AUCTORES
Globalize your Research
Review
*Corresponding Author: Meir Djaldetti, Laboratory for Immunology and Hematology Research,Rabin Medical Center, Hasharon Hospital, 7, Keren Kayemet St, Petah Tiqva, Israel.
Citation: M Djaldetti. (2021) Piperine – An Immunomodulator and Inflammation Mitigator. Journal of Clinical and Laboratory Research. 2(5) DOI:10.31579/2768-0487/027
Copyright: ©2021 Meir Djaldetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 25 May 2021 | Accepted: 31 May 2021 | Published: 02 June 2021
Keywords: piperine; black pepper; inflammation; macrophages; cytokines
Black pepper, one of the most widespread spices, gained the entitlement “King of spices” founded on its peculiar pungent test and therapeutic properties, both owed to its active alkaloid - piperine. Mounting evidence indicates that piperine possesses immunomodulatory and therapeutic activities. The aim of this mini review was to summarize the role of piperine in abolishing inflammation, its part in the immune activity of peripheral blood mononuclear- and a number of other cells, its capacity to elicit production of inflammatory cytokines and its function as a synergist endorsing the beneficial therapeutic effect of conventional anti-inflammatory drugs.
Nutrition has permanently been the main concern of humankind. Reasonable enough parallel with food our ancestors fostered senses of taste and made efforts to enhance flavor using spices that within time rapidly increased in quantity and quality. Moreover, hundreds of centuries ago our predecessors became aware that a great number of spices and herbs possess therapeutic properties. This knowledge prompt them to use plants for treatment of diseases and wounds, thus paving the way traditional herbal medicine became established and further developed [1]. Among the numerous spices in use today, one of the most broadly applied is the black pepper (Piper nigrum) which originated in India, but quickly spread worldwide and became the highly valuable “King of Spices” [2, 3]. Actually, the source of its distinct pungent flavor is attributable to one of its most active alkaloids - piperine. A significant number of studies have shown that piperine, in spite of its culinary qualities, possesses valuable physiological and medical assets, such as anti-inflammatory, antioxidant, antiseptic, anticancer and even antiepileptic properties that render it useful in a few acute and chronic health conditions detailed in comprehensive studies and reviews [4-10]. In addition, it has been found that piperine has pronounced immunomodulatory and biological properties [11]. The current concise review was designed to summarize the effect of piperine on the immune system, the capacity of human peripheral blood mononuclear cells to produce inflammatory cytokines, as well as the ability of this alkaloid improve the beneficial effect of certain drugs and spices.
It has been documented that piperine, either alone or in combination with other remedies, is effective in treatment of chronic diseases such as inflammatory conditions, diabetes and reduction of insulin-resistance, liver diseases and others [12]. Based on observations from traditional medicine that piperine exerts beneficial effects as an anti-inflammatory medication, researchers carried out studies to clarify the mode of its immunomodulatory activity [13]. Since macrophages are the main immune executors involved in inflammation the question arises as for the functional relationship between macrophages and piperine. Considering the fact that macrophage polarization that precedes inflammation is dependent in part on the intercellular adhesion molecules-1 (ICAM-1) Gholijani et al. [14] have shown that piperine restrains the inflammatory process by inhibition of ICAM-1 expression which is up-regulated during inflammation. Additionally, repressed expression of macrophages’ ICAM-1 molecules improves their function in removing apoptotic and necrotic cells that accumulate following inflammation injury [15]. Furthermore, the anti-inflammatory activity of piperine is due to its ability to block TNFα induced expression not only of ICAM-1, but also of other cell adhesion molecules such as VCAM-1 (vascular cell adhesion molecule-1) and E-selectin [16]. Studies with mice revealed that piperine controls LPS stimulated peritoneal macrophages by strongly incitement of their mTORC1 activity operating as a regulator of protein synthesis and by increased IL-6 and TNFα production [17]. Consequently, the macrophages upsurge their phagocytic capacity, avoid apoptosis and amplify their antibacterial ability. The proficiency of piperine to modify inflammatory cytokine production by macrophages is important. It was found that IL-1β, a cytokine tightly involved in the inflammatory pathway, produces a complex in the presence of piperine, thus preventing the activity of the cytokine in the progress of inflammation [18]. In mice with traumatic brain injury piperine was shown to decrease seizures by reducing the production of the pro-inflammatory cytokines TNFα and IL-1β [19]. According to Liang at al. [5] administration of piperine to LPS stimulated macrophages and to Escherichia coli infected mice caused a remarkable decrease in IL-1β production with suppression of inflammation and pyroptosis. The compelling anti-inflammatory potential of piperine and its ability to suppress cytokine storms, such as those observed in severe cases of COVID-19 infections, prompted researchers to suggest it as an adjuvant in the therapeutic efforts against this outbreak [20, 21]. Research on the anti-inflammatory properties of long pepper (Piper longum) and cubed pepper (Piper cubeba) extracts containing piperine has been carried out on LPS induced THP1 monocyte derived macrophages. The results showed that these extracts are able to reduce dose-dependently the secretion of the main pro-inflammatory cytokines TNFα and IL-1β [22]. LPS treated mouse macrophages (RAW 264.7 cells) stimulated by piperine showed subdued production of prostaglandin E2 and nitric oxide, as well as that of TNFα, inducible NO synthase (iNOS) and COX-2 [23]. Chuchawankul et al. [24] detected a noticeably inhibited cell proliferation of human peripheral blood mononuclear cells (PBMC) exposed for 72 hours to piperine. According to the authors this phenomenon is due to suppressed T cell proliferation since these are the major proliferating cells when PBMC are stimulated by PHA. In addition, the production of IL-2 and IFNγ by PHA activated PBMC was dose-dependently inhibited. Higher piperine concentration remarkably reduced these cytokines secretion, findings indicating a strong relationship between cell proliferation IL-2 and TNFα production. The anti-inflammatory properties of piperine have been observed in obesity induced inflammation [25]. The authors treated Raw 264.7 macrophages with rat adipose tissue-conditioned medium and exposed the cells to piperine, as well as to various spice-derived components and observed a markedly dose-dependently inhibited macrophage migration. However, in difference from the other spice derived components used in the study that of piperine did not affect the production of TNF-α.
It appears that piperine exerts anti-inflammatory properties in cells other than monocytes and macrophages. CTLL-2 T lymphocytes treated with piperine have shown an inhibited IL-2 signaling [26]. In addition, piperine was able to inhibit T cell proliferation and suppressed T cell transition through the mitotic S and G2/M phase and to restrain the generation of IFNγ, IL-2, IL-4 and IL-17A [27]. In an asthma mouse model piperine inhibited the production of Th2 cytokines i.e. IL-4 and IL-5 in the bronchoalveolar lavage fluid and the immunoglobulin E production in the serum [28]. Based on these findings piperine was suggested by the authors to be considered as an additional treatment modality of autoimmune diseases. It has been revealed that piperine possesses a noticeable affinity towards CD4 and CD8 T cell receptors, increases cell viability and restores cytokine production by deltamethrin injured cells, characteristics that may clarify its immunomodulatory role [29]. Piperine applied on IL-1β stimulated synoviocytes obtained from patients with rheumatoid arthritis remarkably inhibited the production of the pro-inflammatory cytokines IL-6 and PGE2. Given orally to rats with collagen induced arthritis piperine significantly reduced the production of the pro-inflammatory cytokines IL-1β, TNFα and PGE2 and increased the level of the anti-inflammatory cytokine IL-10 [30]. Similar inhibition of the pro-inflammatory cytokines was observed when piperine was administered intraperitoneally to mice with LPS-induced mastitis [31]. The secretion of the pro-inflammatory cytokines TNFα, IL-6, IL-1β and PGE2 by LPS stimulated BV2 cells, that are microglial macrophages in the central nervous system, was reported to be subdued by piperine [32]. In an animal model with Staphylococcus aureus endometritis piperine inhibited the inflammatory process and reduced the expression of TNFα, IL-1β and IL-6, while that of the anti-inflammatory cytokine IL-10 was increased. The authors showed that the effect of piperine was due to inactivation of NF-kB and MAPKs pathways, both controllers of inflammatory cytokine production [33]. Piperine treated LPS stimulated mouse dendritic cells showed a reduced expression of the pro-inflammatory cytokines IL-6 and TNFα as well as a reduced migration towards lymph nodes [34]. Treating bone marrow derived LPS stimulated dendritic cells with piperine Bae at al. [35] documented a suppressed production of TNFα and IL-12, while the expression of IL-6, also a pro-inflammatory cytokine, was not affected. According to the authors these findings proceeded through inhibition of stress-related c-jun N-terminal kinases (JNK). Notably, not only piperine itself but also black pepper (Piper nigrum) aqueous extracts exert an immunomodulatory effect expressed by a dose dependent proliferation and increased production of T helper-1 cytokines by splenocytes, whereas the generation of T helper-2 cytokines was reduced [36]. Alagawany et al. [37] supplemented the diet of birds (quails) with red and black pepper oil mixture and reported that their antioxidant and immunity parameters became statistically improved compared to controls. Mice with thymic atrophy and splenomegaly induced by cadmium, known by its immunotoxicity, showed marked recovery in body weight, cell viability and restored IL-2 and IFNγ secretion after administration of piperine [38,39].
The beneficial effect of piperine on inflammatory reactions can be amplified when administered jointly with conventional therapeutic remedies. The favorable results obtained by administration of thymoquinone on the hepatotoxic and neurotoxic effect observed in mice given microcystin were markedly intensified when it was delivered together with piperine and were expressed by both improvement of the liver and brain biochemistry tests, as well as with a marked decrease in the production of the pro-inflammatory cytokines IL-1β, IL-6 and TNFα [40]. The therapeutic activity of piperine has been shown to be more pronounced when administered with natural alkaloids extracted from plants and fruits. In a murine model of systemic lupus erythematosus piperine combined with resveratrol suppressed the level of the pro-inflammatory cytokines TNFα, IL-6 and IFNα indicating a potential therapeutic capacity of these alkaloids [41]. In a mouse model of Mycobacterium tuberculosis, treatment of splenocytes concomitantly with piperine and rifampicin induced an enhanced activation of Th-1 lymphocyte response with an increased production of IFNγ and IL-2 compared with that obtained with each one of the above components given alone [42]. Oral medication of rabbits with ampicillin and norfloxacin supplemented with piperine improved the bioavailability of the antibiotics [43]. Administration of piperine with a variety of spices has been shown to produce an additive positive biological and pharmacological effect. Piperine given with curcumin was able to abolish the oxidative stress and caspase 3 of deltamethrin known to exert a potent immunotoxic effect in both humoral and cell mediated immunity. However, in vitro studies indicate that phenotypic and cytokine changes are better expressed with piperine compared to curcumin [44]. In patients with type 2 diabetes given curcumin and piperine the serum levels of adiponectin, leptin, and TNF-α were lower than those given placebo [45]. Treatment of iron deficiency with iron preparations supplemented with piperine improved iron absorption and its bioavailability [46]. It has been reported that piperine, at its liposomal formation, promotes the antibacterial activity of gentamicin and exerts better effect against MERSA infections [7, 47]. Piperine may increase of bioavailability of phenytoine, propranolol and theophylline in healthy volunteers detected by plasma concentration curve (AUC), an activity that should be considered in cases with seizures, heart conditions and lung diseases. In patients with pulmonary tuberculosis the plasma concentrations of rifamipicin was been found to be elevated [48]. In addition, investigations showed that piperine may act as a synergist to tetracycline, an observation that could be useful for the treatment of bacterial infections [49]. Combined administration of piperine with natural polyphenolic compounds, such as curcumin, luteolin, and resveratrol are capable to restrain the immense release of pro-inflammatory cytokines such as TNFα, INFγ, IL-1β, IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, MCSF, HGF occurring during cytokine storms in immunocompromised patients including those with COVID-19. [50]. It has been reported that piperine exerts a significant radioprotection in irradiated human lymphocytes expressed by a marked diminution of micronuclei number compared with irradiated non piperine-treated cells. This effect was more impressive when the lymphocytes were pretreated with both piperine and curcumin [51]. Rats given piperine before irradiation showed lesser elevation in serum TNF-α, IL-1β and IL-6 [52].
The widespread consumption of black pepper poses the question if the spice may induce adverse effects. The immunotoxic events of piperine have been investigated in mice given the alkaloid at doses of 1.12, 2.25 or 4.5 mg/kg body weight for five days. No toxic effects were noted at these doses, but higher ones, i.e. 2.25 and 4.5 mg/kg, hematologically administered, resulted in a reduction in total leucocyte counts with an increase in the neutrophils’ percentage. These doses suppressed the mitogenic response of B-lymphocyte to lipopolysaccharide. The authors’ conclusion is that the dose of 1.12 mg of piperine per kg body weight may be considered as immunologically safe since it is deprived of immunotoxicity [53]. In another study feeding rats with piperine at doses of 0, 5, 15, or 50 mg/kg per body eight for 90-days no adverse effects we observed [54].
Summarizing the presented data it may be stated that piperine exerts an immunomodulatory activity not only by prompting PBMC capacity for anti-inflammatory cytokine production, but also by affecting the immune activity of lymphocytes and a number of other cells. Piperine, as an immunomodulator, may express beneficial synergistic effects with other drugs and spices, virtues that permit to affix a number of medical benefits to a renowned appetizing spice.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
