Mini Review | DOI: https://doi.org/10.31579/2692-9759/166
First-Level Specialist in Angiology and Vascular Surgery. Assistant Professor of Angiology and Vascular Surgery.
*Corresponding Author: Edel Eduardo Iglesias, First-Level Specialist in Angiology and Vascular Surgery. Assistant Professor of Angiology and Vascular Surgery.
Citation: Edel Eduardo Iglesias, (2025), Therapeutic angiogenesis in patients with chronic arterial insufficiency stage IIB. Enrique Cabrera Hospital, 2024, Cardiology Research and Reports, 7(3); DOI:10.31579/2692-9759/166
Copyright: © 2025, Ramachandran Muthiah. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 07 May 2025 | Accepted: 16 May 2025 | Published: 26 May 2025
Keywords: therapeutic angiogenesis; granulocyte colony growth factor (G-CSF)
The work presented by Dr. Edel Iglesias and collaborators addresses the effectiveness of therapeutic angiogenesis through the use of granulocyte colony growth factor (G-CSF) in patients with chronic arterial insufficiency stage IIb, a condition that severely limits the quality of life and mobility of those who suffer from it. The study was conducted at the Enrique Cabrera Hospital during 2023 and used a quasi-experimental before-and-after design, with a sample of 34 patients who did not respond to conventional treatment.
The work presented by Dr. Edel Iglesias and collaborators addresses the effectiveness of therapeutic angiogenesis through the use of granulocyte colony growth factor (G-CSF) in patients with chronic arterial insufficiency stage IIb, a condition that severely limits the quality of life and mobility of those who suffer from it. The study was conducted at the Enrique Cabrera Hospital during 2023 and used a quasi-experimental before-and-after design, with a sample of 34 patients who did not respond to conventional treatment.
Contributions and relevance
The research highlights the importance of regenerative medicine as a therapeutic alternative for patients who are not candidates for surgical revascularization. The use of G-CSF to mobilize hematopoietic stem cells represents an innovative and less invasive approach that can be applied even in resource-limited settings. The results show significant improvements in the ankle-brachial index and claudication distance, suggesting significant functional recovery for patients. Furthermore, the study identifies predominant risk factors such as smoking and hypertension, providing valuable information for the prevention and comprehensive management of the disease.
Critical analysis
The main contribution of this work lies in the application of an accessible and less invasive regenerative therapy, adapted to the conditions of the Cuban healthcare system. The use of G-CSF to mobilize stem cells represents an innovative strategy, especially valuable in contexts where resources for more complex procedures are limited.
Strengths
• The study addresses a problem of high prevalence and clinical relevance in the older adult population.
• It proposes a viable therapeutic alternative that is adaptable to different hospital settings.
• It presents clear quantitative results that demonstrate the clinical improvement of treated patients.
Limitations
• The sample size is small, which limits the generalizability of the results.
• The quasi-experimental design does not allow definitive causality to be established, although it does suggest a positive association between the intervention and the observed results.
• No adverse effects or long-term follow-up were reported, which are relevant aspects in regenerative therapies.
Compared with other studies, this study aligns with the international trend of exploring cell therapies for vascular diseases, but it stands out for its practical approach and adaptability to resource-limited healthcare systems.
This work constitutes a significant contribution to the field of angiology and regenerative medicine in Cuba, demonstrating that therapeutic angiogenesis with G-CSF can improve vascular function and quality of life in patients with stage IIb chronic arterial insufficiency. The findings support the need for continued research and expanding access to innovative therapies in the Cuban healthcare system.
Dear Editorial Team, Clinical Medical Reviews and Reports. My experience with the journal was highly positive. The peer-review process was rigorous, constructive, and completed in a timely manner. The reviewers provided valuable comments that helped improve the quality and clarity of our manuscript. The editorial office was professional, responsive, and supportive throughout all stages of the publication process. Communication was clear and efficient, and any questions were addressed promptly. Overall, I found the journal to maintain high scientific standards and an excellent publication workflow. I would be pleased to consider submitting future work to this journal. Best wishes from, Elena Popa.
It was my pleasure to submit my testimonial concerning the Reviewer Board of our Scientific Journal “Brain and Neurological Disorders”. The Reviewers focused on some modifications and their contribution was helpful. The ladies of our Editorial Office were also supported my efforts. It was my honor to have such a co-operation and I am looking forward for more collaboration.
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Thank you for the speedy and efficient peer review process. I appreciate the fact that your peer reviewers do not take months to respond like with some other journals. I would also like to thank the editorial office for responding quickly to my questions. It is an excellent journal. I plan to submit more manuscripts in the future. Best wishes from, Robert W. McGee
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Working with you and your team on our recent publication in JCRR has been a truly wonderful and enjoyable experience. The responses were prompt, and the reviewers were patient, constructive, and highly professional. One reviewer in particular gave me the feeling that a professor was carefully reading and commenting on my coursework, which was deeply touching. The entire process was straightforward and hassle‑free, with no tedious online forms to complete. I highly recommend this journal. Best wishes from, DR Aibing Rao, Head of R&D
I Appreciate the Opportunity to Share my Experience with the Journal of Clinical Research and Reports. The peer review process was timely and constructive, and the feedback provided helped improve the quality of our manuscript. The editorial office was professional, responsive, and supportive throughout the process, ensuring smooth communication and efficient handling of the submission. Overall, it was a positive experience collaborating with your team.
Dear Mercy Grace, Editorial Coordinator of Obstetrics Gynecology and Reproductive Sciences, We would like to express our gratitude for your help at all stages of publishing and editing the article. The editors of the magazine answer all the necessary questions and help at every stage. We will definitely continue to cooperate and publish other works in the Obstetrics Gynecology and Reproductive Sciences! Best wishes from, Alla Konstantinovna Politova,
