Using Artificial Intelligence-Based 3D Smile Design: REBEL in Prosthetic Rehabilitation with Patient's Personal Preferences. Case-1

Research Article | DOI: https://doi.org/10.31579/2690-1919/367

Using Artificial Intelligence-Based 3D Smile Design: REBEL in Prosthetic Rehabilitation with Patient's Personal Preferences. Case-1

  • Soumia A Al-Maghreby 1
  • Abdulwahab I Al-kholani 2*
  • Arwa Al-maswari 3
  • Anas Abdulwahab Al-Kholani 1

1 Postgraduate Dental Student, Restorative and Esthetic Dentistry Department, Faculty of Dentistry, Sana’a University, Sana’a, Yemen.

2 Professor of Restorative Dentistry, Dental Implant Consultant, Restorative and Esthetic Dentistry Department, Faculty of Dentistry, Sana’a University, Sana’a, Yemen.

3 Assistant professor of Restorative Dentistry, Dental Implant Consultant, Restorative and Esthetic Dentistry Department, Faculty of Dentistry, Sana’a University, Sana’a, Yemen.

*Corresponding Author: Abdulwahab Ismail Al-Kholani, Professor of Restorative Dentistry, Dental Implant Consultant, Restorative and Esthetic Dentistry Department, Faculty of Dentistry, Sana’a University, Sana’a, Yemen.

Citation: Soumia A Al-Maghreby, Abdulwahab I Al-Kholani, Arwa Al-maswari, Anas Abdulwahab Al-Kholani, (2024), Using Artificial Intelligence-Based 3D Smile Design: REBEL in Prosthetic Rehabilitation with Patient's Personal Preferences. Case-1, J Clinical Research and Reports, 15(4); DOI:10.31579/2690-1919/367

Copyright: © 2024, Abdulwahab Ismail Al-Kholani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 03 April 2024 | Accepted: 15 April 2024 | Published: 30 April 2024

Keywords: psychological; prosthetic rehabilitation; dental implant

Abstract

Each smile is unique, and smiles reflect the different shapes, textures, and colors of the teeth and their combinations. When creating a new smile design dentists need to consider the biology, structure, function, and esthetics to create the fifth dimension of the smile. This approach is completely different from the conventional one. A smile reflects the personality and emotional state of the patient, and the translation of this into a new smile design occurs either by analog methods or digitally. A smile is a person's ability to express a wide range of emotions with the movement and structure of the teeth, dentofacial, esthetic lips, social and psychological (Rambabu et al, 2018) it also determines how well a person functions in society. When a person has a harmonious smile (Paolucci et al, 2012) it is always assumed that it increases self-esteem and their ability to interact properly and more confidently in their surroundings.

Introduction

Each smile is unique, and smiles reflect the different shapes, textures, and colors of the teeth and their combinations. When creating a new smile design dentists need to consider the biology, structure, function, and esthetics to create the fifth dimension of the smile. This approach is completely different from the conventional one. A smile reflects the personality and emotional state of the patient, and the translation of this into a new smile design occurs either by analog methods or digitally. A smile is a person's ability to express a wide range of emotions with the movement and structure of the teeth, dentofacial, esthetic lips, social and psychological (Rambabu et al, 2018) it also determines how well a person functions in society. When a person has a harmonious smile (Paolucci et al, 2012) it is always assumed that it increases self-esteem and their ability to interact properly and more confidently in their surroundings.

In the last two decades, smile designing has progressively evolved from physical analog to digital designing which has advanced from 2D to 3D.

Smile esthetics concerns represent one of the most important issues of daily dental treatments. Regardless of the cases' difficulty, the patients usually look for better-looking smiles. Often the final esthetic results may fail to meet the patient's expectations due to disharmony between the smile design and the patient's identity.

To achieve an optimal esthetic result from dental treatment, we need to create a suitable smile design that satisfies patients’ expectations largely influenced by psychological features of character, social status, and education (Gurel, 2020; Paolucci et al, 2012). 

Various DSD software products are available but do not consider the personality factor in designing the smile (Omar and Duarte, 2018).

Before initiating any treatment, it is necessary to visualize the desired outcomes. It then becomes possible to formulate the steps required to achieve this result.

The fifth dimension of the smile

The smile design in dentistry so far till recent years has been based on four dimensions: biology, structure, function, and aesthetics. The esthetic parameters were dependent on age, gender, and sex. However, in reality, none of these dimensions took into consideration the personality of the patient, even though a 'perfect' smile design should reflect this. Patient identity, which includes personality, is therefore the fifth dimension of the smile.

The key to this translation of the patient's personality and feelings into the new smile design is visual language.

Visual Language

Each type of line or shape has a specific emotional meaning. 

Lines represent the most basic elements of visual language. Horizontal lines, because they conform to gravity, express stability, passivity, and calmness. In contrast, vertical lines represent the movement of the point against gravity, expressing strength and power, just as inclined lines arouse the sensation of instability, tendency to movement, and dynamism. Curved lines are associated with delicacy, sensuality, and feminine gender (Figure. 1a-d) and (Figure. 2a-d).

The combination of lines generates the most basic forms, transferring to them their expressions. 

Thus, the vertical rectangle expresses strength by the predominance of the vertical element on the horizontal, the triangle dynamism, the oval delicacy, the square stability, and immobility by the balance between its vertical element and the horizontal one. These basic shapes can be observed in the facial contour as well as in the shapes of the incisors and the three-dimensional configuration of the dental arrangement.

Figure 1a-d. vertical lines and rectangular shapes express strength due to the predominance of the vertical element on the horizontal (a) the horizontal line expresses stability and immobility due to the balance between the vertical and horizontal elements (b) the inclined lines and triangular shapes express dynamism (c), and the oval and round snape express delicacy (d). 

Figure 2a-d. (a) vertical lines and rectangular shapes express strength due to the predominance of the vertical element on the horizontal the inclined lines and triangular shapes express dynamism (b). the oval and round snape express delicacy (c), and the horizontal line expresses stability and immobility due to the balance between the vertical and horizontal elements (d).

The knowledge of the visual language is therefore applied to the main expressive elements of a smile design (dental shapes, incisal edge, interdental ratio dominance, and 3D positioning of the teeth in the arch). It determines the following four smile design types (Figure. 3).

Figure 3. The visual language knowledge applied to the main expressive elements of smile design such as dental shapes, incisal edge, interdental ratio or dominance, and 3D positioning of the teeth in the arch determined four smile design types with primary expression, from top to bottom: strong, dynamic, delicate, and calm.

Strong: The design is composed mainly of rectangular dental shapes, strong dominance of the central incisors and canines on the lateral incisors (radial symmetry) as well as plane incisal edge and rectilinear 3D dental positioning on the arch in the occlusal view.

Dynamic: Triangular or trapezoidal dental shapes, standard dominance, inclined incisal edge, and angled 3D dental positioning on the arch.

Delicate: Oval dental shapes, medium dominance, curved incisal edge, and standard 3D dental positioning.

Calm or stable: Smoothly rounded square dental shapes, weak dominance (current symmetry), horizontal incisal edge, and 3D rectilinear or standard dental positioning on the arch.

The Rebel software

Rebel software is an artificial intelligence-based program that enables the simultaneous generation of stereolithography (STL) files of digital wax models.

Software for creating a customized smile that takes into account the patient’s personality, and biological, structural, functional, and aesthetic parameters to create a three-dimensional smile.

The Dellinger and Eysenck personality tests give insights about the patient’s personality and enable the dentist to directly feed the data into the software and patient preferences, and personality, and the facial analysis is formulated into a mathematical formula wherein the 2D image is designed and transformed into a 3D smile design.

Including the patient’s personality in the design of the smile will enable clinicians to offer patients new smiles that reflect them holistically.

It is considered to be an online facility that produces three-dimensional, custom smile designs (Sanketh, et al. 2023).

 

Esthetic Analysis and Rebel Simplicity

Esthetic design can be challenging for clinicians and dental technicians. Rebel Simplicity is a recent digital previsualization technique that allows the dentist to:

– Perfectly design the new smile;

– Improve the communication between the dental team members involved in the treatment;

– Obtain better communication and achieve better patient motivation; and

– Visualize the final esthetic result even before the treatment is started.

3D Rebel smile design plays an important role in temporaries during different steps of treatment procedures.

This method makes it possible to share the treatment plan among team members and to create a 3D visualization of the case in the patient’s mouth. The digital project will be tested and approved before starting the actual treatment. Accordingly, it will allow the dentist to present the appropriate therapeutic solutions.

Case presentation -1

A woman of age 55 required esthetic prosthetic rehabilitation of her teeth. The patient is not satisfied with her teeth. After the full-face picture of the patient with an Intraoral view was taken (Figs.4a-c).  The main complaint is the poor esthetic appearance, teeth discoloration, poor old restorations, generalized gingival recession, periodontitis with pus discharge, and inappropriate old Class III composite restorations in all anterior teeth.

In the first visit, digital impressions of both arches were taken. A complete photographic protocol was followed according to the Rebel Simplicity protocol.   

Figure 4a-c. Intraoral view shows the poor esthetic appearance, teeth discoloration, poor old restorations, generalized gingival recession, periodontitis with pus discharge, and inappropriate old Class III composite restorations in all anterior teeth.

Esthetics-based treatment planning

A workflow for an esthetic case starts with the collection of the data, history of the patient, clinical findings, X-rays, models, photos, and maybe videos. Then one of the most important parts of the whole step is to start communicating with the patient regarding their expectations from this esthetic treatment (Trushkowsky, 2020).

The most important step of the workflow is the design part; however, at this stage, verbal communication is not enough. Any esthetic procedure is very subjective, and without materializing the esthetic smile design, it will not be possible for the dentist to explain what he/she would want to deliver to the patient at the end of the treatment (Figure. 5).

Figure 5. The most important part of the workflow is the design part. This is the heart of any esthetic treatment that will differentiate a more committed dentist from an average one. The final esthetic smile design and treatment planning should also be based on this mockup, which should fulfill the expectations of the patient.

The Rebel workflow

Rebel provides the simplest steps for transferring all the necessary information to the Rebel digital laboratory.

These are the three mandatory steps:

1. Single central incisor mock-up and intraoral digital scanning.

2. A full-face photographic protocol.

3. A Simple interview/questionnaire.

  1. Single central incisor mock-up and intraoral digital scanning

In certain circumstances, a composite mock-up is performed on one (or two) of the central incisors to identify the incisal edge position vertically and the position of the facial surface buccolingually. In this case, the central incisor mock-up is not indicated (Figure 6).

Figure 6. This figure illustrates the intraoral digital scan.

2. Full-face photography protocol

The software needs to have a five full-face photography protocol to get the facial recognition of the patient and relate the 3D intra-oral digital scan to the facial features. The mandatory five full-face pictures are the following (Figure. 7a–e.).

Figure 7a–e. The full-face photography protocols. Five mandatory photos need to be taken: (a) smiling; (b) lips at rest; (c) 12 o’clock position; (d) retracted mouth open, and (e) retracted mouth closed.

  1. Full-Face Smiling

Keep the patient in the same position with the eyes open and parallel to the horizon and keep the head upright (NOT tilted to the right, left, up, or down). This time ask the patient to keep the lips apart with a soft smile (if possible, show the incisal edges of the maxillary incisors).

  1. Full-Face Rest Position

This photo is for the automatic facial recognition part of the software, and part of the new REBEL smile design will be based on this facial perception of the patient.

Technically, the forehead and the ears of the patient must be visible. If the patient has long hair, please keep it away from the face. It is crucial to keep the head upright (NOT tilted to the right, left, or up and down), preferably position the eyes parallel to the horizon, and keep the lips apart.

  1. Face 12 O'Clock Position

There are two simple ways of taking this specific photo.

The first and easiest choice will be to keep the patient in the same position and ask him/her to bend the face 45° forward while having a full smile and take a photo that will show the relationship to the upper centrals and the displayed arch position to the lower lip line.

Or the dentist can lay down the patient into a supine position on the dental chair and move him/herself to 12 o’clock position ask for a full smile and take a photo from 45°.

  1. Full-Face Retracted Open Mouth

The patient should be asked to hold the full mouth retractors, again keeping the position of the eyes parallel to the horizon, keeping the head upright (NOT tilted to the right, left, or up and down), and keeping the mouth open (upper jaw and lower jaw) separated.

  1. Full-Face Retracted Open Mouth

The same protocol above should be repeated, however, this time with the teeth (upper jaw and lower jaw) closed.

The result of the facial analysis for this case was a combination of dynamic, delicate, and calm, and the dominant temperament was dynamic (Fig. 9).

3. Simple interview/questionnaire.

3. Simple interview/questionnaire.

The interview was performed which indicates the character and the personality of the patient and was completed in less than a minute through a questionnaire in the software and gave the primary and complementary character of the patient.

The temperamental type of everyone is defined by a unique combination of diverse characteristics of the four main temperaments. Therefore, for a precise and practical evaluation of it, it is necessary to apply a specific questionnaire.

The optimal tooth shape is determined with the help of the interview. The questionnaire is based on popular psychological tests for personal self-assessment.

The first question is an adapted test by Dellinger, and the other three questions concern personality traits based on the theory and questionnaire by Eysenck (Yankov et al. 2016).

The data resulting from the interview/questionnaire are checked by an algorithm in the software, which automatically calculates the patient's temperament and personality.

The result of the questionnaire for this case was a combination of strong, dynamic, delicate, and calm, and the dominant temperament was calm (Figs 8 and 10).

The Rebel workflow was completed, the software guided the dentist to exit, and with a mouse click, the file was immediately sent to the Rebel digital laboratory.

Figure 8: Based on the data from the interview, the software algorithm automatically calculates the temperament (personality), and the way the patient wants to be perceived. The temperament combines strong, dynamic, delicate, and calm.

Figure 9: The software dictates the perception of the face through recognition of the full-face photographs and the reflection of the personality according to the questionnaire. which immediately demonstrates in graphics (visually) the strength of the characteristics 'strong. dynamic, delicate, calm' and their relation to the patient's face and personality. The software uses this information to create a new smile design based on the visual language.

Figure 10: At this stage, any specific designs such as the expected position of the buccal corridors, perfect imperfections that need to be emphasized, the intensity of the surface texture, etc, are chosen by clicking as the dentist is guided by the software. Any extra optional features or comments can be added in the text box, if necessary.

Rebel digital laboratory

The next step was the conversion of the 2D digital project into a 3D mock-up through the Rebel digital laboratory and the creation of a digital wax-up, The Al-based algorithms of the software decided on the main elements of the new smile, it also chose the ideal (most natural) individual tooth shape relative to the facial perception and personality of the patient. Once this design is automatically placed over the digitally scanned original maxilla of the patient and rendered, an STL file of this new digital wax-up is made.

Back to chairside/3D printing

The STL file was then sent to the dentist via email, ready to be 3D printed (Figs. 11a and b). Once a 3D-printed model is made, then it easily transfers the design to the patient's mouth by making a silicone impression 

of the digital wax-up, duplicating all the details such as the line angles that give the teeth their ideal shape, surface texture, etc. The harder this silicone transfer impression, the more precise the transfer will be (Figs. 12a and b). This transfer should be done before anything else, and the dentist should evaluate the new design. The APT or final mock-up was conducted before starting the tooth preparation (Figs. 13 a and b), Not only does this achieve the ideal 3D smile design, but it also creates a great opportunity for the dentist to communicate the 3D smile design to the patient, The final esthetic design was approved at this point.

After this esthetic approval, the final functional digital wax-up was completed with digital software, using the esthetic smile design (created by Rebel) as a base


Figure 11. a and b. The STL file is received via email from Rebel Digital Laboratory and is 3D printed.

Figure 12. a and b. Once a 3D-printed model is made, then it easily transfers the design to the patient's mouth using a silicone impression of the digital wax-up that is created using a provisional material of choice.

Figure 13 a and b. The visualization of the APT in the mouth and its relation to the facial appearance. The software created this design. No group of teeth is dominant. Square tooth shapes (orange), a rounded incisal silhouette (white), and a slightly inclined tooth axis (blue), are all based on the facial perception and personality of the patient. As can be seen in this illustration the software can create a smile design with many different combinations of the different shapes. lines. and line angles.

Tooth preparation through the Aesthetic Pre-evaluative Temporaries (APT)

The APT restoration was used as a precise guideline to prepare the tooth structure based on the planned final tooth contours. The tooth structure undergoes only the more conservative preparation or even no preparation in certain areas using depth cutter burs through the APT restoration according to the pre-established goals. The previous silicone index is also used to check the preparation depths (Figure. 14a and b).

Figure. 14. (a) the APT restoration. (b) Preparation depths are marked with a pencil.

Finalizing the Case

After teeth preparation, the case was digitally scanned. 

The patient is dismissed with the provisional restoration, the case is sent to the laboratory, and the veneers are produced. These veneers were then bonded on the patient’s teeth.

Figure 15a–c. The final result: The zirconia-based porcelain layered veneer demonstrating natural, lifelike details was performed and applied over the teeth. The smile flows with the facial appearance and the personality of the patient, who is extremely happy with the new smile design.

Conclusion

The Merge of the basic rules of esthetics together with the reflection of the facial analysis and the personality of the patient in the smile design creates a more natural and personalized smile (character/temperament) (Fig 15). (Pashley et al. 2011). 

This principle supposes harmony between the smile design and the patient’s personality. The new smile creates more natural and personalized smiles

The Rebel concept, which can be applied very easily and rapidly, can help the dentist or ceramist to achieve this goal in the most simplistic, practical, and personalized way. Finally, before any further investigation and research is done, if the result of applying this technique does not satisfy the patient due to the subjectivity of the matter, the dentist can always make minor modifications to adopt this design according to the patient’s wishes.

References

Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.

img

Virginia E. Koenig

Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.

img

Delcio G Silva Junior

Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.

img

Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

img

Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

img

Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

img

Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

img

Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

img

Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

img

Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

img

Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

img

Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

img

Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

img

Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

img

Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

img

Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

img

Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

img

Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

img

Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

img

Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

img

Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

img

Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

img

Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

img

Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

img

Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

img

S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

img

Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

img

George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

img

Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

img

Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

img

Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

img

Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

img

Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

img

Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

img

Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

img

Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

img

Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

img

Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

img

Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

img

Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

img

Luiz Sellmann