AUCTORES
Globalize your Research
Review Article
*Corresponding Author: Emmanuel Ifeanyi Obeagu, Department of Medical Laboratory Science, Kampala International University, Uganda.
Citation: Esther Ugo Alum, Okechukwu P. C. Ugwu, Emmanuel Ifeanyi Obeagu, (2024). Beyond Conventional Therapies: Exploring Nutritional Interventions for Cervical Cancer Patients, J, Cancer Research and Cellular Therapeutics, 8(1); DOI:10.31579/2640-1053/180
Copyright: ©2024, Emmanuel Ifeanyi Obeagu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 14 January 2024 | Accepted: 24 January 2024 | Published: 01 February 2024
Keywords: cervical cancer; dietary micronutrients; chemotherapy; radiation therapy; antioxidants; HPV infection
All over the world, cervical cancer (CC) is the fourth most common cause of fatalities from cancer in women. This study investigates the critical role of dietary micronutrients in preventing and managing CC, considering the profound impact of malnutrition on cancer patients undergoing chemotherapy and radiation therapy. The study digs the global significance of dietary factors in cancer cases, emphasizing the preventive potential of specific nutrients. Notably, carotenoids, folate, and vitamins C and E emerge as pivotal players due to their functions in regulating DNA synthesis, repair, and cell survival. The study explores the complex landscape of CC, spanning its epidemiology, risk factors, and conventional therapies, highlighting the challenges faced in improving survival rates. The focus then shifts to the potential protective mechanisms of dietary interventions, emphasizing the need for individualized counseling and nutritional strategies. Reactive oxygen species and oxidative stress, linked to lifestyle and dietary choices, are discussed in relation to CC development. The manuscript extensively examines the impact of carotenoids, vitamins C and E, and other nutrients on CC prevention, elucidating their antioxidant properties and potential to mitigate the harmful effects of therapy-induced toxicity. The elucidation encompasses various dietary sources and their role in influencing HPV infection risk. The manuscript concludes with an in-depth analysis of specific nutrients such as carotenoids, vitamins C and E, folic acid, and additional compounds like apigenin, genistein, quercetin, sulforaphane, and tea polyphenols in the context of CC prevention and management. Understanding the intricate interplay between diet, nutrition, and CC development is crucial for devising effective preventive and therapeutic strategies at every stage of the disease.
After lung cancer, colorectal cancer, and breast cancer, cervical cancer (CC) cause of fatalities from cancer in women all over the world. Women in lower socioeconomic levels and between the ages of 25 and 69 are more common [1]. The primary risk factor for CC (96.6%) is HPV [2]. Only the 16 and 18 HPV variants (70–76%) are linked to CC [3]. There are about 100 HPV variants. The risk of having HPV increases from 2 to 10 times with the initiation of sexual activity. More sexual partners, beginning a sexual relationship before the age of 18, adolescent pregnancy, multiparity, and smoking all make it worse [4]. Cervical cancer is mostly preventable if efficient screening and immunization programs are implemented. Nonetheless, vaccination rates are still low, and few women have access to quality medical care [5]. As a result, there are significant global differences in the number of women diagnosed with cervical cancer each year, over 500,000 of whom die from the disease in low- and middle-income nations [6]. There are essentially two central therapy choices for the treatment of cervical cancer. Surgery is the recommended course of treatment for localized illness when no lymph node metastases have been found or risk factors are present. These therapeutically designed procedures range from radical hysterectomy or total mesometrial resection, which includes significant pelvic and paraaortic lymphadenectomy, to conization that preserves fertility. The mainstay of care for patients with locally advanced cervical cancer is definitive chemoradiotherapy (CRT) followed by brachytherapy (BT) [7]. BT is a key aspect of definitive therapy regimens for individuals with locally advanced cervical cancer [8]. By successfully targeting the residual amount of disease and optimally sparing neighboring organs at threat, it provides a highly uniform exposure and dispersion of radiation, maximizes local control, and minimizes toxicities [9]. When compared to radiation therapy alone, concomitant chemotherapy has greatly increased the persistence level of patients with cervical cancer. Therefore, platinum-based chemotherapy regimens are typically the first choice for patients who qualify for them [10]. Additionally, a mix of bevacizumab, an inhibitor of vascular endothelial growth factor, with cisplatin, paclitaxel, or topotecan showed a significantly higher likelihood of survival but was also linked to increased toxicity [11]. The treatment of many solid tumors has changed recently thanks to immunotherapies, which are always developing. Pembrolizumab, a programmed death 1 (PD-1) inhibitor, has been approved by the FDA for use in patients with cervical cancer who have met treatment goals and recurrence following chemotherapy. These patients' tumors must exhibit PD-L1 (combined positive score (CPS) ≥1). Immune checkpoint inhibitors are being studied in multiple settings, including the CALLA (durvalumab), NCT02635360 (pembrolizumab), and NRG-GY017 (atezolizumab) trials, for CC treatment, pending additional data. Moreover, therapeutic vaccination techniques (e.g., NCT02853604) and adoptive cell therapies (e.g., NCT03108495) are currently being studied [12]. Accordingly, tisotumab vedotin, an antibody-drug conjugate (ADC), has been approved against tissue factor and monomethyl auristatin E (MMAE) for the treatment of CC. This approval was granted following the completion of the NCT03438396 multicenter, open-label, single arm, phase 2 trial (innovaTV 204/GOG-3023/ENGOT-cx6), which demonstrated efficacy and safety [13]. In spite of these developments, survival rates have not increased dramatically in the last 20 years, and the prospects for women who have dogged, recurring, or metastatic illness in particular is still not good. Toxicology is the unifying denominator of all treatment plans. Finding palliative therapies for the toxicity brought on by chemotherapy is therefore critically important. It's interesting to note that numerous research point to the ability of nutrient-rich plant-based resources to shield animals against the toxicity of a common chemotherapy drug (methotrexate) [14-16]. Between 20 and 60 percent of cancer cases worldwide are thought to be caused by dietary variables [17]. Individualized counseling and nutritional intervention, which combine dietary prescription with nutritional therapy, have been shown to be highly effective in the treatment of a number of disorders, including rheumatoid arthritis [18], diabetes mellitus [22], HIV infection [20, 21], and cervical cancer [22]. In this case of cervical cancer, the stage of the malignancy is crucial [23].
It is well recognized that eating a balanced diet can help lower the risk of cervical cancer and increase resistance to HPV infection. Carotenoids (both vitamin A and non-vitamin A precursors), folate, and vitamins C and E are among the micronutrients that have been shown to have a suppressive effect on HPV infection [24-27]. Therefore, the advantages of different nutrients in CC must be investigated and taken into consideration in CC pharmacology research as a primary preventative and enhanced treatment strategy.
Effect of Dietary Nutrient Intake on Management and Prevention of Cervical Cancer
HPV infection is the main root cause of the illness. A precancerous lesion typically takes 10 to 20 years to progress to malignancy. Additionally, it has been demonstrated that CC is associated with a number of traits, more sexual partners, beginning a sexual relationship before the age of 18, adolescent pregnancy, multiparity, smoking, and contraceptive pills (OC) [4]. Furthermore, the consumption of different nutrients in the food is a major factor in the development or avoidance of CC. Reactive oxygen species are produced by normal metabolic processes as well as lifestyle choices like food, exercise, and smoking (ROS). Overproduction of reactive oxygen species (ROS) causes oxidative stress. Macromolecules such as lipids, proteins, and DNA are harmed by this [28-31]. Numerous chronic diseases like diabetes mellitus [32-38], cardiovascular conditions [39-441, and cancer [45-47] have been linked to oxidative stress. On the other hand, ROS levels can be adjusted by intracellular antioxidants such as glutathione [48, 49].
A lack of antioxidants may make people more susceptible to oxidative stress, which raises the possibility of developing cancer. It has been demonstrated that exogenous antioxidant supplementation reduces oxidative damage by scavenging reactive oxygen species and preventing the oxidation of intracellular macromolecules. It is noteworthy that exogenous antioxidants can be found in good amounts in fruits, vegetables, nuts, and legumes [50-54]. Consuming fruits, vegetables, nuts, and legumes may therefore have a preventive effect on the occurrence of cervical malignancies. Researchers have documented the protective properties of plant-based materials against a range of cancer risks [45-47].
Red and processed meats, pickles, salted or dried fish, dipping sauces, chips, snacks, instant noodles (which are categorized as part of the western diet), and a low consumption of olive oil are all linked to an increased risk of HPV infection, according to Barchitta et al. Furthermore, there was an increased risk of HPV infection for women who did not adhere to the Mediterranean diet (MD), which consists of fish, vegetables, legumes, fruits, nuts, milk, cereals, and a high proportion of polyunsaturated fats. In summary, strong adherence to MD can result in a 60
This manuscript underscores the pivotal role of dietary micronutrients, such as carotenoids, folate, and vitamins C and E, in the prevention and management of cervical cancer. Recognizing the significant impact of malnutrition on cancer patients undergoing conventional therapies, the study advocates for individualized nutritional interventions. The complex interplay between diet, oxidative stress, and HPV infection is thoroughly explored, emphasizing the potential of specific nutrients to mitigate therapy-induced toxicity and enhance overall treatment outcomes. As cervical cancer continues to pose a global health challenge, understanding and incorporating dietary strategies into comprehensive care approaches could prove instrumental in improving patient outcomes at various stages of the disease.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
