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Research Article | DOI: https://doi.org/10.31579/2693-4779/049
*Corresponding Author: Jochanan E. Naschitz, Bait Balev Nesher and The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Citation: O Zalyesov, M Badarny, N Zaygraykin, J E. Naschitz. (2021) Use of the frailty tools FI MDS and FI Rockwood to predict outcomes of inpatient rehabilitation after proximal hip fracture. Clinical Research and Clinical Trials. 4(1); DOI: 10.31579/2693-4779/049
Copyright: © 2021 Jochanan E. Naschitz, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 07 June 2021 | Accepted: 28 June 2021 | Published: 02 July 2021
Keywords: frailty; hip fracture; rehabilitation; functional independence measure (FIM); clinical frailty scale; inpatient rehabilitation; MMSE
Background Among factors which affect the outcome of rehabilitation after hip fracture, the role of pre-fracture frailty has not been defined.
Objective To assess the impact of frailty on rehabilitation outcome in elderly persons with proximal hip fracture. Setting Geriatric rehabilitation center.
Design Retrospective observational study.
Subjects Forty consecutive patients with proximal hip fracture.
Methods The following parameters were calculated: FI-MDS frailty index, Rockwood Clinical Frailty Scale (FI Rockwood), Functional Independence Measure (FIM) on discharge, absolute functional gain (ΔFIM), length of stay (LOS), and FIM gain per day (ΔFIM/LOS). FIM discharge ≥90 and motor FIM discharge >58 indicated success in rehabilitation.
Results There were 31 women and 9 men, mean age 80 years. The mean pre-fracture FI MDS was 10 points (SD 5.8) out of 58 possible, the mean FI Rockwood score was 3 (SD 1.7) out of 7 possible. The mean admission FIM was 76.6 (SD 16), the mean discharge FIM was 92.7 (SD 19.3), mean LOS 22.5 days (SD 9.7), mean ΔFIM/LOS 0.8 (SD 0.6). Pre-fracture frailty was associated with worse outcome of rehabilitation: FI MDS predicted discharge FIM ≥90 with OR 0.86, p 0.012; FI Rockwood predicted discharge FIM ≥90 with OR 0.68, p 0.027; FI MDS predicted discharge motor FIM >58 with OR 0.91, p 0.07; FI Rockwood predicted discharge motor FIM >58 with OR 0.71, p 0.027.
Conclusions Though pre-fracture frailty correlated with FIM on discharge, neither frailty tool was specific enough to predict success in rehabilitation and the necessary length of rehabilitation. Translating frailty scores in tools adequate for clinical decision making remains an aim for future studies.
1. Among factors which shape the outcome of rehabilitation after hip fracture, the role of frailty is not well defined.
2. Two frailty tools were used in the present study: the FI-MDS frailty index and the Rockwood Clinical Frailty Scale.
3. Both are appropriate for subjects with physical and cognitive limitations.
4. Our study showed an inverse correlation between pre-fracture frailty and achievement in rehabilitation.
5. Tough reliable and easy to use, neither FI-MDS nor the Rockwood Clinical Frailty Scale were specific in predicting successful rehabilitation after hip fracture.
Numerous factors affect the outcome of rehabilitation in patients with hip fractures, including the patient's age, gender, pre-fracture functional ability, cognitive condition, affective status, comorbidity, social support, and the number of treatments [1-5]. The outcome of inpatient rehabilitation after hip fracture surgery may well be affected by frailty that pre-existed to hip fracture. It is assumed that frailty tools may help in guiding management decisions in patient care [6-13].
Frailty is understood as the increased vulnerability to stressors and limited homeostatic reserves to stabilize declines across multiple physiologic systems. Adults who are frail are prone to developing disease and have worse disease outcomes. Frailty that predicts greater clinical risk [14]. No single frailty assessment tool has become dominant. Fried LP et al. labeled an operational phenotype of frailty. Accordingly, frailty is a clinical syndrome in which three or more of the following alterations are present: unintentional weight loss (4.5 kg in the past year), self-reported exhaustion, weakness (by grip strength measurement), slow walking speed, and low level of physical activity [15]. Many other frailty scores have been proposed [16-20]. Ideally a frailty tool should be quick, reliable, and easy to use in clinical settings. These demands are not met by most frailty tools which are in common use but are well served by two instruments: the FI-MDS frailty index [21] and the Rockwood Clinical Frailty Scale [22]. The two latter do not require examination of physical performance nor the need of patients’ self-reporting their impairments. The FI MDS and FI Rockwood are informed by cognitive, motor and social functioning, disability and morbidities, influenced by psychological factors and social support. Thus, the frailty score is the equivalent of a battery of tests. The FI MDS and FI Rockwood are both appropriate for use in subjects with physical impairment and cognitive decline, features often met in older subjects recovering from hip fracture.
In the present study we assessed whether pre-fracture frailty affected the outcome of rehabilitation in older persons with proximal hip fracture. The FI-MDS frailty index and the Rockwood Clinical Frailty Scale were used as comprehensive measures of the patients' health status before fracture. The Functional Independence Measure (FIM) on discharge served as a measure of rehabilitation outcome.
The Institutional Review Board approved this retrospective observational study and waived the need for obtaining patients' informed consent. The study was conducted in a 40- bed rehabilitation department that admits mainly orthopedic patients. Included were consecutive patients aged 65 years or older transferred from orthopedic surgery to the geriatric rehabilitation ward. Excluded were non-cooperative subjects, those having an infected operation site, and those temporarily prohibited to tread. The following study parameters were appraised, each-one by independent observers: the FIM at the time of admission, FIM at the time of discharge, the absolute functional gain (calculated as the difference between FIM discharge and FIM admission, i.e. ΔFIM), the daily gain of FIM (calculated by dividing the absolute functional gain by the length of stay in rehabilitation, i.e. ΔFIM/LOS), the Rockwood Clinical Frailty scale (FI Rockwood), the frailty index calculated from the Minimum Data Set document (FI-MDS), the Mini–Mental State Examination of Folstein (MMSE), and the length of stay in rehabilitation (LOS).
Pre-fracture frailty was assessed by physicians who were directly involved in the patients' care. Two frailty tools were used, the FI-Rockwood [22] and FI-MDS, the latter was calculated from the Minimum Data Set document [23]. From the MDS document a list of 58 deficits was derived representing multiple functional domains. Each deficit was assigned either 0 (absence of the condition or attribute) or 1 (presence of the condition or attribute). The body mass index was assigned score 0 unless it was < 18.5 kg/m2 or ≥ 30 kg/m2, in which case a score of 1 was assigned. Medication usage was scored according to the number of medications used: 6-9 score 1; 10-14 score 2; 15-19 score 3; > 20 score 4. The mean of the deficits was expressed as a proportion of the total 58 points, ranging from 0 (no deficits) to 100% (58 deficits) [23]. By the Rockwood Clinical Frailty Scale the examiner’s intuitive perception of a patient’s disability and cognitive impairment was represented by a score ranging from 1 (robust health) to 7 (complete functional dependence) [22]. The Mini–Mental State Examination (MMSE) of Folstein [24] was used assess the patients' cognitive state at the time of admission.
The Functional Independence Measure (FIM) is used in rehabilitation to explore an individual's physical, psychological, and social functions and to monitor the progress under rehabilitation. The FIM has two subscales: the motor subscale, consisting of 13 items related to self-care, transfers, and locomotion, and the cognitive subscale, consisting of 5 items related to comprehension, expression, and memory. Each item is assigned a rating of 1-7, where 1 denotes the necessity for assistance and 7 denotes complete independence [25]. The 'FIM admission' is administered within 3 days of admission to rehabilitation and the 'FIM discharge' within 3 days before discharge by the same team. According to common knowledge, total FIM on discharge ≥90 or motor FIM on discharge >58 signify that a person can be discharged home [6].
Rehabilitation involved the diagnosis of a person’s problems and needs, defining rehabilitation goals, and therapeutic interventions in order to regain maximum self-sufficiency. Rehabilitation was provided by a multidisciplinary team consisting of physicians, occupational therapists, physical therapists, social workers, speech and language therapists, dietitians, and nurses. The patients received 5 days per week standard physical therapy (i.e., walking, climbing stairs, balance, muscle strength, and range of motion) and occupational therapy (i.e., basic ADL, instrumental ADL, and environment advice). The outcome of rehabilitation was evaluated by three measures: 1). the absolute functional gain from admission to discharge, i.e. ΔFIM, 2). FIM discharge ≥ 90, and 3) motor FIM discharge >58.
We assessed which degree of pre-fracture frailty is compatible with rehabilitation success, the latter corresponding to FIM discharge ≥90 or motor FIM discharge >58. Statistical analysis by MedCalc® Statistical Software version 19.8 (MedCalc Software Ltd, Ostend, Belgium; https://www.medcalc.org; 2021) used descriptive statistics, Pearson’s correlation, Receiver Operating Characteristic curve, and logistic regression analysis, as appropriate. P < 0.05 was considered significant.
The data of 45 consecutive patients who met the inclusion criteria were reviewed. Five patients could not complete rehabilitation because of intercurrent illness needing hospitalization and were excluded from the analysis. Among the remaining 40 subjects there were 31 women and 9 men, their mean age was 80 years. The FI scores, MMSE, FIM on admission, FIM on discharge, motor FIM on discharge, ΔFIM, LOS and ΔFIM/LOS are shown in Table 1.
The mean ΔFIM (FIM improvement from admission to discharge) was 16.6 points (SD 9.9). The mean functional gain was of 0.8 FIM points per day (SD 0.6). The correlations between pre-fracture frailty by either method and FIM at the time of discharge are shown in Figure 1.
Also represented in this figure are the pace of FIM improvement under rehabilitation (delta FIM / LOS) and the correlation between discharge FIM and LOS. It is noticed that a longer LOS compensated for a slower pace of improvement as to attain greater FIM at the time of discharge.
Alike FI MDS, FI Rockwood correlated poorly with ΔFIM/LOS: R -0.15, p 0.35. Two measures serve as surrogate indicators that a patient is fit to be discharged home: a total FIM discharge ≥90 and a motor FIM discharge >58 (17). In the present cohort, five patients scored FIM ≥90 on admission; their number increased to 20 at the time of discharge.
Logistic regression analysis showed that pre-fracture frailty, by FI MDS as well as by FI Rockwood, is associated with and determines success in rehabilitation (Table 2).
By means of receiver operating characteristic (ROC) curves the performance of pre-fracture frailty scores in achieving determined FIM discharge thresholds were analyzed. The data is shown in Table 3 and Figure 2.
For total FIM discharge ≥90, pre-fracture FI MDS best cutoff was ≤12.1, sensitivity 88.5% and specificity 53.8%; pre-fracture FI Rockwood best cutoff was ≤4, sensitivity 73% and specificity 53.8%. Similar results were observed for motor FIM discharge >58. Dose response plots provide graphical illustration of frailty score-related probability that patients will reach desired total FIM threshold at the time of discharge. Similar constructs were seen for motor FIM discharge >58 (not shown).
An additional analysis, by setting the total FIM discharge threshold at ≥85, showen comparable results as for total FIM discharge threshold ≥90.
The question addressed was whether frailty scoring can be to predict success in rehabilitation after hip fracture. Can severity of frailty predict, better than clinical judgment, situations when rehabilitation after hip fracture is futile? A positive answer to this question would be important for clinical decision making. The short time frame needed to answer this question in rehabilitation after hip fracture offered the prospect to arrive at a clear answer. Indeed, pre-fracture frailty correlated with FIM on discharge, but neither frailty tool was sensitive and specific enough to predict success in rehabilitation and the length of stay in rehabilitation.
The outcome of rehabilitation is difficult to measure because several outcomes are relevant and because the relevant outcomes are affected by multiple factors in addition to treatment [26]. In practice, the use of one representative predictor of outcome, e.g., total FIM discharge or motor FIM discharge, is a necessary compromise. The validity of FIM for determining outcomes of rehabilitation is well established [27]. In a study of 117.168 Medicare beneficiaries receiving inpatient rehabilitation for hip fracture a discharge motor FIM score 58 yielded the best balance in sensitivity and specificity for discriminating patients discharged to the community from those discharged to an institution. FIM motor was equally effective as FIM total and more effective than FIM cognition to this aim, Moreover, FIM motor ratings alone were as effective as a multivariable model in discriminating patients discharged to the community from those discharged to an institution [6]. From a clinical perspective, a diagnostic tool based on a single standard measure and a defined threshold of success (e.g. discharge FIM) is more practical and meaningful than values obtained from a composite model [6], and it also is most popular [28]. Both indices, the total FIM discharge and motor FIM discharge, were used in our study.
Frailty as a predictor of short-term functional recovery after a pathological event has been investigated in diverse conditions, such as trauma, general surgery, chemotherapy, kidney transplantation, and decisions to treat hyperparathyroidism [17,23-28]. A comprehensive literature survey investigated the association of frailty (by means of the Clinical Frailty Scale) with an outcome, mostly in hospitalized patients. Frailty was predictive in 74% of the cases, highlighting its utility in the care of older patients [29]. On the other hand, in the assessment of cardiac preoperative risk, incorporating frailty in existing models require further validation and have not been widely adopted [30,31]. Research is needed to quantify the predictive ability of validated frailty instruments in the context of different surgical procedures and existing surgical risk indices [32,33].
Functional recovery after hip fracture was connected to the degree of frailty in previous [5,6,28] as well as in the present study. The lower was the pre-fracture frailty score the higher was the probability of success in rehabilitation. Both frailty tools, the FI MDS and FI Rockwood, fitted well to the population of the present study, where the patients' physical and cognitive limitations would impede on performance of motor tests and on self-reporting. Pre-fracture FI MDS and FI Rockwood corelated strongly (p <0.0001) with FIM discharge score ≥90 and motor FIM discharge score >58 (Figure 1). However, their predictive accuracy was disappointing: for FIM discharge score ≥90 the best discrimination of success from failure was provided by FI MDS 12.1 with 88.5% sensitivity but merely and 53.8% specificity. Comparable results were found for FI Rockwood. Beyond commonsense used for the first triage, frailty tools performed with insufficient specificity in predicting the outcome of rehabilitation. Moreover, the frailty tools were inaccurate in predicting the pace of improvement under rehabilitation. For the disadvantaged, a longer stay in rehabilitation compensated for slower improvement (Figure 2).
Frailty impacts the outcome of rehabilitation after proximal hip fracture. Yet, frailty tools are not useful to predict success of rehabilitation nor the necessary length of stay in rehabilitation. Translating frailty scores into clinically sensible tools to predict outcomes remains an aim for future studies.
Oxana Zalyesov in the design of the study, acquisition of data; Muhamd Badarny in assessment of patients’ FIM; Natalia Zaygraykin in the planning the study, review of the literature, data analysis; Jochanan E. Naschitz, conceiving and planning, data analysis, writing the manuscript
There were neither personal nor financial conflicts of interest to this study.
No funding was provided for this study.
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