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*Corresponding Author: Gabriel Edem, Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria.
Citation: Gabriel Edem, Christopher Sakpa, Vitalis Ezeuko, (2023), Exploring the Scientific Basis behind the Therapeutic Efficacy of Uvaria chamae: A Major Plus to Alternative Medicine, J. New Medical Innovations and Research, 4(6); DOI:10.31579/2767-7370/060
Copyright: © 2023, Gabriel Edem.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 08 September 2023 | Accepted: 15 September 2023 | Published: 25 September 2023
Keywords: uvaria chamae; anti-oxidant; phytochemical analysis; proximate analysis; acute toxicity; DPPH assay
Background: From time immemorial, medicinal plants have been used in the treatment and management of diseases, Uvaria chamae is such plant. The aim of this study was to unravel and explore the scientific basis of the root extract of the plant behind its effectiveness in ameliorating illnesses using several biochemical and pharmacological assays.
Materials and Methods: Uvaria chamae roots were obtained from a local community in Akwa Ibom State of Nigeria. The roots were washed, air-dried, blended and soaked in ethanol for few days, filtered and the filtrate dried in a water bath. The dried sample were divided into portions for phytochemical, proximate and DPPH assays. Acute toxicity test of Uvaria chamae’s root was also done to ascertain its safety.
Results: Results obtained from this investigation revealed the presence of several anti-oxidants, ash, carbohydrate, lipid, fibre, protein and energy. The root of Uvaria chamae also exhibited strong scavenging reducing capacity using DPPH assay. Acute toxicity test revealed the overall safety of the plant.
Conclusions: The root extract of Uvaria chamae possesses strong anti-oxidant capacity, no wonder the rationale behind its use in the treatment and management of a wide range of diseases.
Uvaria chamae is a small tree that belongs to Annonaceae family [1]. It is called “Nkanaika ikot” among the Ibibios, “Mmimi ohia” among the igbos, “Kas kaifi” among the Hausas, “Akisan” among the Yorubas and ogholo among the Esan people of Edo state of Nigeria. It has a yellow fruit when ripened and the pulp is widely consumed by locals, the carpels are arranged in a finger-like pattern. The three major parts (root, stem and leaves) of the plant have been reported to have a wide spread medicinal significance. The plant can be used in the treatment of a wide range of diseases including diarrhoea, treatment of cerebral diseases, amenorrhea, piles, hematuria, hemolysis, miscarriage and for the relief of pains during child birth [2]. In West Africa, the plant has been reported to possess febrifugal and purgative abilities. In alternative medicine, combination of the root, leave and stem extracts are used for the treatment of dysentery, vomiting, gastroenteritis, tonsilits, wounds and inflammation [2]. Uvaria chamae posesses antibiotic abilities, Oluremi et al. [3] reported the inhibitory capacity of the combined extracts of the root, leaf and stem of the plant on Escherichia coli, Staphylococcusaureus and Klebsiella spp. The antibacterial ability of the plant extracts against many drug resistant bacteria is a crucial breakthrough in the management of drug resistant bacteria. Antibacterial ability of Uvaria chamae against wound isolated strains of Pseudomonas aeruginosa and Proteus mirabilis was evaluated by Dora et al. [4] using agar cell technique. They reported a greater inhibitory effect of the root extract of Uvaria chamae on test isolates and resistance with no inhibitions noticed from Pseudomonas aeruginosa and Proteus mirabilis. This antibacterial ability of the plant has attracted more audience in the use of the plant for the prevention and treatment of several inflammatory diseases and diseases associated with cardiovascular system [5,6]. Uvaria chamae have been reported to be used in alternative medicine in sickle- cell disease management in West Africa [7]. Uvaria Chamae root have been reported to increase peristaltic action on the gastrointestinal tract and could be used as a mild laxative in sickle cell patients to address constipation [8]. Because of its antispasmodic properties, it could be used as a good sedative and could be used to relieve cardiac insufficiency, cough and problems associated with circulation [9]. The anti-ulcer capacity of Uvaria chamae was reported by Chilaka et al. [10] who revealed its potent anti-ulcer activity in Wistar rats when compared to a standard anti-ulcer drug, cimetidine, hence the rationale behind the use of the plant in alternative medicine in the management of gastric ulcer. Uvaria chamae have been reported to possess anti-venomous activity against snakebite envenomation, this is in support of a folkloric claim that Uvaria chamae is used in the treatment and management of snakebite/wounds in Africa. Gabriel et al. [11] reported the use of the plant in the protection against N. nigricollis venom-induced lethality in rats which validate the therapeutic rationale of its effectiveness in the management of snake envenomation. Despite all these scientific reports about the plant, much are still needed to be investigated about the plant, particularly the scientific basis/foundation behind these therapeutic abilities in alternative medicine, hence the rationale for undergoing this study. In this study we, investigated the antioxidant potentials of the root extract of Uvaria chamae using proximate and phytochemical analysis (both qualitative and quantitative) as well as its scavenging reducing activity using DPPH assay.
Plant Collection and Identification
Uvaria chamae root was obtained from a thick bush in Ikot Efre Itak, a local community in Ikono Local Government Area of Akwa Ibom State, Nigeria. The plant was taken to the Department of Plant Biology and Biotechnology, University of Benin for Identification and authentication by a Plant Biologist. Herbarium number UBH-U353 was assigned to the plant.
Preparation of Plant Extract
The roots were excavated from the soil, washed and cut into sizeable pieces. About 500g of the roots were air-dried for seven (7) days, pulverized with the use of electric blender and macerated in 70% ethanol for 72 hours. The solution was filtered and taken to water bath to dry at 450C. Obtained dry matter was sieved and stored in the refrigerator using an air-tight container for further analysis. Different portions of the extract were used for proximate/phytochemical analysis and DPPH assay.
Proximate Analysis: This was done using the method described by [12]
Determination of Moisture
A crucible (empty) was dried in an oven at about 107◦C. The crucible was allowed to cool in a desiccator and weighed, W1 was assigned. The pulverized plant sample (Uvaria chamae) was weighed in the crucible and subsequently dried at about 107◦C, W2 was assigned. The crucible with the plant sample (Uvaria chaemae) was allowed to cool in a desiccator and the weight measured, W3 was assigned. Moisture content was calculated in percentage as % Moisture content = W2 − W3/ W2 − W1 ×100.
Determination of Total Ash
A heat-resistant crucible was oven-dried for about 10 minutes at 107◦C. It was cooled in a desiccator and the dry weight was taken, W1 was assigned. Afterwhich, the pulverized plant sample (Uvaria chamae) was measured in the crucible and reweighed, W2 was assigned. Incineration of the sample was done using a furnace, after which the remaining inorganic material was cooled and weighed, W3 was assigned. Percentage ash content was evaluated as: % Ash content = W3 − W1/ W2 − W1 × 100.
Determination of Crude Fibre
The dried sample of Uvaria chamae was weighed in an empty crucible, W1 was assigned. 100ml of neutral detergent solution and 0.5g of sodium sulfite (NA2SO3) were added to the crucible, accompanied by few drops of octanol at room temperature. The mixture was boiled for 60 minutes, filtered and the residue was double washed in both boiling water and finally in cold acetone. It was oven-dried at about 107◦C for at least 8hours, cooled in a desiccator and weighed, W2 was assigned. The percentage of the neutral detergent fibre of the sample was calculated as:
Proximate Analysis
Proximate analysis of Uvaria chamae root extract was evaluated and presented in table 1. Proximate evaluation showed the presence of moisture, ash, crude fibre, lipids, crude protein, carbohydrate and energy. The moisture content of the plant (10.600±0.000%) was higher than total ash (3.660±0.000%), total lipids (0.86±0.00%) and crude protein (2.650±0.010%). Total ash content signifies an appreciable quantity of mineral elements in the root of Uvaria chamae. There was an appreciable quantity of carbohydrate (42.720±0.010%) but higher than the crude fibre content (40.060±0.000%) of the plant. These carbohydrate and fibre contents are good sources of energy and roughages respectively. The high energy content (189.200±0.000KJ) is due to the appreciable quantity of carbohydrate present.
| Components | Value |
| Moisture (%) | 10.600± 0.000 |
| Total ash (%) | 3.660±0.000 |
| Crude fiber (%) | 40.060±0.000 |
| Total lipids (%) | 0.860±0.000 |
| Crude protein (%) | 2.650±0.010 |
| Carbohydrate (%) | 42.720± 0.010 |
| Energy (KJ) | 189.200± 0.000 |
Table 1: Proximate analysis of Uvaria chamae Root Extract
Qualitative Phytochemical Analysis
Qualitative preliminary phytochemical screening was evaluated and presented in table 2. It revealed the presence of alkaloids, flavonoid, phenols, steroid etc.
| Phytochemical constituents | Inference |
| Alkaloids | +++ |
| Flavonoid | +++ |
| Phenols | +++ |
| Glycoside | + |
| Steroid | + |
| Saponin | ++ |
| Terpenoid | _ |
| Coumarins | ++ |
| Phytosterols | + |
| Diterpenoids | ++ |
| Triterpenoids | +++ |
| Amino acid | +++ |
| Tannin | +++ |
| Phlobatannin | _ |
| Anthraquinone | + |
| Cardiac glycosides | + |
| Quinone | +++ |
*- Absent, + present, ++ moderately present, +++ abundantly present
Table 2: Qualitative Phytochemical Analysis of Uvaria chamae Root Extract
Quantitative Phytochemical Analysis
Similarly, result of quantitative phytochemical screening was evaluated and presented in table 3. It revealed the presence of the following compounds with their number of secondary metabolites, tannin (154.100 ± 1.730mg/100g), alkaloid (107.200 ± 0.550mg/100g), saponin (77.570± 1.190mg/100g), Phenolic compounds (177.600 ± 0.750mg/100g), flavonoid (165.900± 0.610mg/100g) and glycoside (10.16±0.01mg/100g). Phenolic compounds (177.600± 0.750mg/100g) were significantly higher than tannin and others.
| Parameter | Value (Mean±S.E.M) |
Tannin(mg/100g) Alkaloid(mg/100g) Saponin(mg/100g) Phenol(mg/100g) Flavonoid(mg/100g) Glycoside(mg/100g) | 154.100 ± 1.730 107.200 ± 0.550 77.570 ± 1.190 177.600 ± 0.750 165.900 ± 0.610 10.160 ± 0.010 |
Table 3: Quantitative Phytochemical Analysis of Uvaria chamae Root Extract
Effect of Root Extract of Uvaria chamae on DPPH Reducing Radical Activity
The DPPH radical was effectively and strongly scavenged by the root extract of Uvaria chamae which revealed the presence of antioxidant potentials. A dose dependent increment was observed within the range of concentrations (0-100 µg/ml) of root extract. The percentage inhibition of scavenging activities of the root extract at a given concentration of 100µg/ml was found to be 32.39%. The percentage inhibition for Uvaria chamae sample was concentration dependent up to the given concentration of 100µg/ml. Free radicals were scavenged by the root extract in a concentration dependent manner. Antioxidant capacity of Uvaria chamae root depends on the presence of total phenolic compounds. The higher, the concentration, the higher, the percentage of inhibition (Table 4).
| S/N | Extract(µg/ml) | Absorbance(nm) | % Inhibition |
| Blank (0) | 0.000 | 1.451 | 0.000 |
| 1 | 20.000 | 1.205 | 16.950 |
| 2 | 40.000 | 1.199 | 17.370 |
| 3 | 60.000 | 1.164 | 19.780 |
| 4 | 80.000 | 1.076 | 25.840 |
| 5 | 100.000 | 0.981 | 32.390 |
Table 4: Effect of Root Extract of Uvaria chamae on DPPH Reducing Radical Activity
LD50 of Uvaria chamae
Acute toxicity test result (LD50) of root extract of Uvaria chamae showed that there was no death at 5000mg/kg body weight within 24 hrs. Ultimately, the root extract of the plant was relatively safe.
For many centuries, medicinal plants have been reported to contain substances of therapeutic importance for the treatment of many forms of ailments and diseases [16]. In Nigeria, many people still believe in the usefulness of herbal medicine for treatment of several degrees of diseases. Plants are very useful in the development of drugs. From this current investigation, Uvaria chamae has been found to contain various substances of great clinical and medical influences. Proximate evaluation of the root extract of the plant revealed the availability of moisture, ash content, crude fibre, lipids, protein, carbohydrate and energy, this proximate component has great health benefits and useful in traditional medicine and its practice. Proximate components and other environmental factors determined the shelf life of medicinal plants [17]. It has been reported that moisture content of plant materials greater than 15% stands the risk of contamination by bacteria and fungi [18]. Findings from our present investigation showed that the moisture content of root extract of Uvaria chamae (10.600± 0.000%) has low moisture content and therefore can be stored or preserved with little or no risk of invasion of microorganisms and insects, thus increasing the plant’s shelf life. The ash content of the plant demonstrates the availability of inorganic minerals. These inorganic minerals include calcium, zinc, potassium and mercury. The ash content in the plant was evaluated to be 3.360±0.000%. Generally, minerals have been reported to be useful for the mental and physical wellbeing of an individual [17]. The high fibre content of the plant was estimated to be 40.060±0.000%, fibres are roughages which can promote optimal gut health, reduce the risk of cardiovascular disease and maintain body weight. From our findings, Uvaria chamae root is a very good source of roughage. The lipid content of the plant was quantified to be 0.860± 0.000%, lipids have been reported to possess therapeutic capacity in animals by preserving insulin sensitivity [19]. Lipid content of the plant greatly contributes to its medicinal efficacy. Similarly, the protein content of the plant was estimated to be 2.650± 0.010%, proteins function as hormones, enzymes and can be considered as part of blood, skin, muscle and even cartilage. An amino acid (glycine) which is a building block of protein has been reported to be a precursor in the biosynthesis of porphyrins which are precursors of the heme portion of hemoglobin [20]. Nutritionally, about 0.8g/kg body weight of dietary protein intake is recommended daily for humans irrespective of age or sex [21]. The root of Uvaria chamae can therefore be recommended as an important source of dietary protein. Carbohydrate composition of the root extract of Uvaria chamae was estimated to be 42.720±0.010%, carbohydrate which is in appreciable quantity is another source of energy in food. Studies have shown that diets with low carbohydrate level can reduce the risk of heart diseases as well as controlling diabetes associated with obesity [22]. In this regard, the root of Uvaria chamae stands a better chance because it is locally consumed by the locals for many purposes. Total energy of the plant was estimated to be 189.200± 0.000KJ, this high energy level in the plant is traceable to the appreciable quantity of carbohydrate. It can be a very good source of energy to humans, this is because energy is used in the maintenance of the body’s essential functions such as cellular growth and repair, respiration, blood transport, enhances physical exercise and recreational activities. Phytochemical investigation and quantitative estimation of the percentage yield of chemical constituents in the plant revealed the presence of alkaloid, flavonoid, phenols etc. These phytochemicals serve as natural occurring antibiotics which help the body in the fight against bacterial and pathogen invasion and are responsible for the medicinal use of Uvaria chamae in Africa. Presence of alkaloid in the plant is necessary for the survival and protection of the plant against bacterial and fungal activities. Alkaloid has been reported to possess anti-malarial, anti-hypertensive and anti-cancer effects [23]. The high content of alkaloid in the plant (107.200 ± 0.550mg/100g) clearly showed its ability to ameliorate the inflammatory actions of some heavy metals in many organs of the body as reported by many authors. Psychotropic and stimulant effects of alkaloid have been reported to be useful as recreational drugs [24]. Flavonoids have been reported to have antioxidant effects and have been portrayed to hinder the initiation, promotion and advancement of tumors [25]. Other biological activities of flavonoid include anti-inflammatory, anti-allergic, anti-viral and antibacterial tendencies. Flavonoids interfere with enzymes that produce estrogen, thereby reducing the risk of estrogen-induced cancers. The high presence of flavonoid (165.900 ± 0.610mg/100g) indicated the high antioxidant capacity of the plant with the ability to protect the body against free radicals and oxidative stress. This result is in agreement with Okwu and Iroabuchi [26] who reported a high availability of flavonoids in the root of the plant. Phenolic compounds have also been found to be present in the plant (177.600 ± 0.750mg/100g). Phenols have been indicated to increase secretion of bile, reduce blood levels of cholesterol and lipid, possesses anti-inflamatory, anti-tumour and anti-depressant capacities [27, 28]. This anti-tumour capacity of the plant due to phenol was reported to ameliorate cancer in various organs. Phenols can contract the uterine smooth muscle of a Guinea pig. High dosage of Uvaria chamae have been reported to prepare the uterus and reduce fatique thereby producing strong and regular uterine contraction which facilitates parturition, the very reason why it is used in the Eastern part of Nigeria to facilitate labour [29]. Glycoside was found to be present (10.160 ± 0.010mg/100g) in the plant and it has been reported to be used in treatment of congestive heart failure as a result of its direct impact on the force of myocardial contraction [30]. Glycoside also act directly on the smooth muscle of the vascular wall coupled with its impact on the neural tissues and electrical activities of the cardiovascular system [30]. Presence of saponin revealed the protective and ameliorative capacity of the plant, saponin have been reported to be protective, antimicrobial and inhibitive to moulds and invasive attacks. Saponin has anti-carcinogenic effect and has been found to affect growth, reproduction and intake of food in animals. It has antifungal and anti-viral potentials [31]. Presence of coumarins revealed the anti-cancer property of Uvaria chamae and they constitute a useful category of pharmacological agents and possess a wide range of physiological abilities. Coumarins possess anti- inflammatory, anti-cancer, anti-coagulant, anti-bacterial and analgesic properties. They are also involved in comparative immune system modulation. Similarly, phytosterols decrease total serum cholesterol level, decrease low density lipoproteins, has anti-inflammatory effect, possesses antioxidant capacity and can offer protection against various forms of cancer such as colon and breast cancers, the anti- carcinogenic potential of the root extract may also be linked to the presence of phytosterols in the plant [32]. Dipertenoids, triterpenoids, amino acid, anthraquinone and quinone were evaluated to be present in the plant, diterpenoids possesses anti-inflammatory, antimicrobial, anti-tumour activities and immune-modulatory activities. Triterpenoids have been reported to have antiviral, antibacterial, antioxidation, antihypertensive and anti-tumor potentials, moreso, it can exhibit cell death (apoptosis), cell cytotoxicity, cell cycle arrest and anti-invasion properties. Amino acid is the building block of proteins which are useful in driving metabolic reactions, maintaining hydrogen ion concentration and fluid balance, guarding the immune system and repairing body tissues. Anthraquinones have been reported to be used as laxatives, used to reduce constipation, arthritis and multiple sclerosis. It has a strong anti- cancer capacity. Quinones are significant in blood coagulation; they function as cofactors in the electron transport system and useful in cellular respiration. Availability of these bioactive compounds signify why the root of Uvaria chamae is used in the treatment of various degrees of diseases. The root extract of Uvaria chamae was able to decrease DPPH stable free radicals. This is an indication that the root extract possesses many bioactive components that are capable of removing odd electrons by donating hydrogen to a free radical. Scavenging activity of the root of Uvaria chamae indicated a decrease in DPPH concentration. The results so far revealed a significant correlation and relationship between the root extract of Uvaria chamae and the percentage of inhibition of free radicals. The scavenging activity of the plant was concentration based and could be due to the existence of phenolic compounds and others. This result is in line with previous results obtained using DPPH assay to evaluate the antioxidant capacity of various plants. DPPH was used to evaluate the antioxidant ability of phenol in the plant and the result brought to light, the high content of phenol (177.600 ± 0.750mg/100g) in the plant when compared to other bioactive ingredients. Result obtained from acute toxicity studies showed that the root extract of Uvaria chamae was relatively safe with an oral LD50 of 5000mg/kg which is in conformity with the results published by Eugenia [33] concerning the relative safety of Uvaria chamae at LD50 > 2500mg/kg. The use of LD50 has become useful to determine the general toxicity of a chemical compound or plant extract [34]. It evaluates the adverse impacts following the exposure of animals to either a single of multiple doses of a substance or test agent under investigation within 24 hours via oral, inhalation or intraperitoneal routes [35]. Absorption of these administered agents elicit adverse effects thereby resulting in fatality. Results from LD50 test serve as a guide in selecting dosages. The root extract of the plant is safe due to the absence of toxic metabolites as one of its constituents.
The root extract of Uvaria chamae possesses strong anti-oxidant potentials, no wonder the rationale behind its use in the treatment and management of a wide range of diseases.
We sincerely thank and appreciate tertiary education trust fund (TETFUND) for sponsoring this research work.
Authors have declared that there is no existing conflict of interest.
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
