Review Article | DOI: https://doi.org/10.31579/2578-8949/211
1Department of Dermatology, El-Aml Specialized Hospital, Cairo, Egypt.
2Department of Dermatology, El-Mataria Teaching Hospital, Cairo, Egypt.
3Department of Dermatology, Al-Haud Al-Marsoud Hospital, Cairo, Egypt.
*Corresponding Author: Ahmed Adel Ali Ali, Department of Dermatology, Al-Haud Al-Marsoud Hospital, Cairo, Egypt.
Citation: Ahmed Adel Ali Ali, Aliaa Atef, Fatema Saber, (2023), Therapeutic Outcomes and Efficacy of Intralesional 5-Fluorouracil in the Management of Cutaneous Warts: A Multi-Centric Prospective Cohort Study, Dermatology and Dermatitis, 9(1); DOI:10.31579/2578-8949/211
Copyright: © 2023, Ahmed Adel Ali Ali. This is an open-access article distributed under the terms of The Creative Commons. Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 06 November 2023 | Accepted: 17 November 2023 | Published: 24 November 2023
Keywords: Warts; 5-fluorouracil; intralesional therapy; randomized controlled trial; dermatology; HPV; treatment efficacy
Background: Cutaneous warts are common viral skin infections caused by human papillomavirus (HPV) and often present therapeutic challenges due to recurrence and resistance to conventional treatments. Intralesional therapies, including 5-fluorouracil (5-FU), have emerged as promising alternatives, demonstrating targeted cytotoxic effects on infected keratinocytes. Previous randomized and comparative studies have reported favorable clearance rates and acceptable safety profiles for intralesional 5-FU in treating different wart types.
Objective: to evaluate the efficacy and safety of intralesional 5-FU in the treatment of cutaneous warts and to assess treatment response, side effects, and recurrence rates.
Methods: A multi-centric prospective cohort study was conducted on patients with clinically diagnosed warts at a dermatology outpatient clinic. This multicenter study was conducted across three dermatology centers in Cairo, Egypt. Patients received intralesional 5-FU (50 mg/mL) injections every two weeks for up to six sessions. Clinical evaluation included wart type, number, and response to treatment, categorized as complete, partial, or no response.
Results: Sixty patients were included, with a mean age of 29.5 ± 8.8 years. The majority had plantar warts (56.7%). Complete response was achieved in 83.3% of patients, while 16.7% showed partial response. No recurrence was observed among completely cured patients. Pain was reported in all patients (100%), while mild erythema occurred in 13.3%. A significant association was found between treatment response and number of sessions (p = 0.006).
Conclusions: Intralesional 5-FU is an effective and safe treatment modality for cutaneous warts, with high clearance rates and minimal recurrence. Despite mild local side effects, it represents a valuable therapeutic option, particularly for resistant cases.
Cutaneous warts are benign proliferative lesions of the skin caused by infection with human papillomavirus (HPV), affecting a significant proportion of the population worldwide. Despite their self-limiting nature in some cases, many warts persist, spread, or recur, leading to both physical discomfort and psychosocial burden [1]. Various therapeutic modalities have been employed, including topical keratolytics, cryotherapy, laser therapy, and immunotherapy; however, no single treatment has demonstrated universal efficacy. Recurrence, prolonged treatment duration, pain, and variable response rates continue to make wart management a clinical challenge [2].
Intralesional therapies have gained increasing attention as they deliver medication directly into the lesion, enhancing local drug concentration while minimizing systemic effects. Among these, 5-fluorouracil (5-FU), an antimetabolite that inhibits DNA synthesis in rapidly dividing cells, has shown promising results in treating HPV-infected keratinocytes [3].
Despite growing evidence supporting intralesional 5-FU, the available literature remains limited by small sample sizes, heterogeneity in treatment protocols, and lack of standardized randomized controlled trials. Additionally, comparative data on response rates, recurrence, and predictors of treatment success are still insufficient. Some systematic reviews highlight variability in outcomes and emphasize the need for well-designed clinical trials to establish its efficacy and safety more conclusively [4-6].
Given the ongoing challenges in wart treatment and the promising yet inconclusive evidence regarding intralesional 5-FU, this study was conducted to provide more robust clinical data on its therapeutic value. Therefore, the aim of this study was to evaluate the efficacy and safety of intralesional 5-fluorouracil in the treatment of cutaneous warts and to assess treatment outcomes, adverse effects, and recurrence rates.
This multi-centric prospective cohort study was conducted and performed on a total of 60 patients with clinically diagnosed cutaneous warts. This multicenter study was conducted across three dermatology centers in Cairo, Egypt at the Department of Dermatology of El-Aml Specialized Hospital, the El-Mataria Teaching Hospital, and Al-Haud Al-Marsoud Hospital, from June 2022 to May 2023. These centers provided a diverse patient population and enhanced the generalizability of the study findings. All procedures were performed in accordance with ethical standards for human research.
In our study, participants were selected based on clearly defined inclusion criteria to ensure appropriate patient representation. Eligible patients were those aged between 18 and 60 years, including both males and females. All participants had clinically diagnosed cutaneous warts and presented with one or more lesions. Additionally, only patients who were willing to provide informed consent were included. Participants were required to demonstrate the ability to comply with scheduled follow-up visits throughout the study period. Furthermore, all included patients agreed to clinical photography for documentation and assessment of treatment response.
Patients were excluded from our study if they had conditions that could interfere with treatment safety or outcome assessment. This included pregnant or lactating women, as well as immunocompromised individuals or those receiving chemotherapy. Patients with major systemic illnesses were also excluded. Certain wart types and conditions were not considered, including facial warts and condyloma acuminata. Individuals with Raynaud’s phenomenon or peripheral vascular disease, known hypersensitivity to 5-fluorouracil, or hematological disorders were excluded due to potential risks. Additional exclusion criteria included a history of keloid formation, active infection, inflammation, or unhealed wounds at the injection site, and receipt of any wart treatment within the previous month. Patients with needle phobia were also excluded to ensure compliance and procedural feasibility.
1. Pre-Procedure Preparations
Before initiation of treatment, all patients underwent thorough evaluation and preparation. Written informed consent was obtained after explaining the study objectives, procedure steps, expected outcomes, and possible adverse effects. A detailed history was taken, including personal, present, past, and family history, with special emphasis on wart characteristics (onset, duration, number, size, and prior treatments).
A complete dermatological examination was performed to document the type, number, and location of warts. Baseline clinical photographs were obtained for future comparison. The treatment area was assessed to exclude any signs of infection, inflammation, or contraindications. Patients were instructed about the procedure, expected pain during injection, and the need for multiple sessions.
2. Procedure
Intralesional injection of 5-fluorouracil (5-FU) (50 mg/mL) was performed under aseptic conditions. Initially, superficial paring of each wart was carried out using a sterile surgical blade to remove hyperkeratotic layers and enhance drug penetration. The area was then cleansed with alcohol.
Using a 1 mL insulin syringe with a 30-gauge needle, 5-FU was injected directly into the base of each wart at a dose of 0.1–0.2 mL per lesion, depending on its size. The endpoint of injection was blanching of the lesion, indicating adequate intralesional distribution.
The procedure was repeated at two-week intervals. A maximum of six sessions was allowed, or treatment was discontinued earlier if complete clearance of the wart was achieved.
3. Post-Procedure Care
After each session, patients were provided with detailed post-procedure instructions. They were advised to keep the treated area clean and dry for 12–24 hours, followed by gentle cleansing with mild soap and water. Application of any topical medications was avoided unless prescribed.
Patients were informed that mild pain, redness, or swelling at the injection site was expected and usually transient. Cold compresses were recommended during the first 24 hours to alleviate discomfort. Normal daily activities could be resumed immediately; however, patients were advised to avoid excessive pressure, friction, or trauma to the treated area, particularly in plantar warts.
Patients were instructed to monitor for adverse effects such as excessive pain, ulceration, blistering, discharge, or signs of infection. In such cases, they were advised to seek medical attention promptly. General advice included avoiding scratching or picking the lesion and maintaining good hygiene.
4. Follow-Up
Patients were followed up at two-week intervals during the treatment period. At each visit, clinical assessment included evaluation of wart size, number, and response to treatment, categorized as complete, partial, or no response. Side effects were recorded systematically. Serial clinical photographs were taken at baseline and during follow-up visits.
After completion of treatment, patients were followed up one month after the final session to assess recurrence or any increase in lesion size. This follow-up period allowed evaluation of both treatment efficacy and durability of response.
Sample Size: The sample size of 60 patients was determined based on feasibility and previous studies reporting high efficacy of intralesional 5-FU. This number was considered sufficient to assess treatment outcomes and safety while allowing basic statistical analysis. Additional patients were initially screened to account for exclusions and dropouts.
Our study was conducted in accordance with the ethical principles of human research. All participants were fully informed about the study objectives, procedures, potential benefits, and possible adverse effects before enrollment. Written informed consent was obtained from all patients prior to participation. Patient safety and well-being were prioritized throughout the study, and all procedures were performed under appropriate aseptic conditions. The study protocol adhered to institutional and international ethical standards.
Statistical analysis: Data were analyzed using the Statistical Program for Social Science (SPSS) version 24. Qualitative variables were presented as frequencies and percentages, while quantitative variables were expressed as mean ± standard deviation (SD). The mean represents the average value, calculated by dividing the sum of observations by their total number. The standard deviation was used to measure the dispersion of data around the mean, where a low SD indicates values clustered closely around the mean, and a high SD reflects greater variability.
For inferential analysis, appropriate statistical tests were applied according to the type of data. The independent sample t-test was used to compare the means between two groups for quantitative variables. The chi-square (χ²) test was applied to assess associations between categorical variables across the studied groups.
The level of statistical significance was determined using the p-value. A p-value less than 0.05 was considered statistically significant, while a p-value less than 0.001 was considered highly significant. A p-value greater than 0.05 was regarded as statistically insignificant.
Illustrative Case Presentation:
To further demonstrate the clinical effectiveness of intralesional 5-fluorouracil (5-FU), we present a representative case from our cohort.
Figure 1: Clinical images demonstrate the lesion prior to treatment and after complete resolution, highlighting the effectiveness of intralesional 5-FU in achieving clearance of plantar warts.
A 50-year-old male patient presented with a solitary lesion on the plantar surface of the right foot, persisting for approximately 3 months. The lesion was initially small and asymptomatic but progressively increased in size and became painful, particularly during walking and weight-bearing activities. The patient denied any prior treatment before presentation.
On clinical examination, a well-defined hyperkeratotic papule was observed on the plantar aspect of the foot, characterized by a rough surface and the presence of thrombosed capillaries (black dots), consistent with a diagnosis of plantar wart. The lesion was tender upon lateral pressure, further supporting the diagnosis.
The patient underwent intralesional injection of 5-fluorouracil (50 mg/mL) following standard protocol. Superficial paring of the lesion was
performed prior to injection to enhance drug penetration. A total of 0.1–0.2 mL of 5-FU was administered directly into the base of the lesion. The procedure was repeated at two-week intervals.
After a total of five treatment sessions, the patient demonstrated marked clinical improvement, with complete resolution of the lesion and restoration of normal skin lines. Pain during ambulation resolved completely. No significant adverse effects were observed apart from mild transient pain during injection.
Follow-up evaluation one month after the final session revealed no evidence of recurrence.
The results of the present study are demonstrated in the following tables.
| Variable | Category | N | % |
| Sex | Male | 32 | 53.3% |
| Female | 28 | 46.7% | |
| Age (years) | Mean ± SD | 29.5 ± 8.8 | — |
| Range | 18 – 52 | — |
Table 1: Demographic Characteristics of Studied Patients.
Out of 60 patients, males constituted 53.3% (n=32) and females 46.7% (n=28). The mean age was 29.5 ± 8.8 years, with a range of 18–52 years.
| Variable | Category | N | % |
| Wart Type | Plantar | 34 | 56.7% |
| Common | 24 | 40% | |
| Mosaic | 2 | 3.3% | |
| Wart Site | Sole | 26 | 43.3% |
| Fingers | 20 | 33.3% | |
| Toe | 10 | 16.7% | |
| Lateral Foot | 4 | 6.7% | |
| Number of Warts | 1 wart | 56 | 93.3% |
| 2 warts | 2 | 3.3% | |
| 5 warts | 2 | 3.3% | |
| Number of Sessions | 2 sessions | 10 | 16.7% |
| 3 sessions | 20 | 33.3% | |
| 4 sessions | 12 | 20% | |
| 5 sessions | 6 | 10% | |
| 6 sessions | 12 | 20% |
Table 2: Clinical Characteristics of Studied Patients.
Plantar warts were present in 56.7% (n=34), common warts in 40% (n=24), and mosaic warts in 3.3% (n=2). The sole was affected in 43.3% (n=26), fingers in 33.3% (n=20), toes in 16.7% (n=10), and lateral foot in 6.7% (n=4). Single warts were observed in 93.3% (n=56), while 2 and 5 warts were each present in 3.3% (n=2). Regarding sessions, 33.3% (n=20) required 3 sessions, 20% (n=12) required 4 sessions, and 20% (n=12) required 6 sessions.
| Side Effect | N | % |
| Pain | 60 | 100% |
| Erythema | 8 | 13.3% |
Table 3: Side Effects Among Studied Patients.
Pain was reported in 100% (n=60) of patients, while erythema occurred in 13.3% (n=8).
| Response | N | % |
| Complete Response | 50 | 83.3% |
| Partial Response | 10 | 16.7% |
Table 4: Treatment Response
Complete response was achieved in 83.3% (n=50), while partial response occurred in 16.7% (n=10). No recurrence was observed among complete responders.
| Variable | Category | Complete (N=50) | Partial (N=10) | Test | P-value | Significance |
| Age (years) | Mean ± SD | 34.6 ± 8.3 | 39.8 ± 10.9 | T = -1.2 | 0.239 | NS |
| Sex | Male | 22 (44%) | 10 (100%) | χ² = 5.2 | 0.022 | S |
| Female | 28 (56%) | 0 (0%) | — | — | — | |
| Wart Site | Sole | 24 (48%) | 2 (20%) | χ² = 2.47 | 0.480 | NS |
| Fingers | 16 (32%) | 4 (40%) | — | — | — | |
| Toe | 8 (16%) | 2 (20%) | — | — | — | |
| Foot | 2 (4%) | 2 (20%) | — | — | — | |
| Wart Type | Plantar | 30 (60%) | 4 (40%) | χ² = 1.09 | 0.579 | NS |
| Common | 18 (36%) | 6 (60%) | — | — | — | |
| Mosaic | 2 (4%) | 0 (0%) | — | — | — | |
| Number of Warts | 1 wart | 48 (96%) | 8 (80%) | χ² = 5.3 | 0.07 | NS |
| 2 warts | 0 (0%) | 2 (20%) | — | — | — | |
| 5 warts | 2 (4%) | 0 (0%) | — | — | — | |
| Number of Sessions | 2 sessions | 10 (20%) | 0 (0%) | χ² = 14.4 | 0.006 | S |
| 3 sessions | 20 (40%) | 0 (0%) | — | — | — | |
| 4 sessions | 10 (20%) | 2 (20%) | — | — | — | |
| 5 sessions | 6 (12%) | 0 (0%) | — | — | — | |
| 6 sessions | 4 (8%) | 8 (80%) | — | — | — |
Table 5: Correlation Between Response and Variables
Mean age was 34.6 ± 8.3 years in complete responders and 39.8 ± 10.9 years in partial responders (p=0.239). All partial responders were males (100%, n=10), while females constituted 56% (n=28) of complete responders (p=0.022).
For wart site, complete response occurred in 48% (n=24) of sole cases versus 20% (n=2) partial (p=0.480). Plantar warts showed 60% (n=30) complete response versus 40% (n=4) partial (p=0.579).
Single warts showed 96% (n=48) complete response versus 80% (n=8) partial (p=0.07).
Regarding sessions, 60% (n=30) of complete responders required 2–3 sessions, while 80% (n=8) of partial responders required 6 sessions (p=0.006).
X2: Chi-square test. S: p-value < 0.05 is considered significant. T: independent sample T test. NS: p-value> 0.05 is considered non-significant.
Cutaneous warts are common viral infections caused by human papillomavirus (HPV) and remain a frequent challenge in dermatological practice due to their tendency for persistence, recurrence, and variable response to treatment. Although multiple therapeutic modalities are available, including cryotherapy, surgical methods, and topical agents, none provide consistently satisfactory outcomes for all patients. Recurrence and resistance to therapy are still major concerns, particularly in plantar and recalcitrant warts. In recent years, intralesional therapies, including 5-fluorouracil (5-FU), have gained attention due to their targeted action and promising efficacy. However, existing studies show variability in response rates, limited follow-up for recurrence, and insufficient evaluation of factors influencing treatment outcomes [7].
Despite growing evidence supporting intralesional 5-FU, there remains a clear gap in the literature regarding its effectiveness across diverse patient populations and clinical settings. Many previous studies are limited by small sample sizes, single-center designs, or lack of comprehensive analysis of demographic and clinical predictors of response. Furthermore, the relationship between treatment sessions and clinical outcomes, as well as long-term recurrence patterns, is not fully established [8].
Consequently, our study was conducted to evaluate the efficacy and safety of intralesional 5-FU in the treatment of cutaneous warts in a multicenter setting. In addition, it aimed to analyze the association between patient-related and lesion-related factors and treatment response, with particular emphasis on identifying predictors of therapeutic success and assessing recurrence outcomes.
Our study included 60 patients with a slight male predominance, where males represented 53.3% (n=32) and females 46.7% (n=28). The mean age was 29.5 ± 8.8 years, ranging from 18 to 52 years. This indicates that cutaneous warts predominantly affected young adults in our cohort, which is consistent with increased exposure to environmental risk factors and HPV transmission in this age group.
Regarding clinical features, plantar warts were the most common type, observed in 56.7% (n=34) of patients, followed by common warts in 40% (n=24), while mosaic warts were rare (3.3%, n=2). The most frequently affected site was the sole (43.3%, n=26), followed by fingers (33.3%, n=20), toes (16.7%, n=10), and lateral foot (6.7%, n=4). Most patients (93.3%, n=56) presented with a single wart, while only 6.6% had multiple lesions. Regarding treatment sessions, 33.3% (n=20) required 3 sessions, 20% (n=12) required 4 sessions, and 20% (n=12) required 6 sessions, reflecting variability in treatment response. The predominance of plantar lesions aligns with previous reports emphasizing their recalcitrant nature, which is largely attributed to their depth and continuous pressure during ambulation [9]. The sole was the most frequently affected site (43.3%), followed by fingers, toes, and the lateral aspect of the foot. Most patients (93.3%) presented with a single lesion, a factor generally associated with a more favorable prognosis compared to multiple warts.
Regarding treatment response, our study demonstrated a high efficacy of intralesional 5-FU, with complete response achieved in 83.3% of patients (n=50), while partial response was observed in 16.7% (n=10). Importantly, no recurrence was reported among patients who achieved complete clearance, indicating sustained therapeutic effect. These findings are encouraging and are largely consistent with previously published data evaluating intralesional 5-fluorouracil (5-FU) in wart management.
Comparable results were also reported by Zoheir et al. [10], who observed complete resolution in 80% of patients with plantar warts, partial response in 15%, and no response in 5%. Sepaskhah et al. [11], in a comparative study between intralesional 5-FU combined with lidocaine and epinephrine and cryotherapy, found that 64.3% of patients in the 5-FU group achieved complete clearance after six weekly sessions.
However, response rates have varied across studies. Sunny and Doshi [12] reported a lower complete clearance rate of 38.89%, with 61.11% of patients showing residual lesions. This discrepancy may be explained by differences in lesion characteristics, particularly the inclusion of endophytic palmoplantar warts, which often have higher viral loads and thickened stratum corneum that may hinder adequate drug penetration. Variability in HPV subtypes and host immune responses may also contribute to differences in treatment outcomes.
Other investigations further support the efficacy of intralesional 5-FU. Bdaiwi and Abdul-Saheb [13] documented an 80% complete response rate in patients with cutaneous warts. Srivastava et al. [14] reported an even higher clearance rate of 95.38%, highlighting both the effectiveness and safety of this modality in palmoplantar lesions. Ghonemy et al. [3] observed complete resolution in 76.7% of patients treated with intralesional 5-FU, while Kannambal et al. (15) reported a 60% clearance rate in recalcitrant warts. Likewise, Kamal et al. [9] demonstrated excellent outcomes in 75% of patients, and Yazdanfar et al. [16] reported a 64.7% response rate. Earlier work by Iscimen et al. [16] also showed a 70% complete clearance rate in plantar warts.
Regarding safety, all patients (100%, n=60) experienced pain during injection, making it the most common adverse effect. Mild erythema was observed in 13.3% (n=8) of patients. No serious complications such as ulceration, necrosis, or scarring were reported, suggesting that intralesional 5-FU is generally safe and well tolerated. These findings indicate that intralesional 5-fluorouracil (5-FU) is a relatively safe therapeutic option. Our observations are in agreement with Sepaskhah et al. [11], who reported that intralesional 5-FU was associated with minimal adverse effects compared with more aggressive modalities such as cryotherapy or surgical removal.
Similarly, Kamal et al. [9] identified localized pain and irritation as the most frequent side effects following intralesional 5-FU administration. Iscimen et al. [16] documented erythema and edema in a limited number of patients treated for plantar warts, without any cases of necrosis or permanent scarring.
Furthermore, Sunny and Doshi [12] similarly reported that injection-related pain was the principal adverse event in their 5-FU group, with occasional hyperpigmentation around treated lesions. Collectively, these findings reinforce that intralesional 5-FU is generally well tolerated, with side effects that are typically mild and self-limiting.
As regards Correlation Between Response and Patient Variables, the statistical analysis in our study revealed several meaningful relationships between patient characteristics and treatment outcomes. A significant association was identified between sex and therapeutic response (P = 0.022), with females showing better outcomes. Specifically, females constituted 56% of complete responders, while males represented 44%, and all cases with partial response were males (100%). This pattern may suggest a role of biological or immunological differences in influencing the effectiveness of intralesional 5-fluorouracil (5-FU), although further research is needed to confirm this.
A highly significant correlation was also observed between the number of treatment sessions and clinical response (P = 0.006). Most patients who achieved complete clearance required fewer sessions, with 60% responding within 2–3 sessions, whereas 80% of partial responders required 6 sessions. This indicates that early improvement is a strong indicator of successful treatment, while persistence after multiple sessions may reflect resistance and the need for alternative therapeutic approaches. Similarly, Zoheir et al. (10) demonstrated variability in session requirements, with a proportion of patients achieving complete resolution after three or four sessions, while others required up to six sessions.
On the other hand, no statistically significant relationships were found between treatment response and age (P = 0.239), wart location (P = 0.480), wart type (P = 0.579), or number of lesions (P = 0.07). Although Bristow (17) suggested that certain anatomical sites, particularly plantar lesions, may exhibit greater resistance to therapy, our findings did not support a significant association between site and outcome. The mean age was 34.6 ± 8.3 years among complete responders and 39.8 ± 10.9 years among partial responders, indicating that age had no substantial impact on treatment outcome. Likewise, response rates were similar across different wart sites and types. Although a higher complete response rate was observed in patients with a single wart (96%) compared to those with multiple lesions (80%), this difference did not reach statistical significance.
The effectiveness of intralesional 5-FU can be explained by its multiple mechanisms of action. As a pyrimidine analog, it disrupts DNA and RNA synthesis in rapidly proliferating cells, including those infected with HPV. Additionally, its intralesional administration may stimulate local immune responses, enhancing viral clearance. This targeted delivery allows for high drug concentration at the lesion site while reducing systemic exposure and associated side effects.
Clinically, intralesional 5-FU offers several advantages over traditional treatment options. It provides a localized, effective therapy with a high clearance rate and a favorable safety profile safety (18). Notably, our study also demonstrated no recurrence among patients who achieved complete response, suggesting durable treatment effects and potential long-term viral eradication or immune-mediated control.
The results of our study demonstrate that intralesional 5-fluorouracil (5-FU) is an effective and clinically applicable treatment for cutaneous warts, achieving a high complete response rate with no recurrence among completely treated patients. The multicenter nature of our study enhances the clinical relevance of these findings by reflecting outcomes across different clinical settings and patient populations, thereby improving external validity. The significant association between fewer treatment sessions and better outcomes highlights the importance of early response as an indicator of therapeutic success.
From a practical perspective, intralesional 5-FU offers a localized, minimally invasive treatment option with acceptable tolerability. Future perspectives should focus on expanding multicenter trials with larger sample sizes and longer follow-up durations to confirm sustained efficacy, assess long-term recurrence, and explore combination or alternative therapies for resistant cases.
Our study possesses several strengths that support the validity of its findings. It included a well-defined cohort of patients (N = 60) with clearly documented demographic and clinical characteristics. Additionally, the study comprehensively evaluated multiple factors affecting treatment response, including age, sex, wart type, site, number, and number of sessions. Another important strength is the clear documentation of treatment outcomes, including both complete and partial responses, as well as the absence of recurrence in completely treated cases, which adds clinical significance to the results.
Despite its strengths, our study has certain limitations that should be considered when interpreting the results. The predominance of patients with a single wart may have influenced the analysis of the relationship between wart number and treatment response. In addition, the study lacked a control or comparison group, which makes it difficult to directly compare intralesional 5-FU with other treatment modalities. The follow-up duration was also limited, which restricts the ability to assess long-term recurrence beyond the study period.
In conclusion, our study demonstrates that intralesional 5-FU is a highly effective and safe treatment for cutaneous warts, with a complete clearance rate of 83.3% and no observed recurrence among responders. The number of treatment sessions was identified as a significant predictor of response, while other demographic and clinical variables showed no significant influence. The multicenter design further strengthens the applicability of these findings in real-world clinical practice.
Based on the findings of our study, intralesional 5-FU can be recommended as an effective therapeutic option for the management of cutaneous warts, particularly in cases requiring a localized approach. Early evaluation of treatment response is important, as patients with delayed improvement may require alternative or adjunctive therapies. Future research should focus on larger multicenter studies with extended follow-up to validate these results and assess long-term outcomes.
Acknowledgment: none
All authors contributed significantly to our study. Ahmed Adel Ali Ali contributed to study design, data collection, analysis, and manuscript drafting and was responsible for the main supervision and performed the intervention procedures. Aliaa Atef participated in patient recruitment, clinical assessment, and data interpretation. Fatema Saber contributed to data collection, follow-up, and revision of the manuscript. All authors reviewed and approved the final version of the manuscript.
The authors declare that there are no conflicts of interest regarding the publication of our study.
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Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
