AUCTORES
Research Article
*Corresponding Author: Mihir Y. Parmar, Head & Professor, Department of Pharmacology.
Citation: Mihir Y. Parmar, Kautuk Shah, Zalak D. Dave, Palak Landge, (2024), Creation and Valuation of Ayurvedic Herbal Soothing Balm for Chemical Induced Wound, J, Clinical Case Reports and Studies, 5(8); DOI:10.31579/2690-8808/219
Copyright: ©, 2024, Mihir Y. Parmar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 31 August 2024 | Accepted: 18 September 2024 | Published: 30 September 2024
Keywords: excision; herbal soothing balm; o/w emulsion; wound
Wounds are physical injuries that results in a breach or observance of the skin. Proper heal of wounds is very essential for the restoration of disrupted anatomical stability and disturbed functional status of the skin. Wound healing is a multifaceted but generally orderly process. Chronological impressions of dedicated cell types first clear the provocative injury and then progressively build the scaffolding to fill in any resulting defect. Cream is defined as semisolid emulsions which may be oil in-water (o/w) or water- in- oil (w/o) type and these semisolid emulsions are meant for external applications. Presently whole world including the developed country recognized the importance of traditional medicine and encouraging the research on herbal or ethnomedicine as they safe and less toxic. In this study we have formulated an herbal cream (o/w) type satisfying almost all the pharmaceutical parameters which showed better tissue restoration and healing capacity. The wound healing activity of herbal cream was experimentally evaluated by excision wound model. The experimental data of wound size area and histopathologcal study expressed that, healing in the cream treated group of animal was significant as compared to control group of animal.
Wound may be defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue. It is produced by physical,chemical, thermal, microbial, or immunological damage to the tissue. Wound healing or wound repair is the body’s natural process of regenerating dermal and epidermal tissue.
Healing requires the collaborative efforts of various tissues and cell lineages. It involves aggregation of platelets, clotting of blood, fibrin formation, and an inflammatory response to injury, alteration in the ground substances, angiogenesis and re-epithelialisation. Healingprocess is not complete until the disrupted surfaces are firmly knit by collagen[1-3a, 4].
Cream is definedas semisolid emulsionswhich are oil in-water (o/w) or water- in- oil (w/o) type and these semisolid emulsions are intended for external applications. Creams are often composed of two phases. Oil-in-water (o/w) emulsions are most useful as water-washable bases, whereas water-in-oil (w/o) emulsions are emollient and cleansing agents.An emulsifying agent is used to dispersethe aqueous phase in the oily phase or vice versa [5-8].
World Health Organization (WHO) as well our countryhas been promotingtraditional medicine becausethey are less expensive, easily available and comprehensive, especially in developing countries[3, 5].
It is also true that eight percent of the world’s population relies on medicinal plants for their primary health care. Whole world includingthe developed countryrecognized the importance of traditional medicine and has treatmentstrategies, guidelines and standard for ethnomedicine [6, 9, 9a].
Although various types of cream is considered for wound healing but these are still appearsto be limited in rate of tissue regeneration. Henceafter a depth review regarding pathogenesis as well as different traditional and alternative therapy for wound healing, we have taken up the project to develop and formulate an herbal cream which will be effectiveand has betterrate of tissue regeneration [2, 3]. The herbal cream that is planned to be formulated for wound healingwill be oil/water (o/w) emulsion type which will be less oily, less greasyand less stickyin nature so that patientcompliance is more and will be beneficial for all kind of people in our society.
After thorough review of Traditional System of Ayurvedic and Homeopathic system of medicine we have selected following herbs to formulate the cream for wound healing action.
In Our research our attempt to formulate most complete Herb-O-Seal cream that contains herbs which will satisfy almost all the mechanism to heal a wound effectively.
Collection of Plant Materials
The dried crude drugs of Calendula officinalis, Arnica Montana and extracted powder of Aloe verawere collected from G Hakim supplier, Vadodara. The fresh leaves of Clerodendrum indicum was collected from Silvasa, Gujarat. The dried root of Panax ginsengwas collected from G Hakim supplier, Vadodara. Rose hip oil was collected from Vasu Pharma, Vadodara.
Chemicals
The Chemicals used during the experiments were of analytical grade. Lanolin (Lions & Co), White Petroleum (Chemfine), Tween 60, Stearic acid (Hi-media Lab), Mineral oil, Triethanolamine, Propylene Glycol (Merck Lab), Betadine; Povidone- iodine IP 5%w/w, (Cipla medicare) etc were used.
Instruments
Freeze Dryer, Homogenizer, Centrifuge (REMI), Viscometer (Brookfield DV-E viscometer), Digital Balance (Delux Instrument), Digital pH meter (Sigma) etc were used.
Extraction of plant materials
The extractions of crude drugs were carriedout by Simple Maceration method using water (aqueous extract) as menstruum with occasional stirring.Liquid mixture is then pressedand filtered to get a clear liquid extract.The clear liquidis then subjected to freezedrying in order to get a solid mass [19, 20].
Formulation of herbal cream (O/W emulsion)
Ingredient of oil phase (A) was melted in a beaker by using water bath on constant stirring. Components of aqueous phase (B) were mixed together and warmed to about same temperature of oil phase (up to 700C). The preservative methyl paraben and concentrated aqueous extract of the plants were added into aqueous phase and heated. Then oil phase was added to water phase little by little on constant stirring and perfume was added to it when the temperature was 350C - 400C. Six different formulations (F1-F6) were prepared by using varying concentration of aqueous extract, stearic acid and liquid paraffin [8, 21, 22].
Pharmaceutical evaluation of cream
The formulations or creams were evaluated for different pharmaceutical parameters: such as Type of emulsion (Dye method and Dilution method), Homogeneity, Appearance, After feel, Type of smear, Removal, Creaming or coalescence, Globule size analysis, pH (Digital pH meter, systronics), Extrudability, Viscosity,(Brookfield Viscometer), stability testing and Spreadability. The best formulation was selectedon basis of their pharmaceutical parameters and evaluated for wound healingactivity [7, 23-25].
In Vivo Evaluation of Herbal Cream
Skin irritation Test
The cream was evaluated for primary skin irritation test on experimental animals (shaved back of the rats) to evaluate the safety of cream[3,5, 6,].
Evaluation of wound healingactivity
Wistar albino rats of either sex, weighing between 200-250 gm, were kept under standard environmental conditions of temperature, humidity (25±0.5oC) and 12 hr light/dark cycle. Animals were fed with standard pellet diet and water ad libitum. The research was conducted in accordance to the protocol approved by Institute Animal Ethics Committee (IAEC), Krishna School of Pharmacy & Research, KPGU (Registration no- 1372/c/10/CCSEA).
The rats were separated into three groups i.e. Group 1-Control (Base Cream treated /no extract), Group 2-Standard (Povidone-Iodine treated/Betadine) and Group 3- Test (Formulated Herbal Cream). On the day of experiments rats were anesthetized by administering Ketamine (50 mg/kg/ip). A full thickness of the excision wound with circular area of 176 mm2 (width 1.5 cm and depth 0.2 cm) was made on the shaved back (dorsal thoracic region) of the rats. The wounding day was considered as day 0. The wounds were treated with topical application of the cream once daily till complete epithelisation. The wounds were monitored and the area of wound size was measured on 3, 6, 9, 12, 15 & 18th of post-wounding day. The wound size area and mean % wound closure/contraction were noted. The results were reported in Mean±SEM and the data was analyzed using ANOVA [2, 3, 26-29, 29a].
Histopathological studies of wounded skin
On day 18th the experiment was terminated and tissue of wound area was removed from the surviving animals for histopathological examination. Sample tissues were fixed in 10% formalin and were embedded in paraffin wax. Serial sections (5μm thickness) of paraffin embedded tissues were cut. The tissues stained by haematoxylin and eosin, (H & E) and after that they were examined by electronic microscope [29-31].
Pharmaceutical evaluation of herbal cream
F6 Herb-O-Seal Cream was found to be best and satisfactory compared to all other formulations. It had light Yellow appearance, gave a cool and smooth feel on application which was maintained after tested the stability study. Stability was determined by exposing the formulation to various temperatures such as 4°C, 27°C & 37°C for specified period. The pH of the formulation was found to be 6.60 which is good for skin (pH=6.8). The creams also showed good Spreadability (16.17 g.cm/sec) when measured using slides. Lesser the time taken for separation of two slides resultant better Spreadability. Spreadability was calculated by using the formula. (S= M.L/T). Where S= Spreadability, M= Weight tied to upper slide, L= Length of glass slides and T= Time taken to separate the slides completely from each other. After application of the cream the type of smear formed on the skin was found to be non-greasy and easily removed on washing with tap water. The viscosity of the creams was found to be 17,650 cps, with 25 rpm, which indicates that the prepared cream was easily spreadable with small amount of shear [Table 1].
Ingredients | Formulation (% w/w gm) |
Aq. Extract of Panax ginseng | 5.0 |
Aq. Extract of Calendula officinalis | 5.0 |
Aq. Extract of Arnica Montana | 2.0 |
Aq. Extract of Clerodendrum indicum | 1.0 |
Aloe vera | 3.0 |
Rose hip oil | 4.0 |
White petrolatum | 0.8 |
Liquid paraffin | 8.3 |
Lanolin | 0.8 |
Stearic acid | 16.7 |
Propylene glycol | 3.5 |
Triethanolamine | 1.0 |
Tween 60 | 5.0 |
Methyl paraben | 0.1 |
Water | q.s |
Table 1: Final composition of Herbal Cream (Formulation F6)
Skin irritation test
This test was conducted to evaluate the irritation caused by the prepared cream on the intact skin of animals. The results showed that the formulation (F6) was devoid of any primary skin irritation or sensation or erythema, or edema even after 48 hrs of application on the rat skin. None of the animal showed any skin reaction.
Wound healing activity
The results of wound healing activity by excision wound model are presented in Table 2 and Figure 1A, 1B, 1C. The values of wound area are presented in mm2 at 0, 3, 6, 9, 12, 15 and 18th days. The results indicate that standard cream and test herbal cream both significantly (P < 0>
Figure 1A: Wound at day 0:
Figure.1B: Wound size area (mm2) at different days interval
Figure 1C: Wound at day 0;
Groups | Wound size area in mm2 (Mean ± SEM) | ||||||
Day 0 | Day 3 | Day 6 | Day 9 | Day 12 | Day 15 | Day 18 | |
Control | 176.60 ± 0.93 | 162.45 ± 0.83 | 113.00 ± 0.85 | 63.58 ± 0.65 | 38.46 ± 0.93 | 19.62 ± 0.95 | 10.36 ± 0.33 |
Standard | 172.44 ± 0.83 | 136.66 ± 0.85 | 66.44 ± 0.89 | 30.13 ± 0.63 | 13.83 ± 0.91 | 3.10 ± 0.33 | 0.26 ± 0.05** |
Test | 174.24 ± 0.85 | 136.78 ± 1.21 | 72.34 ± 0.89 | 30.17 ± 0.63 | 16.62 ± 1.06 | 3.20 ± 0.35 | 0.28 ± 0.05** |
The treated, standard groups are compared with the control group. *** P < 0>P < 0>P < 0>
Table 2: Effect of herbal cream on Wound size at different day’s interval
Table 3 and Figure 2 represents percentage (%) wound healing (wound contraction) at 9 and 18th days for control, standard and the test groups. It is observed that wound contracting rate of animals treated with herbal cream and standard cream significantly higher (P < 0>Groups % Wound contraction of excision wound (Mean ± SEM) Day 0 Day 9 Day 18 Control 0 39.96 ± 3.83 75.33 ± 3.85 Standard 0 58.33 ± 1.66 95.53 ± 3.85 ** Test 0 57.66 ± 2.33 95.53 ± 3.85 **
The treated, standard groups are compared with the control group. *** P < 0>P < 0>P < 0>
Table 3: Effect of herbal cream on % wound contraction of excision wound at different days interval
Figure 2: % Wound contraction of excision wound at different days interval
Histopathological study
The characteristics observed during histopathological examination were the proliferation of fibroblasts, granulation tissue, collagen fibre and tissue remodelling etc. Compared to control groups the above mentioned
parameters were more conclusive and decisive in case of both standard and test group. This histopathological observation also provided additional evidence for the experimental wound healing activity. The details of histopathological data are given in Figure 3, 4 & 5.
Figure. 3/4/5: Histological image of Control, Standard and Test at HEX20
The prepared cream was pleasant, coolant, easily spreadable and washable thereby there is a chance of increased the patient compliance. Formulated cream significantly promotes wound healing than control or non-medicated group. The activity may be mainly due to free radical scavenging activity, antioxidant activity and anti-inflammatory effect of the polyphenols and flavonoids present in the different extract. Some of herbs reported to act by supplying Vitamin C and by promoting tissue regeneration. However, further depth and structured study, would be beneficial to assess its usefulness and mechanisms more exactly. This study can be helpful for upcoming researchers to select these herbs for the formulation and evaluation of other cosmetic applications which can be claimed for their efficacy with scientific data.
MP*, KS, ZD, PL
Disclosures
No conflicts of interest, financial or otherwise, are declared by the authors.
Author Contributions
MP, PL had done review of literature and experimental work. MP drafted manuscript; MP, KS, ZD, evaluated and analyze the data. MP & PL edited and revised manuscript; MP approved final version of manuscript.
The authors are thankful to Management of Krishna School of Pharmacy & Research, Dr. Kiran and Pallavi Patel Global University (KPGU), Vadodara, Gujarat, India for providing all the supports to carry out the research work.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.