperthyroid | 5 | 2.9 |
Parkinson disease | 5 | 2.9 |
Brain cyst | 1 | 0.5 |
Table 1- Prevalence of medical co-morbidities among elderly schizophrenic patients.
This amount of medical comorbidity was significantly higher in comparison with the local aged group of people with about 80% comorbidity (z= -3.2458 , p<0.0012, CI 95%=-0.1761,-0.0435) (28) (Table 2).
Comorbidity | Elderly schizophrenic patients (Percentage) | Senior group of local people (Percentage) | Z | P | CI |
Diabetes | 23.2% | 15.6% | 2.36 | 0.01 | -0.14,-0.01 |
Hypertension | 44.6% | 41.5% | 0.75 | 0.44 | -0.11,0.05 |
Chronic obstructive pulmonary disease | 7.73% | 10.8% | 1.18 | 0.23 | -0.02,0.08 |
Coronary artery disease | 14.8% | 37.5%
| 5.07 | 0.00 | 0.12,0.28 |
Renal disease | 19.6% | 6% | 5.62 | 0.00 | -0.18,-0.08 |
Malnutrition | 30% | 5.8 % | 11.32 | 0.00 | -0.37,-0.26 |
Gastrointestinal disorder | 8.33% | 45.89% | 8.92 | 0.00 | 0.29,0.45 |
Osteoarthritis | 30.35 | 79.2 | 12.74 | 0.00 | 0.42,0.58 |
Table 2 – Elderly schizophrenic patients versus senior group of local people, as regards the frequency of medical co-morbidities.
Listed co-morbidities included diabetes , hypertension, falls, congestive heart failure, chronic obstructive pulmonary disease, osteoarthritis , cancer , coronary artery disease, liver disease, renal disease, stroke, thyroid disease, bed sore, aspiration/asphyxiation, seizure , hyponatremia , malnutrition , anemia , gastrointestinal bleeding , prostate enlargement , cataract, Parkinson disease and brain cyst (Table 1). Among them falls, hypertension and osteoarthritis were the most prevalent disorders with a percentage around 48.8%, 44.6% and 30.35%, respectively (Table 1). The next co-morbidities included malnutrition (30%), aspiration / asphyxiation (29.1%), prostate enlargement (27.7%), diabetes (23.2%), seizure (20.2%), renal disease (19.6%), bed sore (17.8%), hyponatremia (16%), coronary artery disease (14.8%), gastrointestinal disorder (8.33%), cataract (8.33%), liver disease (7.73%) and hypothyroidism (7.73%). The remaining co-morbidities, including congestive heart failure, chronic obstructive pulmonary disease, cancer, stroke, anemia, Parkinson disease and brain cyst, were less than six percent, individually. As said by the findings, hypertension, renal disease and malnutrition were significantly more prevalent among male patients (p<0.0000, p<0.0045 and p< 0.0018, in turn) and hyponaremia, aspiration/asphyxiation and seizure, were significantly more prevalent among female patients (p<0.0075, p<0.0000 and p<0.0009, one-to-one) (Table 3).
Comorbidity | Males (n=101) | % | Females (n=67) | % | Z | P | CI |
Diabetes | 28 | 27.7 | 11 | 16.4 | 1.69 | 0.08 | -0.01,0.24 |
Hypertension | 60 | 59.4 | 15 | 22.3 | 4.72 | 0.00 | 0.21,0.52 |
Falls | 47 | 46.5 | 35 | 52.2 | 0.72 | 0.46 | -0.21,0.09 |
Congestive heart failure | 4 | 3.96 | 3 | 4.47 | 0.16 | 0.86 | -0.06,0.05 |
Chronic obstructive pulmonary disease | 8 | 3.9 | 5 | 2.9 | 0.10 | 0.91 | -0.07,0.08 |
Osteoarthritis | 29 | 28.71 | 22 | 32.83 | 0.56 | 0.56 | -0.18,0.10 |
Cancer | 4 | 3.9 | 3 | 4.4 | 0.16 | 0.86 | -0.06,0.05 |
Coronary artery disease | 13 | 12.8 | 12 | 17.9 | 0.89 | 0.36 | -0.16,0.05 |
Liver disease (hepatitis) | 9 | 8.9 | 4 | 5.97 | 0.69 | 0.17 | -0.05,0.11 |
Renal disease | 27 | 26.7 | 6 | 8.9 | 2.83 | 0.00 | 0.05,0.30 |
Stroke | 4 | 3.9 | 1 | 1.4 | 0.92 | 0.35 | -0.02,0.07 |
Hyperthyroid | 3 | 2.97 | 2 | 2.98 | 0.005 | 0.99 | --0.05,0.05 |
Hypothyroid | 8 | 7.92 | 5 | 7.46 | 0.10 | 0.91 | -0.07,0.08 |
Bed sore | 14 | 13.8 | 16 | 23.8 | 1.66 | 0.09 | -0.21,0.01 |
Aspiration / Asphyxiation | 17 | 16.8 | 32 | 47.7 | 4.31 | 0.00 | -0.44,-0.16 |
Seizure | 12 | 11.8 | 22 | 32.8 | 3.31 | 0.00 | -0.33,-0.08 |
Hyponatremia | 10 | 9.9 | 17 | 25.3 | 2.67 | 0.00 | -0.26,-0.04 |
Malnutrition | 50 | 49.5 | 14 | 20.8 | 3.12 | 0.00 | 0.09,0.39 |
Anemia | 5 | 4.9 | 4 | 5.9 | 0.28 | 0.77 | -0.07,0.05 |
Gastrointestinal disorder | 9 | 8.91 | 5 | 7.46 | 0.33 | 0.73 | -0.07,0.09 |
Prostate enlargement | 28 | 27.7 | - | - | - | -- | - |
Cataract | 8 | 7.92 | 6 | 8.95 | 0.23 | 0.81 | -0.09,0.07 |
Parkinson disease | 3 | 2.97 | 2 | 2.98 | 0.00 | 0.99 | -0.05,0.05 |
Brain cyst | 1 | 0.9 | 0 | 0 | - | - | - |
Table 3 –Prevalence of medical co-morbidities among male and female elderly schizophrenics.
According to the findings and in comparison with the senior people of local people, while diabetes, renal diseases and malnutrition were significantly more frequent, coronary artery disease, gastrointestinal disorder and osteoarthritis were significantly less frequent among the present sample of chronic old schizophrenic patients (Table 3).
While the co-occurrence of mental and physical conditions is very common in clinical settings, the exact nature of relationship between them is very complex and hitherto not well understood (29). So far, very little work has been done on medical comorbid disorders among patients with mental illnesses since comorbidity was rarely the main objective of studies (5). Additionally, while comorbidity is generally associated with mortality, consequences of specific disease combinations depend on many issues (11). It is clear that in elderly people, each body system undergoes changes, which occur over many years and are considered normal among senior people (10) However, these changes often place the elderly persons at high risk for the development of various diseases (15). So, it is very important to differentiate normal from pathological alterations in order to prevent wrongly treatment of normal changes and failing to treat those that result from ailments (29). Back to our discussion and with respect to clinical profile of medical comorbidity among senior schizophrenic patients, almost most of patients had some kind of registered non-psychiatric co-morbidity that demanded specific attention by a primary care physician or specialist. Thus, in comparison with senior group of local people (28) a significantly higher proportion of comorbidity was evident among the present sample. Such a finding was in harmony with the outcomes of Brown et al. (12)., Andrés et al. (5)., and Vigod et al. (7)., who believed that psychiatric patients have been widely reported to be at an increased risk of morbidity and mortality due to physical disorders and comorbidity between medical and mental disorders is the rule rather than the exception. But it was not in harmony with the conclusions of Daumit et al. (25), who had found no significant increased risk of morbidity or mortality associated with the presence of these comorbidities in severe mental patients. Besides, among the listed comorbidities in current assessment, falls, hypertension and osteoarthritis were the most prevalent medical complications. These outcomes are partially consistent with the findings of Hendrie et al. (17), who had found hypertension, osteoarthritis and diabetes as the most prevalent medical comorbidities among aged mental patients. But in contrary to him, in the present assessment there was not any significant difference regarding prevalence of hypertension between the present sample of schizophrenics and senior group of local people. Besides, while his claim regarding higher prevalence of falls in comparison with the primary care controls was not approvable here, due to deficiency of reliable native recording, falls was meaningfully higher among our patients, in comparison with other recorded items. Anyhow, the impact of demographic variances should not be ignored, since his samples included more females, a variety of ethnic groups and outpatients from primary care clients, while our samples included more males, single ethnic group (Persians), and only inpatients. Also with respect to other major co-morbidities in the present assessment, like malnutrition, diabetes, seizure, renal disease, coronary artery disease, gastrointestinal disorder and hypothyroidism , our findings were to some extent in harmony with reports of Zubenko et al. ( 30 ), Zgueb et al. ( 31 ), Räsänen et al. (32 ), Gausset et al. ( 33 ), Lim et al. ( 34 ), Hewer et al. ( 35 ), Tabbane et al. (36 ), Abiodun et al. ( 37 ) And Kamara et al.(38 ), who had found, as a general rule, infections, lung, gastrointestinal, urogenital and cardiovascular diseases as the most prevalent medical comorbidities among severe mental patients; Because they were comparable only with respect to urogenital and cardiovascular diseases. Our results regarding the remaining rarer co-morbidities, like congestive heart failure, chronic obstructive pulmonary disease, cancer and stroke, again, were not coherent with the outcomes of Hendrie et al. (17) and Tabbane et al. (36). Furthermore, since medical problems like, bed sore, aspiration/asphyxiation, seizure, hyponatremia and malnutrition, had not been pointed out or surveyed in the parallel studies, further assessment becomes difficult. On the other hand, as said by the conclusions of the current evaluation, hypertension, renal disease and malnutrition were significantly more prevalent among male patients and hyponaremia, aspiration/asphyxiation and seizure, were meaningfully more prevalent among female patients, which may display a gender-based difference in this regard. While such a difference could depend partly on the route of care, and somewhat on biological grounds, it may perhaps offer facts for future studies, too. Likewise, in comparison with the local senior persons, diabetes, renal diseases and malnutrition were significantly more frequent among the present sample of chronic elderly schizophrenic patients, a finding which was again, unharmonious with the findings of Hendrie et al. (17). Anyhow, while the impact of physical comorbidity on psychiatric readmission is still unsatisfactorily investigated problem, there is a growing interest among specialists and academics in the impact of physical comorbidity on a variety of outcomes in mental disorders, such as mortality, health-related quality of life and health care spending, which is noticeably higher for patients with comorbid disorders (10). The comorbidity of mental and physical disorders is on the increase and as pointed out by Sartorius this topic is becoming a main challenge to medicine in the 21st Century (14). Future research should address these topics with more in-depth studies since new understandings in this field could lead to better prevention approaches to reduce psychiatric readmissions (15). In this regard, teaching regarding the normal changes of aging should be the first intervention made with all aging adults to help them understand what is going on in their bodies. In addition, many interventions are available to compensate for these changes as well as to prevent the development of disease as a consequent of these interventions (29). Short duration of assessment, small sample size, restriction of study to a single academic center and lack of parallel and concomitant control groups, were among the weaknesses of the present evaluation. Surely, further methodical researches are needed to define proper care and interventions for this vulnerable group of patients.
While in comparison with senior group of local people the rate of medical co-morbidities, particularly diabetes, renal diseases and malnutrition, were significantly higher in chronic elderly schizophrenic patients, a significant difference, as well, was palpable regarding the interrelated items between male and female patients, which demands further methodical and gender-based studies to define proper care and interventions for this vulnerable group of patients.
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
