AUCTORES
Globalize your Research
Case Report
*Corresponding Author: Eva Mazzotti, UOC of Oncology, Sant'Andrea University Hospital – Rome, Italy.
Citation: Monia Specchia, Eva Mazzotti, Federica Mazzuc, (2024), Electrochemotherapy to Treat a Single Thoracic Metastasis in Patient with Breast Cancer., International Journal of Clinical Case Reports and Reviews, 19(1); DOI:10.31579/2690-4861/507
Copyright: © 2024, Eva Mazzotti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 08 August 2024 | Accepted: 26 August 2024 | Published: 02 October 2024
Keywords: elettrochemotherapy; breast cancer; loco-regional procedure; electropulsation; clinoporator; case report
Electrochemotherapy represents one of the therapeutic breakthroughs in the oncology field. In this case report, we describe a woman diagnosed with breast cancer in 2005. The case was treated surgically with right breast mastectomy, with axillary dissection for estrogen receptor positive ductal carcinoma, followed by a course of chemotherapy. Radiotherapy and hormonal adjuvant therapy with aromatase inhibitor were used for 8 years and the treatment plan was completed in 2014.
After 17 years from the surgery, a thoracic Hight Resolution Computed Tomography scan showed a single node localized in right intercostal space, treated with a loco-regional treatment without complications. This allowed us to make the patient disease-free again.
This case opens a choice in a loco-regional treatment to offer at a patient a new chance.
Breast cancer is the most common tumour in women and the leading cause of death from cancer in women worldwide [1,2]. The prevalence of long-term survivors increased and therefore also the risk of late breast cancer recurrence gets higher [3,4].
The most common metastatic target sites are 60% of metastatic breast cancer patients have lung or bone metastasis in their life [5,6].
Oligometastatic breast cancer is characterized by a limited number and sites of metastasis, it may have a definitive remission with individualized treatment and multidisciplinary management [7,8]. Standard treatments for oligometastatic breast cancer include local treatments (surgery and radiotherapy); systemic therapies according to histological type (chemotherapy, endocrine therapy, and immunotherapy) are generally avoided [9,10]. Due to lack of randomized trials and the heterogeneity of breast cancer biology, treatment options for patients with oligometastatic breast cancer are different [9,10].
Electrochemotherapy (ECT) is an option in this setting based on preclinical and clinical studies [11]. ECT combines electropulsation of tumour cells, by local application of electric pulses, and administration of antineoplastic drugs such as cisplatin or bleomycin, either intravenous or intratumoral. Several clinical studies have demonstrated that ECT provides safety and efficacy in non-invasive locoregional treatment for chest wall breast cancer recurrence [12].
We are describing herein the case of a postmenopausal patient with an history of HER2 positive breast cancer who presented a single thoracic node after 17 years of clinical and instrumental exams during follow up.
A 65-year-old Caucasian woman in good clinical conditions presented during a visit programmed in follow up a thoracic pain in the high right intercostal space.
The patient was diagnosed with breast cancer in 2005 and treated surgically with right breast mastectomy, with axillary dissection for estrogen receptor positive (ER) ductal carcinoma, followed by adjuvant radiotherapy and chemotherapy.
Immunohistochemical results highlighted PgR positive, Ki 50%, HER2 FISH amplified, stage III.
After surgery patient was treated with adjuvant chemotherapy with Epirubicine and Cyclophosphamide (EC) for 4 cycles followed by Paclitaxel and Trastuzumab weekly for 12 cycles and subsequently subcutaneous administration of Trastuzumab alone every three weeks for 1 year of treatment. She received radiotherapy and hormonal adjuvant therapy with aromatase inhibitor for 8 years. Treatment was completed in 2014.
Patient underwent to regular follow up visits, laboratory tests and imaging exams every six months.
Seventeen years after surgery, in November 2021, patient reported outbreak of thoracic pain in the last right intercostal spaces.
Total body Computer Tomography (TbCT) scan was negative for bone and visceral metastasis. Breast ultrasound and mammography were also negative to signs of local relapse. She started a generic anti-inflammatory therapy without benefit. Followed by specific treatment with Gabapentin assuming late chemotherapy-induced neuropathy, with minimal response in pain relief.
One month later patient underwent to thoracic Hight Resolution Computed Tomography (HRCT) scan that showed a single node localized in right intercostal space (Figure 1).
Figure 1: Thoracic Hight Resolution Computed Tomography image.
A single node localized in right intercostal space is detected (December, 2021).
Positron emission tomography (PET/CT) with fluorodeoxyglucose (FDG) confirmed the presence of a single metastatic lesion in right costal space that received contrast.
Three different treatment proposals have been made: superior right lobectomy was the surgeon suggested treatment, single stereotaxic short court radiotherapy, and ECT treatment.
For ECT there were not contraindications, patient was in good general condition, ECOG performance status scale was 0, she had not known significant comorbidities she did not use any drugs. Thoracic nodule was single, stellar shape, adjacent to the coast, it was not impossible to be reached with electrode.
Multidisciplinary team discussion was performed and radiotherapy, surgery and ECT were the options suggested by the clinicians.
Patient refused radiotherapy because she experienced toxicity. She experimented a sever cutaneous toxicity during adjuvant treatment of
breast cancer after surgery and she rejected this possibility. Surgery with pulmonary lobectomy is also refused by the patient as pulmonary lobectomy is a burdensome surgical treatment associated with long post-operative rehabilitation and a decrease in lung function. ECT was the choice treatment.
One day before the treatment physical examination, laboratory tests (blood count, coagulation, renal and hepatic functionality) and cardiologic evaluation were carried out. A written informed consent to the ECT and to the publication of the study results were obtained. Treatment was performed under general anesthesia (deep sedation with Propofol) with standard hemodynamic monitoring.
This procedure was conducted in the presence of a multidisciplinary team constituted by oncologist, interventional radiology, anesthetist and specialized nurse. Procedure was performed under CT scan guide. The Cliniporator EPS-02 produced by IGEA was adopted (Figures 2 and 3).
Figure 2 Electrochemotherapy procedure.
Preparation for ECT procedure.
Figure 3: Electrochemotherapy procedure.
The electrodes’ introduction.
According to European Standard Operating Procedures on Electrochemotherapy (ESOPE) guidelines, ECT was performed with bleomycin intralesional. Three electrodes were introduced in intercostal space with CT scan imaging guide. International units (IU) of bleomycin were introduced in the lesion. After the intralesional chemotherapy administration three electrodes were introduced and needles extruded to penetrate the whole lesion so that the electric field could cover the entire volume of it. The entire procedure lasted 20 minutes, and a sample of the lesion was taken for histological confirmation. The patient was hospitalized for 2 days receiving antibiotic prophylaxis with cephalosporins.Procedure was well tolerated, without side effects. The histological examination confirmed the presence of single Metastasis originating from the previous carcinoma of the breast.Thoracic HRTC was performed one day after ECT treatment and no signs of lung damage were found. Thoracic HRTC performed one month after the procedure showed downstaging of the lesions (Figure 4).
Figure 4: Thoracic Hight Resolution Computed Tomography (HRCT) image.
Lesion necrotic pattern (January, 2022).
Subsequent instrumental chest examinations first highlighted the necrotic pattern of the lesion and then the complete resolution of the case (Figures 5 and 6).8
Figure 5: Thoracic Hight Resolution Computed Tomography (HRCT) image.
Lesion necrotic pattern (September, 2022).
Figure 6: Thoracic Hight Resolution Computed Tomography (HRCT) image.
Lesion resolution (February, 2023).
Three months after, a Thoracic Hight Resolution Computed Tomography (HRCT) showed an additional downstaging of the treated lesion (Figure 7).
Figure 7: Thoracic Hight Resolution Computed Tomography image.
Additional downstaging of the treated lesion (April, 2023)Patient remain in good clinical condition, she did not report pain, skin was clear, there were no signs of injury. Currently (2024), at clinical and instrumental checks, she is negative for disease recurrence.
Electrochemotherapy is a valid alternative treatment to conventional locoregional treatment especially when patient have a single or multiple cutaneous lesions.
Different molecular subtypes of breast cancer have different behaviors in the sites of distant metastases: Hormone Receptor (HR)+ HER2+ breast cancer subtypes have a major risk of bone metastases, HR– HER2+ subtypes are frequently associated to brain and liver metastasis, lung metastasis is common in all cancer subtypes [13]. The incidence of oligometastatic disease has increased, and the correct definition of the treatment options must be recommended by specialized centers, to allow an improvement in the patient’s quality of life and an increase in overall survival. Radiotherapy and surgery are the most common treatment options for oligometastatic breast cancer. Stereotactic body radiotherapy (SBRT), image-guided radiotherapy (IGRT), radiosurgery are different new types of radiotherapy emerged as potentially curative treatment [7]. Surgery is a good option, but its role is unclear in isolated thoracic metastases from breast cancer [14].
More recently ECT has emerged as an option for the treatment of oligometastatic cancer. It is a local ablative treatment based on reversible electroporation: it combines administration of antineoplastic drug (systemically of locally) with locally applied electric pulses that allow chemotherapy drugs to penetrate in the cell and have a cytotoxic effect [15]. ECT determine high response rate with few side effects.
ECT role is undiscussed in the treatment of cutaneous and subcutaneous lesions, in melanoma and, more recently, ECT treatment in deep tumors has been reported with promising results [11,16], although randomized clinical trials are lacking.
Its greatest advantage is that it is effective in areas previously treated by surgery and radiotherapy and can be used in patients already undergoing chemotherapy without causing systemic toxicity.
Another aspect to highlight is the immediate improvement of the psychological burden of the patient with the complete resolution of the painful symptoms almost immediately.
The peculiarity of this case report is the use of electrochemotherapy in variable geometry with intralesional bleomycin in the only thoracic metastasis from breast cancer.
This case report confirms the excellent local disease control achieved with electrochemotherapy and highlights the need for a multidisciplinary discussion to define the best treatment to propose to a patient who has already undergone multiple treatments such as surgery and radiotherapy.
Acknowledgement
We are grateful to the patient for accepting the idea of publishing this clinical case with the diagnostic images.
None
None
Obtained
Substantial contributions to the conception of the work (FM, MS, EM); Acquisition, analysis, interpretation of data (FM, MS, EM); Drafting the work and revising it critically for important intellectual content (FM, MS, EM); Final approval of the version to be published (FM, MS, EM); Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved (FM, MS, EM).
Yes, if requested
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
