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*Corresponding Author: Amal S. Zaghloul, Fellow of Obstetrics & Gynecology. Ultrasound Special Care Unit for the Fetus, Maternity Hospital Ain Shams University Cairo, EGYPT
Citation: Amal S. Zaghloul (2020) I Evaluation of ultrasonographic fetal kidney length for gestational age detection in late second and third trimesters. J Women Health Care Issues, 3(4); Doi:10.31579/2642-9756/036
Copyright: © 2020 Amal S. Zaghloul, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Received: 28 September 2020 | Accepted: 06 October 2020 | Published: 14 October 2020
Keywords: pregnancy; biparietal diameter; femur length
Accurate estimation of gestational age is necessary to obtain materials for different tests as well as to interpret the results of these tests.Unfortunately sometimes calculation of EDD based on LMP becomes very difficult when (a) The menstrual cycle is irregular; (b) Patient fails to remember LMP or reports inaccurately (c) Pregnancy occurs during lactational amenorrhoea & (d) if patient have bleeding in early pregnancy. After 24 weeks the symphysio-fundal height in cm. approximates to the number of weeks up to 36 weeks of gestation. But a number of factors influence the measurement including multiple gestation, IUGR, diabetic pregnancy, maternal size, variation in fetal lie & engagement as well as inter & intra observer measurement variation.Ultrasonic measurement of fetal biometry (CRL, BPD, FL) are considered to be reliable when they are performed in first & early 2nd trimester (<24 weeks).
In this study, we aimed to evaluate the accuracy of ultrasonographic fetal kidney length measurement as a new parameter for estimation of gestational age in late second and third trimester in correlation to other commenly used parameters as, BPD, FL, AC.
This study was conducted on 122 pregnant women attending antenatal care clinics of Obstetrics and Gynecology department Soliman Fakeeh Hospital, KSA. All were in the late second and third trimester (between 24-40 weeks) of gestation. Cases included in the study were divided into four gestational age groups with four weeks interval. The length of the fetal kidney was measured. The mean gestational age was calculated on the bases of biparietal diameter (BPD).femur length (FL) and abdominal circumference (AC). The fetal kidney measurements were obtained by the same sonographer to avoid interobserver variation using (GE machine E8) and were compared with gestational age using statistical analysis
No statistically significant differences were found between the right and the left renal measurements in cases in which the two kidneys were imaged In this study, during the second and third trimester the mean kidney length showed gradual rate of increase. the mean kidney length was found to be 30.52.1 mm at mean gestational age of 26weeks and became at the mean gestational age of34 weeks, 40.4103 mm(:(±1.98) and at mean gestational age of 38 week it measured44.41mm((±2.1).
In addition, we found a positive correlation between kidney length and gestational age. We suggested regression Formula to calculate it.
Conclusion:
Throughout this study, we can conclude that Fetal kidney length could be used with accuracy in the late second and third trimester especially in women who are uncertain of date of LMP and are booked late for ANC.however its accuracy is decreased when we use it in late third trimester.Other ultrasonographic parameters used for estimation of the gestational age as BPD ,AC are less satisfactory ,when compared with femur length and kidney length.
An accurate estimation of gestational age is considered a main determinant of maternity care quality as fetal growth assessment and to schedules the date of labor. Any fault in its estimation may lead to perinatal morbidity or even mortality [1].
On the other hand, development of new diagnostic ultrasound has created more possibilities for accurate assessment of pregnancy dating. In the first trimester gestational age (GA) can be estimated by ultrasonic measurement of crown rump length (CRL) as well as the diameter and the volume of gestational sac [2].
Other biometric indices like femur length (FL), fetal biparietalediameter. (BPD), head circumference. (HC), transcerebellar diameters (TCD), clavicle lengths (CL) and foot length are used for estimation of GA during different trimesters of pregnancy [3].
Fetal biometry measurements are considered accurate indices for estimation of GA in the early 2nd trimester. However, as the age of fetus advances the biological diversity of Fetal size limits the accuracy of these parameters and makes an accurate dating in late 2nd and 3rd trimesters is difficult. So, new studies try to introduce more confident parameters as the associations of kidney sizesin a normal fetus with GA [4].
In 1987 Goldstein and his colleagues used the fetal colonic echogenicity with transverse diameters of the colon to detect intestinal development which used as an indicator of gestational age [5].
Fetal kidneys in the 2nd and 3rd trimesters typically have the same configurations as in postnatal life and their appearance depends on the GA at which the study is conducted .Estimation of the length of the fetal kidney was found to be highly correlated with the gestational age, and so estimation of length of fetal kidney was advised for estimation of the fetal maturity(Ibrahim, 2017).
Aim of the work
The aim of this work is evaluation the accuracy of ultrasonographic fetal kidney length measurement as a new parameter for estimation of gestational age in late second and third trimester in correlation to other commonly used parameters as BPD, FL and AC.
Subjects and Methods
A total of 122 pregnant women attending the antenatal care clinic of Obstetrics and Gynecology department, Soliman Fakeeh Hospital, (KSA). Between January 2019 and February 2020 were studied cross sectionally from 24 weeks to 40 weeks gestational age. All have singleton fetus. Their LMP was well known and confirmed by initial ultrasonographic scan before 20 weeks.
All cases were subjected to the following: Full history taking, Routine general and obstetric examination and Routine antenatal care investigation. Ultrasound examination was done by (GE machine, E6) Ultrasound medical machine equipped with a multi frequency 5-7.5 MHZ abdominal probes.
Fetal kidney length (FKL) measurement was done and other fetal measurements BPD, FL, AC were obtained.
The studied cases were divided into four gestational age groups with 4 weeks interval divided as:
Selection criteria:
(1) Singleton pregnancy
(2) Gestational age between (24-40 weeks).
(3) Women sure of the date of their LMP.
The following cases were excluded from the study:
Ultrasonographic examination of cases to assess the following parameters:
The same sonographer examined all cases to avoid interobserver variability.
A- Measurement of the biparietal Diameter (BPD):
This measurement was taken from transaxial sonograms of the fetal head at the level of the paired thalami and cavum septi pellucidi The BPD was measured from the outer edge of the cranium nearest the transducer to the inner edge of the cranium farthest from the transducer (outer to inner measurement) and perpendicular to the midline .
B- Measurement of the femur Length (F.L)
The length of the diaphysis of the fetal femur was often used for gestational age prediction. The entire femur was imaged, and the thin bright reflection of the cartilaginous epiphysis should not be included in the measurement.
C- Measurement of the abdominal circumference (A.C):
The fetal abdominal circumference was measured on transverse scan at the outer perimeter of fetal abdomen at the level of the fetal stomach and intrahepatic portion of the umbilical vein both the anteropostrior and the other transverse diameter were taken.
D – Measurement of the fetal kidney length (FKL):
Fetal kidney identification before 17 weeks may be very difficult for a routine sonographist. We choose 24 weeks for beginning of our study because identification of the kidneys is difficult at the beginning of the second trimester. The kidneys are not easily distinguished from the liver and bowel since the renal capsule cannot be identified at this stage. Conversely, at 24 weeks of gestation the renal capsule is highly echogenic.
The fetal kidneys were best identified in transverse plane (Fig I&II) where they could be seen on either side of the fetal lumbar spine after determination of the fetal lie; the transducer was rotated to an axial plane and kept perpendicular to the fetal spine.
II- Longitudinal imaging of the fetal kidneys (16th week of pregnancy)
All the measurements were performed during fetal apnea. For the kidney length measurements, the fetus was scanned in the transverse plane until the kidneys were visualized just below the stomach. The probe was then rotated through 90° to outline the longitudinal axis of the kidneys.
Where there were difficulties measuring both kidneys (due to the position of the fetus), the mother was allowed to wander outside the investigation room for 30–45 min and then return for repeat scanning. At the outset, failure to obtain measurements of kidneys at any stage led to automatic exclusion from the study, we did not find any differences between measurements from both kidneys. It was therefore no longer an exclusion criterion. Care was taken to exclude the adrenal glands in the measurements. Fetal biometric indices were measured blind to the kidney length measurements.
Location of major landmark. Such as the heart, liver, aorta, kidneys and urinary bladder helped in determination of the correct level of section. Coronal and sagittal scans could be obtained through the proper rotation of the transducer from this axial plane.
The long axis of the fetal kidney was obtained in a paraxial scan (fig 4) of the fetal abdomen at the level of the fetal lumbar spine. The superior and inferior poles of the kidney were marked and the longitudinal scans were obtained at sequential intervals until the maximum mid sagittal plane was determined. This represented the renal length. From the same long axis image of the fetal kidney.
Length of the kidney along its main axis. This parameter was measured on a longitudinal parasagittal cut of the fetal abdomen. Markers were placed on the image of the renal capsule with care being taken to exclude the adrenal gland and expose the upper pole of the kidney from the shadow of the lowermost ribs. Care was also taken to clearly distinguish the lower pole of the kidney from the gastrointestinal tract, especially the colon. The measured length of the kidney was checked on coronal imaging whenever possible. In order not to overestimate the length of the kidney, it is important to distinguish the upper pole of the kidney from the adrenal gland. In this respect, it should be borne in mind that unlike the kidney, the central part of the adrenal gland is not highly echogenicity.
Furthermore, the investigator should seek to identify the continuity of the renal capsule in the region of the upper pole of the kidney. Top quality sonographs allow clear identification of the adrenal gland as a relatively large triangular structure lying over the superomedial part of the kidney. The cortex and medulla of the adrenal gland give a highly characteristic image which is denser than that of the kidney.
Statistical Analysis
The data were entered, checked and analyzed using Epi- Info version 6.02 and SPP for windows version 8.
This cross-sectional observational study includes 122 pregnant females in four gestational age groups with 4 weeks interval divided as:
Group 1: gestational age from 24-28 weeks
Group 2: gestational age from 28 -32weeks
Group 3: gestational age from 32-36weeks
Group 4: gestational age from 36-40weeks
Regarding the sonographic appearance of the fetal kidney, in the present work, we identified both fetal kidneys in 111cases and it was difficult in 11 cases due to position of the fetus.Both kidneys were identified as an elliptical profile in longitudinal section and a circular profile in transverse section .There is no significant difference between right and left fetal kidney length. The results of this study are collected, Arranged, Tabulated, analyzed statistically and are presented in tables as follows : The mean age of cases was distributed as 28.19±4.78 with minimum 17 and maximum 39, GA was distributed as 31.95±4.62 with minimum 24 and maximum 40. 34.45% of studied cases was nullipara (P0) and 65.55% were multipara (P1,p2,p3and >p3). BMI was distributed as 26.85±3.98 with minimum 18.4 and maximum 35 .About two third of studied cases were obese and overweight.The mean fetal kidney length at mean gestational age of 26weeks30.5mm (±2.1) ranging from (27.10 to34.40mm) and at mean gestational age 30 weeks measured 36.2355mm (±o. 1.56728), ranging from (33 to 38.9 mm) and at the mean gestational age of34 weeks, it measured 40.4103 mm(:(±1.98537) ranging, from (35.10to 46.30mm).and at mean gestational age of 38 week it measured44.41mm((±2.1).There is highly significant correlation between GA and all parameters (BPD, FL, KL, and AC). There was significant difference among different GA category regard all parameters. There is Significant regression with suggested formula, and the most accurate parameters were the FL and kidney length (r2= 0.965 and 0.905 respectively), while the least accurate was the BPD (r2= 0.581). The highest correlation is with kidney length at 24-28 weak (r = 0.992), but this correlation become week with advancement of GA especially kidney length in 36-40 weak (r = 0.516).No significant difference between GA and GA estimated by each parameter p value> 0.05).
Determination of an accurate GA is very essential and mandatory in prenatal medicine .Estimation of an accurate GA and assessment of the fetal maturity is so crucial in a lot of clinical cases ,as cases of severe preeclampsia, chronic hypertension ,diabetic pregnancies ,antepartum hemorrhage,RH isoimmunization ,post maturity and so on .Induction of labour in such cases Markedly affected by the estimated GA . Failure in estimating GA accurately can result in unnecessary induction, dysfunctional labor, operative delivery, iatrogenic prematurity or postmaturity [6].
Ultrasonographic fetal biometry is the most widespread method used to establish GA. Various sonographic biometric parameters commonly used are Crown Lump Length (CRL), Biparietal diameter (BPD), Head circumference (HC), Abdominal circumference (AC) and Femur length (FL). CRL measurements accurately predict GA to within ± 5-7 days but can be employed only in cases who present in 1st trimester [7].
In early 2nd trimester BPD, FL, HC and AC can predict GA with fair accuracy (±10-11days, ±10- 20 days, ±10-14 days and ±10-14 days respectively). These parameters might be inaccurate in late pregnancy, especially when a pregnant woman cannot recall her LMP. Furthermore, there is a substantial evidence that the standard derivation for these indices are widen as pregnancy progresses and this will be even worse if the head is too low or an obvious plane cannot be obtained, which together will mislead the measurement of BPD and H [6].
Therefore, accurate estimation of GA in late 2nd and 3rd trimester still remains a problem., there is no single fetal measurement used for accurate estimation of gestational age in 3rd trimester [8].
Therefore, many researches have been conducted to determine a precise estimation of GA using ultrasonic measurements throughout the second and the third trimester .Various non-traditional sonographic parameters for estimating GA are being studied like transverse cerebellar diameter, fetal foot length, epiphyseal ossification centers, amniotic fluid volume and placental grading.Ozat and his colleagues suggested that fetal sacral length can be used in dating labor due to the significant correlation between GA and sacral length they found [9].
Sherer and his colleagues used fetal hard palate width as an indicator of GA between 15- and 41-weeks' gestation. But the assessment of these measurements needs advanced ultrasonic skills. Therefore, we need other parameters that can give an accurate GA and can be measured easily [10].
Our study was conducted to evaluate the accuracy of fetal kidney length as a parameter of fetal gestational age measurement. 122 pregnant women in the second and third trimester with gestational ages ranging from 24-40 weeks were studied cross sectionally to get ultrasound measurement of fetal kidney length.
In current study, the age range of participants was 17-39 years, with a mean age 28.19±4.78 years.
From studied cases 34.45% were nulliparous and 65.55% were multipara. The BMI range of participants was (18.4-35.6), with a mean BMI 26.85±3.98. About two third of studied cases were obese and overweight.
In the present work, we observed statistically non-significant differences in fetal kidney length between the right and left kidneys in cases in which the two kidneys were imaged. Similar findings were reported by [11].
Brennan and his colleagues conducted systematic review to determine the role of ultrasound imaging in evaluating fetal kidney growth and stated that overall the evidence strongly supported no significant difference between right and left kidney size (17of the 18 included studies) [12]. So, we used mean kidney length for final statistical analysis.
Findings in the current study revealed that, the mean fetal kidney length at the mean gestational age of 26weeks was 30.5mm (±2.1) ranging from (27.10 to34.40mm) and at mean gestational age 30 weeks measured 36.2355mm (±o. 1.56728), ranging from (33 to 38.9 mm) and at the mean gestational age of34 weeks, it measured 40.4103 mm(:(±1.98537) ranging, from (35.10to 46.30mm).and at mean gestational age of 38 week it measured44.41mm((±2.1).
That is consistent with Chitty and Altman who found that mean kidney length at 26w, 30w, 34w and 38w was 30.3±0.12, 36.0±0.12, 40.3±0.12and 43.2±0.12 respectively [13] , Ahmadi and his colleagues found that mean kidney length at 26w,30w,34w and 38 was 29.38 ,35.23 , 39.7,42.45 respectively [11].
But in contrast to our study, some studies recorded that mean kidney length at different GA were lower than in our study found [14].
A number of reasons could explain these differences. These include the number of operators (multiple vs. two skilled operators), type of study (cross-sectional vs. longitudinal), estimation of gestational age (rounded vs. exact), quality of ultrasound machine characteristics of subjects (only uncomplicated pregnancies vs. all pregnancies) and observer bias (non-blind vs. blind study).Improvement in sonographic technology may be the key factor resulting in our larger measurement as compared with earlier studies.
In the present study, all sonographic measurement was performed by single skilled sonologist. The mean BPD, FL, and AC measurements at various gestations observed in our study were similar to measurements obtained by [15].
There was highly significant correlation between them and GA and the highest significant correlation was with FL (r = 0.982) followed by fetal kidney length (r = 0.980),however this correlation became week with advancement of GA especially kidney length in 36-40 weak (r = 0.516). Also our study showed that there was linear regression equations defining the relationship between gestational age and the various parameters used for gestational age estimation in the studied groups. There is Significant regression with suggested formula, and the most accurate parameters were the FL and kidney length (r2= 0.965 and 0.905 respectively), while the least accurate was the BPD (r2= 0.581).
These finding are consistant with that of Konje and his colleagues who stated that Kidney length and femoral length were most accurate single parameters for predicting gestational age [16].
In Yusuf and his colleagues study there was significant correlation between kidney length , BPD,FL and AC and GA and concluded that any one of the parameters can be used to determine gestational age [8].
Also Kaul and his colleague found strong correlation between fetal kidney length and gestational age (correlation coefficient r=0.958).so fetal kidney length was the most accurate single parameter for estimation of gestational age closely followed by FL.Abdominal circumference was the most inaccurate single parameter for estimation of gestational age [6].
The difference of mean fetal kidney length and other parameters in obese patients reported in the present study could be explained by that a thicker maternal abdominal wall is associated with reduced feasibility of completing an ultrasonography examination in a pregnant patient who is obese, and with poor image quality. The absorption of ultrasonography waves by subcutaneous fat makes ultrasonography more difficult and may result in poor scans and prevent proper measurement of both kidneys.
Throughout this study, we can conclude that
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Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
