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*Corresponding Author: Giovanni Petracca, medical director at the General Surgery Department of the “G. Jazzolino” of Vibo Valentia italy.
Citation: Giovanni Petracca, (2024), Reprint-Necrotizing fasciitis: a case report and a review of the literature, Dermatology and Dermatitis, 9(6); DOI:10.31579/2578-8949/147
Copyright: © 2024, Giovanni Petracca. This is an open-access article distributed under the terms of The Creative Commons. Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 01 February 2024 | Accepted: 22 February 2024 | Published: 16 September 2024
Keywords: necrotizing fasciitis; shock; skin graft
Necrotizing fasciitis is a soft-tissue infection characterized by extensive necrosis of subcutaneous fat, neurovascular structures, and fascia. In general, fascial necrosis precedes muscle and skin involvement, hence its namesake. Initially, this uncommon and rapidly progressive disease process can present as a form of cellulitis or superficial abscess. However, the high morbidity and mortality rates associated with necrotizing fasciitis suggest a more serious, ominous condition. Diagnosis may be delayed because of the initial minimal skin cellulitis, even as the subcutaneous tissue suffers extensive necrosis and pronounced systemic toxicity develops. A delay in diagnosis can result in progressive advancement highlighted by widespread infection, multiple-organ involvement, and, ultimately, death. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) might be useful in cases where signs are equivocal or diagnosis is in doubt. Computed tomography scans are estimated to have a sensitivity of 80% for detecting necrotizing soft tissue infections. We present a case of limb salvage in a 52-year-old patient with misunderstood type 2 diabetes mellitus and progressive fascial necrosis. A detailed review of the literature is presented, and current treatment modalities are described. Aggressive surgical debridement, comprehensive medical management of the sepsis and comorbidities, and timely closure of the resultant wound or wounds are essential for a successful outcome.
Necrotizing fasciitis is a soft tissue infection characterized by extensive necrosis of subcutaneous fat, neurovascular structures and fascia.
Background: the characteristic of this case was aggression and rapid extension.
Case presentation: a 59-year-old woman was observed in a very serious condition, with fever and a large necrotic area that smelled of the right inguinal-femoral region in extension to the thigh. No history of illness. Obesity.
Diagnosis may be delayed due to minimal initial cutaneous cellulite. A delay in diagnosis can lead to the progression of the disease shown by shock, multiple organ failure and, ultimately, death. Computed tomography and Magnetic Resonance Imaging could be useful in cases where the signs are equivocal or the diagnosis is in doubt.
A detailed review of the literature is presented and the current treatment modalities are described. In this case, the aggressive surgical debridement, the complete medical management of sepsis and comorbidities and the timely closure of the wound by dermo-epidermal grafting were essential for a positive result.
Conclusions: necrotizing fasciitis is an uncommon life-threatening soft tissue infection, which spreads rapidly and progressively along the deep fascia. The prognosis depends on accurate diagnosis and immediate treatment.
Necrotizing fasciitis is an uncommon life-threatening soft tissue infection, which spreads rapidly and progressively along the deep fascia [1].
It was named ‘necrotizing fasciitis’ in 1952, from necrosis, which means death of a portion of tissue, and fascia, which refers to the fibrous tissues that enclose and connect the muscles [2].
The predisposing conditions are mainly diabetes mellitus, alcoholism, end-stage renal disease, malignancy, liver cirrhosis, malnutrition, gout, corticosteroid use, and trauma [3-6].
Diagnosis may be delayed because of the initial minimal skin cellulitis, even as the subcutaneous tissue suffers extensive necrosis and pronounced systemic toxicity develops [7].
The progression of the disease is fulminant and the mortality is high, despite effective antibiotic treatment [8,9].
The prognosis depends on accurate diagnosis and immediate treatment. In addition to delay in diagnosis and treatment, several risk factors, such as more than one underlying condition, thrombocytopenia, anemia, and older age, have been shown to influence mortality [10].
Higher mortality in patients with streptococcal toxic shock syndrome and in disease associated with certain bacteria has been reported [11-13].
Necrotizing fasciitis death rate is very high (20-40%) [14].
A 59-years-old woman was got into observation in a very serious condition, stupor with fever and extensive necrotic area smelling of the right inguinal-femoral region in extension to the thigh (fig. 1). No history of disease. Obesity. Heart rate being 105 bpm, respiratory F of 25 acts /minute and AP of 80/60 mmHg.
Figure 1: necrotic area smelling of the right inguinal-femoral region.
Laboratory parameters showed only a glycaemia alteration (338mg/100ml) and a leucocytosis (16.000 WBC with a neutrophilia equal to 80%). Thorax x-ray were normal. ECG was sinus rhythm with rate 105 bpm. CT scan shows gas bubbles in the subcutaneous tissue in the groin and thigh (figure. 2).
Figure 2: CT scan
It was then started a wide-spectrum antibiotics therapy (Meropenem 1g x 3/die; Teicoplanina 400 mg x 2/die), antifungal therapy (Flucanazolo 400 mg/die), rehydration therapy, low-molecular-weight heparin (LMWH). The patient was subjected, under general anesthesia, a debridement until the appearance of vital tissue (fig.3). Multiple biopsies carried out during the operation too underwent cultural and histomorphopathological analysis. After just 24 hours there took place a rapid development of the clinical picture with the appearance of areas of cutaneous necrosis extending to the right knee.
Figure 3: debridement until the appearance of vital tissue
Every day it was carried debridement until the gradual achievement of the fascia (two weeks after admission) (figure.4).
Figure 4: two weeks after admission.
Gradually, the general conditions have improved. Given a good toilet of the wound, he began, after about two weeks of admission, treatment with hyperbaric oxygen therapy for eight cycles. After about a month, the wound was clean with granulation tissue formation (figure. 5).
Figure 5: After about a month, granulation tissue formation.
After about two months of daily medication, there was a significant reduction of the wound surface (figure.6-7).
Figure 6: After about a month, granulation tissue formation.
Figure 7: After about a month, granulation tissue formation.
It was then underwent to surgery of wound reconstruction, by partial-thickness skin graft (fig.8-9).
Figure 8: partial-thickness skin graft.
Figura 9: partial-thickness skin graft.
After seven days, the skin graft area was healed (figure.10-11)
Figure 10: area skin graft after seven days.
Figure 11: area skin graft after seven days.
and after ten days, the skin donor site was healed (figure. 12).
Figure 12: skin donor site after ten days.
Necrotizing skin infections were first described by Jones in 1871, although at the time the term hospital gangrene was used [15].
The term necrotizing fasciitis was coined by Wilson in the 1950s to describe necrosis of the fascia and subcutaneous tissue with relative sparing of the underlying muscle [2].
Necrotizing fasciitis is characterized by rapid destruction of tissue, systemic toxicity, and, if not treated aggressively, gross morbidity and mortality. Early diagnosis and aggressive surgical treatment reduce risk; however, it is often difficult to diagnose NF, and sometimes patients are treated for simple cellulitis until they rapidly deteriorate [16].
Antibiotic therapy is mandatory, and early surgical exploration and debridement is critical to ensuring a good outcome.
Different terms and classifi cations have been used to describe necrotizing infections of the skin and subcutaneous tissue. These include necrotizing fasciitis, synergistic necrotizing cellulitis, streptococcal myonecrosis, and gas gangrene. This variety of classifications and terminology has been based on affected anatomy, microbial cause, and depth of infection. Awareness of this helps to reduce confusion.
FN can be classified in two types:
• Type 1 or plymicrobial: caused by aerobic and anaerobic bacteria, it target patients showing one or more risk factors (subjects aged 50 or over, diabetes mellitus, immunodeficiency, past surgical operation, penetrating trauma, omphalitis in newborns, colon carcinoma pierced colich diverticola, appendicular abscess etc.) it is the most frequent type (about 80% of the cases).
• Type 2 or monomicrobial: it’s caused by group A Strptococci only (or in association whit the Staphylococcus aureus), it targets subjects of any age who do not present any risk factor; it makes up for the 20% of the cases [14].
Pathology.
Most cases commence with trauma to the skin surface (eg, from a penetrative injury or even acupuncture needles, as was the case with our patient), with seeding of bacteria. Infection starts in the deep tissue planes, and the epidermis might not be initially affected. The clinical disease is expressed when infective organisms spread through the tissue along the deep fascia. Bacteria rapidly multiply within viable tissue, although fibrous attachments between subcutaneous tissues and fasciae limit spread to areas like the hands, feet, and scalp. Lack of fi brous attachments in the trunk and limbs, however, can lead to widespread infection and tissue destruction. Infection also spreads to venous and lymphatic channels, leading to edema. The spread of bacteria results in thrombosis of blood vessels in dermal papilla, resulting in ischemia and gangrene of subcutaneous fat and dermis [17]. If the fascia is breached,infection of the muscle leading to myositis occurs. Gas-producing organisms such as Clostridium species can give rise to subcutaneous gas, from which stems the descriptive term gas gangrene.
In addition, infections with toxin-producing bacteria (S aureus and S pyogenes) can lead to a toxic shock–like syndrome. herefore, seemingly limited infection can result in septic shock and multiorgan failure.
Risk factors.
Often, patients presenting with NF have some predisposition to infection (Diabetes, Chronic disease, Immunosuppressive drugs (eg, prednisolone), Malnutrition, Age > 60 years, Intravenous drug misuse, Peripheral vascular disease, Renal failure, Underlying malignancy, Obesity).
Precipitating events causing necrotizing fasciitis:
Traumatic: Surgery, Minor invasive procedures (eg, joint aspirations, acupuncture), Intravenous drug use, Penetrating injuries (eg, insect and animal bites).
Nontraumatic: soft tissue infection, burns, childbirth 18Risk factors for NF in the pediatric population include malnutrition and skin infections such as varicella [19,20].
Clinical features.
Patients with NF can present with constitutional symptoms of sepsis (eg, fever, tachycardia, altered mental state, diabetic ketoacidosis) alone or with evidence of skin inflammation, which makes diagnosis a little more straightforward.
Limbs are among the most common sites of infection. Common sites of infection included the lower extremities (28%), upper extremities (27%), perineum (21%), trunk (18%), and the head and neck (5%) [21].
Patients with NF are usually systemically toxic, initially presenting with fever (temperature greater than 38°C), tachycardia, diaphoresis, and possibly even an altered mental state or diabetic ketoacidosis. The physical examination should include all parts of the body to search for skin inflammation. This is especially necessary for patients who present with sepsis of which the source is not obvious [22].
Most patients present with signs of skin inflammation (ie, pain, skin edema, and erythema).
Necrotizing fasciitis typically presents with patchy discolouration of the skin with pain and swelling, but without a defined margin or lymphangitis [23].
Progression of NF is marked with the development of tense edema, a grayish-brown discharge, vesicles, bullae, necrosis, and crepitus. Hemorrhagic bullae and crepitus are sinister signs, with the likelihood of underlying fascia and muscle being compromised [24].
Localized pain is another clue to NF. As the disease is a deep-seated infection, the epidermis is minimally involved at initial presentation. The patient might complain of pain out of proportion to the degree of dermal involvement or pain that extends past the apparent margin of infection. Certain patients, notably those with diabetic neuropathy with loss of sensation, can experience minimal pain, resulting in a missed diagnosis. This is especially likely in concealed sites of infection, such as the perineum or oral cavity. A patch of anesthesia over the site of erythema is also sometimes described in NF. This is thought to be due to infarction of cutaneous nerves in necrotic subcutaneous fascia and soft tissue [25].
Disease progression
Necrotizing fasciitis can follow a hyperacute or a subacute course of progression. The patient with a hyperacute course presents with sepsis and rapidly progresses to multiorgan failure. Diagnosis of sepsis is obvious, and these patients are hospitalized. Several authors have described a subacute variation of NF [26-28].
These patients have an indolent disease course, with festering soft tissue infection. After the infection reaches a certain threshold, sudden deterioration is an important clinical feature. Aggressive surgical debridement is the cornerstone of treatment in these cases. Progression of disease is invariable in this group, and a delay in diagnosis can lead to greater soft tissue loss and mortality.
Diagnosis and decision for surgical exploration.
The criterion standard for diagnosis of NF is histology of tissue specimens obtained during surgical exploration, which was demonstrated in our case description. During surgical exploration, tissue integrity and depth of invasion can be assessed. Fascial necrosis and loss of fascial integrity indicate a necrotizing infection. Muscle involvement and necrosis are indicative of an advanced stage. To help decide which patients require surgical exploration, particularly in those with equivocal clinical signs, laboratory and radiologic tests might sometimes be useful.
Leukocytosis with neutrophilia, acidosis, altered coagulation profile, impaired renal function, raised creatinine kinase levels, and raised inflammatory markers, such as C-reactive protein levels, are all helpful if viewed within the whole of the clinical context.
Plain x-ray films can demonstrate subcutaneous gas, but this is a specific not a sensitive finding (positive in fewer than 25% of cases) and absence of gas does not exclude NF [29].
Computed tomography and magnetic resonance imaging (MRI) might be useful in cases where signs are equivocal or diagnosis is in doubt. Asymmetrical fascial thickening, fat stranding, and gas tracking along fascial planes are important imaging findings. Computed tomography scans are estimated to have a sensitivity of 80% for detecting necrotizing soft tissue infections [30].
In summary, if clinical suspicion is high, surgeons can opt to explore and perform tissue biopsies rather than delay treatment for imaging studies. Additional bedside tests include needle aspiration and incision biopsy. Negative results, however, cannot exclude NF. Surgical exploration is preferable. Macroscopic findings during surgical exploration include gray necrotic tissue, lack of bleeding, thrombosed vessels, “dishwater” pus, noncontracting muscle, and a positive “finger test” result, which is characterized by lack of resistance to fi nger dissection in normally adherent tissues.
Treatment
Once the diagnosis is made, treatment must begin on multiple fronts. First, surgical consultations should be urgently requested with the intention of early wound debridement for collection of tissue cultures, excision of all nonviable tissue, and delineation of the extent of the disease. (This is also important as tissue hypoxia limits the efficacy of intravenous antibiotics). It is important to educate patients about the gravity of their condition and the risk of increased mortality if surgical debridement is not performed. Until blood culture results are available, wide spectrum coverage with intravenous antibiotics is started. These antibiotics cover S pyogenes, S aureus (including community-acquired MRSA if indicated, according to local resistance patterns), and Gram-negative aerobes and anaerobes as clinically indicated.
Surgical treatment involves a large removal of all the necrotizing tissue through skin and subcutaneous incisions as far as the fascia, in parallel to the vessels and the nerves that have to be isolated and not thuced. The adipose tissue and the fascia have to be excised. The surgical openings are left open for subsequent medications carried out every 24 hours or less in the operating room, and possibly for a surgical “second-look” [14].
During the operation exudate samples and tissue biopsies will be collected and relative culural and cytological test will be carried out.
Subsequently to predict skin graft reconstruction.
Hyperbaric oxygen has also been used as an adjunct to surgery and antibiotics. Its role is still ill-defined. Some authors have reported a reduction in mortality, morbidity, and need for repeated debridement in up to two-thirds of cases [31,32]
Well-controlled randomized controlled trials are still lacking.
Moreover, a retrospective review by Golger et al showed that morbidity associated with NF was higher in patients who underwent hyperbaric oxygen therapy [21].
Prognosis
Mortality due to NF is considerable. Without surgical intervention, mortality approaches 100%. More recent data indicate a mortality of 16.4% for community-acquired necrotizing soft tissue infections and 36.3% for postprocedural necrotizing infections. All of these patients were managed in hospital with intravenous antibiotics and surgical interventions. Considering medical progress in the last 135 years, mortality is still substantial. Diabetic patients, especially those presenting with diabetic ketoacidosis or hyperosmolar hyperglycemic nonketotic acidosis have higher rates of death and longer lengths of hospital stay [33].
A delay in surgery of more than 24 hours was an independent risk factor for mortality [1].
Necrotizing fasciitis is an uncommon life-threatening soft tissue infection, which spreads rapidly and progressively along the deep fascia. The predisposing conditions are mainly diabetes mellitus, alcoholism, end-stage renal disease, malignancy, liver cirrhosis, malnutrition, gout, corticosteroid use, and trauma. The progression of the disease is fulminant and the mortality is high, despite effective antibiotic treatment. That is why early diagnosis is needed.
Wide-spectrum antibiotic therapy followed up by surgery and, when it is possible, by hyperbaric therapy as well, thus aiming at a substantial reduction of both morbidity and mortality rates, unfortunately still very high.
The prognosis depends on accurate diagnosis and immediate treatment. In addition to delay in diagnosis and treatment, several risk factors, such as more than one underlying condition, thrombocytopenia, anemia, and older age, have been shown to influence mortality.
Summary
Necrotizing fasciitis is a soft tissue infection characterized by extensive necrosis of subcutaneous fat, neurovascular structures, and fascia. In general, fascial necrosis precedes muscle and skin involvement, hence its namesake. Initially, this rare and rapidly progressive disease process may present as a form of cellulitis or superficial abscess. However, the high rates of morbidity and mortality associated with necrotizing fasciitis suggest a more serious and threatening condition. Diagnosis may be delayed due to minimal initial skin cellulitis, even if the subcutaneous tissue suffers extensive necrosis and pronounced systemic toxicity develops. A delay in diagnosis can result in disease progression evidenced by widespread infection, multiple organ involvement, and ultimately death. Computed tomography (CT) and magnetic resonance imaging (MRI) might be helpful in cases where signs are equivocal or the diagnosis is in doubt. Computed tomography scans are estimated to have a sensitivity of 80% for detecting necrotizing soft tissue infections. We present a case of limb salvage in a 52-year-old patient with type 2 diabetes mellitus and progressive fascial necrosis. A detailed literature review is presented and current treatment modalities are described. Aggressive surgical debridement, comprehensive medical management of sepsis and comorbidities, and timely closure of the resulting wound(s) are essential for a successful outcome.
Declarations
- Ethical Approval and Consent to participate: not applicable
- Consent for publication: not applicable
- Availability of supporting data: not applicable
- Competing interests: not applicable
- Funding: not applicable
- Authors' contributions: not applicable
- Acknowledgements: not applicable
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Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
