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*Corresponding Author: Hemali B. Gunt, Burt’s Bees, 211 West Pettigrew St. Durham NC 27701, USA.
Citation: Hemali B. Gunt, Jeannette Jakus, Burt’s Bees, (2024), Natural Skin Care Regimen Improves Clinical Parameters and Quality of Life in Children with Atopic Dermatitis, Dermatology and Dermatitis, 9(6); DOI:10.31579/2578-8949/171
Copyright: © 2024, Hemali B. Gunt. This is an open-access article distributed under the terms of The Creative Commons. Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 07 August 2024 | Accepted: 23 September 2024 | Published: 30 September 2024
Keywords: alternative medicine; herbaceous pharmaceuticals; normal remedies; complete healthcare; plant-located therapies; pharmacological projects; dispassionate evidence; control of product quality; uniformity; drug interplays
Background: Atopic dermatitis (AD) is a prevalent, chronic inflammatory skin disorder, characterized by xerosis, itching and recurrent eczematous lesions. The condition also has major psychosocial implications for patients and their families. A daily skincare regimen of gentle cleansing and moisturization is an important part of atopic dermatitis therapy.
Objective: This study evaluated the tolerability and efficacy of a nature-based shampoo/wash and moisturizer in children with mild to moderate atopic dermatitis
Methods: This open-label study involved 23 children (6 months – 13 years) with atopic dermatitis. A daily skin care regimen of nature-based shampoo/wash and moisturizer was used for 4 weeks. The primary endpoint was tolerability assessed through clinical grading of erythema, dryness and roughness. The study pediatrician graded the eczema condition using the Eczema Area and Severity Index (EASI), and assessments of stratum corneum hydration and transepidermal water loss were performed before and after treatment. Parent/guardian completed two validated quality of life questionnaires.
Results: Twenty children completed the study. Clinical evaluations showed significant improvement in subjects’ atopic disease with daily use of nature-based regimen. Significant reduction in dryness and roughness was observed, indicating that both products were well-tolerated. Moisture content and transepidermal water loss measurements showed directional improvements in skin barrier function.
Parent/guardian reported significant improvements in quality-of-life assessments.
Conclusions: The study demonstrated that nature-based skin care regimen was well tolerated and improved quality of life and skin condition in children with atopic dermatitis and can be used either alone or in adjunction with traditional treatment for disease control.
Atopic dermatitis (AD) is a chronic, relapsing skin condition characterized by pruritus, inflammation, and xerosis. The disease is common, affecting an estimated 15-30% of children and 2-10% of adults.1,2 The specific cause of AD is unknown, but the disease is often associated with elevated serum IgE levels and a personal or family history of type I allergies, allergic rhinitis, and asthma. AD often begins in infancy, with a high percentage of children experiencing their first episode before one year of age.1–4 The disease represents a significant burden not only for those afflicted, but for family members as well.1,5
Treatment AD often requires pharmacological intervention. However, AD is associated with an epidermal barrier defect and nonpharmacological topical interventions such as moisturizer or emollient application are a mainstay of therapy, since these products help hydrate the skin and may augment barrier function and repair.6,7 Avoidance of triggering factors is also recommended. Allergens and irritants can act as triggers, and in general, limited use of non-soap cleansers is preferred.6–8 Minimizing the presence of superfluous ingredients such as perfumes and dyes in skin care products is also desirable.
We conducted a 4-week clinical study to assess the suitability of a regimen comprising liquid shampoo/wash and lotion products based on natural ingredients for daily use by children with AD. Clinical grading and bioinstrumentation were key to judging the regimen’s safety and efficacy. However, the study also incorporated two validated quality of life instruments to assess the burden of disease on the subjects and on their caregivers.
Test Articles
Subjects or parents/guardians of enrolled subjects used a natural ingredient-based liquid shampoo/wash product to cleanse themselves/their child during the study. This product combined effective cleansing and convenience; the latter was considered important given the lower end of the age range under study.
Additionally, subjects/parents used a natural ingredient-based lotion to moisturize their/their child’s skin.
Ingredient listings for the natural ingredient-based shampoo/wash and moisturizer test articles are provided in Table 1.
| Test Article | Ingredient Listing |
| Shampoo and wash product | Water, decyl glucoside, coco-betaine, lauryl glucoside, isoamyl laurate, sucrose laurate, glycerin, natural fragrance, betaine, potassium cocoyl hydrolyzed soy protein, hydrogenated palm glycerides citrate, tocopherol, lecithin, xanthan gum, citric acid, sodium chloride, coco- glucoside, glyceryl oleate, potassium sorbate, sodium benzoate, ascorbyl palmitate, phenoxyethanol, limonene. |
| Lotion/moisturizer product | Water, helianthus annuus (sunflower) seed oil, glycerin, cetyl alcohol, zea mays (corn)starch, avena sativa(oat) kernel flour,aloe barbadensis leaf juice, butyrospermum parkii (shea) butter, hydrolyzed jojoba esters, jojoba esters, kaolin, lecithin, xanthan gum, citric acid, sucrose stearate, zinc oxide, sodium PCA, sucrose polystearate, glyceryl laurate, sodiumstearoyl lactylate, potassium sorbate, sodium benzoate, phenoxyethanol. |
Table 1: Ingredient listing for the test articles used in this study.
Clinical In-Use Study
A single-center, clinical in-use study was conducted under the supervision of a board-certified pediatrician to assess the test articles’ skin tolerance and efficacy over four weeks of daily use. The target study population comprised otherwise healthy infants and children aged 6 months to 12 years with mild to moderate AD. The study protocol and all associated documents were reviewed and approved by an institutional review board. A parent or legal guardian provided informed consent for each prospective subject before they underwent any study-related procedures.
Prospective subjects acclimated under controlled environmental conditions (68-75 °F, 35-65% relative humidity) for at least 15 minutes upon arriving at the clinical testing facility. The study pediatrician then evaluated each individual’s skin using the Eczema Area and Severity Index (EASI) to assure that enrolled subjects had mild (EASI score from 1.1-7.0) or moderate (EASI score from 7.1-20.0) AD.9 The demographics of the enrolled study population are summarized in Table 2. The study pediatrician also scored erythema, dryness, and roughness as tolerance parameters on a 4-point scale (0 = none to 3 = severe). Qualifying subjects then had stratum corneum hydration (Corneometer CM 825, Courage + Khazaka electronic GmbH, Köln, Germany) and transepidermal water loss (TEWL, Tewameter TM300, Courage + Khazaka) measurements taken from an uninvolved area on a randomly assigned leg. Hydration measurements were made in triplicate at apposed sites and averaged; a single TEWL measurement was made.
Atopic Dermatitis Severity (EASI) Mild, N (%) Moderate, N (%) |
16 (69.6) 7 (30.4) |
Age at Enrollment (Months) Mean (SD) Median Range |
57 (45.3) 54 6 - 148 |
Sex Female, N (%) Male,N (%) |
8 (34.8) 15 (65.2) |
Fitzpatrick Skin Phototype I II III IV V |
2 5 3 3 10 |
| Key: N = number, SD = standard deviation. |
Table2: Demographics of enrolledsubjects.
Subjects’ parents/guardians completed Patient Oriented Dermatitis Measure (POEM) for children and Family Dermatology Quality of Life Index (FDLQI) questionnaires to assess subjects’ perceived dermatitis severity and the impact of the subjects’ disease on other family members, respectively.10,11 Completing the POEM required parents/guardians to rate how frequently, within the previous week, seven specific events/behaviors related to their child’s disease had occurred. Responses
were scored from 0 to 4, corresponding to ‘no days’ and ‘every day’. The maximum POEM score is 28. Similarly, the FDLQI required parents/guardians to respond to a series of 10 questions to assess the impact of their child’s disease on them during the past month. Responses are scored from 0 to 3, corresponding to ‘not relevant/not at all’ and ‘very much’. The maximum FDLQI score is 30.
Parents or guardians of qualifying subjects were provided with the test articles along with instructions for use. The liquid shampoo/wash product was to be used at least once but not more than twice daily for cleansing the body and hair. The moisturizer was to be applied twice daily; immediately after cleansing and 10-12 hours later. An additional daily application of the test moisturizer to dry skin areas was allowed, if necessary. Parents or guardians recorded each use of the test articles in a supplied study diary.
Subjects returned to the clinical testing facility after four weeks for final evaluation. Completed study diaries were collected and checked to assure compliance. After subjects acclimated, the study pediatrician evaluated EASI and scored tolerance parameters. Stratum corneum hydration and barrier function were measured as at baseline then subjects’ parents/guardian completed POEM and FDLQI questionnaires to assess perceived changes in their child’s dermatitis severity and the disease’s impact on other family members.
Only data for subjects who completed the study were included in the statistical analysis. Demographic data collected at the baseline visit were tabulated, and summary statistics were calculated for graded parameters, instrumental measurements, and questionnaire responses. The change-from-baseline values for each endpoint at each evaluation were calculated on a per subject basis, then mean values were tested for difference from zero using non-parametric statistical tests for grades and questionnaire data, and parametric tests for instrumental data. A two-tailed significance level of α = 0.05 was used for all statistical analyses.
Children with mild to moderate AD were the target population for this clinical study. Consistent with this, subjects’ incoming EASI scores ranged from 1.2 to 12.0, with an average baseline EASI score of 4.1 (Table 3). This reflects that the majority of enrolled subjects (~70%) had mild AD. Graded erythema was absent at baseline, but graded dryness and roughness scores were also in the ‘mild’ range. Twenty-three subjects qualified to enter treatment. One subject was dropped for noncompliance and one subject was lost to follow-up. There was one adverse event reported (erythema), which was mild in severity and judged possibly related to test article use. This adverse event resolved without further intervention. Thus, data from twenty subjects who completed the study were analyzed.
Clinical evaluation showed that subjects’ atopic disease improved with treatment (Table 3). The average EASI score decreased significantly from 4.1 to 3.5. Erythema graded as a tolerance parameter remained absent at study end; however, the other graded parameters, dryness and roughness, both decreased significantly from baseline. These clinical results support that the regimen comprising natural-based liquid shampoo/wash and lotion products was well-tolerated, and in fact improved subjects’ skin condition over 4 weeks of daily use.
| Graded Endpoint | Baseline | Week 4 | P-valuea |
| EASI score,mean (SD) | 4.1 (3.00) | 3.6 (3.04) | 0.004 |
| Tolerance parameters | |||
| Erythema, mean(SD) | 0.0 (0.00) | 0.0 (0.11) | 1.000 |
| Dryness, mean(SD) | 0.6 (0.54) | 0.5 (0.43) | 0.025 |
| Roughness, mean (SD) | 0.7 (0.38) | 0.6 (0.37) | 0.025 |
aWicoxon signedrank test. Key: SD = standard deviation. |
Table 3: Average graded endpointvalues at baselineand study end.
AD is associated with skin dryness and barrier compromise. Values for these parameters tend be lower and higher, respectively, than in healthy individuals, even on uninvolved skin sites.12–14 Stratum corneum hydration values measured on uninvolved leg skin at baseline averaged about 23 AU, placing them in the range associated with ‘very dry skin’ (Table 4).15 Baseline TEWL values measured with the Tewameter®
on uninvolved leg skin averaged 11.3 gm·m-2·hr-1, somewhat higher than the value measured with this instrument on the legs of healthy individuals.16 Thus, baseline instrumental measurements made on enrolled subjects’ legs are consistent with the expectations for AD.
| Instrumental Endpointa | Baseline | Week 4 | P-valueb |
| Corneometer, mean(SD) | 23.2 (7.42) | 26.6 (8.65) | 0.259 |
| TEWL, mean(SD) | 11.3 (3.39) | 10.4 (3.08) | 0.311 |
aCorneometer unitsare AU; TEWLunits are gm·m-2·hr-1. bPaired t-test. Key: SD = standard deviation; TEWL = transepidermal water loss. | |||
Table 4: Average instrumental endpoint values measuredat baseline and study end.
Stratum corneum hydration values measured on subjects’ legs increased by about 2.6 AU (about 11%) from baseline to study end, suggesting that the treatment increased moisture in the stratum corneum. However, the increase was not statistically significant. TEWL values decreased by about 0.9 gm·m-2·hr-1 (about 8%) over treatment, indicating improvement in the stratum corneum barrier. But again, this change was not statistically significant. The instrumental data are consistent with directional improved skin condition as a result of using the natural-based liquid shampoo/wash and moisturizer products.
AD creates a burden not only for those afflicted, but also on those around them.1,5 In the case of children, parents or guardians are most affected. This study used two validated instruments to assess the burden of disease on the child from the parents’/guardians’ standpoint (POEM), and the impact of the disease on the child’s family (FDLQI). Baseline responses to the POEM showed that itching, sleep disturbances, and cracked, flaking, and dry/rough skin were the symptoms most frequently affecting subjects (Table 5). The average POEM Total Score was 12.5, which is consistent with ‘moderate dermatitis’.10 Thus, disease severity was greater based on parents’/guardians’ POEM ratings of their child’s disease status than on clinical assessment. In terms of effect on family, time spent looking after the child and emotional distress experienced due to their atopic disease were the attributes that most affected parents’/caregivers’ quality of life (Table 6). However, overall, the FDQLI responses were relatively low, with only the mean for time spent caring for the child exceeding 1.0, i.e. this attribute was rated as having ‘a little’ impact on the caregivers’ quality of life. The relatively low baseline scores generated in the FDLQI might reflect the disease severity or the young age of the enrolled subjects, or the special bond between child and parent/guardian.
Over the lastweek, on how many days/nights... | Baseline mean (SD) | Week 4 mean (SD) |
P-valuea |
| has your child’sskin been itchybecause of their dermatitis? | 3.5 (1.32) | 2.2 (1.76) | 0.016 |
| has your child’ssleep been disturbed because of theirdermatitis? | 1.5 (1.67) | 0.7 (1.13) | 0.023 |
| has your child’sskin been bleeding because of their dermatitis? | 0.6 (0.94) | 0.4 (0.99) | 0.406 |
has your child’sskin been weeping or oozing clear fluid because of their dermatitis? | 0.4 (0.81) | 0.2 (0.49) | 0.500 |
| has your child’sskin been cracked because of their dermatitis? | 1.9 (1.66) | 1.2 (1.51) | 0.078 |
| has yourchild’s skin beenflaking off because of their dermatitis? | 2.0 (1.49) | 1.0 (1.59) | 0.011 |
| has your child’s skinfelt dry or rough because of their dermatitis? | 3.6 (0.82) | 2.5 (1.64) | 0.008 |
| POEM TotalScore | 12.5 (6.19) | 8.1 (7.08) | 0.003 |
aWilcoxon signedrank test. Key: SD = standard deviation. |
Table 5: Average parent/guardian responses to the Patient OrientedDermatitis Measure questionnaire.
Over the last month how much... | Baseline mean(SD) | Week 4 mean(SD) |
P-valuea |
| emotional distress haveyou experienced due to your relative/partner’s skindisease (e.g. worry, depression, embarrassment, frustration)? | 0.9 (0.67) | 0.4 (0.49) | 0.027 |
has yourrelative/partner’s skin disease affected your physical well-being (e.g. tiredness, exhaustion, contribution to poor health, sleep/rest disturbance)? | 0.6 (0.75) | 0.2 (0.37) | 0.016 |
| has your relative/partner’s skindisease affected yourpersonal relationships with him/her or with otherpeople? | 0.2 (0.41) | 0.1 (0.22) | 0.375 |
| have you been having problems with other peoples’ reactions due to your relative/partner’s skindisease (e.g. bullying, staring, need to explain to others about his/her skin problem)? | 0.1 (0.31) | 0.1 (0.22) | 1.000 |
| has your relative/partner’s skindisease affected your social life(e.g. going out, visiting or inviting people,attending social gatherings)? | 0.1 (0.22) | 0.1 (0.31) | 1.000 |
| has your relative/partner’s skindisease affected yourrecreation/leisure activities (e.g. holidays, personal hobbies, gym,sports, swimming, watching TV)? | 0.2 (0.52) | 0.2 (0.37) | 1.000 |
| time have youspent on looking after your relative/partner (e.g. putting on creams, giving medicines or looking aftertheir skin)? | 1.3 (0.98) | 1.2 (0.93) | 0.753 |
| extra housework haveyou had to do because of your relative/partner’s skindisease (e.g. cleaning, vacuuming, washing, cooking)? | 0.5 (0.95) | 0.2 (0.41) | 0.250 |
| has yourrelative/partner’s skin disease affected your job/study (e.g. need to take time off, not able to work, decrease in the numberof hours worked, having problems with peopleat work)? | 0.2 (0.41) | 0.1 (0.22) | 0.375 |
has your relative/partner’s skindisease increased yourroutine household expenditure (e.g. travel costs,buying special products, creams, cosmetics)? | 0.6 (0.75) | 0.2 (0.52) | 0.031 |
| FDQLI TotalScore | 4.6 (3.56) | 2.5 (1.54) | 0.035 |
aWilcoxon signedrank test. Key: SD = standard deviation. |
Table 6: Average parent/guardian responses to the Family Dermatology Quality of Life Index questionnaire.
Consistent with the clinically observed improvement in subjects’ atopic disease, the caregiver-assessed change in subjects’ skin condition shown by the POEM also improved. Ratings for all seven questions improved from baseline and significant changes were observed for several symptoms that received high frequency ratings at baseline, i.e. the frequencies of itching, sleep disturbances, and flaking and dry/rough skin were significantly reduced. The change in frequency rating for cracked skin was nearly significant (P = 0.078). The POEM Total Score decreased significantly from 12.5 to 8.1, although this score remained in the ‘moderate dermatitis’ range.10 The improvement in subjects’ atopic disease also lessened the burden on their caregivers, as reflected in the FDQLI. Of the ten parameters probed by this instrument, three remained the same and seven improved at study end. Respondents’ emotional distress, physical well-being, and household expenditure responses were significantly improved, as was the average FLQLI Total Score, which decreased from 4.6 to 2.5.
A four-week clinical in-use study was conducted among children with atopic dermatitis using a regimen comprising liquid shampoo/wash and lotion products that are based on natural ingredients. Treatment effects were judged using a 3-pronged approach that included clinical grading, bioengineering measurements, and validated life-quality questionnaires. These measures consistently showed that the regimen was well-tolerated and improved subjects’ skin condition and quality of life, as well as the quality of life of their caregivers. Taken together, these results show that the tested shampoo/wash and lotion products are appropriate for use as part of daily skin care in the management of atopic dermatitis.
This study was 100% funded by Burt’s Bees, Inc. The authors would like to thank Keith Ertel, KDE Scientific Consulting, LLC for the preparation of this manuscript. Final editing was executed by the authors.
Disclosures
Hemali B. Gunt is an employee of Burt’s Bees, Inc (Durham, NC, USA). Jeanette Jakus is a consultant to Burt’s Bees, Inc.
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The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
