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*Corresponding Author: A.Krishna Sailaja, Department of pharmaceutics, RBVRR Women’s college of pharmacy, Affiliated to Osmania University, Hyderabad.
Citation: A.Krishna Sailaja and Sepuri Syeda Hafsa Fatima. (2023) Comparative Safety and Efficacy of Different Classes of Antibiotics for Treating Common Bacterial Infections: A Systematic Review and Meta Analysis, J. Biomedical Research and Clinical Reviews. 8(3); DOI:10.31579/2692-9405/158
Copyright: © 2023, A.Krishna Sailaja. this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 20 July 2023 | Accepted: 27 July 2023 | Published: 31 July 2023
Keywords: antibiotics; bacterial infections; safety; efficacy; risk factors; antibiotic resistance
Antibiotics are medications used to treat bacterial infections in humans and animals. They function by killing germs or making it difficult for bacteria to thrive and multiply. Antibiotics can be administered in a variety of ways: Orally (via the mouth). This could be in the form of pills, capsules, or liquids. Topically. This could be a cream, spray, or ointment applied to your skin. Eye ointment, eye drops, or ear drops are all possibilities. By injection or intravenously (IV). This is often reserved for more serious infections. There’s various classes of antibiotics used for the treatment of bacterial infections. Some of the major classes are penicillin, cephalosporins, macrolides, tetracyclines, fluoroquinolones, aminoglycosides and sulphonamides. Antibiotics are used to treat a wide range of illnesses that impact many different regions of your body, from your innermost organs to the skin's outer surface. Hence determining safety and efficacy of antibiotics in treatment of antibiotics is important since it is also known to have risk factors.
Role of Antibiotics: Antibiotics are a class of medications used to treat illnesses caused by certain bacteria. Antibiotics must be used correctly in order to help reduce antibiotic resistance. [1] Antibiotics may be used to treat bacterial infections that: are unlikely to clear up without antibiotics; may infect others if not treated; may take too long to clear up without treatment; and may carry the risk of more serious complications. [2]. Antibiotics are classified according to their chemical structure. However, antibiotics within each class often have various effects on the body and may be effective against different microorganisms. [3]
1. Penicillin
2. Cephalosporins
3. Macrolides
4. Tetracyclines
5. Fluoroquinolones
6. Aminoglycosides
7. Sulfonamides [3]
1. Penicillin: One of the most widely used antibiotics in the world, penicillin has a wide range of therapeutic indications. Penicillin is effective against a wide range of infections caused by gram-positive cocci, gram-positive rods, the majority of anaerobes, and gram-negative cocci. [4].
Mechanism of Action: Penicillin kills bacteria by blocking the completion of the production of peptidoglycans, the structural component of the bacterial cell wall [5].
Efficacy: These antibiotics have an extended track record of usage, and the shortage of significant side effects documented in these investigations lends credence to their reputation as safe medications. The fact that no rise in significant adverse events has been recorded in the literature despite widespread use provides reassurance. [6]
Adverse effects: Diarrhea, Headache, Stomach upset, Nausea or vomiting, Rash or hives (typically mild to moderate), Injection site pain (with penicillin G) are the most common adverse effects of penicillins (affecting at least 1% of users). Muscle spasms, black hairy tongue, oral thrush, and vaginal yeast infection [7]
Storage: Keep this medication in the original container, properly closed, and out of the reach of children. Keep the pills at room temperature and away from excessive heat and moisture (do not store them in the bathroom). Keep the oral solution tightly covered in the refrigerator and discard any unused medication after 14 days. It should not be frozen [8].
2. Cephalosporins: Cephalosporins are an antibiotic class. Antibiotics are drugs that are used to treat bacterial infections. Antibiotics are classified into various categories, which are generally referred to as classes. Cephalosporins are beta-lactam antibiotics. Depending on the infection, they can be given orally or injected into a vein (intravenous injection). [9]
Mechanism of action: Many cephalosporins, such as cephalexin, cefotaxime, and ceftazidime, bind to Penicillin binding protein 3 (PBP3) in a manner similar to penicillin, resulting in the production of elongated and filamentous cells. Transpeptidase is an enzyme found in bacteria that cross-links with the existing peptidoglycan chain to maintain the cell wall's integrity. Cephalosporin binding to the PBP3 receptor deforms the cell wall and kills bacteria. Cephalosporin also activates autolytic enzymes in bacteria, causing bacterial lysis. [10]
Efficacy: First-generation cephalosporins are more effective against Gram-positive bacteria, while some Gram-negative bacteria are also affected. Gram-positive and Gram-negative bacteria are both targeted by second-generation cephalosporins. However, they are slightly less efficient against Gram-positive bacteria than first-generation cephalosporins. Many Gram-negative bacteria and bacteria that have not reacted to first- or second-generation cephalosporins are effective against third-generation cephalosporins. Cephalosporins of the fourth generation are effective against both Gram-positive and Gram-negative bacteria. They are typically used for more serious infections or in patients with compromised immune systems. In the United States, ceftaroline is the only fifth-generation cephalosporin available. It's frequently used to treat infections that are resistant to other antibiotics, such as MRSA. [11]
Adverse Effects: Adverse responses to cephalosporins are uncommon in the laboratory. Eosinophilia and thrombocytosis are frequently observed, but they are most likely not unfavorable reactions, but rather indicators of infection healing. Other hematological responses have been recorded in a small number of patients and have been quickly reversed when medication was discontinued [12]
Storage: This medication must be carefully preserved. Consult your doctor or pharmacist about proper storage methods. Dry powder vials should be kept at room temperature and away from direct sunlight. Before using a reconstituted solution, check the expiration date. [ 13]
3. Macrolides: Macrolides are a type of antibiotic that is used to treat gram-positive and gram-negative bacterial infections. Erythromycin, azithromycin, and clarithromycin are examples of these drugs. All of these antibiotics can be taken orally to treat mild to severe bacterial infections of the respiratory, gastrointestinal, and genitourinary tracts; erythromycin can also be given intravenously, and azithromycin has an ocular formulation to treat bacterial conjunctivitis. [14]
Mechanism of action: Macrolide antibiotics work by inhibiting protein synthesis by targeting the bacterial ribosome. They bind to and partially occlude the nascent peptide exit tube. As a result, macrolides have been regarded as 'tunnel plugs' that halt protein production. Recent research, on the other hand, shows that macrolides selectively impede the translation of a subset of cellular proteins, and that their activity is critically dependent on the nascent protein sequence and the antibiotic structure. [15]
Efficacy: A judgment was reached regarding the efficacy of the pharmaceuticals used. The final effectiveness of erythromycin in infectious illnesses was 60%, azithromycin was 80%, and midecamycin was 55%. In dysbiosis, erythromycin and azithromycin were 100
After a systematic review, meta analysis consisting of a thorough data extraction process and assessment of the Comparative study of Safety and efficacy of different classes of antibiotics in treating common bacterial infections has been determined. With various risk factors that also stand a chance of major improvement. This study has given a broad outlook on the spectrum of antibiotics and their generations in the treatment and resistance of bacteria.
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