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Case Report
*Corresponding Author: Aziz Slaoui, Gynaecology-Obstetrics and Endocrinology Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V, Rabat, Morocco.
Citation: Aziz Slaoui, Hanaa Lazhar, Noha Amail, Najia Zeraidi, Amina Lakhdar, et al (2023), Meigs Syndrome: about an Uncommon Case Report. J. Women Health Care and Issues. 6(1); DOI:10.31579/2642-9756/135
Copyright: © 2023 Aziz Slaoui, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 03 December 2022 | Accepted: 26 December 2022 | Published: 05 January 2023
Keywords: meigs syndrome; tumoral markers; ovarian fibroma
Background
Ovarian fibroma is a very unusual epithelial tumor representing less than 1% of all ovarian tumors. It can be asymptomatic and discovered during surgery or be associated with a pleural effusion preferentially located on the right side and a more or less abundant free ascites in the framework of the so-called Meigs syndrome. The challenge of management then lies in distinguishing benign from malignant since clinically, radiologically and biologically everything points towards malignant which requires radical surgical treatment. We report here the case of a 69-year-old postmenopausal patient with a clinical form of Meigs' syndrome that strongly suggested ovarian cancer.
Case Presentation
We hereby report here the case of a 69-year-old patient, menopausal, gravida 4 para 3 with 3 live children delivered vaginally and one miscarriage. She presented with ascites, hydrothorax and a solid tumor of the ovary. Serum CA 125 and HE 4 levels were very high. ROMA score was highly suggestive of malignancy. A hysterectomy with adnexectomy was performed. It was only the histological evidence of ovarian fibroma and the rapid resolution of its effusions that confirmed Meigs syndrome.
Conclusions
Meigs syndrome is an anatomical-clinical entity that associates a benign tumor of the ovary, ascites and hydrothorax. Highly elevated CA 125 and HE-4 tumor markers often point clinicians towards a malignant tumor and compel radical surgical treatment. This case report reminds us once again that only histology confirms the diagnosis of cancer.
Epithelial tumors of the ovary are very diverse in nature and often pose difficult diagnostic problems [1]. On the one hand, it is necessary to be able to confirm their organic nature in order not to over-treat a functional lesion, and on the other hand, it is also necessary to be able to assess their benign or malignant nature. Among them, we can mention the fibroid of the ovary which is a very unusual tumor representing less than 1% of all ovarian tumors [1]. Ovarian fibroma may be asymptomatic and discovered during surgery or it may be associated with a pleural effusion preferentially located on the right side and a more or less abundant free ascites in the so-called Meigs syndrome. We herein report the case of a 67-year-old menopausal patient with a clinical form of Meigs' syndrome that strongly suggested ovarian cancer.
Case Presentation
We hereby report here the case of a 69-year-old patient, menopausal, gravida 4 para 3 with 3 live children delivered vaginally and one miscarriage. She had been operated for ovarian torsion in her childhood treated by left adnexectomy and given the delay in management and ovarian necrosis. She presented to our facility with dyspnea, uncounted weight loss, fatigue, cough, abdominal pain and constipation. At our admission examination, the patient's general condition was altered by asthenia. She was polypneic at 28 cycles per minute and her blood pressure was 130/80 mmHg. Her weight and height were respectively 67 kg and 1.63 m with a BMI of 26.2. The abdominal examination was marked by abdominal bloating and diffuse dullness. The speculum examination revealed a healthy cervix and the vaginal touch coupled with the abdominal palpation revealed a mobile and solid right latero-uterine mass. Ultrasound examination showed abundant ascites, a uterus of normal size and morphology associated with a heterogeneous, poorly delineated right latero-uterine tissue mass of about 142x95 mm. The ascites fluid was transudate. The thoracic-abdominal-pelvic CT Scan revealed the presence of a right basal pleural effusion, a large intraperitoneal effusion and a large right pelvic fleshy mass 160 mm in transverse axis and 100 mm in anteroposterior axis, appearing to originate from the right adnexa. Biologically, the tumor markers were highly increased with CA 125 at 1028.3 IU/l, while HE-4 was 122.1 pmol. ROMA score was strongly suggestive of malignancy.
In view of the clinical and paraclinical context, the diagnosis of Meigs syndrome was evoked but ovarian cancer was also strongly feared. Thus, a preoperative paraclinical workup was proposed for surgery and came back normal.
After obtaining the patient's written consent, an exploratory laparotomy by median approach was performed under general anesthesia. On exploration, we found a very abundant ascites formed by a citrine yellow liquid of about 2.5 liters; a large ovoid ovarian tumor pedicled at the expense of the right ovary measuring 22 cm long axis and 15 cm short axis, bumpy, irregular surface, firm consistency, pearly white appearance, overhanging the uterus, more or less twisted but easily mobilizable without any adhesion. A careful exploration did not find any peritoneal carcinosis. Nevertheless, in view of the strong suspicion of malignancy, we performed a hysterectomy with right adnexectomy associated with an omentectomy, an appendectomy and biopsies of the diaphragmatic cupolas (Figure 1).
Figure 1: Photography of the total hysterectomy specimen without adnexal preservation showing a hard, smooth, yellowish tumor developed in front of the right ovary, measuring 15 cm in diameter.The large tumor removed was hard, smooth, yellowish in color, measuring 16 x 14 cm, and weighed 1350 g (Figure 2).The surgical specimens were sent to a histopathology laboratory. Pathological examination of the surgical specimen showed macroscopically a firm greyish solid tumor and microscopically a connective tissue tumor consisting of small regular spindle cells forming intersecting bundles and corresponding to a fibroid of the ovary. The rest of the biopsies were free of any malignancy. The post-operative course was uneventful. There was a very remarkable clinical recovery with disappearance of signs and drying of the pleural and peritoneal effusions. The patient was discharged after 6 days of hospitalization. Postoperative follow-up at 6 and 12 months was strictly normal.
Figure 2: Photography of the tumor removed measuring 16 x 14 cm, hard, smooth and yellowish in color.
Demons-Meigs syndrome was first described by Spiegel Berg in 1866 [2]. Demons et al. in 1887 provided a pathophysiological explanation for the presence of hydrothorax and Meigs in 1954 published 84 cases [2 – 5]. It is a very uncommon anatomical-clinical entity that occurs in 0.25% of ovarian tumors and most often affects women in the pre- and post-menopausal period, between the ages of 40 and 50 [6]. In its typical form, it groups together the Funck-Brentano conditions which are three [7]. First there are the anatomical/clinical conditions with the association of pleurisy, ascites and an ovarian fibroid. Then, there are the evolutionary conditions with recurrence of the pleural effusion after puncture and its drying up after. Finally, the physic-chemical conditions are defined by an identical pleural and ascitic fluid, in the form of a serofibrinous transudate without germs or neoplastic cells. The pleural effusion is located on the right in almost 65% of cases; however, an effusion on the left (15%) or bilaterally (20%) is possible [8 – 9]. The syndrome is also characterized by prognostic conditions, and recovery without sequelae after removal of the ovarian tumor is known. Our observation strictly meets the definition of the Demons-Meigs syndrome, by the association of an ovarian fibroid, ascites and hydrothorax and by the perfect recovery after surgical removal.
The pathophysiology of ascites and hydrothorax in Demons-Meigs syndrome is still debated and remains hypothetical. The vascular (venous and lymphatic) theory seems to be more convincing because it is unicist, although several pathophysiological hypotheses have been put forward. In 1944, Dockerty et al. [10] explained the appearance of ascites by a partial obstruction of venous return, linked to a torsion of the pelvic tumor. Serous fluid then transudates through the capsule. For Meigs et al. [11 - 12], the genesis of ascites is explained by an increase in pressure in the intratumoral lymphatics causing fluid to leak through the peritoneum. The passage of peritoneal fluid to the pleural cavity is thought to be via transdiaphragmatic lymphatic channels. This network is more developed on the right than on the left because of the liver mass, hence the right-hand predominance of the pleural effusion. The ascites is thought to be caused by fluid loss due to tumor oedema resulting from compression or torsion of the fibroid on its axis. In this case report, the hydrothorax was also found on the right.
Ovarian fibromas are usually large tumors with an average size of 140 mm; the largest reported ovarian fibroma measured 300 mm × 200 mm × 100 mm [13]. Their macroscopic appearance is very variable, most often a solid stromal tumor (as in our case) and more rarely a cystic tumor called cystadenofibroma [1]. Clinically, the major difficulty is to differentiate between ovarian fibroma and other solid ovarian tumors. Ovarian malignant tumor is all the more easily evoked as fibroid of the ovary is almost always associated with ascites and pleural effusion, which is known as Meigs' syndrome [14].
Moreover, Meigs’ syndrome is not specific to ovarian fibroids as there are pseudo Meigs syndromes [15], hence the major interest of pelvic ultrasound. In cystic ovarian tumors, it allows the benign or malignant character of the tumor to be approached with a sensitivity of 90% and a specificity of 87% [16; 17]. But in solid tumors, as in our case, this sensitivity is less accurate because the images are more varied and less specific. The most frequent image of the ovarian fibroid is that of a solid hypodense polylobed mass without calcification. The performance of this morphological ultrasound is improved today by the use of Doppler, which allows the type of tumor to be better defined and has been shown to be useful [18]. CT and MRI give images that are no more specific than those observed on ultrasound. Their interest lies above all in the detection of peritoneal, diaphragmatic or epiploic carcinosis, the absence of which is an important element pointing to benignity in this context [15].
The contribution of tumor markers remains to be discussed. CA 125 elevation in ovarian fibroma was first reported by O'Connel et al. in 1987 [19] and all cases published thereafter have been associated with elevated CA 125 [13; 15; 20 – 23] with a mean of 1200 IU/l and extremes of 286 IU/l [22] and 2360 IU/l [20]. The level found in our observation is within this range. Overall, the levels recorded in ovarian fibroids are much higher than those observed in ovarian cancers [2]. This association of ovarian fibroids with a significant elevation of CA 125 is a finding that is still open to discussion as to its pathophysiological explanation. Rouzier et al. [15] suggested an attempt at an explanation by formulating the hypothesis that this hypersecretion of CA 125 would be of mesothelial origin and related to a mechanical irritation (for example a torsion) or an increase in intraperitoneal pressure. To date, the marker HE-4 has only been studied once by Danilos et al. [24] who, like us, observed high seric levels with a very favorable ROMA score for malignancy. Although the latter may have contributed greatly to the better management of ovarian cancer, we have reached its limits here.
Finally, mistakenly considered as a malignant tumor, we opted, as many authors before us, for radical treatment which proved to be useless [15, 7]. Favorable spontaneous evolution showed that Meigs syndrome closely mimics ovarian neoplasia and proves that the existence of ascites and/or pleural effusion are not necessarily synonymous with malignancy in the presence of an ovarian tumor. Again, only histological evidence confirms ovarian cancer.
Conclusions
Meigs syndrome is an anatomical-clinical entity that associates a benign tumor of the ovary, ascites and hydrothorax. Highly elevated CA 125 and HE-4 tumor markers often point clinicians towards a malignant tumor and compel radical surgical treatment. This case report reminds us once again that only histology confirms the diagnosis of cancer.
Abbreviations
CA 125: Cancer Antigen 125
HE-4: Human Epididymis protein 4
ROMA: Risk of Ovarian Malignancy Algorithm
BMI: Body Mass Index
CT: Computerized
MRI: Magnetic Resonance Imaging
Declarations
Conflicts of interest
The authors declare that they have no competing interests.
Sources of funding
There are no funding sources to be declared.
Ethical approval
Ethics approval has been obtained to proceed with the current study.
Consent
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Author contribution
AS: study concept and design, data collection, data analysis and interpretation, writing the paper. HL: study concept, data collection, data analysis,writing the paper. NA: study concept, data collection, data analysis, writing the paper. NZ: study design, data collection, data interpretation, writing the paper. AL: study design, data collection, data interpretation, writing the paper. AB: study design, data collection, data interpretation, writing the paper. AK: study concept, data collection, data analysis, writing the paper.
Guarantor of Submission
The corresponding author is the guarantor of submission.
Acknowledgements
None.
Availability of data and materials
Supporting material is available if further analysis is needed.
Provenance and peer review
Not commissioned, externally peer-reviewed.
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