Opinion Article | DOI: https://doi.org/10.31579/2640-1045/233
1Department of Public Health and Institute of Biomedical Sciences, Faculty of Health Sciences, University of Carabobo, Venezuela.
2Department of Public Health, Faculty of Health Sciences, University of Carabobo, Venezuela.
3School of Medicine, Faculty of Health Sciences, University of Carabobo, Venezuela.
*Corresponding Author: Gilberto Bastidas, Department of Public Health and Institute of Biomedical Sciences, Faculty of Health Sciences, University of Carabobo, Venezuela.
Citation: Bastidas G, Maurera D, Báez M, Peña M, Bastidas D, et al, (2026), Trichinella Spiralis Molecules in the Treatment of Obesity, J. Endocrinology and Disorders, 10(1); DOI:10.31579/2640-1045/233
Copyright: © 2026, Gilberto Bastidas. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 13 January 2026 | Accepted: 20 January 2026 | Published: 29 January 2026
Keywords: obesity ; cardiovascular diseases; diabetes mellitus; and cancer
The prevalence of obesity has increased in most countries in recent decades with no signs of slowing down. This excessive accumulation of adipose tissue and its associated comorbidities (cardiovascular diseases, diabetes mellitus, and cancer), with an estimated prevalence of 4 billion people by 2025, is considered a major public health problem worldwide. Due to its multifactorial nature, numerous studies have been conducted to control this epidemic [1-4].
The prevalence of obesity has increased in most countries in recent decades with no signs of slowing down. This excessive accumulation of adipose tissue and its associated comorbidities (cardiovascular diseases, diabetes mellitus, and cancer), with an estimated prevalence of 4 billion people by 2025, is considered a major public health problem worldwide. Due to its multifactorial nature, numerous studies have been conducted to control this epidemic [1-4].
Trichinella spiralis is a zoonotic nematode parasite that infects a wide range of mammalian hosts, including humans (through the consumption of raw or undercooked meat), causing trichinellosis. This parasite employs sophisticated strategies to ensure its survival in the host, particularly by modulating the immune response, which for T. spiralis involves both innate and adaptive mechanisms within a complex and multifaceted reaction [5].
Specifically, T. spiralis generates a Th2-type immune response in the host that acts positively on regulatory T cells without affecting the helminth. This response also includes the activation of macrophages (M2) in adipose tissue, which is key to improving obesity, glucose metabolism, and lipid metabolism (perhaps through intracellular lipid accumulation mediated by CCAAT enhancer-binding protein alpha [C/EBPa] and peroxisome proliferator-activated receptor gamma [PPARγ]) [5-13].
Given that most anti-obesity drugs developed to date have been withdrawn from the market due to adverse effects, the need to develop new drugs arises. This opens the door to research on immunomodulatory effects with molecules derived from T. spiralis due to their anti-adipogenic action on adipocytes (3T3-L1). Undoubtedly, the landscape to be elucidated is diverse [14, 15].
Conflict of interests
The authors have no conflict of interest to declare. The authors declared that this study has received no financial support.
Dear Editorial Team, Clinical Medical Reviews and Reports. My experience with the journal was highly positive. The peer-review process was rigorous, constructive, and completed in a timely manner. The reviewers provided valuable comments that helped improve the quality and clarity of our manuscript. The editorial office was professional, responsive, and supportive throughout all stages of the publication process. Communication was clear and efficient, and any questions were addressed promptly. Overall, I found the journal to maintain high scientific standards and an excellent publication workflow. I would be pleased to consider submitting future work to this journal. Best wishes from, Elena Popa.
It was my pleasure to submit my testimonial concerning the Reviewer Board of our Scientific Journal “Brain and Neurological Disorders”. The Reviewers focused on some modifications and their contribution was helpful. The ladies of our Editorial Office were also supported my efforts. It was my honor to have such a co-operation and I am looking forward for more collaboration.
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Thank you for the speedy and efficient peer review process. I appreciate the fact that your peer reviewers do not take months to respond like with some other journals. I would also like to thank the editorial office for responding quickly to my questions. It is an excellent journal. I plan to submit more manuscripts in the future. Best wishes from, Robert W. McGee
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Working with you and your team on our recent publication in JCRR has been a truly wonderful and enjoyable experience. The responses were prompt, and the reviewers were patient, constructive, and highly professional. One reviewer in particular gave me the feeling that a professor was carefully reading and commenting on my coursework, which was deeply touching. The entire process was straightforward and hassle‑free, with no tedious online forms to complete. I highly recommend this journal. Best wishes from, DR Aibing Rao, Head of R&D
I Appreciate the Opportunity to Share my Experience with the Journal of Clinical Research and Reports. The peer review process was timely and constructive, and the feedback provided helped improve the quality of our manuscript. The editorial office was professional, responsive, and supportive throughout the process, ensuring smooth communication and efficient handling of the submission. Overall, it was a positive experience collaborating with your team.
Dear Mercy Grace, Editorial Coordinator of Obstetrics Gynecology and Reproductive Sciences, We would like to express our gratitude for your help at all stages of publishing and editing the article. The editors of the magazine answer all the necessary questions and help at every stage. We will definitely continue to cooperate and publish other works in the Obstetrics Gynecology and Reproductive Sciences! Best wishes from, Alla Konstantinovna Politova,
