AUCTORES
Globalize your Research
Review
*Corresponding Author: Aamir Jalal Al-Mosawi, Advisor doctor and expert trainer, The National Center of Training and Development and Baghdad Medical City, Baghdad, Iraq.
Citation: Aamir Jalal Al-Mosawi, (2024), Unveiling Adult Polycystic Kidney Disease: Historical Perspectives and Evidence-Based Management Approaches ,Clinical Medical Reviews and Reports; 6(9): DOI: 10.31579/2690-8794/242
Copyright: © 2024 Aamir Jalal Al-Mosawi,, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 08 November 2024 | Accepted: 15 November 2024 | Published: 22 November 2024
Keywords: Adult polycystic kidney disease; early diagnosis; evidence-based therapies; expert opinion.
Background: Adult polycystic kidney disease is an important contributor to chronic renal failure, marked by a highly variable clinical trajectory and progression to chronic renal failure. Diagnosis typically relies on ultrasound imaging, with genetic testing being less commonly necessary. Management strategies aim to delay the onset of chronic renal failure or slow its progression, involving interventions such as antihypertensive medications, dietary protein restriction, and prompt treatment of urinary tract infections.
This paper aims to present the case of an Iraqi patient diagnosed early, prior to the onset of renal failure, and to outline evidence-based treatment options.
Patients and methods: A thirty-year-old female with recurrent urinary tract infections sought evaluation following her uncle's recent diagnosis of chronic renal failure due to adult polycystic kidney disease. Her uncle had developed progressive symptomatic uremia at age 52, accompanied by gradual hearing loss, a rare association with this condition. Her aunt had succumbed to chronic renal failure.
Results: The patient exhibited normotension and renal function tests revealed normal values. A renal ultrasound depicted normal-sized kidneys with multiple cysts observed bilaterally, with the largest measuring 3 centimeters, confirming the diagnosis of adult polycystic kidney disease.
Conclusion and expert opinion: This article delves into the realm of adult polycystic kidney disease, offering insights into its historical context, diagnostic methods, and evidence-based management strategies. Beginning with the earliest recorded case in history, the narrative progresses through key milestones in understanding the disease, emphasizing diagnostic techniques such as ultrasound imaging. The current evidence-based expert opinion suggests that the long-term use simvastatin plus octreotide-long-acting release monthly injection in patients with adult polycystic kidney disease to slow the growth of cysts and the deterioration in renal function. The use of tolvaptan can also be considered, but it is associated increased adverse effects such as thirst, polyuria, and hepatic injury.
Adult polycystic kidney disease is an important contributor to chronic renal failure, marked by a highly variable clinical trajectory and progression to chronic renal failure. Diagnosis typically relies on ultrasound imaging, with genetic testing being less commonly necessary. Management strategies aim to delay the onset of chronic renal failure or slow its progression, involving interventions such as antihypertensive medications, dietary protein restriction, and prompt treatment of urinary tract infections [1-4].
Stephen Báthory (Figure-1A), a Polish king, is the earliest recorded individual with adult polycystic kidney disease. After dying at about the age of 53 years, and during post-mortem procedures aimed at preserving his body as a mummy, his surgeon, Jan Zigulitz, assisted by Dr. Buccella, noted the enlarged, irregularly surfaced kidneys resembling those of a bull.
Figure-1A: Stephen Báthory (September 27, 1533-12 December 12, 1586), King of Poland and Grand Duke of Lithuania (1576-1586)
However, at that time, the king's death was not attributed to renal disease. In 1933, Franciszek Walter (Figure 1B), a professor from Krakow Medical School, convened a meeting of physicians and historians to analyze the abnormalities observed during the king's autopsy. It was concluded that the king succumbed to uremia resulting from polycystic kidney disease.
In 1793, Matthew Baillie (Figure 1C) distinguished the vesicular cysts characteristic of this disorder from hydatid cysts, coining the term “False hydatids of the kidney.”
Figure-1B: Professor Franciszek Ksawery Walter (1885-1950)
Figure-1C: Matthew Baillie (October 27, 1761-September 23, 1823), a British physician and pathologist
In 1888, Félix Lejars (Figure-1D) from Paris emphasized that the cysts in this condition were present on both sides and named the condition “Polycystic kidney”.
Figure-1D: Félix Lejars from Paris
In 1983, Szabó and colleagues highlighted the utility of diagnostic ultrasound for early detection of polycystic kidney disease, a practice increasingly recognized as reliable [2].
This paper aims to present the case of an Iraqi patient diagnosed early, prior to the onset of renal failure, and to outline evidence-based treatment options.
Patients and methods
A thirty-year-old female with recurrent urinary tract infections sought evaluation following her uncle's recent diagnosis of chronic renal failure due to adult polycystic kidney disease. Her uncle had developed progressive symptomatic uremia at age 52, accompanied by gradual hearing loss, a rare association with this condition. Her aunt had succumbed to chronic renal failure.
The patient exhibited normotension and normal echocardiographic findings. Renal function tests revealed normal values (serum creatinine: 0.6 mg/dL, blood urea: 19 mg/dL). A renal ultrasound (Figure-2) performed on January 6, 2024, depicted normal-sized kidneys with typical texture and cortical thickness. Multiple cysts were observed bilaterally, with the largest measuring 3 centimeters, confirming the diagnosis of adult polycystic kidney disease.
Management strategies for adult polycystic kidney disease focus on delaying the onset or slowing the progression of chronic renal failure through interventions such as antihypertensive therapy, dietary modifications, and prompt treatment of urinary tract infections.
In 1996, Maschio et al. reported a three-year placebo-controlled study which included 583 patients with renal insufficiency resulting from a variety of diseases, and included 64 patients with adult polycystic kidney disease. Three hundred patients were treated with an angiotensin-converting-enzyme inhibitor, benazepril, while 283 patients were treated with placebo.
After three years, thirty-one patients who received benazepril experienced doubling of the base-line serum creatine level or required for dialysis, while fifty-seven patients who received placebo experienced doubling of the base-line serum creatine level or required for dialysis (P<0>However, the study found that although benazepril had a protective effect against the progression of renal insufficiency in several kidney diseases, it was not effective in polycystic kidney disease [5].
Figure-2: Renal ultrasound confirming the diagnosis of adult polycystic kidney disease
In 2001, van Dijk et al. from the Netherland emphasized that experimental animal studies showed that Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, the statins can retard the progression of chronic renal insufficiency. They reported a clinical study which included ten patients adult polycystic kidney disease who had normal cholesterol level whom were treated in random order for one month with simvastatin 40 mg a day or placebo.
Simvastatin treatment was associated with marked increase in glomerular filtration rate and, effective renal plasma flow (P<0>
In 2005, Piero Ruggenenti from Italy and his research group proposed somatostatin as a therapeutic avenue, theorizing its inhibitory effect on fluid secretion within renal cysts, thereby impeding cyst expansion. The renal cysts in adult polycystic kidney disease are filled with fluid secreted mostly by the tubular epithelium lining the cysts through secondary chloride transport.
They thought that the fluid filling can possibly be inhibited by somatostatin resulting in shrinkage of the cysts. They reported a six-month cross-over, placebo-controlled study which included patients with mild-to-moderate renal insufficiency caused by autosomal-dominant adult polycystic kidney disease. Twelve patients were treated with octreotide-long-acting release (A long-acting somatostatin) 40 mg intramuscularly four weekly.
The increase in renal volume was markedly lower in patients treated with somatostatin than in patients who received placebo. Ruggenenti and his research group reported that the use of somatostatin for six months was well tolerated and safe, and can slow the expansion of renal volume in adult polycystic kidney disease. Therefore, somatostatin treatment can inhibit growth of smallest cysts.
Their study demonstrated reduced renal volume expansion in patients with adult polycystic kidney disease treated with octreotide-long-acting release [7].
In 2010, Anna Caroli from Italy and her research group reported a post hoc analysis of the study of Piero Ruggenenti from Italy and her research group reported that octreotide treatment also reduced liver volumes in the patients with adult polycystic kidney disease [8].
Also in 2010, Marie C Hogan from the United States and her research group reported favorable outcomes with octreotide treatment in patients with autosomal dominant polycystic kidney and liver disease, with reductions in liver and kidney volumes.
They reported a one-year placebo-controlled study which included 42 patients with autosomal dominant polycystic kidney and liver disease (34 patients had polycystic kidneys and 8 had polycystic liver disease). Twenty-eight patients were treated with octreotide-long-acting release depot (A long-acting somatostatin analogue) up to 40 mg every four weeks (+/-5 days), and fourteen patients received placebo.
Octreotide treatment was associated with reduction in liver volume, while liver volume almost remained unchanged in the patients who received placebo (P=0.048). Octreotide treatment prevented the increase kidney volume, while the patients who received placebo experienced an increase in kidney volume (P=0.045). Changes in GFR were similar in both groups. Octreotide was found to be well-tolerated and was considered to have acceptable side effects.
In 2011, Maria V Irazabal from the United States and her research group emphasized the preliminary evidence from experimental studies suggesting that tolvaptan (Specific vasopressin receptor antagonists) can retard disease progression in polycystic kidneys animal models.
They reported a study which included twenty patients with adult polycystic kidney disease which showed that tolvaptan treatment can markedly decrease total kidney volume and renal cyst volume especially of larger cysts when the renal function is maintained. The effect of tolvaptan was attributed to inhibition of V (2)-driven adenosine cyclic 3, 5-monophosphate generation and to the aquaretic effect (Promotion of the excretion of water without electrolytes) [10].
Also in 2011, Higashihara et al. from Japan showed highlighted tolvaptan's efficacy in cyst growth retardation in adult polycystic kidney disease in 2011, despite concerns regarding its long-term safety [11].
In 2012, Torres et al from the United States and their collaborators reported a placebo-controlled study which included 1445 patients adult polycystic kidney disease, and showed that a three-year tolvaptan treatment retarded the increase in total renal volume and slowed the loss of renal function, but tolvaptan was associated with a higher discontinuation rate than placebo because of the occurrence of adverse side effects [12].
In 2013, Caroli et al. from Italy and their collaborators reported a three-year placebo-controlled study which included 75 patients with adult polycystic kidney disease. 38 were treated with two 20 mg intramuscular injections of octreotide-long-acting release, and 37 patients received placebo.
At one year, MRI studies showed that octreotide-long-acting release treatment was associated with much less increase in total kidney volume. It was possible to study thirty-five patients treated with octreotide-long-acting release, and thirty-five patients who received placebo with MRI at three years. Octreotide-long-acting release treatment was again associated with less increase in total kidney volume
Thirty-seven patients treated with octreotide-long-acting release, and thirty-two patients received placebo experienced at least one adverse effect (p=0·16). Patients with serious adverse effects were similarly distributed in the treated patients and in the patients received placebo. Nevertheless, four patients treated with octreotide-long-acting release experienced acute cholecystitis or cholelithiasis [13].
In 2019, Norberto Perico from Italy and his research group reported octreotide's efficacy in slowing cyst and kidney growth and delaying progression to end-stage renal disease, with fewer serious infections compared to placebo. They reported a study which included 100 patients adult polycystic kidney disease who had glomerular filtration rate between 15 to 40 ml/min/1.73 square meters.
Fifty-one patients were treated with two intramuscular injections of 20 mg octreotide-long-acting release every four weeks for 3 years, forty-nine patients received placebo.
The study showed that octreotide-long-acting release treatment can slow growth of cysts and kidneys and slow the progression to end-stage renal disease. Of 63 patients with chronic kidney disease stage 4, three of the patients treated with octreotide-long-acting release, and eight of the patients received placebo developed end-stage renal disease (P = 0.036). Three of the patients who received placebo experienced a serious renal cyst rupture/infection and one patient developed a serious urinary tract infection/obstruction. However, only one patient of the patients treated with octreotide-long-acting release experienced a serious infection of renal cyst [14].
In 2023, Lu et al. from China conducted a meta-analysis affirming tolvaptan's efficacy in preserving renal function and reducing complications in adult polycystic kidney disease, notwithstanding increased adverse effects. Their meta-analytic study included 13 placebo-controlled studies which included 3575 patients with adult polycystic kidney disease. The study showed that tolvaptan treatment was associated with slowing of the deterioration in renal function, slowing the increase in total kidney volume, and reduction of complications including renal pain, urinary tract infections, hematuria, and hypertension.
However, tolvaptan increased adverse effects such as thirst, polyuria, and hepatic injury [15].
This article delves into the realm of adult polycystic kidney disease, offering insights into its historical context, diagnostic methods, and evidence-based management strategies. Beginning with the earliest recorded case in history, the narrative progresses through key milestones in understanding the disease, emphasizing diagnostic techniques such as ultrasound imaging.
The current evidence-based expert opinion suggests that the long-term use simvastatin plus octreotide-long-acting release monthly injection in patients with adult polycystic kidney disease to slow the growth of cysts and the deterioration in renal function. The use of tolvaptan can also be considered, but it is associated increased adverse effects such as thirst, polyuria, and hepatic injury.
Acknowledgment
Some of the figures in this paper were included in previous author’s publications, but the author has the copyright of all the figures and sketches included in this paper.
Conflict of interest: None.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
