AUCTORES
Globalize your Research
Case Report
*Corresponding Author: Jonathan De Jesus Ulloa Peregrina, Eduardo Vazquez N General Hospital, Puebla.
Citation: Ulloa Peregrina JDJ, Lien Chang LEJ, (2024), Leukemia Secondary to Lymphoblastic Lymphoma with Development of Aplasia Medullary Post Induction of Hypercvad, Report of Case Clinical and Revision of The Literature, Journal of Clinical and Laboratory Research, 7(4); DOI:10.31579/2768-0487/132
Copyright: © 2024, Jonathan De Jesus Ulloa Peregrina. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 19 February 2024 | Accepted: 29 February 2024 | Published: 08 March 2024
Keywords: lymphoblastic lymphoma;secondary lymphoblastic leukemia; secondary bones marrow aplasia; hyper-cvad
We describe the case of a patient with lymphoblastic lymphoma who received 8 cycles of chemotherapy with subsequent development of secondary acute lymphoblastic leukemia, requiring initiation of a remission induction chemotherapy scheme based on Hyper-CVAD, developing secondary bone marrow aplasia.
Secondary leukemias are broadly defined as a group of cancers that arise after the existence of a previous malignant neoplasm or patients treated previously with cytotoxic therapy, that is to say chemotherapy or radiotherapy. [1, 2]
The most important group of therapy-related leukemias is that associated with alkylating agents or topoisomerase II inhibitors such as etoposide, doxorubicin and mitoxantrone which have been associated with specific cytogenetic abnormalities in the chromosomes [5 or 7] and in the MLL gene (11q23) [2,3,4]
The course and prognosis depend on the cytogenetic and clinical characteristics. molecular to that presented at the time of diagnosis
Although secondary acute myeloid leukemia (s-AML) has been widely described, it is knows very little about secondary acute lymphoblastic leukemia (s-ALL).
Isolated case series report an s-ALL rate of less than 1perecentage of all acute leukemias 5, its pathogenesis is mainly attributed to the effect of therapies cytotoxic on hematopoietic progenitor cells [2.]
Normally, topoisomerase II plays multiple roles in survival cell phone, so as replication, transcription, condensation and segregation chromosome, allowing a segment of double-stranded DNA to pass through another achieving like this alter its topology.
Toposimorese II inhibitors generate DNA double-strand breaks causing cell death, therefore its side effects generate alterations genetics mainly MLL, PML, RARA and AML1 (RUNX1), and translocations chromosomal as 11q23, being he guy further frequent of translocation in t-AML and acute leukemias [6]
It has been described that the latency from the first diagnosis of malignant neoplasia until the diagnosis of s-ALL is in a range of 60 to 77 months, patients who have a history of hematological malignancies, as well as carriers of the MLL gene rearrangement compared to other cytogenetic subgroups present a shorter latency period [1, 5, 7]
Breast cancer has been the most reported previous diagnosis followed by lymphoproliferative neoplasms (non-Hodgkin lymphoma, chronic lymphocytic leukemia, lymphoma Hodgkin's disease, multiple myeloma) and thyroid, lung, brain, ovary and prostate [2,8,9,10,] likewise family history of lymphomas seems to increase five times the risk of secondary acute leukemia [7]
There is little literature on the treatment of secondary leukemias by absence of prospective studies that directly compare the results, in addition of a worry regard to a elderly morbidity and mortality related with he treatment given previous exposure to cytotoxic therapies.
Patients with secondary leukemia can be expected to have a rate of initial complete response of just over 50perecentage, most of them relapse and Studies suggest that despite continuing with intensive chemotherapy after remission, just around of 10perecentage can be long-term survivors
The Hyper-CVAD chemotherapy (CT) regimen with or without tyrosine inhibitors kinase, has been one of the regimens mostly used to induce remission to these patients even without being able to define it as a first-line regimen, and particularly when a patient with s-ALL is being considered for transplant allogeneic of progenitor cells hematopoietic (TaCPH).
In younger adults, if an HLA-matched sibling donor is available, the TaCPH can be the option preferred and, probably, represent the only possibility of cure, although there are no data from prospective studies that establish this definitively. absolute way.
Older adults who cannot tolerate the side effects of intensive chemotherapy They could be included in clinical trials of targeted therapies. This therapeutic area remains unsatisfactory and further studies are needed to demonstrate effectiveness in treatment schemes [2,3]
Case Clinical
Current condition began in December 2018 with inflammation and growth of the left parotid gland, of rapid evolution, going to a private doctor who decided to treat it as parotitis, with unspecified medications, without improvement of the symptomatology. In March 2019, there was a new increase in the size of the tumor. neck, going to a private hospital, where they requested a tomography in which showed a tumor in the left neck measuring 10 cm in its greatest diameter (not shown). has no study or report), so he was scheduled for a parotid biopsy left and periparotid tissue, which was performed on 06-07-19, reporting lymphoma lymphoblastic with immunohistochemistry positive for Bcl2, CD3 and TdT. (See figures 1.2 and 3) He is evaluated by an external hematologist, who begins first-line CHOP chemotherapy. like (without prednisone or anthracycline due to apparent early cardiotoxicity) for eight cycles, start he 06-15-19 and the ended the 11-29-19, decreasing injury tumor to 18 mm in its largest diameter and isolated nodes of 14 and 15 mm in the neck, with a reduction of 53perecentage compared to baseline, classifying it as a partial response according to to the RECIST 1.1. Was valued by the Service of radiation oncology, who they decide apply radiotherapy 3600 cGy in 18 sessions ending on 07-31-20. It is documented complete remission with new tomographic study. It is valued for the first time in our service on 10-05-2020 with a new simple and contrasted neck tomography, thorax, abdomen and pelvis with late venous phase negative for measurable lesions and no measurable. In November 2020, he attended the Hematology consultation at our unit. presenting evil state general, pallor integumentary and diaphoresis profuse with blood cytometry result leukocytes 3.7/ µ L, neutrophils 0.9/ µ L lymphocytes 2.4/ µ L, hemoglobin 11.9 g/dl, platelets 30,000/ µ L, chemistry blood DHL 884 U/l, bone marrow aspirate was performed with a report of 100perecentage blasts, which They measure 12 to 16 microns in diameter, with scant cytoplasm and vacuoles inside, cores variegated the most cerebriforms, with 0 to 1 nucleolus evident in his inside. Immunophenotype with detection of 74perecentage blasts, CD45+, HLA-DR+, CD34-, TdT+, CD10+, CD19+, CD79+, CD33+, concluding B acute lymphoblastic leukemia common with aberrant CD33 secondary to lymphoma lymphoblastic of cells T, deciding to start remission induction chemotherapy with a Hyper- Reversed CVAD phase B on 11-11-20 applying each phase with 28-day intervals, receiving last phase on 06-23-21, completing the four cycles and documenting no detection of malignant clone by flow cytometry (minimal residual disease of bone marrow negative). On 08-18-21 he entered the Emergency Department with syndrome hemorrhagyparous by gingivorrhagia, documenting cytometry hematic with leukocytes 320/ µ L, neutrophils 144/ µ L, hemoglobin 4.8g/dl, platelets 27000/ L. If suspected of relapse medullary HE makes biopsy of marrow I mean with report of cellularity 30perecentage, (See figure 4) presence of the 3 series cell phones, TdT negative, CD3 negative, discarding infiltration leukemic I lymphomatous. HE concludes aplasia medullary secondary and continues with maintenance chemotherapy adjusted POMP scheme (mercaptopurine fiftyperecentage and methotrexate 44perecentage) without reinductions, for keep figures acceptable cells in peripheral blood. On 06/07/22 he had blood cytometry with leukocytes 2.6/ µ L, neutrophils 0.9/ µ L, hemoglobin 14 g/dl, platelets 58000/ µ L, so bone marrow aspirate was performed with minimal residual disease negative for neoplastic phenotype, maintenance chemotherapy dose is again adjusted POMP (methotrexate twentyperecentage and Mertaptopurine(50perecentage) Follow-up he day 08-18-22 continuing with POMP chemotherapy regimen adjusted to said doses, cytometry hematic of control leukocytes 2.8/ µ L, neutrophils 1.6/ µ L, platelets 113,000/ µ L, hemoglobin 13.6g/dl.
Figure 1: Hematoxylin and Eosin (lymph node).
Figure 2: Myeloperoxidase (lymph node).
Figure 3: CD56, BCL 6 (lymph node).
Figure 4: Bone marrow 10 Discussion.
The leukemias lymphoblastic high schools are an entity bit characterized due to the limited literature and absence of protocols therapeutic, No being possible estimate the survival neither choose between a scheme chemotherapy or other, probably be an entity underdiagnosed due to the high mortality to short and medium term, masking symptomatology with the neoplasia malignant of base. This associated mostly to agents’ chemotherapy as the inhibitors of the topoisomerase II and the agents’ alkylating agents, the which are used frequently in the most of regime’s chemotherapy for different guys of cancer mostly of mother and lymphomas. Our patient account with antecedent of to have received cyclophosphamide unknown dose, which could have been the trigger for developing leukemia. HE decides Start Q.T. with scheme Hyper-CVAD, he which has been he mainly used, presenting multiple paintings of neutropenia febrile with resolution of the same to the introduce recovery of the series granulocytic, with suitable answer in each cycle, presenting minimal residual disease negative for neoplastic cells at complete the first and fourth QT cycles documenting negative cerebrospinal fluid leukemic infiltration, which improves the prognosis. When spinal aplasia is evident secondary, which could be associated with high doses of chemotherapy drugs, He decided adjust dose of Q.T. of POMP for keep figures acceptable in lines peripheral cell phones. At the moment, he patient HE finds completing oral maintenance and has fully returned to oral activities daily.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
