AUCTORES
Globalize your Research
Research Article
*Corresponding Author: Sharjeel Chaudhry, Endocrinology Division, Olive View-UCLA Medical Center, David-Geffen UCLA Medical School, CA, USA.
Citation: Sharjeel C., Zarmina E., (2024), Oral Health and Dental Treatment Needs in Thalassemia Major Patients, Journal of Clinical and Laboratory Research. 7(1); DOI:10.31579/2768-0487/117
Copyright: © 2024, Sharjeel Chaudhry. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 15 November 2023 | Accepted: 15 December 2023 | Published: 15 January 2024
Keywords: oral health; abnormalities; haemoglobin
Abnormalities in haemoglobin is a defining characteristic of hemoglobinopathies, encompassing conditions such as sickle cell anaemia and thalassemia. Thalassemia major, a condition marked by profound anaemia resulting from insufficient haemoglobin production, impacts a significant global population. The objective of this study was to enhance comprehension of the oral health needs specific to individuals with thalassemia major, to improve the provision of healthcare services for this population. A descriptive multicentric cross-sectional study was undertaken including a cohort of 42 individuals diagnosed with severe thalassemia. The assessment of the participants' oral health was conducted with the DMFT/DMFT Index and the OHI-Simplified (OHI-S). The research revealed a significant occurrence of dentofacial abnormalities and dental treatment requirements, thereby emphasizing the importance of complete oral health care for those diagnosed with thalassemia. Individuals diagnosed with thalassemia major may present a distinctive facial attribute referred to as "Chipmunk facie" or "Rodent facie," which arises from the enlargement of the maxilla and zygomatic bone. Malocclusion, along with dental caries and oral ulcers, is a prevalent dental and facial abnormality observed within the study population. The findings of this study underscore the imperative of early detection and intervention of oral health concerns among individuals with thalassemia. Regular dental examinations and prompt intervention for dental and facial abnormalities confer advantages to individuals afflicted with thalassemia. The research highlights the importance of enhancing oral health awareness and providing education to the community as a means to enhance the provision of oral health care for those with thalassemia. The integration of dental care into thalassemia management necessitates the collaborative efforts of medical and dental professionals. Notwithstanding the perceptive conclusions drawn from the study, further research employing larger and more diverse sample sizes is necessary to substantiate and advance the obtained findings. The findings of this study will have significant implications for the development of enhanced management procedures and targeted oral health care programs for those diagnosed with thalassemia major, hence offering substantial benefits to this population. By emphasizing the significance of oral health in the context of thalassemia care, we can augment the overall well-being and quality of life of patients.
Hemoglobinopathies are a set of hereditary illnesses that lead to structural abnormalities in the heme molecule and globulin chains of haemoglobin. Hemoglobinopathies, such as sickle cell anaemia and thalassemia, are commonly encountered [1]. According to the World Health Organization (WHO), the prevalence of hemoglobinopathies is estimated to impact approximately 5percentage of the global population [2]. The prevalence of hemoglobinopathies has significantly increased as a result of population migration, particularly in places where these conditions were formerly limited to the Middle East, Asia, and Africa.
Thalassemia major is a hereditary blood illness characterized by a deficiency in haemoglobin production, resulting in the manifestation of severe anaemia. This particular form of hemoglobinopathy is highly frequent, impacting a significant number of individuals on a global scale [7]. Individuals diagnosed with thalassemia major encounter considerable obstacles across various medical domains, including oral health. Dental complications are among the several manifestations of oral health issues associated with thalassemia major. Malocclusion and tooth decay are dental and skeletal problems that are associated with thalassemia and other hemoglobinopathies [3]. The management and treatment of thalassemia major, which may encompass blood transfusions and iron chelation therapy, might provide additional challenges in terms of oral health concerns and the need for dental care [18].
Thalassemia, a genetic blood condition, is caused by mutations in the genes responsible for the globin proteins located on chromosome 16, as well as the globin chains found on chromosome 11. The presence of this genetic anomaly hinders the production of haemoglobin, resulting in significant impairment of the capacity of erythrocytes to facilitate the transportation of oxygen [4]. Individuals with thalassemia commonly encounter the presence of anaemia, which can manifest in varying degrees of severity, spanning from mild to profound. Thalassemia can be classified into distinct subtypes, namely homozygous, heterozygous, and compound heterozygous, by employing clinical and genetic criteria to determine the specific globin chain that is affected [6].
The enlargement of the maxilla and zygomatic bone is observed due to the hyperplasia of the bone marrow associated with erythropoiesis. This, in turn, has an impact on the development of the teeth and facial structures in individuals with thalassemia. The aforementioned growth leads to the development of unique facial characteristics sometimes referred to as "Chipmunk facie" or "Rodent facie." Additionally, oral manifestations such as malocclusion, dental caries, and other forms of tooth damage may also arise [5,2]. The absence of awareness of the need to maintain optimal oral health may hinder individuals with thalassemia from accessing the necessary dental treatment. The primary objective of this study is to enhance the comprehension of dental treatment requirements and oral health among individuals diagnosed with thalassemia major, with the ultimate goal of improving the efficacy of healthcare systems in meeting their needs [8]. The present study employs a descriptive multicentric cross-sectional design to underscore the significance of oral health management in individuals with thalassemia.
A descriptive multicentric cross-sectional study was conducted from July to August 2023, with a sample of 42 persons diagnosed with severe thalassemia. Participants for the non-probabilistic convenience sampling were selected from hospitals and thalassemic care facilities [3]. A structured, self-administered questionnaire was distributed to patients diagnosed with thalassemia major who were seeking treatment at specialized thalassemia care institutions. The questionnaire encompassed various sections inquiring about the participant's biography and dental health, including fundamental details such as name and residence, along with more specific inquiries.
The comprehensive evaluation of the patient's general well-being encompassed various aspects, including an examination of their mouth cavity as well as consideration of their demographic characteristics. The dental and oral health of the participants was evaluated by employing the Decayed Missing Filled Teeth Index (DMFT/dmft Index) for permanent and primary teeth, along with the Oral Hygiene Index—Simplified (OHI—S). The researcher performed an intra-oral examination utilizing a mouth mirror and a curved explorer. Furthermore, the clinical examiner documented any oral symptoms exhibited by the participants.
The data collected was analyzed using SPSS, a statistical software commonly utilized in social science research, with a significance level set at p less than 0.05. The prevalence of dentofacial abnormalities and treatment demands among patients with Thalassemia major were calculated and organized in a tabular format for ease of reference. This research endeavour aims to enhance our understanding of the distinctive oral healthcare requirements of individuals diagnosed with thalassemia major, as well as to develop effective strategies for improving their dental well-being. The outcomes of this research will provide a valuable contribution to the advancement of enhanced management protocols and specialized oral healthcare programs for individuals diagnosed with thalassemia, ultimately leading to an enhancement in their overall quality of life [17].
The study included a cohort of 42 individuals diagnosed with severe thalassemia. The age of the participants varied from 19 to 42, with an average age of 28.6. The study observed a higher proportion of male participants (57.1percentage) compared to female participants (42.9percentage). All participants in the study exhibited a significant presence of thalassemia, with beta-thalassemia being the more predominant form (71.4percentage) compared to alpha-thalassemia (28.5percentage). The study sample consisted of individuals with an average age of 16.5 years, and their disease durations varied between 7 and 30 years. Thalassemia has the potential to present itself across many age groups, with the mean age of onset being approximately 8.4 years. Between 40percentage and 55percentage of the participants indicated a familial history of thalassemia. The initiation of iron chelation therapy occurred within the age range of 5 to 12 years for the majority of participants, comprising 66.7percentage of the total sample. A total of 52.4percentage of the participants opted for deferroxamine as their chelation medication, whilst 47.6% chose deferrasirox for the same purpose. Moreover, a significant proportion of the participants, specifically 61.9percentage, required blood transfusions. A significant proportion of the participants (71.4percentage) also reported encountering oral health problems. The dental and oral health of the participants was assessed utilizing the Decayed Missing Filled Teeth Index (DMFT/DMFT Index) for both permanent and primary teeth. The evaluation also involved the utilization of the Oral Hygiene Index—Simplified (OHI—S). The researcher conducted an intra-oral examination using a mouth mirror and a curved explorer, via which oral symptoms were identified in all of the participants. The most commonly reported symptoms were tooth decay (59.5percentage), gum bleeding (45.2percentage), and misplaced teeth (38.1percentage).
Based on the results, it was seen that 28.6percentage of the participants exhibited a high frequency of dental visits, while 42.9percentage engaged in dental visits periodically. The remaining 28.6percentage of participants reported never seeing the dentist. A significant proportion of the participants, specifically 69percentage, express a sense of assurance in the domain of dental
care. Frequent occurrences of dental and facial abnormalities were observed in individuals diagnosed with thalassemia major. The dentofacial abnormalities that were found to be most commonly observed in the study population included malocclusion (59.5percentage), gingival bleeding (45.2percentage), dental caries (40.5percentage), and oral cavity infections (35.7percentage). Furthermore, it was shown that 28.6percentage of the participants experienced facial swelling, while 21.4percentage exhibited the presence of oral ulcers. A total of 9.5percentage of the participants exhibited protruding jaws, while 14.3percentage experienced symptoms such as dry mouth and/or tooth spacing. Additionally, 14.3percentageof the participants displayed pale gums and/or linings.
The present investigation aimed to examine the oral health status and dental treatment needs of individuals diagnosed with thalassemia major, a hereditary blood condition defined by a deficit in the generation of haemoglobin. Thalassemia major, a condition that has a significant global prevalence, can give rise to many medical consequences, encompassing complications in dental and oral health [8]. The primary objective of the study was to improve dental health and overall quality of life for individuals with thalassemia by gaining a more comprehensive understanding of their oral healthcare requirements and devising effective interventions to meet those needs. The study indicates that individuals diagnosed with thalassemia major exhibit a heightened susceptibility to oral health complications [9]. A significant proportion of the participants indicated suboptimal oral health, with nearly all of them needing dental intervention to address various dentofacial issues. The most often cited oral health concerns among individuals with thalassemia were tooth decay, bleeding gums, and misplaced teeth. Based on previous research [5,7], individuals diagnosed with thalassemia major and other hemoglobinopathies have a significant occurrence of dental and skeletal complications.
The participants in this study were affected by a medical condition referred to as “Chipmunk facie” or “Rodent facie”. This condition is defined by the enlargement of the maxilla and zygomatic bone, which is caused by hyperplasia of the bone marrow in conjunction with erythropoiesis [10]. The observed growth patterns had an impact on the development of teeth and facial structures, hence playing a role in the manifestation of malocclusion and other dental conditions. The presence of dental and facial abnormalities in a significant proportion of participants underscores the critical importance of early oral health care and therapies for individuals with thalassemia. The outcomes of the study provide insights into the motivations behind thalassemia patients' utilization of dental services. Several participants reported that they had never visited a dentist, even though a portion of them did so on an occasional or frequent basis [11]. Patients diagnosed with thalassemia may experience a deterioration in their oral health due to a lack of awareness of the disorder or limited availability of dental care. It is imperative to impart knowledge and instil in this collective the significance of maintaining optimal oral hygiene and adhering to routine dental examinations, accomplished through educational initiatives and upbringing.
The findings of this study hold practical significance for the oral health treatment of individuals with thalassemia. Individuals diagnosed with major thalassemia must be provided with comprehensive medical care, encompassing regular dental evaluations [12]. The implementation of preventive dental care, regular dental examinations, and prompt identification and management of dental and oral health conditions can greatly improve the overall well-being of these individuals. To formulate tailored oral health care regimens, dentists must engage in interdisciplinary collaboration, particularly with medical doctors who specialize in the treatment of individuals affected by thalassemia. Several concerns regarding the study warrant careful consideration. Notwithstanding a generally positive outlook, it is important to note that the generalizability of these findings to the broader thalassemia community may be limited due to the utilization of a cross-sectional research design and the very small sample size employed in this study [13]. To enhance our understanding of the oral health requirements of individuals with thalassemia, it is imperative to conduct longitudinal studies that encompass bigger and more representative samples. By doing so, we can acquire a more comprehensive body of information in this area. To mitigate the possibility of answer bias inherent in self-administered questionnaires, future research endeavours may incorporate clinical examinations or interviews with participants as a means to validate the veracity of reported oral health concerns. The comprehensive findings of this descriptive multi-centre cross-sectional study underscore the significant oral health challenges encountered by individuals diagnosed with thalassemia major [14]. The necessity for a complete oral intervention for individuals with thalassemia is underscored by the presence of dental and facial abnormalities observed in a number of the subjects involved in the study. The findings of this study will make a valuable contribution to enhancing the well-being and overall health of individuals with thalassemia by providing insights that can inform the development of targeted oral healthcare interventions [15]. Further research and enhanced interdisciplinary cooperation between medical professionals and specialists in geriatrics are necessary to adequately address the unique oral health requirements of individuals diagnosed with thalassemia. It is imperative to ensure the proper integration of dental care within thalassemia management guidelines.
This study is descriptive, multicentric, and cross-sectional in nature, and offers significant insights into the oral healthcare needs of individuals diagnosed with thalassemia major. The findings indicate a noteworthy occurrence of dentofacial abnormalities and dental care requirements among individuals with thalassemia, emphasizing the importance of complete oral healthcare for this specific group. Individuals diagnosed with thalassemia major experience challenges in the development of their dental and facial structures as a consequence of the disorder's impact on the generation of haemoglobin. Individuals with thalassemia necessitate specialized care and attention due to their atypical facial characteristics and compromised dental well-being. The findings of this study underscore the imperative of implementing preventive measures and timely intervention to address oral health issues among individuals with thalassemia. Regular dental examinations and prompt treatment have the potential to enhance the quality of life for these individuals. This study highlights the oral health needs of individuals with thalassemia and their families. Enhancing patient accessibility to dental care is crucial in fostering oral health and overall well-being as an essential element of thalassemia management.
The findings of this research will provide valuable assistance in the advancement of improved management protocols and specific oral healthcare initiatives for individuals with thalassemia. By prioritizing the maintenance of their oral health, we can optimize their general well-being and improve their overall quality of life. Subsequent research endeavours should be undertaken to corroborate and expand upon these findings, employing larger and more heterogeneous samples, as well as longitudinal investigations. The collaboration between medical and dental professionals is of utmost importance in effectively integrating dental care into the management of thalassemia and delivering comprehensive care for those diagnosed with thalassemia major. The results of this study provide an opportunity for enhanced comprehension and improved approaches toward addressing the specific oral healthcare needs of individuals diagnosed with thalassemia. Placing oral health as a central aspect in the comprehensive therapy of thalassemia patients' overall well-being has the potential to improve their quality of life.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
