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*Corresponding Author: Richmond Ronald Gomes, Associate Professor, Medicine, Ad-din Women’s Medical College Hospital Dhaka, Bangladesh
Citation: Richmond R. Gomes (2021). A Rare Case of Pneumoperitoneum in Pregnancy: Perforation of Tubercular ileal Ulcer. J. Obstetrics Gynecology and Reproductive Sciences; 5(8) DOI:10.31579/2578-8965/086
Copyright: © 2021, Richmond R. Gomes, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 19 June 2021 | Accepted: 21 August 2021 | Published: 30 October 2021
Keywords: intestinal tuberculosis; peritonitis; ileum; perforation; caseating granulomatous inflammation
The incidence of tuberculosis (TB) is rising worldwide, despite the efficacy of the BCG vaccination. Populations at greatest risk of contracting TB are migrant communities, as well as immunocompromised individuals. The diagnosis of intestinal tuberculosis can often present as a diagnostic conundrum, due to its nonspecific and varied presentation, often mimicking inflammatory bowel disease or malignancy. Free perforation is one of the most feared complications of the intestinal tuberculosis. The terminal ileum is the most common site of perforation, while the majority of (90%) perforations are solitary. We present a 25 year old 17 weeks primi presented with peritonitis with solitary perforation of terminal ileum with miscarriage of fetus and subsequent surgical wedge resection of ileum and ileo-ileal anastomosis. Histology revealed presence of Langerhan’s cell with caseating granulomatous inflammation. There was no radiological evidence of pulmonary tuberculosis. Patient was started on anti-tubercular therapy and responded well. This present case underscores the importance of biopsy specimens taken from the margins of patients with ileal perforation to avoid the misdiagnosis of such condition.
TB remains a global epidemic, with an estimated 10.4 million new cases diagnosed worldwide in 2019. Of these, there was a slight male preponderance, 56% of all new cases, as compared to 34% for women. TB in children contributed to the remaining 10% of new cases. TB mortality rates are alarmingly high and in 2018, approximately 1.8 million deaths were attributable to TB, amongst whom those coinfected with Human Immunodeficiency Virus (HIV) made up a quarter of total deaths. Perforation of a hollow viscus leading to peritonitis is a common surgical emergency. Although peptic ulcer perforations account for the majority of cases of peritonitis, small bowel perforations are also commonly encountered. Usually, these small bowel perforations are secondary to enteric fever or trauma, but at times, non- specific ileal perforations are also seen. Tuberculosis remains an uncommon cause of perforation of the small bowel, even in areas where tuberculosis is rampant. The incidence of intestinal perforation in patient with abdominal tuberculosis in close to that of 2.0% recorded in one of the largest series from India [1-2]. Free intestinal perforation (4.9%) is an uncommon complication of intestinal tuberculosis because of reactive thickening of the peritoneum and formation of adhesion with surrounding tissue [1-3]. It has a poor prognosis with mortality rate higher than 30% [1-3]. Diagnostic and treatment modalities, even in pregnancy, are similar to the non-pregnant population. We report a case of 17 weeks pregnancy with a free tubercular perforation of the ileum that presented with peritonitis and was managed at our hospital.
A 23 year old lady and 8 weeks into her first pregnancy when she commenced her antenatal care. Her Body Mass Index (BMI) at booking was only 17.23 kg/m, with a booking weight of 42 kg. She had been experiencing intermittent, dull, right-sided lower abdominal pain that was associated with diarrhea along with low grade fever, for 3 months and in this span of time, her weight had decreased markedly by 8 kg. Her primary healthcare provider at the district maternal and child health clinic subsequently treated her for acute gastroenteritis twice in the following weeks, but she experienced no improvement in her symptoms.
At 17 weeks of gestation, she was admitted under department of gynaecology and obstetrics of our hospital with the complaint of sudden onset of diffuse abdominal pain and vomiting for 1 day. She had been compliant to her oral hematinics therapy and denied any history of dysuria, constipation, haematuria, haematemesis, haematochezia., shortness of breath or night sweats. He denied any history of recent travel or contact with anyone infected with tuberculosis.
On physical examination, she appeared ill-looking, pale, afebrile and moderately dehydrated. Pulse was 120 beats/min, regular, blood pressure 90/60 mm of Hg. On palpation, her fundal height corresponded to 16 weeks of gestation. Abdomen was grossly distended with tenderness, rigidity and guarding were elicited diffusely all over abdomen. Bowel sound was sluggish. However, she did not exhibit any signs of preterm contraction and renal punch was negative. Transabdominal scan revealed a singleton fetus, with parameters corresponding to her gestation with no evidence of ruptured ectopic pregnancy. On the very next day she developed spontaneous preterm contractions and spontaneous abortion occurred.
She had hemoglobin of 9.4 g/dl(MCV 83.1, MCh 28.8) and a white cell count of 5.87 × 109 with N:48%, L:45%. As her pain worsened, repeat abdominal examination revealed obliteration of upper border of liver dullness and absent bowel sound. Serum lipase, random blood sugar, renal and liver function tests were non conclusive. X-ray abdomen in erect posture antero-posterior view showed free air under both the domes of the diaphragm (figure-1).She was kept nothing per oral. Parenteral fluid, analgesics and broad-spectrum antibiotic were commenced. She was also transfused with 1 unit of packed cells. An urgent ultrasound abdomen was arranged, which revealed a heterogeneous collection in the subhepatic region and multiple enlarged mesenteric lymph nodes. A diagnosis of likely perforated appendicitis was made and she underwent an emergency laparotomy.
Laparotomy was performed by a midline incision and revealed purulent peritoneal fluid, mainly in the pelvis. The terminal ileum had a small perforation along the anti- mesenteric border, about one foot proximal to the ileocaecal junction. There were no other significant findings on laparotomy. There was evidence of multiple enlarged mesenteric lymph nodes. Ileal wedge resection with ileo-ileal anastomosis was done. Appendix was normal. The edges of the perforation were sent for histopathological examination.
The histopathological report of the perforation margins that were sent intra-operatively revealed caseating epithelioid cell granulomas with Langhans' giant cells and a dense mixed inflammatory cell infiltrate within the mucosa and submucosa (Figure-2). On receiving this report, the patient was started on anti-tubercular treatment. Her pulmonary TB work-up including chest X-ray, sputum for acid fast bacilli (AFB), and Mantoux test was negative. Screening tests for HIV were negative.
She was seen in outpatient clinic one-month post operatively and he was symptoms free.
She had put back most of her weight.
Extrapulmonary tuberculosis (EPTB) is thought to be a result of reactivation of a prior dormant TB focus. Immunocompromised individuals have been found to be more susceptible to EPTB16 Gastrointestinal TB is the sixth commonest site of extrapulmonary disease [17, 18] accounts for 11% of all EPTB. Its occurrence is attributed to four mechanisms: hematological, swallowing of infected sputum in patient with active pulmonary TB, ingestion of milk or food contaminated with mycobacterium bovis, and contiguous transcoelomic spread from adjacent organs19.The ileocaecal region is affected in 75% of abdominal TB and this can present with perforation, abdominal mass, obstruction, and malabsorption [6,16,20,21]. Viscus perforation due to TB is very rare and occurs more commonly in immunosuppressed patients [22]. Pregnancy is a physiological state of relative immunosuppression. Hence, the risk of viscus perforation after contracting abdominal TB in pregnancy may be increased, as was the case in our patient.
Abdominal tuberculosis is common in Bangladesh and India, more in young [1]. Intestinal tuberculosis can occur both primary and secondary to a tuberculous focus at different sites [8]. Primary intestinal tuberculosis (without pulmonary involvement) is one of the commonest forms of extrapulmonary tuberculosis. The infection is usually caused by ingestion of unpasteurized or contaminated milk contaminated by Mycobacterium bovis, that leads to a primary infection of the intestine in the absence of pulmonary disease[4].The tubercle bacillus is protected against digestion in the stomach by its fatty capsule .Intestinal tuberculosis commonly affects the ileocaecal region because of the following reasons: 1) the terminal ileum is an area of physiological stasis; 2) it has abundant lymphoid tissue; and 3) it has a high absorptive capacity. Thus, after the initial infection occurs in the Peyer's patches, mucosal edema and sloughing occur, leading to the formation of typical tubercular ulcers that lie transversely to the long axis of the ileum. The disease may spread further by dissemination through the lymphatics and by caseation, may heal by fibrosis, or may even remain confined to the area if the host's defence mechanisms are adequate [5].
The complications of intestinal tuberculosis are bowel obstruction (31.7%), intestinal perforation (4.9%), enterocutaneous fistula (2.4%) and small bowel volvolus due to mesenteric lymphadenitis (2.4%)[10].There are three main pathological forms of tubercular enteritis: 1) ulcerative, 2) hypertrophic, and 3) ulcerohypertrophic5. The ulcerative form of the disease is more common than the others, but these ulcers rarely perforate. Fibrosis and the formation of adhesions to adjacent intra-abdominal organs account for the low incidence of perforation seen in tuberculosis [2, 5]. However, if perforation occurs, the patient presents with the signs and symptoms of peritonitis. Although it is well documented that the incidence of perforation in patients with intestinal tuberculosis varies from 1% to 11%, the majority of these perforations (70%–80%) are not truly perforations of such tubercular ulcers, but are ‘blow outs’ of the small bowel secondary to distension due to distal obstruction (strictures or adhesions). As such, true or ‘free’ perforations are rare, and only a few cases have been reported to the present in the world literature, with an overall mortality rate of nearly 70%. Recently, vasculitis of the mesenteric vasculature due to tuberculosis has been implicated as a contributory factor, but the exact mechanism by which some patients develop perforation and others is not established [5,6,7] . A single perforation is present in 90.0% of cases [2].Multiple perforations occur in 40.0% of patients and are associated with poor prognosis[9].
Caseating necrosis surrounded by chronic inflammatory tissue is the hallmark of tuberculosis. The characteristic histopathology is seen more often in affected lymph node than in the bowel [8, 11]. The symptoms anaemia, lymphocytosis, and elevated ESR, tuberculin test positive in 42.0
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