AUCTORES
Globalize your Research
Review Article
*Corresponding Author: Abyt Ibraimov, International Higher School of Medicine, Bishkek, National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan.
Citation: Abyt Ibraimov, (2022), How could a modern man arise? A mini review. Biomedical Research and Clinical Reviews, 7(4); DOI: 10.31579/2692-9406/136
Copyright: © 2022 ,Abyt Ibraimov, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 25 October 2022 | Accepted: 04 November 2022 | Published: 27 December 2022
Keywords: human origin; human adaptation; human evolution; human karyotype; heterochromatin regions; human body heat conductivity
Usually, a modern man as a biological species means that he has conceptual thinking, large neocortex, speech, great physiological flexibility, the ability to adapt to different climatic conditions of the Earth, hairless skin, 46 rather than 48 chromosomes, the existence of purely human forms of pathologies (alcoholism, drug addiction, obesity, atherosclerosis, high altitude pulmonary edema), the ability to long-distance running etc. It is believed that all these unique features of a human are the result of the evolution of specific structural genes. The hypothesis that the broad variability of chromosomal heterochromatin regions, rather than structural genes, played a major role in the origin of modern man is discussed.
It is commonly believed that modern man (Homo sapiens sapiens) originated around 150 000 - 200 000 years ago on the African continent. 30,000-50,000 years ago, some of them began to migrate from East Africa, began to populate the Eurasia, and eventually reached South America. This enterprise turned out to be so successful that currently only their descendants live on Earth and other hominins who began to explore Eurasia, Australia and Oceania even earlier than the ancestors of modern man, for unknown reasons, have not survived. By 40 000 years ago however modern people – H. s. sapience -to have been the sole occupants of the Europe and Asia. Why other hominids failed to achieve such success is the subject of long-standing debate. Eventually, man took the top of the food chain and created a civilization.
From our point of view, out of all the existing hominin species, only one was lucky because only he managed to go this way: at first he acquired a hairless skin and a large brain → became the owner of 46 instead of 48 chromosomes, as in other higher primates → managed to adapt to more severe than the climatic conditions of East Africa → invented a tool, clothes and housing → carried out cultural evolution, formed states and created civilizations.
How did it all start?
We believe that the beginning of human evolution was the acquisition of hairless skin and, as a consequence, the emergence of a large brain. Perhaps this process began at a time when one or more hominid populations found themselves in a very favorable climatic environment rich in high-calorie food.
Let's imagine such a situation; in search of food, some population of the ancestors of modern man found himself near a tropical lake rich in high-calorie food. However, such luck has confronted individuals in the population with a very serious adaptive problem. The fact is that the consumption of high-calorie food [2,3] will inevitably lead to the production of excess thermal energy, which must be removed outside the body in a timely manner so as not to disrupt the temperature homeostasis in the body in a tropical climate. This problem was especially aggravated due to the presence of a fur, which prevented the effective removal of excess heat outside the body. As we believe, this problem eventually led to the disappearance of the fur. Given this, the heat-protection function of hair passed over to the layer of subcutaneous fat and that in the process of evolution skin ceases to be only the barrier-protective organ, it also becomes the organ of sense (for details see [4-6]).
From 48 to 46 chromosomes.
A fundamental feature of chromosomes in higher eukaryotes, including man, is the presence of two evolutionally consolidated types of genetic material: euchromatin and heterochromatin. Euchromatin, the conservative portion of the genome, contains transcribed structural genes, while heterochromatin, the variable portion of the genome, is predominantly composed of non-transcribed repeated DNA sequences. Heterochromatin is universally distributed in the chromosomes of all the eukaryotes - plants, animals and man, accounting for 10% to 60% of their genome. Chromosomal heterochromatin regions (HRs) account for about 15% - 20% of the human genome [7-11].
To-date two types of constitutive heterochromatin are recognized: С- and Q-heterochromatin. There are several significant differences between them: C-heterochromatin is found in the chromosomes of all the higher eukaryotes, while Q-heterochromatin - only in man (Homo sapiens), the chimpanzee (Pan troglodytes) and gorilla (Gorilla gorilla) [11-15]. Although chromosomal Q-heterochromatin regions (Q-HRs) exist in the genome of three higher primates, their wide quantitative variability is characteristic only to human populations. Q-HRs variability can be found in man only on seven autosomes [3, 4, 13, 14, 15, 21 and 22], as well as on chromosome Y. Individuals in population differ in the number, location, size, and intensity of staining (fluorescence) of these specific chromosomal regions [7-15].
As the amount of food decreases, populations began to expand the territory of their habitat to more severe, including cold areas. Perhaps, just at this stage in the life history of our ancestors, the adaptive changes appeared in their karyotype, which, ultimately, resulted to the emergence of the modern human. We think it highly probable, that the causes of origin of individuals with 46 chromosomes were climate in the East Africa. Middle and Late Miocene ecology was far from being uniform, and such climatic changes as cooling, aridity, seasonal and diurnal temperature fluctuations gradually became dominant environmental factors [16].
It is old-established fact that the chromosome number in the chimpanzee, gorilla and orangutan was 48 and not 46 as in man. However, cause and effect of such chromosome rearrangement is unknown. We believe that the transition from 48 to 46 chromosomes, as well as changes in the composition, localization and amount of chromosomal heterochromatin regions in the karyotype of the ancestors of modern man turned out to be crucial in his formation as a biological species.
A hypothesis has been proposed that natural selection caused merger of two pairs of autosomes carrying Q-HRs into one chromosome. With the fusion of two pairs of autosomes into a single chromosome, apparently, carried on their short arms of Q-HRs with a very high frequency, the number of autosomes bearing the Q-HRs reduced from nine to seven pairs, as in the modern human. Such chromosome rearrangement resulted in two important consequences: а) chromosomal Q-HRs distributed into seven Q-polymorphic autosomes, so that it was possible to give birth to the individuals with different, including the low, number of Q-heterochromatin; b) in the population individuals with low number of Q-HRs appeared, able to adapt to new, harsher climatic conditions. In the changed climate of the East Africa, individuals with less amount of chromosomal Q-HRs in genome were the most adapted. With the lapse of time, these individuals formed a new population in the new territory, where individuals with the number of 46 chromosomes in the genome began to dominate. Thus individuals with different, including the low, number of Q-HRs, got the adaptive advantage and to colonize new ecological zones of the East Africa and Eurasia (for more details see [17-19]).
It is hard to say why the ancestors of P. troglodytes and G. gorilla are unable to use this path. However, it can be assumed that due to the high frequency of chromosomal Q-HRs at all Q-polymorphic loci of these two higher primates, the probability of birth in a population of individuals with different, and especially with a low number of Q-HRs in the genome is simply excluded. Moreover, in the karyotype of gorillas and chimpanzees found a special type of Q-heterochromatin, located on the distal ends of some chromosomes [7, 11, 20 and 23 – in gorillas; 20, 21, 22, 23 – the chimpanzee], which excludes the possibility of birth of individuals with different numbers of Q-HRs in the karyotype. As for other hominins, contemporaries of the ancestors of Homo s. sapiens, it is difficult to say anything, since we do not know what their karyotype was and how the chromosomal HRs were distributed. Of course, we are far from thinking that in the karyotype of our ancestors the other chromosomal rearrangements did not take place, including those, which related to chromosomes without Q-HRs. They, apparently, took place. However, in the process of adaptation only those rearrangements preserved that were not eliminated by natural selection.
The consequences of the new karyotype.
In our opinion, the main consequences of all these complex chromosomal rearrangements are their effect on cell thermoregulation (CT). Based on investigations of chromosomal HRs variability in human populations, condensed chromatin (CC), interphase nucleus and redundant non-coding DNAs in the genome, an attempt is made to justify the view of possible participation of CC in CT. CC, being the densest domains in a cell, apparently conducts heat between the cytoplasm and nucleus when there is a difference in temperature between them.
The mechanism of CT is presented to us as follows. Chromosomes have both internal (repair, recombination, rearrangement, modification, restriction) and external (replication, transcription, packaging, organized movement) molecular activities, which are accompanied, inter alia, by some heat output. If for any reasons the temperature in a nucleus begins to exceed than in cytoplasm there is a need for dissipation of surplus heat outside the nucleus. To do this the nucleus has two options: increasing its volume or increasing the heat conductivity of the nuclear membrane. The first option is limited for obvious reasons. The second option is the more promising one should the heat conductivity of the nuclear membrane be increased somehow. Since the nuclear envelope consists of double-membraned extension of the rough endoplasmic reticulum, the nuclear membrane cannot essentially change its structure. However, it is necessary to remove the surplus heat from the nucleus somehow. Apparently, Nature chose a very simple and effective solution: it increased heat conductivity of the nuclear areas by forming temporary structures in the form of CC around the nucleus, chromocenters and nucleoli. The essence of the proposed hypothesis is the assumption that the CC, nucleoli and chromocenters participate in cell thermoregulation. Namely, they are involved in the removal of excess heat from the "hot” areas of the interphase nucleus through a dense layer of peripheral condensed chromatin in the cytoplasm [20-26].
We have checked this hypothesis on the level of human organism assuming that CT is the basis for heat conductivity of whole cell part of body. It turned out that the level of human body heat conductivity (BHC) really depends on the amount of chromosomal HRs in the genome. Results obtained show that individuals in population truly differ from each other in BHC and its level depends on the amount of chromosomal HRs in human genome [23].
Relevant studies have shown that: a) individuals in a population differ from each other on the level of BHC; b) on the average BHC of males is higher than that of females; c) natives of low altitude regions differ on the average by higher BHC than population of high altitude ones; d) natives of low latitudes differ on the average by higher BHC than populations of high latitudes [22-29].
The consequences of the loss of hair for human.
What is unusual about the human brain is that we are the only largish mammal whose brain size kept pace with our growth in body size. The plausible reason of this phenomenon is his skin, when after having lost its hair it became the largest and almost universal organ of sense, which begins functioning as early as in the prenatal period of human development.
In the heterochromatin part of genome in the direct ancestors of modern human some changes occurred; in addition to Q-HRs, on three pairs of autosomes [1, 9,16], and on the Y chromosome unusually large C-heterochromatin regions appeared, which do not exist in karyotypes of chimpanzee and gorilla. Thus by the total amount of chromosomal HRs the genome of the H. sapiens turned out to be richest one. We assume that assemblage of the greatest amount of chromosomal HRs in the H. sapiens karyotype among the higher primates was the turning point in human evolution, as exactly this circumstance has led to disappearance of hairy cover on his skin. The latter turned out to be the main factor responsible for increase of the brain size during the first years of life of the H. s. sapiens [5,6].
Apparently, the main reasons for appearance of hairless skin were the following factors: 1) increase of BHC because of high Q-HRs and C-HRs content in the genome of the direct ancestor of modern human; 2) quantitative and qualitative changes of the diet composition which lead to increase of heat production in the organism demanding efficient heat loss from the body for preservation of temperature homeostasis; 3) climate of Africa, where the ancestors of the H. sapiens inhabited, had a strong selective influence on such organisms because their bodies have changed towards high heat conductivity and heat production.
It is believed that the loss of hair was beneficial for human in the sense that if he were not naked, he would not begin to manufacture clothes, which is impossible without availability of fine instruments like awl, needle, and other instruments, production of which is connected with fine coordination of hands’ movements. Fire striking and dwelling construction is also impossible without skillful hands even with availability of high intellect. Naked skin made the human not only improve his labor; it also promoted the brain development in another direction. It is possible to say that with appearance of skin a vast area of body has been formed provided with highly differentiated and fine receptors of different signals both from the outer and inner environment. Brain became more complex and started to develop [5,6].
A human, instead of his hair that he has lost, acquired clothes, which is more important in sense that in addition to body protection from cold (physiology) it has an important ethnical and cultural, psycho-emotional, social and economic importance that promotes the technical and scientific progress. In addition, the latter facilitates functioning of the temperature homeostasis in human. Therefore, in reply to the old question, namely; ‘has a human survived because he became intelligent, or, he became intelligent only because he managed to survive’, we have chosen the second version [17,18].
Humans tend to tropicalize their environment virtually everywhere they go. They do this by hands for the most part (clothing, tools, housings, heating). Apparently, transformation of the frontal extremities into skillful hands, bipedality and erect walking are connected with appearance of hairless skin. All the above, in its turn and to a variable degree they have an influence on the human brain size. Thus, the whole evolution of the BHC, skin and brain size is a result of adaptation to constantly changing temperature conditions of the environment. Therefore, we believe that the increase of the human brain size was not the result of drastically changes of the structural genes. Most likely, it was the consequence of more ordinary events, such as evolution of constitutive heterochromatin in chromosomes, BHC and skin.
By the uniqueness of the human karyotype, we mean not so much the number of chromosomes, but something more. In fact, nothing special is hidden behind the number 46. With so many chromosomes, there are animals and plants. Here, in our opinion, the composition and broad quantitative variability of chromosomal HRs in the karyotype are important. The uniqueness of the human karyotype is as follows: 1) unlike other higher eukaryotes, only humans and two other higher primates contain both types of constitutive heterochromatin – C- and Q-heterochromatin; 2) among the higher primates, the largest amount of chromosomal C-HRs is in the human karyotype, and they are localized on his three autosomes (1, 9 and 16) and on Y chromosome. It is to this circumstance that a human owes the highest BHC; 3) unlike chimpanzees and gorillas, the number of chromosomal Q-HRs in individuals in a population is different and it ranges from 0 to 10; 4) such a wide quantitative variability is associated with an uneven distribution of the number of chromosomal Q-HRs on seven Q-polymorphic autosomes; 5) the phenotypic manifestation of such biological variability is the difference between individuals in the population from each other in the levels of BHC, with all the ensuing consequences for the body.
It is difficult to imagine that all the known biological features of man – conceptual thinking, large neocortex, speech, great physiological flexibility, the ability to adapt to different climatic conditions of the Earth, hairless skin, 46 rather than 48 chromosomes, the existence of purely human forms of pathologies (alcoholism, drug addiction, obesity, atherosclerosis, high altitude pulmonary edema), the ability to long-distance running, etc. – originated on the basis of the evolution of structural genes. The simplest theoretical calculations suggest that this is impossible. It is known that there is no direct relationship between the number of structural genes and the complexity of the structure of organisms. So, for example, it was found that by the number of genes in the genome, such different higher eukaryotes as the Arabidopsis plant, mouse and human do not differ significantly and they have about 20,000 genes each. The emergence of such complex traits would require the participation of many genes and their modifications, which are not present in other mammals.
There is nothing unexpected in this. The fact is that a man does not have a single organ, protein or enzyme, which in one form or another would be absent from other living beings. Apparently, genes already existing in mammals were involved in the emergence of unique human features. If there was anything unusual in all this, it was the wide quantitative variability of chromosomal HRs in the human genome. Thus, a species arose that had no analogues in the history of evolution.
If the loss of the hair cover led to the emergence of a large brain with all the ensuing consequences, then the emergence of 46 instead of 48 chromosomes made it possible for the birth of children in the population with different, including a low number of chromosomal Q-HRs. This made it possible for individuals to be able to adapt to different, including cold climatic conditions. However, the mechanisms of human adaptation to climatic conditions other than the tropics of Africa were fundamentally different from those of animals. The latter have adapted to new climatic conditions for hundreds and millions of years with the involvement of structural genes. The uniqueness of human adaptation also lies in the fact that only he managed to populate the entire surface of the Earth, including such extreme natural environments as the Far North and high-altitude areas, while remaining a single, tropical biological species. Moreover, all this happened in a very short period (about 30 000-50 000 years), an event unprecedented in the history of evolution [1]. We believe that such a high rate of adaptation became possible because a human used a mobile non-conservative part of his genome to adapt to different natural environments (for more details see [4,26,28]).
However, the existence of individuals with different BHC in the population and the settlement of temperate and northern geographical latitudes by humans also had negative consequences; purely human forms of pathology (obesity, alcoholism, drug addiction and atherosclerosis) arose, which are not characteristic of other mammals in natural conditions.
Thus, modern man owes his origin and position in the world of living beings on Earth to three factors: hairless skin, large neocortex and wide variability of the BHC in individuals in the population. They, in turn, are the result of the evolution of chromosomal HRs, and not structural genes. The main driving force that led to the emergence of man was the need to adapt to changing environmental conditions. If the formation of modern man was mainly influenced by the broad variability of chromosomal HRs, rather than structural genes, then our evolutionary history was very prosaic: no drama, no purpose, no Creator. It is difficult to get rid of the feeling of dissatisfaction, as if the “mouse gave birth to a mountain”.
Acknowledgements: I apologize to that authors whose work is not cited or is cited only through reviews. The reason for this is only the space limitations of the publication.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
