AUCTORES
Globalize your Research
Review Article
*Corresponding Author: J.A. Jayalal, Professor of General Surgery and Consultant lap Surgeon.
Citation: A. Jayalal, Edwin, Jekin J. Sharon, Bhagavath, (2023), Management of Complex Posterior Horseshoe Anal Fistula by The Modified Hanley’s Procedure -Clinical Experience and Review of 25 Patients, Journal of Clinical Surgery and Research, 4(2); DOI:10.31579/2768-2757/066
Copyright: © 2023, J.A. Jayalal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 20 February 2023 | Accepted: 10 March 2023 | Published: 21 March 2023
Keywords: trauma; urethra; tomography; 3D reconstruction
This is a prospective study carried out with the aim to document clinical experience in the surgical management of posterior horseshoe fistula of cryptoglandular origin using the modified Hanley procedure as a one-stage procedure.
In this study, A modified Hanley procedure was used in 25 patients (20 males and 5 females) who had presented with posterior horseshoe anal fistula (mean age 41 years) for the period from February 2020 to December 2022, and the results of surgical outcomes were analysed.
In this procedure, after optimization and anaesthesia, a malleable probe is inserted into the primary Fistulous tract and directed toward the posterior anal space. A straight transverse incision is placed at the primary opening, towards the tip of the coccyx and posterior anal space. The anal portion of the fistulous tract is unroofed. The side fistula tracts are unroofed and removed in toto.
It is noted complete healing was achieved in all 25 patients within three months postoperative period. Recurrence was found in only three patients after six-month follow-up period. All patients were discharged on the 5th post-operative day None required readmission and post-operative pain was mild and bearable. Narcotic analgesics were not needed after discharge. After undergoing the procedure, the patients fully recovered and within 2-3 weeks all patients were able to return to their work and daily activity.
In conclusion, the posterior complex horseshoe anal fistula, though it has a treacherous fistulous tract can be safely and successfully treated using the modified Hanley's procedure.
An anorectal fistula is an abnormal communication lined with granulation tissue between the surface of the anal canal internally and the perianal skin or perineum externally [1]. Secondary tracts may be multiple and can extend from the same primary opening.
There are a few conditions, having sinuses and do not have internal communications with the anal canal and it should be differentiated:
Most often it is the sequel of the perianal anal abscess spontaneous internal rupture or inadvertent therapeutic intervention. When the perianal fistulous communication is established as it will cause continuous discharge or wetting of the area, resulting in significant implications and impacts on the quality of life and effective working pattern. The perianal fistula causes social hygienic embarrassment and also imparts continuous mild to moderate pain and discomfort. In a few individuals especially those who have associated comorbidities and immunocompromise it can result in frank sepsis or septicaemia [2].
The pre-emptive diagnosis and appropriate management of the perianal fistula remains an enigma due to the involved plethora of procedural methods imparted from the ancient era to the modern sophisticated and complicated yet controversial methods in colorectal surgery. Predominantly surgical methods are considered as the prime and mainstay of therapy with an objective of the adequate draining of the local infective materials resulting in eradication of the fistulous tract with the preservation of the effective sphincter mechanism [2,3].
The choice of surgical approach depends on several factors such as the age, sex, etiologic, location, type, and duration of the fistula, expertise of the surgeon as well as previously performed procedure, and preoperative sphincter function [4].
As over 90% result from a crypto glandular abscess originating from the crypts of Morgagni which are located between the anal orifice and the dentate line and most internal openings of the fistula is located around the anal glands surrounding the dentate line are referred to as anal in origin or low type while fistula that originates above the dentate line as high type fistula 5.
The Anorectal fistula are classified and grouped based on the pathway of the fistulous tract and the structures they pass through before they exit in the perianal region as [5].
Most often the perianal fistula proceeds after the drainage procedure applied for draining the perianal abscess. Perianal drainage though it helps in the drainage of the pus and thereby reduces the inflammatory process, the patient will be at enhanced risk of either developing recurrent perianal sepsis or Perianal fistula. As per the statistics by Gordon et al, in nearly 35- 50%, perianal fistula occurs in patients after the first episode of the perianal abscess [6].
History of Perianal fistula:
References to fistula-in-ano date to antiquity. Numerous publications and treaties on fistula in ano and its fascination has exerted for more than 2000 years. In 430 BCE, Hippocrates made extensive reference to surgical therapy for the fistulous disease, which is still been practiced and he was credited as the first person to advocate the effective use of a seton (Latin seta bristle).
John Arderne (1307-1390), a prolific English surgeon in 1376, wrote Treatises of Fistula in Ano; Haemorrhoids, and Clysters, which had the full description of the fistulotomy procedure and he also mentioned the seton use. Historical references indicate that Louis XIV was treated for an anal fistula in the 18th century. Salmon established a hospital in London (St. Mark's) devoted to the treatment of fistula-in-ano and other rectal conditions.
In the late 19th and early 20th centuries, prominent physicians/surgeons, such as Goodsall and Miles, Milligan and Morgan, Thompson, and Lockhart-Mummery, made substantial contributions to the treatment of anal fistula. Based on their findings and observations various theories on pathogenesis, progression and treatment options were described. However, in these early years in spite of the publication, there were only little changes in the anatomical knowledge, pathogenesis, and the natural progression of the disease.
Parks refined the classification system in 1976, which is still in widespread use. Over the past few decades, many authors have presented new techniques and case series in an effort to minimize recurrence rates and incontinence complications. In spite of these and with more than two millennia of rich knowledge and experience, fistula-in-anal remains a mystifying surgical disease.
Fistula-in-anal is predominantly the sequel of a previously occurred caused anorectal abscess. In the dentate line of the anal canal, there are about 8-10, anal cryptoglandular structures, which are arranged in a circumferential pattern. Normally these cryptoglandular structures pierce and penetrate through the internal sphincter and as a result, they will reach the inter sphincteric plane. This is important as these areas of penetration will pave waves for the infective organism from the anal canal can reach the intramuscular spaces. The hypothesis based on the cryptoglandular theory postulates an infection that normally begins in the anal canal glands can penetrate into the muscular wall of the anal sphincters and will lead to the formation of an anorectal abscess.
When these abscesses are dealt with through incision drainage or when they spontaneously rupture and drain, the left behind granulation tissue will persist and lead to the recurrence of the symptoms The incidence of formation of this granulation tissue and resulting in the development of the fistula tract shall vary from 7 to 40%.
Fistula in ano can develop as a consequence secondary to trauma (e.g., recto anal foreign bodies), Inflammatory bowel diseases like Crohn's disease, acute and chronic anal fissures, colorectal carcinoma, following radiation proctitis, systemic infections like actinomycoses, tuberculosis, and lymphogranuloma venereum secondary to chlamydial infection.
Malouf et al, 8. have explained this pathogenesis as the infection and abscess of the crypt gland in the inter sphincteric space, spread vertically, horizontally, or circumferentially and this determines the site of the fistula. When Circumferential spread occurs, through the inter sphincteric, ischiorectal, or superelevated compartment results in horseshoe fistula8. When the abscess is not drained either surgically or spontaneously adequately, it spread extensively into the ischiorectal space. This spread results in anterior and posterior horseshoe abscesses and fistula.
Horseshoe fistula:
Horseshoe fistula is a complex type of trans-sphincteric fistula that is caused by an infection in the perianal gland present in the midline posteriorly. This infection can extend along the deep postanal space to reach the ischiorectal fossa on one or either side of the anal canal before it drains into the perianal skin. Perianal fistula is termed a Horseshoe fistula when the fistulas tract encircles the anus partially and exits out on either side of the anus 6.
Because of the depth and complexity of the secondary tracks associated with horseshoe fistula, symptoms are usually severe, and the diagnosis can be difficult The Horseshoe fistula occurs more in males and the average incident male-to-female ratio is [1.8] – [1].
The Horseshoe fistula is of two main types 7
Contrary to the general belief that the horseshoe fistula is the cause of the posterior deep anal abscess, the fistula follows the development of deep postanal space abscess as its complication.
They are a particularly aggressive form of anorectal abscess and fistula because there is an erratic pattern of spread in a ring-like fashion to the deep post-anal or rarely to the deep preanal space and then to the ischiorectal space. Therefore, the typical horseshoe fistula is composed of bilateral external openings joined by a deep post-anal communication in the post midline, resulting in a U or horseshoe–shaped configuration9. Patients with horseshoe fistula usually undergo multiple drainages and unsuccessful fistula surgery before they reach to get a definitive diagnosis and treatment. The aggressive nature of this type of fistula is also confirmed by the high rate of Crohn's disease in patients with horseshoe fistula [10,11].
The patients of horseshow fistula usually advised surgery for their problems. There are several operations like fistulotomy, cutting seton, fibrin glue injection, fistula plug, and endorectal advancement flap 11. It was found that all these procedures are just temporary solutions as invariably the fistula recurs. Besides, a lot of complications can occur due to surgery like urinary retention, bleeding, thrombosed pile, fecal impaction, incontinence of stool, anal stenosis, and delayed wound healing. Treatment of horseshow fistula by fecal diversion alone did not resolve horseshoe fistula [12].
Hanley’s procedure:
Horseshoe fistula, as it is a complex fistula will lead to potentially morbid conditions. Hanley, 1965 reported his original procedure for horseshoe fistula which involved the complete division of the posterior 12 o'clock sphincter mechanism down to the deep postanal space, counter drains were placed through each lateral extension and were removed several weeks afterward.
Modified Hanley’s procedure:
The aggressive management of the Horseshoe fistula by Hanley’s procedure obliterated the source of the fistula but at the inevitable price of the high incidence of anorectal incontinence. In 1990 modified Hanley procedure was adopted, in which the posterior sphincter was divided gradually by using a cutting hybrid seton placed around the 6 o'clock sphincter mechanism, this seton was serially tightened until the posterior sphincter was divided and it was tethered by resulting scar tissue12. Hanley's procedure with drainage of deep postanal space and cutting and drainage hybrid setons proved to be safe, and successful and did not result in fecal incontinence. Complete healing of the fistula may take weeks or several months but patients remain functional even with a seton in place [13].
Single-stage modified Hanley’s procedure:
This study presents the effectiveness and the results obtained with single-stage modified Hanley operation in the surgical management of 25 patients presented with a complex horseshoe anal fistula. The Post anal space is reached through a post-anal transverse incision at 60 clock position and the post-anal space is thoroughly curated and drained. The connection of secondary tracts was identified and they are encircled externally and deroofed from the surrounding tissues and reached up to the post-anal space without cutting the post-anal sphincter. The tracts were excised in toto along with the post-anal space. The wound is well irrigated and a Penrose drain is kept and continuous dressing and irrigation did in the postoperative period.
The aim of the study was to document our clinical experience in managing patients with horseshoe fistula of cryptoglandular origin with modification of the Hanley procedure using a single-stage approach.
This is a prospective study done from the period between February 2020 to December 2022, 25 patients 20 males and 5 females presented with chronic horseshoe fistula. Age ranges from 19-73 years.
The inclusion criteria were,
Exclusion criteria included:
Procedure:
All patients were subjected to the preoperative measures which include: detailed history, a thorough and full clinical examination including PR examination to check for sphincter tone, preoperative MRI to demonstrate the extent of fistula, and to demonstrate deep postanal space affection. Routine preoperative laboratory investigations were done and informed consent was taken from all patients. All patients were prepared preoperatively by fasting and enema the night before surgery. All operations were performed with patients in the lithotomy position and under spinal anaesthesia.
During the operation, the fistulous tract was gently probed with a small blunt-tipped, malleable metal probe. The portion of the tract outside the sphincter was laid open and curetted; in addition to the excision of the superficial segment of the lateral tract ischiorectal spaces were curetted as well. The skin and anoderm overlaying the fistulous tract incised.
Postoperative continence was assessed using the classification according to the Wexner score for fecal incontinence and according to Browning and Park's classifications in which category
Patients were in the hospital for a minimum of 5 days and treated with antibiotics, analgesics, and sitz baths. The cases were followed up weekly for the first month and then once in a month for 6 months. Patients were advised to contact us whenever they faced any problems. All the patients had complete healing within 30 days. There was no significant incontinence was reported in our postoperative follow-up.
Patients were able to return to regular work in 3-4 weeks. Incontinence was not in all patients. The recurrent fistula was noted in 2 patients only after a mean follow-up of six months.
Twenty-five patients presented with posterior horseshoe complex anal fistula underwent an anal fistula operation by a single-stage modified Hanley procedure during the study period. Table 1 summarized their characteristic. The median age was 43 years with a predominance of male patients (20 patients, 71.4%). In 16 patients (57.1%) had undergone a previous operation to treat anal sepsis, 21 patients had no previous history of surgery to treat anal fistula, whereas the rest presented with recurrent fistula. Baseline stool or gas incontinence symptoms did not see in all patients. Seven patients involved in this study were diabetics (25%).
Nearly half of patients had high trans-sphincteric fistula in anal and had internal opening above dentate line.
Complete healing was achieved in 10-12 weeks. All patients were followed up for minimum period of six months. None of the patients had bleeding, wound infection, premature dislodgement or slippage of seton. Recurrence was found in three patients (10.7%). The causes of recurrence as shown in table (2) were high type horseshoe fistula, recurrent fistula and in diabetic patients.
Fistula in an is one of the most frequent anorectal pathologies with a spectrum of clinical presentation5. The route and extent of the fistulae and the associated acute suppuration are defined by the origin in the crypto glandular complex and the involvement of the anatomically circumscribed perirectal space The superficial and deep post anal space of Courtney located behind the anal canal. Both communicate on either side with ischio rectal fossa providing the pathway for the formation of horseshoe abscess and fistula [8].
Suppurative anorectal disease involving the deep post anal space comprises less than 15% of all type pf anorectal sepsis 12. Horseshoe abscess and fistula with primary opening the posterior midline, a trans-sphincteric extension to the deep post anal space and bilateral involvement of the ischeo rectal fossa represent the most sever manifestation 13. It remains a complex and challenging a clinical entity due to configuration, depth and the degree of the sphincter involvement. The management of the anal fistula in an effective manner has always been a challenge to the surgeon world over. The conventional operative treatment of the anal fistula is to lay open or completely excise the fistula tract and allow healing by open granulation [14]. In high anal fistula included horseshoe type, complete excision is not possible due to the involvement anal sphincters.
In 1965 Hanley proposed a treatment strategy for horseshoe fistula based on conventional description of post anal space of Courtney. This included bilateral para-anal incision over ischio rectal space to drain the infra levator lateral extensions of the horseshoe and packing with gauze wicks. Hanley proposed technique was a less morbid and more successful alternative to complete un-roofing which had been the standard operation at that time [15].
A decade later Hamilton published his experience with similar technique and reported 6.2% recurrence 16. So, the original Hanley procedure associated with high incidence of fecal and flatus incontinence, in 1990 notification of Hanley procedure done for management of horseshoe fistula using a hybrid seton elastic (glove seton) in order to preserve the anal sphincter and prevent the incontinence.
We adapted single stage modified Hanley’s procedure, for all our patients included in this study in management their horseshoe fistula and the surgical outcome of using this procedure during the study period from February 2020–December 2022 was analysed.
The ischiorectal space were thoroughly curetted and after draining the pus, irrigated with povidone and hydrogen peroxide solution and later with saline. The space is packed with dressing soaked in 4% povidone iodine solution.
In all our patients included in this study the internal openings were noted in the posterior midline at the level of the dentate line which indicates the presence of associated deep post anal abscess. If this abscess is not drained, the definite treatment of the fistula can be achieved, this is the most important point in the surgical treatment of horseshoe fistula.
The presence of horse shoe fistula in this study is diagnosed by the nature of disease, history of discharge and the physical examination only. The patients had purulent, often blood-stained perianal discharge from the two or more external opening in the ischia rectal fossa and also having intermittent pain. MRI, contrast fistula graph and ultrasound for delineating the collection of pus are used as per the need. MRI is mainly used for patients having recurrence of fistula and the complex course. In our observation the MRI is superior to contrast fistula grapy.
Beets Tan et al18,19 evaluated the accuracy of MRI for the detection of anal fistulas and evaluated the additional clinical value of preoperative MRI. He correlated the MRI findings with findings during surgery and found its sensitivity and specify for detecting horse shoe fistula tract as 100% and 100% respectively.
In our study, for few patients we did not perform routine radiological study using MRI and contrast fistula grapy. However, all had extensive clinical evaluation and on table hydrogen peroxide and probe examination.
On the table the course of the fistula tract is confirmed by injecting hydrogen peroxide into the one of the external openings of the horse shoe fistulas. Although the passage of a probe from both the external and internal aspects is the most reliable technique to identify a fistula tract intra-operatively, injection of various substances such as methylene blue, indigo carmine, hydrogen peroxide or even milk has been described and used widely. Hydrogen peroxide is probably the best mean for identifying the internal opening, since the pressure created by the bubbles, may be sufficient to penetrate even a stenotic tract20,21. In our series, we cannulating the fistula tract by blind –tip probe after injecting the hydrogen peroxide is an essential step of the fistula surgery. Probing not only provide the identification of the course of the fistula tract but also facilitate the fistulotomy over the probe. Probing should be gentle, otherwise it will result in creation of a false route which further complicate the operative procedure.
Partial fistulotomy with counter -drainage of lateral tract and posterior midline incision to reach the deep post anal space is made by electrocautery. We prefer electrocautery because it provides a better homeostasis than the traditional knife.
Although horseshoe fistulas are not common but are challenging due to configuration and sphincter involvement. A modified Hanley procedure with drainage of the deep post anal space and end mass removal of the secondary fistulous tracts without cutting the post anal sphincter proved to be a safe successful method and did not result in fecal incontinence.
So, in this study we confirmed that the modified Hanley operation is effective and conservative surgical procedure that eliminates the disadvantage of keeping the seton for a long period and it is useful method for preservation of the sphincter function.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
