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*Corresponding Author: N. Gokarneshan, Department of Fashion Design and Arts Hindustan Institute of Technology and Science Chennai India.
Citation: N. Gokarneshan, Maria Jenita, PG Anandhakrishnan, D. Haritha, and Neeti Kishore, Anish khan, (2022). Properties of Multifilament PGA Suture Coated with Graphene Oxide. J. Neuroscience and Neurological Surgery. 11(5); DOI:10.31579/2578-8868/236
Copyright: © 2022 N. Gokarneshan, This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Received: 01 February 2022 | Accepted: 11 April 2022 | Published: 18 April 2022
Keywords: surface coating; multi filament; dopamine hydrochloride; graphene oxide;polyglycolic acid; surgical suture; friction
With the development of fine surgery and desire for low-injury methods, the frictional properties of surgical sutures are one of the crucial factors that can cause damage to tissue, especially for some fragile and sensitive human tissues such as the eyeball. In this study, dopamine hydrochloride and graphene oxide were used as external application agents to prepare a biological coating for the surface of multifilament surgical sutures. The effects of this biocoating on the surface morphology, chemical properties, mechanical properties, and tribological properties of surgical sutures were studied. The friction force and the coefficient of friction of surgical sutures penetrating through a skin substitute were evaluated using a penetration friction apparatus and a linear elastic model. The tribological mechanism of the coating on the multifilament surgical sutures was investigated according to the results of the tribological test. The results showed that there were uniform dopamine and graphene oxide films on the surface of the surgical sutures, and that the fracture strength and yield stress of the coated sutures both increased. The surface wettability of the surgical sutures was improved after the coating treatment. The friction force and the coe_cient of friction of the multifilament surgical sutures with the dopamine hydrochloride and graphene oxide coating changed little compared to those of the untreated multifilament surgical sutures.
Surgical sutures are a fundamental material in surgical operation, which directly affect the results of suturing [1]. With the development of delicate surgery and desire for low-injury methods, the frictional properties of surgical sutures are one of the crucial factors that can cause damage to tissue. Multifilament surgical sutures with excellent mechanical properties and significant flexibility and pliability are crucial for suturing [2,3]. The twisted structure and the surface roughness of surgical multifilament sutures increase penetration and frictional resistance [4]. Generally, the high frictional behavior of surgical sutures is related to tissue inflammation and increases the recovery time of scars, which results in a second trauma for patients [5].
Coating is a rough surface treatment method for multifilament surgical sutures that fills the interstices between the twisted fibers and reduces the frictional resistance [6]. Various coating materials have been used to improve the frictional properties of surgical sutures; for instance, antibiotic ointment has been used to coat prophylactic surgical sutures, which decreased the coe_cient of friction of the sutures when passed through tissue [6]. Antibacterial materials have been shown to reduce the maximum friction force of braided silk interacting with a skin substitute. Dopamine hydrochloride and cardiomyopathy chitosan coatings have been used to treat multifilament surgical sutures, which barely changed the coefficient of friction of the surgical sutures when sliding through a skin substitute [7].
Surgical sutures are a kind of implant material. The coating materials for sutures should be biocompatible and should barely react with tissue. Graphene oxide (GO) is widely used in the biomaterial coating field due to its superior biocompatibility and mechanical strength [8]. GO coatings have been applied to implant materials to increase their frictional performance, such as magnesium and titanium alloys [9,10]. The application of a GO coating on fibers and fabrics has also been investigated.
Cai et al. [11] applied a GO coating to cotton fabric by thermal reduction under the protection of nitrogen. Chen et al. [12] grafted a GO coating onto poly (p-phenylene benzobisoxazole) (PBO) fiber by a silane coupling agent, which improved the surface roughness and wettability of the grafted fiber. Hu et al. [13] used GO, chitosan, and polyvinyl alcohol as the functional finishing agents to carry out hydrogen bond layer-by-layer self-assembly to modify the surface of cotton fabric, and the results showed that this process can form a film on the fabric’s surface. Dopamine hydrochloride (DA) is a biomaterial [14], and researchers have found that DA can be deposited onto the surfaces of various materials in a buffer solution to form a versatile platform for secondary reactions, which improves the cohesiveness and functionalization of a material [15–17].
It has been aimed to prepare a DA and GO composite coating for the surface of multifilament surgical sutures and to investigate the influence of said coating on the frictional properties of the surgical sutures when penetrated through a skin substitute. The coating was characterized by mass change, a static contact angle, tensile strength, bending yield strength, and surface morphology. The impact of the coating treatment on the frictional properties of surgical sutures was investigated. The friction force of the surgical sutures was tested by using a penetration friction apparatus (PFA) [18,19], and the coefficient of friction was calculated by the elastic model and finite element simulation [20].
The chemical components of GO were evaluated by FT-IR. The spectrum shows that the O–H groups of GO at 3419 cm-1 can be observed. The stretching vibrations of the C=O and C=C of GO were 1734 and 1627 cm-1 respectively. The C–O vibrations in C–OH and the C–O–C vibrations in epoxy were observed at 1384 and 1051 cm-1, respectively. The interlayer spacing of graphite and GO was assessed by XRD according to Bragg’s law, as shown in Equation below
nλ = 2d sinƟ
It has been observed that the reflection of GO is a single peak at 2 = 10.3o, llustrating that the layer spacing is larger. Due to the oxide groups in GO, the water molecules were trapped between the graphene oxide sheets [29,30]. No obvious peak was found in the profile of GO, indicating that the graphite was successfully oxidized to GO. From Figure 3c, it can be seen that the thickness of the GO sheet was 0.93 nm and that the stacking of the GO sheet was 2.1 nm, which is in accordance with the values for the single-layer GO sheet [31].
The surface chemical composites of the PGA surgical sutures with di_erent treatments were confirmed by FT-IR. The stretching vibration of –OH with a carboxyl group (–C=O–OH) can be found in the FT-IR spectrum at 3515 cm-1. The bending vibration peaks of C=O in carboxyl (–C=O–OH) were at 1080 and 1414 cm-1, and the stretching vibration peaks of C=O in carboxyl (–C=O–OH) was observed at 1739 cm-1. The characteristic absorption peak on the surface of the surgical sutures etched by NaOH was stronger. Therefore, it can be concluded that more carboxyl groups were produced after NaOH treatment. It can also be seen from the figure that the stretching vibration absorption peak of –NH/–OH appeared between 3600 and 3100 cm-1 for the PGA multifilament surgical sutures after the DA and GO coating treatment. The bending characteristic absorption peak of –NH was 1578 cm-1, and the stretching characteristic absorption peaks of C–O were 1151 and 1080 cm-1 [32–34].
This confirms that the DA and GO coating adhered to the surface of the surgical sutures.
The surface morphology of the surgical sutures with and without a coating
Treatment has been determined. After the THF treatment, the coating material was removed from the surface of the commercialized surgical sutures. After NaOH etching, the small cracks and dents on the surface of the surgical sutures and fibers became thinner. The defects and specific surface area of the surface of the fiber became larger, providing more adhesion points for the subsequent coating.
After the DA coating, more DA coating particles accumulated on the surface of the sutures.
The small DA particles in the bu_er solution deposited onto the surface of the fiber to form a uniform film [14], so the adhesion to the surface of the sutures was enhanced. The DA coating provided good reaction conditions for the subsequent coating treatment as a secondary reaction platform [15–17].
After the GO coating, a uniform GO film formed on the surface of the suture, which became smoother, and the gap between the fibers was filled.
Tensile fracture strength is an important parameter of surgical sutures. If the tensile breaking strength is too low, the sutures are easily pulled and slipped when they pass through tissues, leading to knots. Too low a tensile fracture strength shortens the absorption time of sutures after an operation, resulting in unsatisfactory suturing and increasing the risk of operation failure. Figure 6a shows the tensile strength and elongation at break of the sutures left untreated and those with NaOH etching and a DA and GO coating. The error bars in the graphs indicate the standard deviation of each measurement. It can be seen that when the sutures were treated with NaOH, the tensile strength of the PGA multifilament surgical sutures decreased from 58.9 to 50.0 N and the elongation at break from 30.4% to 24.2%. This may be because the loss of surgical sutures with the NaOH etching destroyed the structure of the fiber and created defects. It can also be seen from the figure that the increasing range of the tensile strength and elongation at break of the surgical sutures after the DA and GO coating treatment is limited. This is because the adsorption of the coating on the surgical suture is limited, and the adsorption capacity of the coating material cannot continue to increase during the coating treatment.
The bending yield property of surgical sutures is an important parameter that a_ects the friction between surgical sutures and tissues. From Figure 6a, it can be seen that the bending yield strength of the commercial surgical sutures without any treatment was 0.026 cN_cm2, which reduced to 0.016 cN.cm2 after removing the protective layer by THF treatment, and 0.007 cN_cm2 after NaOH treatment. After the DA coating, the suture bending yield strength increased from 0.007 to 0.008 cN.cm2.
Then, with GO coating treatment, the bending yield strength of the suture increased to 0.015 cN_cm2. These results are similar to previous research results [7,28].
The surfaces of the surgical sutures currently on the market are covered by a coating. If the coating is removed, the fibers of multifilament surgical sutures with a multifilament braided structure have no adhesion for the coating, the cohesion between the fibers is reduced, and the bending yield strength is reduced more. NaOH treatment further reduced the strength and diameter of the fibers, and, at the same time, the cohesion between the fibers was further decreased and the surgical sutures were able to bend more easily. However, after the DA coating treatment, the bond strength of the fiber was weak, and so an increase in the bending yield strength was not obvious. For the surgical sutures treated with GO, because GO can form a film on the surface of surgical sutures with DA particles, it filled the gaps between the fibers of the surgical sutures, which improved the cohesion between the fibers, increased the overall hardness of the surgical sutures, and improved the bending yield strength.
Mass change rate is an important parameter to evaluate the effects of treatment on surgical sutures. Figure 7a shows the mass change rate of the surgical sutures with and without a coating treatment. It can be seen that after NaOH etching, the mass loss rate of the PGA multifilament surgical sutures was 16.5%. When the surgical sutures were coated with DA, the mass increase rate was 3.92%. After three GO coating treatments, the mass increase rate of the PGA multifilament sutures was 0.75%. Figure 7b shows the effect of the GO coating treatment on the mass change rate of the surgical sutures with and without a coating. It can be seen that with the increase in the number of coating treatments, the weight of the PGA multifilament surgical suture increases. After three coating treatments, the increase in the mass change rate of the PGA multifilament sutures tended to stabilize. In this experiment, the PGA sutures were treated with three GO coatings.
Wettability Properties
NaOH etching and coating of multifilament surgical sutures influence the wettability properties of the surface. Figure 8 shows the static water contact angle of the surgical sutures with and without a coating treatment. After NaOH etching, the static contact angle of the surface of the sutures decreased to 58o. This is due to the fact that the hydrolysis reaction on the surface of the sutures increased the number of –OH and –COOH groups, which improved their wettability. After the DA and GO coating treatments, the static water contact angle of the surgical sutures increased to 91oand 72o, respectively.
Tribological Properties
Frictional Properties
Figure 9a shows the impact of the coating treatment on the friction force of the multifilament surgical sutures. The friction force of the sutures with THF, DA, and GO coating treatments was 0.72, 0.75, and 0.779, respectively. The friction force differed little between those sutures that did or did not receive a coating treatment.
The coeffcient of friction (COF) is a curricular impact factor that assesses tribological properties, which are defined as the friction force and the normal force. The friction force was tested by PFA, while the normal force of the surgical sutures penetrating through the artificial skin was predicted by a simplified linear elastic model, which is based on the Hertz contact model [18,35]. (4)
According to the classical frictional equation (Equation (5)):
µ = Ff /FN (5)
The thickness of the etching and coating was much less than the diameter of the surgical sutures in this contact condition. It has been observed that the COF of the surgical sutures without treatment, with DA, and with GO was 1.38, 1.37, and 1.42, respectively.
Wear Properties
The wear morphologies of the surgical sutures and skin substitutes have been determined.
It has been found that there is little wear debris present on the commercialized and coated surface of the sutures. There is little difference between the coated surgical sutures and the commercialized surgical sutures. In order to further study the wear performance of the surgical sutures with the DA and GO coating, we observed the three-dimensional wear morphology of the surface of the artificial skin. The wear crack in the skin substitute was similar to that of the commercialized and coated sutures.
Mechanism
In this study, the surgical sutures with different treatments including commercial suture and sutures with either a DA coating or a DA and GO coating—presented similar friction and wear properties. This may be explained by the fact that there was little change in the high stiness and roughness of sutures after the coating treatment. Moreover, the experimental condition in this paper was dry friction. In the contact model, the friction force was composited with adhesion and the deformation component [36].
Ff = Ff ,adh + Ff ,de f
The adhesion component was the main component of the friction force due to the surgical sutures and the skin substitute being viscoelastic materials. The adhesion component was determined by the product of the shear strength and the real contact area Ar between them [37]:
Ff ,adh = Ar
The shear strength of the surgical sutures and the skin substitute was identified. The contact area was the most effective factor in the frictional properties of the surgical sutures. To better reveal the influence of the GO coating on the tribological mechanism of the skin substitute, the artificial skin was penetrated with a surgical suture. It has been found that when the surgical suture was inserted into the planar crack in the skin substitute, the surgical suture deformed under the pressure. Furthermore, the cohesion force of the twisted fibers was low. The resilience force of the skin substitute acted symmetrically on the two surfaces of the surgical suture. Hence, the contact area was similar between surgical sutures with and without a coating, which presented similar frictional properties.
In this study, a DA and GO coating was applied to the surface of multifilament sutures to form a uniform film. The COF of the PGA multifilament sutures with and without a DA and GO coating was 1.37 and 1.42, respectively, which were in the same range. According to the contact mode and the way in which the surgical sutures are inserted, the contact surface was the main factor affecting the friction properties of the surgical sutures penetrating through the skin substitute. Due to the twist structure of surgical sutures, the contact area was similar when the surgical sutures were inserted into the skin substitute; hence, the coating barely affected the frictional properties of the surgical sutures
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