AUCTORES
Globalize your Research
Review Article
*Corresponding Author: Yuri Pivovarenko. Research and Training Center ‘Physical and Chemical Materials Science’ Under Kyiv Taras Shevchenko University and NAS of Ukraine, Kiev, Ukraine.
Citation: Yuri Pivovarenko, (2024), Sodium chloride as an antitumor agent, J Thoracic Disease and Cardiothoracic Surgery, 5(4); DOI:10.31579/2693-2156/098
Copyright: © 2024, Yuri Pivovarenko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 14 May 2024 | Accepted: 31 May 2024 | Published: 07 June 2024
Keywords: cancer; hyponatremia; salt-free diet
It was previously assumed that positive electrization of the human internal environment contributes to cancer. To verify the validity of this assumption, its correlation with the phenomena accompanying cancer is checked. One such phenomenon is cancer-associated hyponatremia, that is, a decrease in the concentration of sodium ions in the blood plasma of cancer patients. So, checking to what extent the stated assumption correlates with cancer-associated hyponatremia, allowed concluding that both positive electrization of the human internal environment and any hyponatremia contribute to cell overhydration. In addition, it has been shown that the ability of sodium ions to positively electrify aqueous media correlates with their ability to retain water. All this, accordingly, led to the conclusion that both positive electrization of the human internal environment and hyponatremia contribute to cell overhydration and, consequently, their transformation into cancer cells. Naturally, all this led to the conclusion that normalizing the content of sodium ions in the blood plasma prevents the occurrence of cancer, while a salt-free diet contributes to its occurrence.
So, it was previously established that positively charged water (i.e., water enriched with uncompensated protons) has exceptionally high both penetrating and hydration abilities [1-5]; it seems that the fact that positively charged water dissolves even graphite (Figure 1), which is considered water-insoluble [6], should be considered as convincing confirmation of the exceptionally high both hydration and penetration capacities of such water.
Figure 1. This is a solution obtained by vigorously shaking graphite powder with positively charged water. It is noteworthy that sediment does not appear in this solution for many years (it is worth taking into account that graphite is considered insoluble in water [6].
Since positively charged water exhibits both of these abilities in relation to various substances, including biopolymers [1-5], over time, it was assumed that this particular water is capable of overhydration cells, thereby promoting their proliferation [2] and, as a consequence, tumor growth [3-5].
(It should be added here that the hypothesis that it is cell hydration that is the primary factor in carcinogenesis was previously put forward by McIntyre [7-8]; thus, the idea was already in the air that it was the increased hydration of cells that turns them into cancer cells.)
It is worth noting here that probably the most direct confirmation of this assumption was obtained by comparing the UV absorption spectra of DNA and RNA solutions prepared in oppositely charged waters with the UV absorption spectra of aqueous suspensions of lymphocytes from healthy people and patients with B-CCL (this abbreviation stands for B-cell chronic lymphocytic leukemia) (Figure 2) [1, 9].
Figure 2. UV absorption spectra of aqueous suspensions of lymphocytes: 1 – suspension of lymphocytes from healthy individuals; 2 – suspension of lymphocytes from patients with B-CCL; both spectra were recorded contra air [7]).
Comparison of these spectra with the UV absorption spectra of DNA and RNA solutions prepared in oppositely charged waters indicates that the nucleic acids of healthy people are in a negatively charged aqueous environment, and the nucleic acids of patients with B-CCL are in a positively charged aqueous environment [1, 9].
Apparently, it is worth adding here that this comparison itself showed the potential possibility of obtaining UV absorption spectra of nucleic acids located in cells.
Despite receiving direct confirmation of this very assumption (Figure 2), additional discussion of its adequacy does not seem superfluous. Therefore, this adequacy is discussed here taking into account the hyponatremia characteristic of cancer patients, that is, the reduced concentration of sodium ions in their blood plasma [10-13].
Firstly, it is worth taking into account that sodium ions are characterized by “positive hydration”, while potassium ions are characterized by “negative hydration” [14]. To better understand what both of these characteristics mean, it is worth comparing the shapes of the precipitates formed by the sodium and potassium salts of DNA (Figure 3). It is also worth considering that the fibers formed precisely by sodium salts of DNA are highly hydrated [15]. Moreover, one can conclude that it is the high hydration capacity of sodium ions that allows the sodium salts of DNA to aggregate, forming fibers (Figure 3, left); in other words, it is the high hydration capacity of sodium ions that converts sodium salts of DNA into hydro gels with adhesive properties. At the same time, one can conclude that it is the dehydration ability of potassium ions that deprives potassium salts of DNA of the ability to aggregate (Figure 3, right).
Apparently, the concepts of “negative hydration” of potassium ions and “positive hydration” of sodium ions [14] also agree well with the fact that potassium ions penetrate biological membranes much more easily than sodium ions [16-17], although the diameter of the potassium ion is greater than the diameter of the sodium ion, since the diameter of the potassium atom is greater than the diameter of the sodium atom [6].
Figure 3. These are precipitates of the sodium (left) and potassium (right) salts of DNA formed in water with a potential of –300 mV: it is obvious that the precipitates of the sodium salt of DNA form fibers, while the precipitates of the potassium salt of DNA are a fine powder. To increase contrast, a phenazine dye, which is well absorbed by DNA salts, was added to both waters used.
Due to the predominantly negative potential of the intracellular environment [16-17] surrounding DNA in vivo, exclusively water with a negative potential was used here [18].
Finally, it is worth considering that, as a rule, the extracellular environment, including blood, is enriched with sodium ions and has a predominantly positive potential, while the intracellular environment is enriched with potassium ions and has a predominantly negative potential [16-17].
After summing up all these ideas and facts, it seems quite likely that it is the ability of sodium ions to positively electrify the extracellular environment that allows it to retain water; therefore, it is likely that hyponatremia reduces the positive potential of the blood plasma and, as a consequence, its ability to retain water outside the cells, both the blood itself and outside the cells surrounding the vessels, thereby promoting their overhydration. It is no less likely that the ability of potassium ions to negatively electrify the intracellular environment does not contribute to the overhydration of any cells. One way or another, all this is in good agreement with the assumption, the adequacy of which is being verified [3-5].
It is worth noting here that all of the above is in good agreement with the fact that cancer stem cells are highly depolarized compared to normal stem cells [19], as well as with the hypothesis that the intracellular concentration of sodium and other elements is related to mitogenesis and oncogenesis [20]. (In any case, all of the above provides additional arguments in favor of the hypothesis that the electrical potential of the tissue fluids of living organisms determines their hydration abilities and, therefore, is an epigenetic factor [21].
Apparently, it is quite appropriate here to provide additional confirmation of the superiority of the hydrating abilities of sodium ions over the hydrating abilities of potassium ions, if any. To obtain the same confirmation, mix unrefined oil containing free fatty acids with ~0.15 M aqueous solutions of sodium and potassium chlorides and shake vigorously. Over time, it will become clear that the emulsion formed by oil with an aqueous solution of sodium chloride does not separate completely (Figure 4, left), unlike the emulsion formed by oil with an aqueous solution of potassium chloride (Figure 4, right).
Figure 4. Over time, emulsions obtained by vigorously shaking unrefined oil with ~0.15 M aqueous solutions of sodium chloride (left) and potassium chloride (right) acquire this appearance. It can be seen that sodium ions are much stronger emulsifiers than potassium ions. The arrow indicates a layer of emulsified oil that persists for a long time in the presence of sodium ions.
After this, it is worth considering that blood is actually a water emulsion. If we take this into account together with the result obtained (Figure 4, left), it turns out that it is sodium ions that provide hydration of non-aqueous blood components, thereby maintaining their emulsified state. From the point of view of the topic under discussion, it is important that the emulsifying ability of sodium ions is comparable to the emulsifying ability of positively charged water (Figure 5, left); perhaps the obvious similarity of the right parts of Figures 4 and 5 should also be taken into account.
Figure 5. Suspensions formed by intensive mixing of liquid oils with positively charged water do not delaminate for several hours, retaining a milky white or yellowish colour (left); suspensions formed by intensive mixing of the same oils with negatively charged water separate within minutes (right) [3-5].
Although the above arguments, which are rather purely physicochemical, seem quite convincing, it is also worth considering the possibility of a more biochemical correspondence between the hyponatremia of cancer patients and the hypothesis being tested. In this regard, it is worth analyzing the consequences of excessive hydration of red blood cells, which do not transform into cancer cells because they cannot divide. So, given that sodium chloride retains water in the blood plasma, it is likely that hyponatremia causes overhydration of red blood cells and, therefore, impairs their ability to carry oxygen, thereby causing symptoms of iron deficiency anaemia, which is common in cancer [22-27]. This, in turn, causes patients with hyponatremia to have to breathe more frequently, which inevitably saturates their body with oxygen gas, which is an obvious precursor to superoxide anions and other reactive oxygen species (ROS), which are now believed to cause cancer [28-30]. So, given this belief, the link between hyponatremia and cancer seems quite clear. Despite this clarity, the involvement of ROS in cancer development is worthy of discussion in terms of the assumption being discussed.
So, it seems quite clear that the generation of mitochondrial superoxide anions [31-35], which are precursors of other ROS, is undoubtedly accompanied by the release of protons:
O2 + H● → O2– + H+ (1).
Figure 6. This is a typical diagram of a working mitochondrion: during oxidative phosphorylation, molecular oxygen is converted into superoxide anions and hydrogen atoms into protons, which are released by mitochondria, according to [31-35].
Therefore, in the presence of molecular oxygen, mitochondria become sources of intracellular protons (Figure 6).
This, in accordance with the assumption made, suggests that it is the protons generated by mitochondria in parallel with superoxide anions [1] that directly cause tumor growth; thus, it is likely that ROS are merely by-products accompanying proton generation and are not the root cause of cancer, contrary to what is currently believed [31 – 35].
To complete the discussion, it is worth considering the fact that a decrease in the concentration of salts in aqueous media, including sodium chloride, increases their ability to dissolve gases, including molecular oxygen [6], in the presence of which mitochondria produce both superoxide anions and protons, according to equation [1] and Figure 6.
This, accordingly, suggests that hyponatremia simultaneously promotes the synthesis of superoxide anions and protons in the mitochondria [1], which may be equally responsible for the development of cancer, especially given the catalytic properties of positively charged water [5].
Anyway, it looks like this discussion was very productive. In any case, it was this discussion that demonstrated the absence of fundamental contradictions between hyponatremia in cancer patients and the assumption being discussed. Moreover, it seems that it was this discussion that demonstrated the unity of the mechanisms that cause overhydration of cells both during positive electrization of the human internal environment and during hyponatremia. It is equally important that during this discussion the adequacy of Macintyre’s hypothesis [12-13] was confirmed.
Thus, there is no doubt that normalizing the sodium chloride content in the blood plasma of cancer patients makes it possible to restore its ability to retain water and thereby increase the effectiveness of various types of anticancer therapy. Given this, a salt-free diet should be considered as promoting the development of hyponatremia and, therefore, cancer.
Moreover, it can be expected that increasing the concentration of sodium chloride in the human body can stop the development of cancer. In any case, the available experimental data justify such expectations. Thus, it was found that a reduced concentration of sodium chloride in the environment of cancer cells stimulates the division of their DNA, and an increased concentration of sodium chloride in the same environment stops DNA division in cancer cells, but stimulates the synthesis of RNA and peptides in them [36]. All this, in particular, suggests that an increased concentration of sodium chloride in the external environment of cancer cells promotes their differentiation and, as a consequence, transformation into normal cells.
Apparently, it is appropriate to add here that literally hyponatremia can be eliminated with the help of other sodium salts. In this regard, the first thing to suggest is sodium hydrocarbonate, that is, baking soda. So, it is this assumption that takes into account the fact that the buffering properties of human biological fluids are based, at least in part, on the buffering properties of aqueous solutions of hydrocarbonates [37-38]. In terms of the assumption under discussion, it is especially important that it is hydrocarbonate anions that make it possible to permanently remove protons from the human body due to such a reaction:
H+ + HCO3– ↔ H2CO3 → CO2↑ + H2O (2) [6].
In any case, it is likely that increasing the buffer capacity of the human body due to additional hydrocarbonates can significantly increase the effectiveness of using hydrogen gas as an anticancer agent [39-40], since it is blood hydrocarbonates that can neutralize the protons undoubtedly produced during hydrogen therapy, according to equation [1]; it seems clear that this assumption is based on equation [2]. It is worth noting here that this assumption is supported by the ability of baking soda to increase the effectiveness of anti-cancer drugs in general [41].
It is worth noting that both sodium chloride and sodium bicarbonate are common and evolutionarily fixed components of the human body [37-38, 42]. This, accordingly, gives every reason to believe that the human body is able to control both, thereby avoiding the undesirable consequences of their overdose.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
