AUCTORES
Globalize your Research
Short Communication | DOI: https://doi.org/10.31579/2690-4861/393
1 Departments of Diagnostic Pathology, Tottori Prefectural Kousei Hospital, Kurayoshi-city, 682-0804 Tottori, Japan.
2 Thoracic Surgery, Tottori Prefectural Kousei Hospital, Kurayoshi-city, 682-0804 Tottori, Japan.
3 Medical Central Laboratory, Tottori Prefectural Kousei Hospital, Kurayoshi-city, 682-0804 Tottori, Japan.
*Corresponding Author: Yuji Ohtsuki MD, PhD., Department of Diagnostic Pathology,Tottori Prefectural Kousei Hospital, Kurayoshi, Tottori 682-0804, Japan.
Citation: Ohtsuki Yuji, Fukino Shunsuke, Irie Aiko, Tatsushima Junji, Nagao Mizuho, et al, (2024), Unique Distribution of Minute Meningothelioid Nodules at The Alveolar Mouths of Peripheral Airways within the identical lung harboring Adenocarcinoma, International Journal of Clinical Case Reports and Reviews, 16(3); DOI:10.31579/2690-4861/393
Copyright: © 2024, Yuji Ohtsuki. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 30 January 2024 | Accepted: 13 February 2024 | Published: 17 February 2024
Keywords: .
.
Minute meningothelioid nodules (MMNs) are not rare lesions in the lungs; however, their specific origin and functions remain unknown [1]. In a previous study, among 81 cases of resected lungs, MMNs were detected in 69 out of 500 surgical biopsies (13.8%) and 12 out of 25 lobectomies (48%) via detailed histochemical examination, with a female predominance at an average age of 62, and only 4 out of 81 cases involved patients younger than 40 years [1]. These findings indicate that MMNs are not congenital in origin [1]. In another report, MMNs were detected in 121 out of 1724 resected lungs (7%) via pathologic examination, with a female predominance [2].
Here, we investigated a pulmonary adenocarcinoma case with unique distribution of MMNs at the alveolar mouths (AMs) of lungs. To the best of our knowledge, such a case has not yet been described even in a report on more than 100 cases of MMNs [2]. Moreover, this report is the first to demonstrate the distribution of MMNs at the AMs of lung peripheral airways.
A lung tumor (size: 1.6 × 1.6 × 1.3 cm) was detected on the lower right lobe of the lungs in a mid-seventieth female with computed tomography (CT), followed by thoracoscopic lobectomy.
Histopathological diagnosis was pulmonary papillary adenocarcinoma with MMNs in vicinity. Many eosinophilic intranuclear bodies were observed in the cancer cells (Figure. 1A), which were immunohistochemically positive for the surfactant protein A(SP-A) (Figure. 1B).
Figure 1: Eosinophilic intranuclear inclusions are found in the tumor cells (1A, arrows), and these inclusions are positive with SP-A antibody with immunohistochemical stain (1B, arrows).
We were interested in the unique microscopic distribution of proliferating meningothelioid cells at the AMs, as shown in Figure. 2A. Meningothelioid cells proliferate in a nest-like or whirl arrangement along the peripheral airways, including the alveolar duct and AMs, and their cell borders are obscure. Here, meningothelioid cells proliferated at the AMs as minute discontinuous nodules (Figure. 2B). The nuclei were small and positive for the progesterone receptor (PGR) (Figure. 2C), vimentin, and epithelial membrane antigen (EMA) (Figure. 2D), but not for neuroendocrine markers. They were morphologically, light microscopically [3], immunohistochemically [4], and ultrastructurally [5] similar to meningothelial cells. Notably, the cells were positive for somatostatin receptor (SSTR)-2a and -5 (Figure. 2E) and immunopositive for antibodies against vimentin and CD56 (N-CAM) but negative for synaptophysin, chromogranin, S100, cytokeratin, and transcription termination factor (TTF)-1 (Figure. 2F), suggesting that proliferating meningothelioid cells are not neuroendocrine in origin but exhibit meningothelial cell differentiation [3,4]. In sharp contrast to TTF-1-positive type II alveolar cells, the proliferating cell nuclei of MMNs were TTF-1-negative. This distribution of MMNs may be due to a function of the chemoreceptors [6,7]. As shown in Figure. 1B, PGR-positive nuclei of MMNs were located at the AMs as isolated discontinuous minute nodules in the stroma. PGR-positivity may be a factor controlling the growth of MMNs [8]. Both SSTR2a and NF2 may be involved in the proliferation, progression, and growth of MMNs [4].
Figure 2: MMN cells are located in the AMs (Fig. 2A, 2B, arrows), positive for PGR(2C, arrows), EMA(2D,arrows),SSTR-5(2E,arrows), but negative for TTF-1(2F,arrows) besides positive original type II alveolar cells in 2F(arrowheads)To date, no studies have indicated the presence of MMNs at the AMs as demonstrated in this report. AMs are important for alveolar epithelial cells and very unstable in response to any kind of microstimulus. AMs are considered as locus minoris resistentiae in the peripheral airways of the lungs. Masson bodies [9] and hyaline membranes [10] arise from the AMs and are induced by internal and external stimuli. In addition to being positive for SSTR-2a and -5, their location at the AMs may aid MMNs in playing key roles as chemoreceptors.
Meningothelioid cells are predominantly monoclonal in growth [11] and exhibit an NF2 deletion [3], which is a common mutation in meningiomas of the central nervous system F(3). Moreover, MMNs constitutively express SSTR2a [4]. Here, proliferating cells and MMNs were positive for SSTR-2a and -5.
MMNs may arise due to ischemic or reactive changes rather than neoplastic changes [8,11]. Moreover, MMNs may be transitional forms between reactive and neoplastic forms [12,13]. Although the exact origin of MMNs, even in the cell lineage, remains unclear, they are often detected in the vicinity of lung cancer [2,8], as observed in the present case.
MMN distribution at the AMs, as demonstrated in this report, is unique and rare. Although the specific functions and origin of MMNs remain ambiguous, they may arise due to ischemic or preneoplastic changes [13].
To the best of our knowledge, this report is the first to show the unique distribution of MMNs immunopositive for SSTR-2a and -5 at the peripheral airways of human lungs. These receptors are involved in cell secretion and proliferation [4].
Therefore, immunopositivity for SSTR-2a and -5 should be considered in addition to meningothelial cell differentiation when determining the functions of MMNs.
The author(s) declare(s)that there is no conflict of interest regarding the publication of this paper.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
