opinion | DOI: https://doi.org/10.31579/2637-8892/232
Department of Clinical Research, Indira IVF Hospital, Udaipur-Lucknow, India
*Corresponding Author: Saumya Pandey, Department of Clinical Research, Indira IVF Hospital, Udaipur-Lucknow, India
Citation: Saumya Pandey, (2023), Toll Like Receptors-Autophagy-Wnt/Crispr-Cas Neuro-Immuno-Inflammatory Biochemical Cross-Talks and Artificial Intelligence in Embryonic Induction and Fertility Management: Translational Health-Biomedical-Life Science Research Snapshot in American and Indian Genetic Landscapes, Psychology and Mental Health Care, 7(6): DOI:10.31579/2637-8892/232
Copyright: © 2023, Saumya Pandey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 28 August 2023 | Accepted: 07 September 2023 | Published: 11 September 2023
Keywords: .
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Toll-like receptors, a family of evolutionarily conserved pathogen recognition receptors, initiate inflammatory responses to foreign pathogens; thirteen TLRs are known till date (TLR 1-13) and their complex signaling mechanisms involve various intermediaries in the signal transduction pathway for an inflammatory/immune response in the target cell [1]. In my expert opinion, “Toll like Receptors-Autophagy-Wnt/CRISPR-Cas-Neuropsycho-Immuno-Inflammatory Biochemical Cross-Talks” triggered “Artificial Intelligence” in embryonic induction and fertility management is an intriguing translational health-biomedical-life science research area with immense neuropsycho-immunotherapeutically relevant clinical/public health impact in deciphering the intricacies of aberrant neurophysiological-psychosexual conditions associated with inflammatory microbiota at the complex maternal-fetal interface in embryonic induction/development in human Chorionic Gonadotropin (hCG)-triggered ovulation in Mycobacterium tuberculi susceptible infertile women of American and Asian-Indian genetic landscapes. CRISPR-Cas genetic bio-engineering technology has emerged as an enigmatic modulator of complex inflammatory diseases including neuropsychological diseases utilizing genome editing and detecting specific DNA/RNA sequences to gene expression control warranting timeline-driven scientific collaborations for immuno-inflammatory disease(s)-management in psychosexual medicine in the global Covid-19/Omicron pandemic and Covid-19 vaccination era [2-3].
“Infertility” is defined as the inability to conceive following 12 months of regular unprotected sexual intercourse; psychosexual counseling-based mental health fertility management intervention(s), marital-relationship counseling/therapy, timely referrals for psychological neuropsychiatric assessments, psychiatric treatments for cognitive impairment, obsessive compulsive disorder, bipolar disorder, schizophrenia, and/or clinical depression are beneficial in overall psychological well-being of patients symptomatic of psychosexual disorders [4-5].
TLR-Autophagy-Wnt biochemical signaling intersections coupled with AI offer fascinating life science research avenues in the mental health management of asymptomatic, borderline and symptomatic clinically infertile women with M. tb. positivity and their azoospermic, oligospermic and/or asthenospermic male partners of American and Asian-Indian genetic profiles [6-7]. Tobacco usage, either smoking (active/passive) or chewing, is a significant predictor of metabolic perturbations/aberrant physiologic milieu in asymptomatic and symptomatic women and men of reproductive age presenting with infertility. Furthermore, psychological/mental health and financial distress associated with the exorbitant cost of infertility treatment procedures, namely in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), etc., should be addressed by organizing quarterly, monthly and/or annual public health awareness campaigns, anti-tobacco signature drives/campaigns, tobacco cessation and infertility awareness lectures/talks, free/complementary 1-1 consultations, medical check-ups, psychosexual counseling sessions, quality time investment with clinically infertile patients, timely follow-ups of patients undergoing Assisted Reproductive Technology procedures, IVF/ICSI, etc. evaluating overall IVF success trends. Moreover, elegant amalgamation of AI algorithms with total number of embryo transfers (ETs, fresh or frozen), oocytes retrieved, oocyte quality, semen quality, sperm counts/morphology/motility, endometrial thickness, anti-Mullerian hormone levels, implantation rates, beta-human chorionic gonadotropin positivity/biochemical pregnancy, and live birth-rates in infertile women undergoing IVF/ICSI would lead to critical insights in evidence-based pragmatic outcomes with enhanced fertility success quotients in genetically disparate population-pools of infertile women of child-bearing age.
The author has no relevant financial disclosures and/or commercial incentives, or personal relationships to declare.
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