AUCTORES
Globalize your Research
Case Report
*Corresponding Author: Yanmin XU, Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No 23 Ping Jiang road of HE XI District Tianjin, PR China.
Citation: Yanmin XU. (2021) Compaired Sacubitril/Valsartan with Benalapril on the Left Ventricular Remordeling of Ami after PPCI: A case-control study. Clinical Research and Clinical Trials. 3(1); DOI:10.31579/2693-4779/024
Copyright: © 2021, Yanmin XU. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 31 January 2021 | Accepted: 19 February 2021 | Published: 01 March 2021
Keywords: sacubitril/valsartan; benalapril; left ventricular remordeling; AMI; PPCI
Background: To compare the effect of sacubitril/valsartan with benalapril on left ventricular remodeling in patients with acute myocardial infarction.
Materials and Methods: 85 patients with acute ST segment elevation myocardial infarction who were treated with PCI in the Second Affiliated Hospital of Tianjin Medical University. The patients were randomly divided into two groups: the experimental group (sacubitril/valsartan, 25-100mg/d, BID) and the control group (benalapril, 5-10mg, QD). Color Doppler echocardiography was performed after 1 month and 3 months respectively, interventricular septal thickness, septal motion amplitude, left ventricular end diastolic diameter, left ventricular end systolic diameter, posterior wall thickness, posterior wall motion amplitude, LVEF, left ventricular weight, left ventricular weight index, NT Pro-BNP, gender, height, weight, body surface area were collected. In order to evaluate the influencing factors in the process of ventricular remodeling, binary multivariate logistic regression analysis was carried out for the indicators with statistical differences in the conclusions of the above control study. Subgroup analysis was carried out and the samples were divided into four subgroups according to gender,age, initial ejection fraction .
Resulst: one month after the treatment of sacubitril/valsartan or benalapril, only the left ventricular end systolic diameter was statistically different between the two groups (P < 0.05), and the other indexes were not statistically different. Three months after treatment with sacubitril/valsartan or benalapril, there were statistical differences in the indexes related to myocardial remodeling between the two groups (P < 0.05). The results of multivariate logistic analysis showed that the index of left ventricular end systolic diameter was statistically significant (or=0.006, 95% CI: 0.733-0.981). Acute myocardial infarction whose LVEF is less than 50%, show sacubitril/valsartan is better than traditional ACEI.
Conclusion: sacubitril/valsartan Compared with benalapril is better on left ventricular remodeling in patients with ST segment elevation acute myocardial infarction.
Chronic heart failure is the end stage of many cardiovascular diseases. Development of the HF phenotype in these patients arise from a complex, progressive, molecular and cellular transformation references “ventricular remodeling”, includes dilation of the ventricle, the formation of scar and geometrical charges in the overall left ventricle(LV) shape (i e, ellipsoid to more spherical) and is driven, in part by neurohormonal pathways. Left ventricular remodeling is characterized by a progressive increase in both end-diastolic (LVEDV) and end-systolic volumes (LVESV). The increase in LVESV can precede the increase in LVEDV, as a consequence of an impaired systolic function that causes a reduction in stroke volume. Post infarct remodeling is a specific type of left ventricular remodeling that is a consequence of an increase in both preload and afterload causing an enlargement of ventricular chamber and a hypertrophy of normal myocardium.
The over reaction of renin-angiotensin aldosterone system (RAAS) is an important driving factor. Anggiotensin II (Ang II) can promote the occurrence and development of ventricular remodeling in patients with cardiac insufficiency. As a compound preparation, sacubitrial/valsartan can inhibit the hydrolysis of brain natriuretic peptide and the biological activity of angiotensin-II, antagonize the over activation of neuroendocrine system, and finally achieve the effect of vasodilation, inhibition of ventricular remodeling and reduction of heart burden,The inhibition of brain natriuretic peptidase and the increase of natriuretic peptide level by sacubitril/valsartan (ARNI) is an important means to treat heart failure and fight against ventricular remodeling and the inhibition of RAAS system over activation is also of great significance to delay myocardial remodeling. The synergistic effect of the two mechanisms can significantly improve the therapeutic effect.
The purpose of this study is to explore the improvement of myocardial remodeling in patients with acute myocardial infarction after short-term treatment and long-term treatment by combining with traditional ACEI drugs.
Research subjects
85 patients with acute ST segment elevation myocardial infarction were enrolled who were treated with PCI in the Second Affiliated Hospital of Tianjin Medical University, the patients were randomly divided into two groups: the experimental group (ARNI 25mg-100mg; BID) and the protocol group (benalapril, 5-10mg; QD).
Inclusion/Exclusion criteria were according to the 2013 ACCF/AHA guideline for the management of ST-elexation myocardial infarction:executive summary: a report of the American college of cardiology foundation/American heart Association Task Force on Practice guideline.
Gender, height, weight, body surface area, NT Pro- BNP were collected respectively, interventricular septal thickness, septal motion amplitude, left ventricular end diastolic diameter, left ventricular end systolic diameter, posterior wall thickness, posterior wall motion amplitude, LVEF, left ventricular weight, left ventricular weight index and were collected respectively using Color Doppler echocardiography after myocardial infarction 1 month and 3 months respectively.
The clinical data of the subjects were collected and analyzed: first, the basic information of the patients, such as gender, height, weight, body surface area and other indicators were analyzed to ensure that there is no difference in the basic information of randomly enrolled patients. In addition, NT Pro-BNP, interventricular septal thickness, septal motion amplitude, left ventricular end diastolic diameter, left ventricular end systolic diameter, posterior wall thickness, posterior wall motion amplitude, LVEF, left ventricular weight, left ventricular weight index were analyzed. In order to evaluate the influencing factors in the process of ventricular remodeling, binary multivariate logistic regression analysis was carried out for the indicators with statistical differences in the conclusions of the above control study and the OR value was calculated. Sub group analysis was carried out and the samples were divided into three subgroups according to sex, age, initial ejection fraction. The intervention effect of ARNI on ventricular remodeling in different populations were studied.
SPSS 21.0 software was used to analyze the clinical and examination data. Measurement data was expressed as mean ± standard deviation and T test was used for comparison between groups. P < 0>
85 patients with acute ST segment elevation myocardial infarction who were treated with PPCI in the Second Affiliated Hospital of Tianjin Medical University. The patients were randomly divided into two groups: the experimental group (sacubitril/valsartan), there were 34 males and 14 females and the control group (Benalapril). There were 27 males and 10 females. Average ages is 68.6±12.6 years old.
After 1 month of treatment, there was a significant difference in the end systolic diameter between the two groups (P < 0>Table 1
Three months after treatment with sacubitril/valsartan or benalapril, there were statistical differences in the indexes related to myocardial remodeling between the two groups (P < 0>Table 2
For acute myocardial infarction patients with LVEF ≤ 50%, the treatment of ARNI is more effective than that of traditional drugs. For the patients with low left ventricular ejection fraction (LVEF ≤ 50%), most of them are anterior myocardial infarction, with large infarct area and serious myocardial damage. The cardiac function and structure were obviously abnormal. In the treatment, ARNI is better than traditional medicine. For the patients with higher left ventricular ejection fraction (LVEF > 50%), most of them are inferior myocardial infarction. The left ventricular function and structure of the patients are not seriously damaged and there is no evidence of cardiac dysfunction. After the treatment of two drugs, there was no obvious abnormality in the indexes of myocardial remodeling in this group.Table 3
The indexes with statistical differences, such as the amplitude of interventricular septal motion, the end diastolic diameter of left ventricle, the end systolic diameter of left ventricle, the amplitude of posterior wall motion and LVEF, were analyzed by logistic regression.The results of multivariate logistic analysis showed that the index of left ventricular end systolic diameter was statistically significant or=0.006 (95% CI: 0.733-0.981), Left ventricular end diastolic diameter was dependently risk of remodeling. Table 4
Left ventricular remodeling is characterized by a progressive increase in both end-diastolic (LVEDV) and end-systolic volumes (LVESV). The increase in preload is sustained by the phenomenon of infarct expansion, which is an enlargement of infarct scar. This causes a segmental increase in the ventricular volume subtended by the expanded infarcted myocardial wall. In infarcted myocardium, ventricular contraction is not symmetrical, because the necrotic segments have lost their contractility. As a result, the force generated by the normal remote myocardium during contraction is not counterbalanced by an equal and opposite force, the infarcted ventricular wall is thus stretched by an increased wall tension that is not homogeneously distributed in the left ventricle [1]. Infarcted wall usually has longer contraction times than the healthy myocardium. This wall motion defect has been recognized as a risk factor for the development of remodeling, and it can be assessed with echocardiography or cine CMR to maintain a normal stoke volume with a reduced number of normally working myocardial segments, the healthy myocardium has to produce a greater pressure[2,3]. The increase in afterload on healthy myocardium causes a hypertrophy of cardiomyocytes. In post infarct ventricular remodeling, hypertrophic cardiomyocytes are longer than normal cardiac cells. Post infarct ventricular remodeling was characterized by a lengthening of cardiomyocytes especially in the area surrounding the infarct scar, but also in remote myocardium. This type of ventricular hypertrophy has been termed eccentric and contributes to the worsening of ventricular dilatation during remodeling [4, 5].Cardiac hypertrophy that occurs during post infarct remodeling is accompanied by an increase in extracellular matrix, which is mainly constituted by collagen. The results are due to an increased activity of cardiac fibroblasts in response to different soluble fibrogenic mediators, such as transforming growth factor-II (TGF-II) and systemic and local activation of renin-angiotensin aldosterone system (RAAS). The mediators of the RAAS that promote ventricular remodeling are angiotensin II and aldosterone. Remodeling is a pathologic process that involves the entire ventricle, leading to a change in its global structure. There are two types of causes of remodeling: mechanical and biochemical. While mechanical causes, as previously described, are an increase in both preload and afterload, biochemical causes are linked to the production of soluble mediators capable of promoting ventricular remodeling. antimyocardial remodeling therapy is very important for improving the prognosis of patients with myocardial infarction. The over reaction of RAAS system is an important driving factor. Angiotensin II can promote the occurrence and development of ventricular remodeling in patients with cardiac insufficiency [9]. Angiotensin II can not only promote cardiomyocyte hypertrophy and intercellular glial deposition, but also accelerate the process of cardiomyocyte apoptosis. Under the action of angiotensin II, c-myc, c-jun, c-fos and other genes are highly expressed, which leads to the increase of fetal protein synthesis and cardiomyocyte proliferation. Angiotensin II can also promote the aggregation of inflammatory factors such as endothelin-1, tumor necrosis factor α, interleukin (IL) and other related inflammatory factors under the guidance of at-1r [10]. Through cell signal transduction, angiotensin II can cause cardiac hypertrophy, apoptosis and myocardial fibrosis, and promote the process of ventricular remodeling.The increase of ventricular pressure can stimulate the production and release of natriuretic peptide, promote the excretion of water and sodium, reduce the myocardial pressure and slow down the process of myocardial remodeling[11]. ACEI and these effects play a key role in the process of myocardial remodeling. McMurray and others reports [12] showed that compared with the placebo group from the SOLVD-T study, the relative risk of cardiac end-point events in patients treated with ARNI was reduced by 43%, of which the cardiovascular mortality rate was reduced by 34%, the admission rate of heart failure was reduced by 49%, and the all-cause mortality rate was reduced by 28%.
At present, the related researches mostly use LVEDV, LVESV, ledvi, LVEF, LVM, LVMI and other indicators to evaluate the degree of myocardial remodeling [6, 7, 8]. The indexes of LVEDV, LVESV and LVM in patients with acute myocardial infarction increased significantly, while LVEF and LVMI decreased significantly. Therefore, the experience of myocardial remodeling in patients with acute myocardial infarction can be roughly described as follows: firstly, the compliance of myocardial necrosis with loss of blood supply is decreased, and at the same time, it is affected by intracardiac pressure. At present, there are few related experiments on the treatment of acute myocardial infarction patients with sacubitril/valsartan instead of ACEI / ARB [13, 14, 15]. In this study, we compared the changes of echocardiography related indexes between ACEI and sacubitril/valsartan in patients with acute myocardial infarction after 1 month and 3 months. Sacubitril/valsartan has therapeutic effect on myocardial remodeling in patients with acute myocardial infarction and can improve the prognosis of cardiac function in such patients, but the treatment time is relatively short (1 month). The therapeutic effect is not significantly different from that of traditional ACEI and only has advantages on the improvement of left ventricular end systolic diameter. However, after a long time (3 months) treatment, the therapeutic effect of sacubitril/valsartan is better than that of ACEI in the treatment of myocardial remodeling in patients with acute myocardial infarction. There were significant improvement effects on the parameters such as interventricular septal motion amplitude, left ventricular end diastolic diameter, left ventricular end systolic diameter, posterior wall motion amplitude, LVEF. It may be related to the increase of brain natriuretic peptide level. In the subgroup analysis of this study, Most of the patients with acute myocardial infarction whose LVEF is less than 50% are anterior wall myocardial infarction, with large infarct area and serious myocardial damage. The cardiac function and structure were obviously abnormal. After treated with sacubitril/valsartan is better than traditional medicine. Most of the patients with LVEF greater than 50% were inferior myocardial infarction. The left ventricular function and structure of the patients were not seriously damaged, and there was no evidence of cardiac insufficiency. After the treatment of two drugs, there was no obvious abnormality in the indexes of myocardial remodeling in two group.
Apoptosis of cardiomyocytes is an important pathophysiological mechanism of cardiac dysfunction in patients with acute myocardial infarction. The high expression of Fas and FasL can be measured in cardiomyocytes of rats with acute myocardial infarction, indicating that cardiomyocytes can also suffer from Fas l cytotoxic effect. The upregulation of Fas and FasL expression is the initiation and mediating process of myocardial necrosis and related inflammatory reaction after acute myocardial infarction. Myocardial necrosis and remodeling are common in patients with acute myocardial infarction. Myocardial remodeling will greatly affect the quality of life and prognosis of patients with myocardial infarction. Therefore, anti-myocardial remodeling therapy is very important for improving the prognosis of patients with myocardial infarction [16, 17, 18].
As a compound preparation, sacubitril/valsartan can inhibit the hydrolysis of brain natriuretic peptide and the biological activity of angiotension-II, antagonize the over activation of neuroendocrine system, and finally achieve the effect of vasodilation, inhibition of ventricular remodeling and reduction of heart burden [19, 20].
There are still some shortcomings and many limitations exit in this study. First of all, the number of cases in this study is small, and the research results may be one-sided, which needs to be further studied by large samples and multi-centers. Secondly, most of the myocardial remodeling occurred in the patients with anterior myocardial infarction. In this study, the number of patients with anterior myocardial infarction was small, and the treatment effect of the patients with inferior myocardial infarction was negative in the comparative study, so there was a deviation in the evaluation of the therapeutic effect of sacubitril/valsartan. Finally, in this study, the dosage of sacubitril/valsartan did not fully comply with the guidelines and it was confirmed by experiments that the application of 4 weeks can have beneficial effects on myocardial remodeling and is linearly related to the dosage of the drug.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
