AUCTORES
Globalize your Research
Mini Review
*Corresponding Author: Božidar Kocmur,, KBC Sestre Milosrdnice Zagreb, Clinic for Diseases of the Heart and Blood Vessels, Institute for Cardiomyopathies, Heart Failure and Heart Valve Diseases.
Citation: French Paradox, Božidar Kocmur (2024), Atherosclerosis and Vine, Cardiology Research and Reports. 6(2); DOI:10.31579/2692-9759/119
Copyright: © 2024, Božidar Kocmur. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 01 March 2024 | Accepted: 08 March 2024 | Published: 18 March 2024
Keywords: heart transplantation; health care; case report
In light of today's scientific knowledge about the causes and process of atherosclerosis, how to explain and interpret the fact, seemingly very illogical, that the French do not have a high mortality from coronary diseases caused by atherosclerosis, despite the high fat content of everyday nutrition? Such epidemiological ilogenicity, called the French Paradox, has been attributed to daily, moderate consumption of red wines, which proved correct [2]. It has been proven that the beneficial effects of red wine in the process of preventing atherosclerosis can be attributed to the effects of the polyphenols present, likewise, these effects do not only apply to red wine, but also to other drinks, alcoholic and non-alcoholic, containing polyphenols [3]. Studies conducted on beer consumption have produced similar results. [18] It should be noted that the effect of alcohol is described by the J curve, suggesting that moderate alcohol consumption reduces the risk of atherosclerosis, unlike abstinence and excessive alcohol lovers, where this risk is noticeably higher. This effect of red wine is attributed, among other agents, to a significantly increased concentration of high density lipoprotein (HDL) [4]. The paper discusses the effect of HDL particles on nascent chylomicrons in the lymphoma system, which, by entering the circulatory system, affects possible association with atherosclerosis.
After such knowledge of the effects of red wine (polyphenols) on the organism, can it be considered that non-consumption of the same and other polyphenols-containing drinks is a certain risk factor? ( In vino veritas)
One of the most important risk factors for the origin and development of atherosclerosis is certainly excessive intake of fat in everyday nutrition. This risk factor, and the way it affects the origin and development of atherosclerosis, is described in article "Atherosclerosis and lymph/risk factors" [1]. In this article, based on verified and proven facts, it is suggested that the primary causes and initiators of atherosclerotic changes in the arterial system of the circulatory system are chylomicrons, especially large ones, which occur under the influence of several risk factors, especially the above-mentioned ones.
"Atherosclerosis is the result of the arterial wall/circulating blood element interactions triggered by environmental factors that influenza individual genetic components. Vascular alteration in the coronary bed comprises some key elements such as early endothelial dysfunction, inflammatory cellular infiltration, lipid deposition, vascular Wall cell proliferation, and Thrombotic complications at lesion sites.” [5]
About atherosclerosis, as a disease of the blood system which is one of the main causes of death of modern civilization, has been published in the past fifty years, several scientific papers explaining and confirming all aspects and characteristics of this disease, from risk factors to consequences, as well as prevention from its occurrence. Unfortunately, despite all this, the fact remains that the mechanism of atherosclerosis is still unknown, with a not-so-optimistic prediction of its immediate solution. The articles published so far [1,6,7] discussed the reasons for such a situation. The conclusion that emerged was that the primary cause and driver of atherosclerotic changes in the artery wall is chylomicron, namely chylomicron of large and extra-large dimensions, insufficiently structured, formed under the influence of several risk factors to which we are exposed. It should be noted that the basic and primary role of chylomicrons is the transport and delivery of consumed lipids, of all kinds, to organs and tissues in the body that are needed for their functionality. On their way, through the lymph, to the circulatory system, chylomicrons are exposed to the influence and influence of many factors, which determine their final size, structure, and functionality at the moment of entry into the circulatory system.
One also forgets or underlines, the very important fact that the primary role of chylomicron is their attachment to the endothelial arteries and capillaries to deliver its lipids (triglyceride) content to the tissue in need. It is precisely in this fact that there is danger and possibility of disturbances in the process of attachment to cells of endothelial arteries and capillaries of such atypical, extremely large, with diameter > 10 times, and with mass n³ time’s larger, chylomicron. This particularly applies to the area of large blood flow turbulence (8), when binding forces are not sufficient to maintain such a large particle on the endothelial surface, resulting in injuries to the arterial endothelium or uncontrolled decay of the chylomicron itself, resulting in an inflammatory process at this site [6,7].
Atherosclerosis is a chronic inflammatory disease manifested as coronary artery disease - myocardial infarction, cerebral arteries - stroke, or as peripheral vascular insufficiency, and tends a progressive process that begins probably in early youth [9]. The process itself is multifactorial and mostly depends on risk factors, obesity, sedentarism, smoking, and the presence of some metabolic disorders. Progress in this process can be reduced or even stopped, avoiding risk factors by changing the lifestyle (weight loss, smoking cessation, exercise, adequate nutrition), and moderate consumption of alcohol, especially red wine, should be added to this.
Moderate consumption of alcohol, especially red wine, leads to an increased concentration of HDL and triglycerides in the blood [10,11]. Since it is known that increased HDL blood concentrations have a protective effect against coronary artery diseases [12], this may also be a mechanism by which the consumption of red wine contributes to the protection against atherosclerotic complications. How?
2. Hdl
“Levels of high-density lipoprotein (HDL) cholesterol are generally inversely associated with the risk for the development of atherosclerosis. The mechanism by which HDL imparts protection from the initiation and progression of occlusive vascular disease is complex and multifactorial. The major anti-atherosclerotic effect of HDL is felt to be reverse cholesterol transport. HDL has been demonstrated to scavenge cholesterol from the peripheral vasculature with transport to the liver, where is it excreted in the biliary system. However, HDL exhibits multiple other physiologic effects that may play a role in the reduced risk for atherosclerosis. HDL has been demonstrated to exhibit beneficial effects on platelet function, endothelial function, coagulation parameters, inflammation, and interactions with triglyceride-rich lipoproteins. Increasing amounts of clinical and experimental data have shown that HDL cholesterol has significant antioxidant effect that may significantly contribute to protection from atherosclerosis” [13].
The first convincing evidence of this connection between HDL and cholesterol and the occurrence of atherosclerotic changes in the circulatory system, and the emergence of cardiovascular diseases, was obtained in a well-known Framingham heart study, after which a generally accepted concept on the role of HDL in preventing cardiovascular diseases was proposed. It was also concluded in this regard that there is „good" HDL cholesterol and“bad" LDL cholesterol. Following such conclusions, many investigations were initiated during the '80 s and `90 s, to influence the risk of cardiovascular diseases by the therapeutic intervention of an increase in blood cholesterol. Although there have been significant new findings in the understanding of molecular and genetic regulation of HDL metabolism in plasma, the method itself did not yield results and proved to be unsuccessful.
“Despite this, most attempts to raise plasma HDL-C concentrations in a cardioprotective way have failed. Recently, hypotheses about the atheroprotective effects of HDL have shifted away from quantity to quality, mostly HDL function in reverse cholesterol transport. Plasma HDL from CVD patients is a poorer acceptor of cellular cholesterol than plasma from healthy controls, independent of plasma HDL-C concentrations. The function of HDL is likely determined by two other factors, stability and composition. The kinetic instability of HDL, which varies according to subclass, is a likely determinant of its reactivity in response to many HDL-modifying activities. HDL composition is also heterogeneous and variable; all HDL particles contain apo AI but only about two-thirds contain apo AII. This occurs despite the fact that apo AI and apo AII are hepatically secreted on separate HDL that later fuse in plasma. HDL also contains traces of other proteins, some of which have not yet been associated with HDL function. One minor HDL species are those that are secreted with intact signal peptides, which enhance their binding to HDL; these HDL have special properties that are independent of cholesterol transport.” [15]
All the aforementioned beneficial effects of HDL in the process of atherosclerosis can be accepted in the context of possible but not finally scientifically proven effects, while the fact that HDL particles interact with triglycerides, chylomicrons and VLDL lipoproteins has been scientifically proven and confirmed for a long time now [14], which in the context of these considerations has an extremely large, perhaps crucial significance
The generally accepted concept of reversible transport of cholesterol indicates that it is a process by which HDL removes the surplus of cholesterol accumulated in the intercellular space of tissues, including skin and arterial walls, and it is returned to the circulatory system by the lymphoma system and excreted via the liver via feces from the body.
“Cholesterol is essential for all cells in the body and it is used extensively as a major structural component of cell membranes and as a substrate for the synthesis of other steroids such as bile acids, vitamin D, and sex hormones such as estradiol, progesterone, androsterone and testosterone, as well as adrenocortical hormones such as aldosterone and cortisone. The liver and small intestine are two crucial organs for cholesterol homeostasis. Indeed, high cholesterol biosynthesis in the liver leads to more very low-density lipoprotein (VLDL) secreted into plasma, thereby increasing plasma total and LDL cholesterol concentrations. Increased quantities of dietary cholesterol also cause plasma cholesterol concentrations to rise in most individuals. Accumulated evidence has clearly demonstrated that elevated total and LDL cholesterol levels in plasma are an important risk factor for the development of cardiovascular diseases in humans and laboratory animals.”[16]
“Accumulated evidence from human and animal studies has clearly demonstrated that one of the most important biological functions for HDL is to regulate reverse cholesterol transport that promotes cholesterol transport from the peripheral tissues, including the aortae, to the liver for biliary excretion (Figure 5). This indicates that HDL plays a critical role in protecting against the development of atherosclerosis through reverse cholesterol transport. It is well known that plasma contains numerous HDL particles that are involved in reverse cholesterol transport.105 In addition, it has long been suspected that the lymphatics may also play an important role in transporting newly effluxed cholesterol from the site of efflux to the circulation because interstitial and lymphatic fluid contains a lot of HDL and apoA-I.109 It is estimated that there is a lymph transport of more than 300 mg per day in humans.110 Most importantly, recent observations have found that the lymphatic vessel route is critical for efficient reverse cholesterol transport from multiple tissues, including the arterial wall.111 Removal of cholesterol by lymphatic vessels is dependent on the uptake and transcytosis of HDL by scavenger receptor class B type I (SR-BI) expressed on lymphatic endothelium,112 which challenges the current view that lymphatic endothelium is a passive exchange barrier for cholesterol transport. Accordingly, these findings may connect lymphatic function to atherosclerosis because lymphatic transport function may facilitate cholesterol clearance in therapies aimed at reversing atherosclerosis.113-115.” [16]
However, it would be uncritical to conclude that this is the only role of the HDL in the body. The previously mentioned fact is that the HDL of four directly participates in the transfer of apolipoprotein C-II, C-III, and E to nascents chylomicrons so that these can become "mature chylomicrons", which means structurally stable and ready to enter the circulatory system. [14] Since the nascent chylomicron contains about 25 copies of apoE and about 180 copies of apoC, [17] it can be assumed how many HDL particles are needed to mature each nascent chylomicron. However, this is not only a problem, but also because chylomicrons are very different in terms of particle size, depending on the length and intensity of lipid absorption, and ranging from 75 to over 1000 nm. The question arises how much does the HDL of particles need at the moment of arrival of particularly large chylomicron particles into the lymph system (cisterna chyli)? We know that each chylomicron particle contains only two chains of ApoB, [17] which poses a great danger to the stability of such large lipid particles in the aqueous medium, therefore it is necessary to present and interact HDL particles, which contribute to their stability by handing over their apoproteins and probably cholesterols and phospholipids.
And now we finally come up with questions from the beginning of the debate, how does red wine affect the appearance and development of atherosclerosis?
3. Wine
In the context of all the above facts and the results of the research presented in this discussion, a very convincing conclusion is reached that red wine (polyphenols present in it) significantly increases the presence of HDL particles in blood and lymph, affects the increased reversible transport of cholesterol via lymph, where HDL particles contribute and participate in the final formation of imagined chylomicron particles, before they enter into the blood circulation.
The lack of decrease in the number of HDL particles in the lymph, especially at the moment of arrival of large structural unfinished and unstable scents of chylomicron particles, leads to the danger that such chylomicrons enter the blood circulation, where they may cause changes in the vascular endothelium, especially the aorta and arteries that come out of it, coronary and cerebral, in a highly turbulent blood flow through the area, as described in [1,6,7].
The result of this effect of red wine has significantly reduced the possibility of atherosclerosis, which has been confirmed in practice. Therefore, the benefits of a moderate drink of red wine, as well as other polyphenols-containing drinks, are real and multiple, from comfort to health preservation. Proven risk factors crucial to the occurrence of atherosclerosis, obesity, insufficient physical activity, smoking, and insufficient consumption of polyphenol can also be considered as specified risk factors. This is why red wine, due to its universal application and acquired civilization habits, has become a very important help for the preservation of health.
Syntagm "In vino veritas" from this discussion has proved to be very appropriate because the consumption of wine, its properties and effects, confirms and indicates that it is chylomicrons that we have to pay full attention to, to get closer to the truth about the causes and mechanism of
atherosclerosis, chronic civilization disease, for which we do not yet have a concrete answer or explanation.
Funding: personally
Conflict of interest: Author certify that they have no conflict of interest, no affiliations with or involvement in any organization or entity.
Ethics approval: Not applicable
Consent to participate: Not applicable
Consent for publication: Not applicable
Availability of data and material: All information available in the attached literature
Code availability: Not applicable
Authors' contribution: Not applicable
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
