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Re – print- An Adjunct Treatment Reverses Chronic Insulin-dependent (Type 1) Diabetes in a Teenager

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Case Report

Re – print- An Adjunct Treatment Reverses Chronic Insulin-dependent (Type 1) Diabetes in a Teenager

  • Steve Yap 1

*Corresponding Author: Steve Yap, DSY Wellness and Longevity Center, Kuala Lumpur, Malaysia.

Citation: Steve Yap (2021) An Adjunct Treatment Reverses Chronic Insulin-dependent (Type 1) Diabetes in a Teenager. J, Biotechnology and Bioprocessing 2(9); DOI: 10.31579/2766-2314/061

Copyright: © 2021, Steve Yap, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 17 October 2021 | Accepted: 23 October 2021 | Published: 02 November 2021

Keywords: Type 1 diabetes mellitus, insulin-dependent diabetes, juvenile diabetes, autoimmune disorder, nutritional therapy

Abstract

Globally, more than 30 million people suffer from diabetes mellitus type 1 (T1DM) characterized by pancreas producing little or no insulin hormone to facilitate glucose entering cells for energy production. T1DM patients tend to suffer a higher overall rate of atherosclerosis, cancer, and end-stage renal failure. No drug or surgical therapy seems to halt its annual upward trend amongst children and young adults. Consequently, a significant number of sufferers turn to complementary or alternative therapies for help to arrest this chronic endocrine condition. This paper discusses how a well-designed evidence-based dietary and nutritional therapy with some lifestyle modifications might offer a solution for this highly complex autoimmune disorder. The treatment outcome demonstrated a partial regeneration of pancreatic islet beta cells with substantial improvement for all relevant serum and urine markers tested.

Case Presentation

Lee J., a slim 24-year old weighting 56kg, worked as an assistant chef at a restaurant serving local delicacies for a small town population in Peninsular Malaysia. He was on insulin injection for the past fifteen years after being diagnosed as suffering from juvenile diabetes (diabetes mellitus type I or T1DM) when he was eight years’ old. After been advised by his regular physician to reduce intake of refined starch and sugar during his initial years of administering his daily insulin, he felt that he was not gaining any weight like the rest of his school friends. Concerned about being laughed at as a ‘weakling’, he decided to resume his favourite noodles, buns, bread, biscuits, titbits, and sweet tropical fruits. He received no serious objections from his prescribing physician after raising this dietary issue with him. Worried about him developing early heart disease or hyperuricemia (elevated blood uric acid levels), his parents had discouraged him from consuming eggs, nuts, seeds, and beans. Over the past decade, the patient noticed that the amount of insulin prescribed for daily injection was raised on several occasions after tests confirmed his serum glucose gradual elevation. Being an insulin-dependent diabetic condition, he was instructed not to leave home without his insulin needle for which his parents paid. Having heard about complementary treatment for diabetes from a relative, he called on DSY Wellness Center to seek advice on how he could organise his diets while minimizing the use of insulin which often caused him to suffer from problems associated with hypoglycaemia (low blood glucose). 

After reviewing his past and present medical records, the patient was advised to gradually make these dietary modifications with the objective of establishing a regular meal pattern with fairly consistent day-to-day caloric and carbohydrate intake:

  1. Reducing substantially the regular intake of refined starches and sugars which require excessive insulin to process. Insulin is secreted primarily in response to blood glucose although dietary fats and protein augment this glucose-induced secretion [1]. Instead, most daily calories intake would come from complex carbohydrates such as leafy vegetables, yam, bamboo shoots, lentils, beans, seeds, and nuts. Dietary fiber intake tends to be consistently low and well below the recommended 30 gram /day in most diabetic patients [2-4].  Except for those prone to allergies, health concerns over bean/nut consumption may be unfounded since hyperuricemia is more likely to be induced by the widely available sweet tropical fruits high in fructose [5] for which the patient had several servings daily. Furthermore, beans and nuts are rich in magnesium which levels are often low in youngsters with T1DM [6] due to increased urinary excretion of this mineral despite good glycemic control [7].
  2. Keeping fat intake to less than 30 per cent of total calories to avoid gaining further adipose (fat) tissues during therapy period [8].
  3. Reducing intake of Trans fatty acids since these man-made fats promote insulin disorders and various other metabolic health problems [9].
  4. Including yellow, green or black tea as beverage. Camellia sinensis (tea) beverages may mildly suppress appetite while reducing glucose and triglycerides by more than 20% [10].
  5. Adding Momordica charantia L. (cucurbitaceae) to daily vegetable juicing or soup. This bitter-tasting melon could lower fasting glucose and improve glucose tolerance [11] by increasing glucose uptake [12] in the presence of some insulin [13]. Just 2 grams/day of the unripe melon has hypoglycaemic effect [14, 15] with higher dosages comparable to some prescription drugs for treating diabetes [16], but with no nephrotoxicity (kidney damage) or hepatotoxicity (liver damage) [17]. Its antidiabetic compounds include charantin, vicine and polypeptide-p [18], which can lower insulin need even on a high fat diet [19]. Improving glycemic control can improve markers of oxidative stress too [20, 21].
  6. Juicing organic and freshly-harvested low-frutose local fruits such as Garcinia mangostana (mangosteen), Mangifera indica (mango) and Psidium guajava (guava). Mangosteen juice may be able to lower blood inflammatory marker C-reactive protein scores after just two months’ therapy [22]. Freshly harvested unripe mango can also lower blood glucose [23]. Non-GMO (genetically modified organism) guava possesses strong free radical scavenging [24] as well as anti-inflammatory and antiglycative properties [25]. Both its hydrophilic and lipophilic antioxidant activities [26] seem to be contributed by its high ascorbic acid (vitamin C) content [27]. 
  7. Serving generous amount of spices. Trigonella foenum-graecum L. (fenugreek) contains emblica officinalis, which can lower fasting blood sugar and glycated hemoglobin (HbA1c) levels in diabetes. Cinnamomum Zeylanicum (cinnamon) is a commonly used spice [28] which appears to mimic the effect of insulin. Indeed, many of T1DM patients are aware of the positive effect of cinnamon on their blood glucose levels [29]. It has hypoglycemic effects [30] which can significantly lower HbA1c score, which is a strong measure of diabetic control [31].  Furthermore, compounds such as the micro-mineral chromium and polyphenols found in cinnamon could improve patient’s insulin sensitivity [32].
  8. Adding cooked non-GMO Triticum aestivum (wheat) sprout to salad or vegetable dishes. Its polysaccharides may stimulate insulin production by pancreatic beta-cells and pancreatic islets [33]. 

The patient was also advised to initiate these lifestyle modifications with immediate effect:

  1. Exercising to improve muscle tone and/or help build a higher muscle mass, which could enhance his body’s sensitivity to insulin [34]. Pancreas of a physically active or fit individual tends to secrete less insulin after being served carbohydrates than do physically unfit individuals [35].
  2. Avoiding ‘diet’ or ‘light’ cola or soft drinks since these beverages could make greater demand for insulin [36].

Ceasing to cook protein food with sugary items under high temperatures. Formation in this manner of Advanced Glycated End-products (AGEs) in food could further damage his insulin-secreting beta cells. AGEs are accelerated in diabetes or during hyperglycaemic conditions, but their production also occurs in settings characterized by oxidative stress and chronic inflammation [37].

When the patient’s first set of blood and urine test results returned, he was advised to continue his insulin injection or any medication unless his regular physician ordered otherwise.  As adjunct therapy, the following nutrients were prescribed to be taken after meals with the reasons explained to him:

  1. Gymnema sylvestre extract: 500 mg three times a day (TID). This herb helps stimulate insulin release from beta cells [38] besides increasing efficiency of this hormone [39]. It also may help regenerate these insulin-producing beta cells [40, 41], lower HbA1c scores and increase C-peptide levels in T1DM patients [42]. 
  2. Multivitamins and minerals: once a day. Some 40% of patients on complementary therapy take a good combination of multivitamins /minerals [28]. Compared to non-diabetics, diabetics tend to excrete significantly more minerals including zinc [43] needed for insulin production. 
  3. Chromium polynicotinate: 200mcg TID. This micromineral can help correct negative chromium balance common in youngsters with T1DM [44]. Being an essential nutrient involved in the metabolism of glucose and insulin, it can reverse glucose intolerance and neuropathy in T1DM [45] although dosages lower than 200mcg/day are unlikely to be effective [46]. 
  4.  Alpha lipoic acid (ALA): 200mg TID. Being an essential cofactor for mitochondrial bioenergetic enzymes, this nutrient improves glycemic control, prevents diabetic neuropathy [47, 48], treats different forms of autonomic diabetic neuropathy [49], improves microcirculation [50],  and ameliorates pathophysiologies of many chronic diseases [51].  Elevated HbA1c raises risk of diabetic retinopathy, which is found in up to 60% of TIDM patients aged 20 and above [52]. Diabetes is associated with elevated oxidative stress including DNA-damaging hydroxyl radical formation [53].
  5. Vitamin A: 10,000 IU BID. This fat-soluble vitamin has immuno-modulatory effects, which are relatively deficient in subjects with established T1DM [54]. Consequently, diets rich in polyphenols and/or vitamin A have protective effects against autoimmune inflammatory attack of the islet beta cells and they have the potential to reduce the pathogenesis of autoimmune diabetes [55, 56].
  6. Mixed tocopherols: 400 IU twice a day (BID).  Vitamin E ameliorates oxidative stress in T1DM and improves antioxidant defence system [57]. Even a modest supplementation can lower HbA1c and triglyceride levels in T1DM patients [58]. Free radical mediated oxidative stress can play a major role in the pathogenesis of diabetes. The glycation of proteins and elevated serum triglyceride levels are two of the major risk factors in the development of complications of diabetes. Vitamin E helps protect residual beta cell function of the pancreas [59]. 
  7. Ascorbic acid: 1g TID. Chronic hyperglycemia in T1DM patients induces permanent alterations of their endothelial function by increased oxidative stress, even after glycemia is normalized.  As a strong antioxidant, vitamin C can normalize endothelial function in these patients [60] and slow progression in hypertension and/or heart disease. It reduces sorbitol accumulation in erythrocytes promoted by hyperglycemia [61] by inhibiting the enzyme erythrocyte aldose reductase [62].
  8. Folate: 800mcg BID. Endothelial dysfunction, a precursor of vascular disease, begins early in T1DM and is associated with low folate status with high-dose folate normalizing endothelial dysfunction [63, 64], although it does not seem to do so in non-diabetics even if obese [65]. 
  9. Nicotinamide: 500mg TID. This non-flushing vitamin B3 inhibits poly (ADP-ribose) polymerase, reduces nitric oxide accumulation in pancreas, and can protect beta cells against radical-induced necrosis [66]. It can preserve baseline C-peptide secretion [67], which augments blood flow in skeletal muscle and skin, diminishes glomerular hyperfiltration, reduces urinary albumin excretion, and improves nerve function in patients with T1DM [68]. Just 25mg/kg of body weight seems effective in reducing insulin-producing beta-cell dysfunction [69].
  10. Vitamin D3: 4000 IU TID. Of the various environmental causes, this anti-autoimmune vitamin is rather well-studied in relation to T1DM [70-74]. Patients may achieve lower HbA1c levels if they have higher serum 25-hydroxyvitamin D levels [75], although some studies showed only a small positive effect on fasting glucose [76].

Magnesium citrate (elemental value 16%): 1g TID. One in four diabetic patients [77] may suffer from hypomagnesemia, which can lead to poor diabetic control with higher HbA1c scores [78], early atherosclerosis [79] and microalbuminuria [80]. Its deficiency can cause retinopathy and hypertension [81], metabolic syndrome [82], and chronic diabetic complications [83] since it is a co-factor in more than 300 different enzyme systems in the body [84]. Insulin injection can enhance renal magnesium excretion [85]. Supplementation can improve insulin sensitivity and may stimulate insulin secretion [86].  

Discussion

T1DM is characterized by the infiltration of activated T-lymphocytes and monocytes into the islets of Langerhans of the pancreas, resulting in chronic inflammation and progressive destruction of the insulin-producing beta cells [87, 88]. Activated T-cells and cytokines secreted from immunocytes act synergistically to destroy these beta cells resulting in the development of this autoimmune disease [89]. Once islet auto-antibodies have developed, the progression to diabetes in antibody-positive individuals is determined by the age of antibody appearance and by the magnitude of the autoimmunity [90]. Globally, some 33 million people suffer from T1DM and its incidence increases by about 3% annually among children [91]. T1DM patients appear to face a higher overall incidence of cancer [92] and end-stage renal failure [93].

Vitamin D receptor (VDR) gene polymorphisms may determine risk of developing T1DM with the environment influencing the association between VDR genotype and T1DM risks [72].  The disorder commonly begins during childhood but may appear later in adulthood in a proportion of 30 to 40% of affected individuals [94].

Parent’s eating habits and the home food environment such as its accessibility and availability are important determinant of their children’s dietary intake [95, 96]. The likelihood of children making positive changes to their diets will be increased if their parents are involved and supportive. Vegetables and low-fructose citric fruits consumption should be raised [97] , while long-chain saturated fats intake should be lowered [98, 99] since atherosclerosis may be well-established when T1DM children reach adolescence [100, 101]. 

Increased intake of omega-3 fatty acids and fish oil is linked to reduced T1DM–associated autoantibody conversion [102]. Use of cod liver oil rich in vitamins A and D in the first year of life is associated with a significantly lower risk of T1DM [103]. Vitamin D3 supplementation in early childhood can offer protection against the development of T1DM [73, 104] as well as helping to reverse its increasing incidence [105].

A long list of environmental factors influences the risks for or progression to T1DM [87], which condition is on the rise globally [106] and especially in children [107]. The presence of multiple autoantibodies seems to have the highest positive predictive value for development of T1DM [108, 109]. Insulin autoantibodies, in contrast to the other autoimmune markers, are the only beta-cell specific antibodies [110].

There may be a link between viral infections and the first appearance or increase in islet antibodies [111-113] although the evidence is weak [114, 115]. However, viral infection of antigen presenting cells can locally raise inflammation and auto-reactive lymphocytes [116]. 

An early onset of T1DM can raise the child’s risk of learning disability [117]. Difficulties in diagnosing T1DM are a significant cause of diabetic ketoacidosis development in children with new-onset disease [118].

A cure for T1DM may require the provision or elicitation of new pancreatic islet beta cells   as well as the reestablishment of immunological tolerance [119]. The limited regenerative ability of the endocrine pancreas may be linked to the defined number of pancreatic progenitors, which is generally incapable of compensatory growth in response to cell loss [120]. The inability to cure this chronic disorder is largely because   of its highly complex pathophysiology [121].

Some 28% of the population in developed nations depends on complementary and alternatives modalities to treat their T1DM [28] although there seems to be  insufficient research evidence to support differing nutritional needs for those with T1DM compared to type 2 diabetes [122].

The Diagnosis

The patient suffered from most of the major symptoms of juvenile diabetes such as polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss [123]. His dramatically reduced HbA1c score after three months’ therapy suggested a much lower level of glycated hemoglobin and a stronger diabetic control. Such a score could also be linked to his lower triglyceride levels [99]. The fasting insulin and glucose levels in November 2013 would suggest his pancreatic islet beta cells were releasing adequate insulin to meet his needs after some dietary modifications. This supports long-held belief that there would still be some functional beta cells in people with longstanding T1DM [124]. His chronic inflammatory conditions improved five-fold accompanied by much lower level urine microalbumin. The patient was delighted with the disappearance of any glucose from his urine sample taken at the end of the third month of therapy.  This positive outcome was confirmed by the patient’s regular physician, who then advised a temporary halt to the administration of insulin pending further monitoring.

Although cytokines such as IL-1alpha, IL-1beta and IFN-gamma are widely implicated in the pathogenesis of autoimmune diabetes [125], local laboratories were unable to test these markers. 

The patient was using the insulin pump and with flexible injection regimens designed for him to lead a normal lifestyle [126]. However, initial test results suggested his inability to benefit fully from these modern conventional therapie.

Extracts from the patient’s three months’ test results for 2013 were as follow:

Table 1.

Conclusion

The health outcome achieved by the patient suggested some form of pancreatic cell mass regeneration consequent upon undertaking this nutritional therapy which involved some lifestyle modifications. Further study involving a higher number of patients with similar conditions is warranted to elucidate its wider therapeutic benefits in the treatment of T1DM.

References

  1. Fu Z, Gilbert ER, Liu D. (2013) Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev. 9(1):25-53.
    View at Publisher | View at Google Scholar
  2. Helgeson VS, Viccaro L, Becker D, Escobar O, Siminerio L. (2006) Diet of adolescents with and without diabetes: Trading candy for potato chips? Diabetes Care. 29(5):982–7.
    View at Publisher | View at Google Scholar
  3. Lodefalk M and Aman J. (2006) Food habits, energy and nutrient intake in adolescents with Type 1 diabetes mellitus. Diabet Med. 23:1225–32.
    View at Publisher | View at Google Scholar
  4. Randecker GA, Smiciklas-Wright H, McKenzie JM, Shannon BM, Mitchell DC, et al. (1996) The dietary intake of children with IDDM. Diabetes Care.19:1370-4.
    View at Publisher | View at Google Scholar
  5. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI et al. (2007) Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr. 86(4):899-906.
    View at Publisher | View at Google Scholar
  6. Fort P, Lifshitz F. (1986) Magnesium status in children with insulin-dependent diabetes mellitus. J Am Coll Nutr. 5(1):69-78.
    View at Publisher | View at Google Scholar
  7. Ponder SW, Brouhard BH, Travis LB. (1990) Hyperphosphaturia and hypermagnesuria in children with IDDM. Diabetes Care. 13(4): 437-41.
    View at Publisher | View at Google Scholar
  8. Bantle J. (1988) The dietary treatment of diabetes mellitus. Med Clin North Am. 72(6): 1285-99.
    View at Publisher | View at Google Scholar
  9. Ascherio A and Willett W. (1997) Health effects of trans fatty acids. Am J Clin Nutr, 66: 1006-10.
    View at Publisher | View at Google Scholar
  10. Zeyuan D, Bingying T, Xiaolin L, Jinming H, Yifeng C. (1998) Effect of green tea and black tea on the metabolisms of mineral elements in old rats. Biol Trace Elem Res. 65(1):75-86.
    View at Publisher | View at Google Scholar
  11. Raman A, Lau C. (1996) Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine. 2(4):349-62.
    View at Publisher | View at Google Scholar
  12. Yibchok-anun S, Adisakwattana S, Yao CY, Sangvanich P, Roengsumran S, et al. (2006) Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities. Biol Pharm Bull. 29(6):1126-31
    View at Publisher | View at Google Scholar
  13. Roffey BW, Atwal AS, Johns T, Kubow S. (2007) Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3-L1 adipose cells. J Ethnopharmacol. 112(1):77-84.
    View at Publisher | View at Google Scholar
  14. Fuangchan A, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, et al. (2011) Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J Ethnopharmacol. 134(2):422-8.
    View at Publisher | View at Google Scholar
  15. Khanna P, Jain SC, Panagariya A, Dixit VP. (1981) Hypoglycemic activity of polypeptide-p from a plant source. J Nat Prod. 44:648–55.
    View at Publisher | View at Google Scholar
  16. Sarkar S, Pranava M, Marita R. (1996) Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes. Pharmacol Res. 33(1):1-4.
    View at Publisher | View at Google Scholar
  17. Virdi J, Sivakami S, Shahani S, Suthar AC, Banavalikar MM, et al. (2003) Antihyperglycemic effects of three extracts from Momordica charantia. J Ethnopharmacol. 88(1):107-11.
    View at Publisher | View at Google Scholar
  18. Krawinkel MB, Keding GB. (2006) Bitter gourd (Momordica Charantia): A dietary approach to hyperglycemia. Nutr Rev. 64(7 Pt 1):331-7.
    View at Publisher | View at Google Scholar
  19. Chen Q, Chan LL, Li ET. (2003) Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr. 133(4):1088-93.
    View at Publisher | View at Google Scholar
  20. Sharma A, Kharb S, Chugh SN, Kakkar R, Singh GP. (2000) Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients. Metabolism. 49:160–2.
    View at Publisher | View at Google Scholar
  21. Santini SA, Marra G, Giardina B, Cottroneo P, Mordente A, Martorana GE, et al. (1997) Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM. Diabetes. 46:1853–8.
    View at Publisher | View at Google Scholar
  22. Udani JK, Singh BB, Barrett ML, Singh VJ. (2009) Evaluation of mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study. Nutr J. 8:48.
    View at Publisher | View at Google Scholar
  23. Lucas EA, Li W, Peterson SK, Brown A, Kuvibidila S, et al. (2011) Mango modulates body fat and plasma glucose and lipids in mice fed a high-fat diet. Br J Nutr. 106(10):1495-505.
    View at Publisher | View at Google Scholar
  24. Adesida A, Farombi EO. (2012) Free radical scavenging activities of guava extract in vitro. Afr J Med Med Sci. 41(S):81-90.
    View at Publisher | View at Google Scholar
  25. Lin CY, Yin MC. (2012) Renal protective effects of extracts from guava fruit (Psidium guajava L.) in diabetic mice. Plant Foods Hum Nutr. 67(3):303-8.
    View at Publisher | View at Google Scholar
  26. Thaipong K, Boonprakob U, Cisneros-Zevallos L, Byrne DH. (2005) Hydrophilic and lipophilic antioxidant activities of guava fruits. Southeast Asian J Trop Med Public Health. 36(S4):254-7.
    View at Publisher | View at Google Scholar
  27. Thuaytong W, Anprung P. (2011) Bioactive compounds and prebiotic activity in Thailand-grown red and white guava fruit (Psidium guajava L.). Food Sci Technol Int. 17(3):205-12.
    View at Publisher | View at Google Scholar
  28. Manya K, Champion B, Dunning T. (2012) The use of complementary and alternative medicine among people living with diabetes in Sydney. BMC Complement Altern Med. 12:2.
    View at Publisher | View at Google Scholar
  29. Fabian E, Toscher S, Elmadfa I, Pieber TR. (2011) Use of complementary and alternative medicine supplements in patients with diabetes mellitus. Ann Nutr Metab. 58(2):101-8.
    View at Publisher | View at Google Scholar
  30. Deng RT. (2012) A review of the hypoglycemic effects of five commonly used herbal food supplements. Recent Pat Food Nutr Agric. 4(1):50-60.
    View at Publisher | View at Google Scholar
  31. Akilen R, Tsiami A, Devendra D, Robinson N. (2012) Cinnamon in glycaemic control: Systematic review and meta-analysis. Clin Nutr. 31(5):609-15.
    View at Publisher | View at Google Scholar
  32. Anderson RA. (2008) Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 67(1):48-53.
    View at Publisher | View at Google Scholar
  33. Lee SH, Lim SW, Lee YM, Lee HS, Kim DK. (2012) Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel. Int J Mol Med. 29(5):913-9.
    View at Publisher | View at Google Scholar
  34. Mayer-Davis EJ, D'Agostino R Jr, Karter AJ, Haffner SM, Rewers MJ, et al. (1998) Intensity and amount of physical activity in relation to insulin sensitivity: The Insulin Resistance Atherosclerosis Study. JAMA. 279:669-74.
    View at Publisher | View at Google Scholar
  35. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. (1991) Physical activity and reduced occurance of non-insulin dependent diabetes mellitus. N Eng J Med. 325:147-52.
    View at Publisher | View at Google Scholar
  36. Fowler SP, Williams K, Resendez RG, Hunt KJ, Hazuda HP, et al. (2008) Fuelling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity (Silver Spring) 16(8):1894-900.
    View at Publisher | View at Google Scholar
  37. Del Turco S and Basta G. (2012) An update on advanced glycation endproducts and atherosclerosis. Biofactors. 10:1002-18.
    View at Publisher | View at Google Scholar
  38. Persaud SJ, Al-Majed H, Raman A, Jones PM. (1999) Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol. 163(2):207-12.
    View at Publisher | View at Google Scholar
  39. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. (1990) Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 30(3):295-300.
    View at Publisher | View at Google Scholar
  40. Liu B, Asare-Anane H, Al-Romaiyan A, Huang G, Amiel SA, et al. (2009) Characterisation of the insulinotropic activity of an aqueous extract of Gymnema sylvestre in mouse beta-cells and human islets of Langerhans. Cell Physiol Biochem. 23(1-3):125-32.
    View at Publisher | View at Google Scholar
  41. Shanmugasundaram ER, Gopinath KL, Radha Shanmugasundaram K, Rajendran VM. (1990) Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J Ethnopharmacol. 30(3):265-79.
    View at Publisher | View at Google Scholar
  42. Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, et al. (1990) Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 30(3):281-94.
    View at Publisher | View at Google Scholar
  43. el-Yazigi A, Hannan N, Raines DA. (1993) Effect of diabetic state and related disorders on the urinary excretion of magnesium and zinc in patients. Diabetes Res. 22(2):67-75.
    View at Publisher | View at Google Scholar
  44. Karagun BS, Temiz F, Ozer G, Yuksel B, Topaloglu AK, et al. (2012) Chromium levels in healthy and newly diagnosed type 1 diabetic children. Pediatr Int. 54(6):780-5.
    View at Publisher | View at Google Scholar
  45. Anderson RA. (2000) Chromium in the prevention and control of diabetes. Diabetes Metab. 26(1):22-7.
    View at Publisher | View at Google Scholar
  46. Guimaraes MM, Martins Silva Carvalho AC, Silva MS. (2013) Chromium nicotinate has no effect on insulin sensitivity, glycemic control, and lipid profile in subjects with type 2 diabetes. J Am Coll Nutr. 32(4):243-50.
    View at Publisher | View at Google Scholar
  47. Golbidi S, Badran M, Laher I. (2011) Diabetes and alpha lipoic Acid. Front Pharmacol. 2:69.
    View at Publisher | View at Google Scholar
  48. Singh U and Jialal I. (2008) Alpha-lipoic acid supplementation and diabetes. Nutr Rev. 66(11):646-57.
    View at Publisher | View at Google Scholar
  49. Tankova T, Koev D, Dakovska L. (2004) Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). Rom J Intern Med. 42(2):457-64.
    View at Publisher | View at Google Scholar
  50. Ziegler D. (2004) Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat Endocrinol. 3(3):173-89.
    View at Publisher | View at Google Scholar
  51. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. (2004) Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem. 11(9):1135-46.
    View at Publisher | View at Google Scholar
  52. Olsen BS, Sjølie AK, Hougaard P, Johannesen J, Marinelli K, et al. (2004) The significance of the prepubertal diabetes duration for the development of retinopathy and nephropathy in patients with type 1 diabetes. J Diabetes Complications. 18(3):160-4.
    View at Publisher | View at Google Scholar
  53. Suzen S, Buyukbingol E. (2003) Recent studies of aldose reductase enzyme inhibition for diabetic complications. Curr Med Chem. 10(15):1329-52.
    View at Publisher | View at Google Scholar
  54. Baena RM, Campoy C, Bayés R, Blanca E, Fernández JM. (2002) Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus. Eur J Clin Nutr. 56:44–50.
    View at Publisher | View at Google Scholar
  55. Wasserfall C and Atkinson M. (2009) Taking a Daily Vitamin to Prevent Type 1 Diabetes? Diabetes. 58(1):24–5.
    View at Publisher | View at Google Scholar
  56. Zunino SJ, Storms DH, Stephensen CB. (2007) Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice. J Nutr. 137(5):1216-21.
    View at Publisher | View at Google Scholar
  57. Gupta S, Sharma TK, Kaushik GG, Shekhawat VP. (2011) Vitamin E supplementation may ameliorate oxidative stress in type 1 diabetes mellitus patients. Clin Lab. 57(5-6):379-86.
    View at Publisher | View at Google Scholar
  58. Jain SK, McVie R, Jaramillo JJ, Palmer M, Smith T. (1996) Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients. J Am Coll Nutr. 15(5):458-61.
    View at Publisher | View at Google Scholar
  59. Pozzilli P, Visalli N, Cavallo MG, Signore A, Baroni MG et al. (1997) Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes (the IMDIAB IV study). Eur J Endocrinol. 137(3):234
    View at Publisher | View at Google Scholar
  60. Ceriello A, Piconi L, Esposito K, Giugliano D. (2007) Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes. Diabetes Care. 30(7):1694-8.
    View at Publisher | View at Google Scholar
  61. Cunningham JJ, Mearkle PL, Brown RG. (1994) Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr. 13(4):344-50.
    View at Publisher | View at Google Scholar
  62. Vincent TE, Mendiratta S, May JM. (1999) Inhibition of aldose reductase in human erythrocytes by vitamin C. Diabetes Res Clin Pract. 43(1):1-8.
    View at Publisher | View at Google Scholar
  63. MacKenzie KE, Wiltshire EJ, Gent R, Hirte C, Piotto L, et al. (2006) Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics. 118(1):242-53.
    View at Publisher | View at Google Scholar
  64. Pena AS, Wiltshire E, Gent R, Hirte C, Couper J. (2004) Folic acid improves endothelial function in children and adolescents with type 1 diabetes. J Pediatr. 144(4):500-4.
    View at Publisher | View at Google Scholar
  65. Pena AS, Wiltshire E, Gent R, Piotto L, Hirte C, Couper J. (2007) Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care. 30(8):2122-7.
    View at Publisher | View at Google Scholar
  66. Kawasaki E, Abiru N, Eguchi K. (2004) Prevention of type 1 diabetes: from the view point of beta cell damage. Diabetes Res Clin Pract. 66(S1):S27-32.
    View at Publisher | View at Google Scholar
  67. Crino A, Schiaffini R, Manfrini S, Mesturino C, Visalli N, et al. (2004) A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes (IMDIAB IX). Eur J Endocrinol. 150(5):719-24.
    View at Publisher | View at Google Scholar
  68. Wahren J , Ekberg K , Johansson J , Henriksson M , Pramanik A , et al. (2000) Role of C-peptide in human physiology. Am J Physiol Endocrinol Metab. 278(5):E759-68.
    View at Publisher | View at Google Scholar
  69. Visalli N, Cavallo MG, Signore A, Baroni MG, Buzzetti R, et al. (1999) A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI). Diabetes Metab Res Rev. 15(3):181-5.
    View at Publisher | View at Google Scholar
  70. Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, et al. (2009) High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol. 46(3):183-9.
    View at Publisher | View at Google Scholar
  71. Vojtkova J, Ciljakova M, Vojarova L, Janíkova K, Michnova Z, et al. (2012) Hypovitaminosis D in children with type 1 diabetes mellitus and its influence on biochemical and densitometric parameters. Acta Medica (Hradec Kralove). 55(1):18-22.
    View at Publisher | View at Google Scholar
  72. Ponsonby AL, Pezic A, Ellis J, Morley R, Cameron F, et al. (2008) Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression ana
    View at Publisher | View at Google Scholar
  73. Zipitis CS and Akobeng AK. (2008) Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 293(6):512-7.
    View at Publisher | View at Google Scholar
  74. Ramos-Lopez E, Brück P, Jansen T, Herwig J, Badenhoop K. (2007) CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabete Metab Res Rev. 23:631–6.
    View at Publisher | View at Google Scholar
  75. Aljabri KS, Bokhari SA, Khan MJ. (2010) Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency. Ann Saudi Med. 30(6):454-8.
    View at Publisher | View at Google Scholar
  76. George PS, Pearson ER, Witham MD. (2012) Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 29(8):e142-50.
    View at Publisher | View at Google Scholar
  77. Mather HM, Nisbet JA, Burton GH, Poston GJ, Bland JM, et al. (1979) Hypomagnesemia in diabetes. Clin Chim Acta, 95:235-42.
    View at Publisher | View at Google Scholar
  78. Vanroelen WF, Van Gaal LF, Van Rooy PE, De Leeuw IH. (1985) Serum and erythrocyte magnesium levels in type I and type II diabetics. Acta Diabetol Lat. 22(3):185-90.
    View at Publisher | View at Google Scholar
  79. Atabek ME, Kurtoglu S, Pirgon O, Baykara M. (2006) Serum magnesium concentrations in type 1 diabetic patients: relation to early atherosclerosis. Diabetes Res Clin Pract. 72(1):42-7.
    View at Publisher | View at Google Scholar
  80. Xu B, Sun J, Deng X, Huang X, Sun W, et al. (2013) Low serum magnesium level is associated with microalbuminuria in Chinese diabetic patients. Int J Endocrinol. 2013:580685.
    View at Publisher | View at Google Scholar
  81. Sharma A, Dabla S, Agrawal RP, Barjatya H, Kochar DK, et al. (2007) Serum magnesium: an early predictor of course and complications of diabetes mellitus. J Indian Med Assoc. 105(1):16, 18, 20.
    View at Publisher | View at Google Scholar
  82. He K, Liu K, Daviglus ML, Morris SJ, Loria CM, et al. (2006) Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 113(13):1675-82.
    View at Publisher | View at Google Scholar
  83. Elamin A, Tuvemo T. (1990) Magnesium and insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 10(3):203-9.
    View at Publisher | View at Google Scholar
  84. Wester PO. (1987) Magnesium. Am J Clin Nutr. 45(5 Suppl):1305-12.
    View at Publisher | View at Google Scholar
  85. Djurhuus MS, Sktt P, Hother-Nielsen O, Klitgaard NAH, Beck-Nielsen H. (1995) Insulin increases renal magnesium excretion. Diabet Med, 12: 664-9.
    View at Publisher | View at Google Scholar
  86. de Valk HW. (1999) Magnesium in diabetes mellitus. Neth J Med. 54(4):139-46.
    View at Publisher | View at Google Scholar
  87. Atkinson M and Eisenbarth G. (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. The Lancet, 358:221–9.
    View at Publisher | View at Google Scholar
  88. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, et al. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 343(4):230-8.
    View at Publisher | View at Google Scholar
  89. Yoon JW and Jun HS. (2001) Cellular and molecular pathogenic mechanisms of insulin-dependent diabetes mellitus. Ann N Y Acad Sci. 928:200-11.
    View at Publisher | View at Google Scholar
  90. Achenbach P, Bonifacio E, Koczwara K, Ziegler AG. (2005) Natural history of type 1 diabetes. Diabetes. 54(S2):S25-31.
    View at Publisher | View at Google Scholar
  91. Gordon-Dseagu V, Shelton N, Mindell J. (2013) Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: a review of the existing literature. Int J Cancer. 132(3):501–8.
    View at Publisher | View at Google Scholar
  92. Zendehdel K, Nyrén O, Ostenson CG, Adami HO, Ekbom A, et al. (2003) Cancer incidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden. J Natl Cancer Inst. 95(23):1797-800.
    View at Publisher | View at Google Scholar
  93. Krolewski AS, Bonventre JV. (2012) High risk of ESRD in type 1 diabetes: call for action: introduction. Semin Nephrol. 32(5):405-6.
    View at Publisher | View at Google Scholar
  94. Fandrich F, Ungefroren H. (2010) Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives. Adv Exp Med Biol. 654:641-65.
    View at Publisher | View at Google Scholar
  95. Arcan C, Neumark-Sztainer D, Hannan P, van den Berg P, Story M, et al. (2008) Parental eating behaviours, home food environment and adolescent intakes of fruits, vegetables and dairy foods: longitudinal findings from Project EAT. Public Health Nutr. 10:12
    View at Publisher | View at Google Scholar
  96. Cullen KW, Baranowski T, Owens E, Marsh T, Rittenberry L, de Moor C. (2003) Availability, accessibility, and preferences for fruit, 100% fruit juice and vegetables influence children's dietary behavior. Health Edu & Behavior. 30(5):615–26.
    View at Publisher | View at Google Scholar
  97. Mayer-Davis EJ, Nichols M, Liese AD, Bell RA, Dabelea DM, et al. (2006) Dietary intake among youth with diabetes: the SEARCH for Diabetes in Youth Study. J Am Diet Assoc. 106(5):689–97.
    View at Publisher | View at Google Scholar
  98. Overby NC, Flaaten V, Veierød MB, Bergstad I, Margeirsdottir HD, et al. (2007) Children and adolescents with type 1 diabetes eat a more atherosclerosis-prone diet than healthy control subjects. Diabetologia. 50:307–16.
    View at Publisher | View at Google Scholar
  99. Faulkner MS, Chao WH, Kamath SK, Quinn L, Fritschi C, et al. (2006) Homocysteine, Diet, and Lipid Profiles in Type 1 and Type 2 Diabetic Nondiabetic Adolescents. J Cardiovasc Nurs. 21:47–55.
    View at Publisher | View at Google Scholar
  100. Jarvisalo MJ, Putto-Laurila A, Jartti L, Lehtimaki T, Solakivi T, (2002) Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes. 51:493–8.
    View at Publisher | View at Google Scholar
  101. Berenson GS, Srinivasan SR, Bao WH, Newman WP, Tracy RE, et al. (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med. 338:1650–6.
    View at Publisher | View at Google Scholar
  102. Norris JM, Yin X, Lamb MM, Barriga K, Seifert J, et al. (2007) Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA. 298(12):1420-8.
    View at Publisher | View at Google Scholar
  103. Stene LC, Joner G; (2003) Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am J Clin Nutr. 78(6):1
    View at Publisher | View at Google Scholar
  104. Lamberg-Allardt C. (2012) Vitamin D in children and adolescents. Scand J Clin Lab Invest Suppl. 243:124-8.
    View at Publisher | View at Google Scholar
  105. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. The Lancet. 358(9292):1500-3.
    View at Publisher | View at Google Scholar
  106. Dahlquist G. (2006) Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis. Diabetologia, 49:20–4.
    View at Publisher | View at Google Scholar
  107. Gale EA. (2002) The rise of childhood type 1 diabetes in the 20th century. Diabetes. 51:3353–61.
    View at Publisher | View at Google Scholar
  108. Pihoker C, Gilliam LK, Hampe CS, Lernmark A. (2005) Autoantibodies in diabetes. Diabetes. 54(S2): S52-61.
    View at Publisher | View at Google Scholar
  109. Bach JF. (1994) Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev. 15(4):516-42.
    View at Publisher | View at Google Scholar
  110. Franke B, Galloway TS, Wilkin TJ. (2005) Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies. Diabetes Metab Res Rev. 21(5):395-415.
    View at Publisher | View at Google Scholar
  111. Wen L and Wong FS. (2005) How can the innate immune system influence autoimmunity in type 1 diabetes and other autoimmune disorders? Crit Rev Immunol. 25(3):225-50.
    View at Publisher | View at Google Scholar
  112. Bach JF. (2005) Infections and autoimmune diseases. J Autoimmun. 25 Suppl:74-80.
    View at Publisher | View at Google Scholar
  113. Couper JJ. (2001) Environmental triggers of type 1 diabetes. J Paediatr Child Health. 37(3):218-20.
    View at Publisher | View at Google Scholar
  114. Gale E. (2012) Viruses and type 1 diabetes: ignorance acquires a better vocabulary. Clin Exp Immunol. 168(1):1-4.
    View at Publisher | View at Google Scholar
  115. Hintermann E and Christen U. (2007) Viral infection - a cure for type 1 diabetes? Curr Med Chem. 14(19):2048-52.
    View at Publisher | View at Google Scholar
  116. von Herrath MG, Holz A, Homann D, Oldstone MB. (1998) Role of viruses in type I diabetes. Semin Immunol. 10(1):87-100.
    View at Publisher | View at Google Scholar
  117. Hannonen R, Komulainen J, Riikonen R, Ahonen T, Eklund K, et al. (2012) Academic skills in children with early-onset type 1 diabetes: the effects of diabetes-related risk factors. Dev Med Child Neurol. 54(5):457-63.
    View at Publisher | View at Google Scholar
  118. Pawłowicz M, Birkholz D, Niedźwiecki M, Balcerska A. (2009) Difficulties or mistakes in diagnosing type 1 diabetes in children?--demographic factors influencing delayed diagnosis. Pediatr Diabetes. 10(8):542-9.
    View at Publisher | View at Google Scholar
  119. Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, et al. (2006) Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science. 311(5768):1775-8.
    View at Publisher | View at Google Scholar
  120. Stanger BZ, Tanaka AJ, Melton DA. (2007) Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature. 445(7130):886-91.
    View at Publisher | View at Google Scholar
  121. Haller MJ, Atkinson MA, Schatz DA. (2010) Efforts to prevent and halt autoimmune beta cell destruction. Endocrinol Metab Clin North Am. 39(3):527-39.
    View at Publisher | View at Google Scholar
  122. Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, et al. (2005) Care of Children and Adolescents with Type 1 Diabetes: A Statement of the American Diabetes Association. Diabetes Care. 28:186–212.
    View at Publisher | View at Google Scholar
  123. Gepts W, De Mey J. (1978) Islet cell survival determined by morphology. An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellintus. Diabetes. 27(S1):251-61.
    View at Publisher | View at Google Scholar
  124. Cooke D and Plotnick L. (2008) Type 1 diabetes mellitus in pediatrics. Pediatr Rev. 29 (11): 374–84.
    View at Publisher | View at Google Scholar
  125. Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P. (2000) IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes. J Clin Invest. 105(4):459-68.
    View at Publisher | View at Google Scholar
  126. Shalitin S and Philip M. (2007) The role of new technologies in treating children and adolescents with type 1 diabetes mellitus. Pediatric Diabetes. 8(S6):72–9.
    View at Publisher | View at Google Scholar

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann