The new method Cancer Therapy via combination “Prolonged medical starvation” with considerably decreased dosage of cytotoxic drugs was borrowed by folk healer Breuss R. Just the mechanism of the new method of cancer therapy operates via targeting of Warburg effect that exerts anticancer internal immunotherapy of an organism. Therefore benefit of new method cancer treatment is oc-curred through using “Prolonged medical starvation” by an organism with the very small dose cyto-toxic drug against cancer disease leading to depression of oncological viral metabolism with exerting mechanism of immunotherapy. The considerably decreased dosage of cytotoxic drugs exerts cellular immune activity of immune phagocytes T cells and humoral immune antibodies from B cells which destruct of the depressed cancer oncological metabolism creating efficient Cancer Therapy. Just the modern methods of Cancer Chemotherapy with large dosage of cytotoxic drugs suppress as cancer oncological viral metabolism as well as immune and hormonal defending systems of a human organ-ism. Therefore often the large dosage of cytotoxic drugs cannot create complete destructions of all cancer oncological viral mechanisms which are occurred as in the cancer neglected organisms as well as leading to either relapse cancer disease or immune resistance to cytotoxic drugs after finished large dosage of cytotoxic drugs in modern methods Cancer Chemotherapy. There were described the bio-chemical and biophysical mechanisms of new method cancer treatment which leads to the benefits for cancer treatment of neglected cancer disease in ill man. The new method cancer treatment uses “Pro-longed medical starvation” with very decreased dosage of cytotoxic drugs which exerts immunother-apy of an organism. It was described the biochemical and biophysical mechanisms of some cancer disease after modern chemotherapy with large dose of cytotoxic drugs causing formations resistance to the cytotoxic drugs and relapse cancer disease after remission of modern cancer disease treatment. This work is substantiated the mechanism operation of the new method cancer treatment, which leads to prevention recurrence cancer disease and resistance to anticancer cytotoxic drugs in comparison with intensive anticancer chemotherapy with large dosages of cytotoxic drugs. Therefore the as-sessing advantage the new method of cancer therapy over the modern method of cancer therapy is substantiated the opportunity to exert mechanism destruction oncological viral mechanism of cancer disease without expression of viral oncogenes (v-oncogenes). Thus the offered new method Cancer Therapy should be put into practical medicine after detail Clinical Trials.

The mechanism of new method cancer treatment operates via targeting Warburg effect of cancer metabolism. The mechanism of new method cancer treatment uses combination “Pro-longed medical starvation” with considerably decreased dosage of cytotoxic drugs. This com-bination leads to the destruction “aerobic oxidation in Glycolysis” of mechanism Warburg ef-fect. There were substantiated the viewpoint of thermodynamic biophysical and biochemical descriptions of the mechanism Warburg effect causing oncogenesis mechanism which mecha-nism is destructed by the new method cancer treatment creating transiting from quasi-stationary pathologic state of an organism into normal stationary state of an organism and cells of an organism via mechanism maintenance stability Internal Energy and Internal Medium ac-cording to first law of thermodynamics. The stability of Internal Energy (∆U) is shown by or-ganism’s stable temperature 36,0°C – 36,9°C, blood stability of pH = 7,35 etc. by which all enzymes operate [1, 2]. There are as the positive influence Environment on a human organism as well as negative influences Environment on a human organism which can be as inorganic substances influences as well as organic substances influence even by living organisms how bacteria and viruses. The defensive mechanism of immune and hormonal systems of an organ-ism resists the negative influences of pathologic substances and pathologic organisms how bacteria and viruses. Considering mechanisms of oncogenesis in different states of an organ-ism, there were described mechanisms of oncogenesis Cancer Tumor Metastases in neglected state of an organism either mechanism of resistance to anticancer cytotoxic drugs or mecha-nism of relapsed cancer disease causing by survival virusal oncogenes of suppressed immune systems and hormonal systems causing by large dosage cytotoxic drugs of modern methods cancer therapy. Firstly, neglected cancer disease cannot be complete treated by modern methods chemotherapy with large dosage of cytotoxic drugs because large doses of cytotoxic drugs create suppression defensive mechanisms of immune and hormonal systems. Secondly, the prevalence etiologic factors over organism’s defensive immune and hormonal systems stimulates driving mechanisms of transmutation normal cells into cancer cells which lead to development Metastases of cancer disease. The prokaryotic organisms of oncologic viruses (v-oncogene) have no the electron transport chain via five Complexes of respiratory system as opposed of the other prokaryotic organisms of different bacteria. All eukaryotic organisms including human organism have electron transport chain via five Complexes of respiratory system. Therefore oncologic viruses (v-oncogenes) live in cancer cells of the human organisms. Oncologic viruses (v-oncogenes) affect cells’ nuclei of weak place of extracellular tissue which is supplied with lack of Basic Internal Energy (Ebas) causing by lack of hormonal support. Lack of cellular walls’ of hormonal support results in disbalance intercellular chemical potential (µinter.cell) & extracellular chemical potential (µouter.cell). Therefore oncologic viruses (v-oncogenes) affect deep level of stem cells maybe Unipotent stem cells or even Oligopotent stem cells due to lack of energy from Basic Internal Energy (Ebas) in deep level of these stem cells which lead to find other cells of an organism with enough deep level energy from Basic Internal Energy. These mechanisms create Metastases. 

An open non equilibrium non linear thermodynamic system of a human organism is subjected to thermodynamic laws where the thermodynamic first law is the following formula: 

H = U + W(int) + W(ext) [H – Enthalpy (Common Energy), U – Internal Energy, W(int) – Internal Work, W(ext) – External Work]. The mechanism maintenance stability Internal Energy (U) (stable temperature 36,0ºC -36,9ºC, stable PH = 7,35 in blood etc.) is depended on interactions between Internal Work (Wint) of an organism and External Work (Wext) of an organism which creates maintenance stability of or-ganism’s Internal Medium (stable concentration substances in blood and neuronal lymph). The stability Internal Energy (U) support stable balance anabolic endergonic processes & catabolic exergonic processes of an organism. It contains three level regulation: highest level regulation [Central Nervous System], high level regulation [“Equilibrium Constant of ionic metabolism”, “Equilibrium Constant of acid –- alkaline metabolism”, “Equilibrium Constant of oxidative – reduction Potentials of metabolism” and “Equilibrium Constant of coagulating system of blood”] and low level regulation [“Equilibrium Constant of endergonic and exergonic process-es of energy exchanges” and “Equilibrium Constant of anabolic and catabolic processes of me-tabolism”] [1. 2]. (Figure 1). 

Figure 1: The Metabolism of a malignant tumor tissue and a normal tissue.

The organism’s mechanisms maintenance stability Internal Energy (U) (temperature 36,0ºC – 36,9ºC and stable PH = 7,35 in blood for enzymes operate etc.) are created stable Internal Medium as constant concentrations of substances in blood and in neuronal lymph as well as stability of quantities of different cells in blood of an organism. Besides mechanism mainte-nance stability Internal Energy (U) of an organism forms mechanisms maintenance stability of balance anabolic endergonic biosynthetic processes & catabolic exergonic oxidative processes which cause stable Stationary State of an organism (1, 2). The affection of an organism’s cells by v-oncogenes results in shift balance anabolic biosynthetic endergonic processes & catabolic oxidative exergonic processes into excessive large anabolic endergonic processes. Excessive large anabolic endergonic processes of cancer disease lead to excessive consumption energy via Acetyl–CoA for anabolic biosynthetic endergonic processes in cancer tissue which cause the overload of “nodal point of bifurcation anabolic and catabolic processes” [NPBac] because of the remained lack Acetyl–CoA for oxidative phosphorilation in catabolic exergonic anaero-bic oxidative processes of Krebs tricarbonic acids cycle (TCA) [3. 4. 5. 6] (Figure 2). 

Figure 2: Krebs tricarboxylic acids cycle (TCA) in catabolic exoergonic process.

Also such shift into excessive anabolic endergonic processes and lack Acetyl-CoA cause par-tial suppression of catabolic anaerobic exergonic processes of oxidative phosphorilation (TCA) in cancer tissue, but some catabolic anaerobic processes remain for cancer cells survival via Krebs tricarbonic acid cycle (TCA) [3. 4. 5. 6] (Figure 3). 

Figure 3: Interaction between anaerobic catabolic processes aerobic catabolic processes via krebs tricarboxylic acids cycle.

The increase of lactic acids production is the necessary mechanism of accumulation energy for huge anabolic endergonic processes in condition glycolysis metabolism which cause enormous consumption energy for anabolic processes in cancer tissue (3, 4, 5, 6) (Figure 1 and Figure 3). Thus Warburg effect mechanism forms oncogenesis of the metabolism of cancer tissue (3, 4). The partial suppression of catabolic anaerobic processes causes shift balance catabolic aerobic exergonic processes & catabolic anaerobic exergonic processes into prevailing catabolic aerobic exergonic oxidative processes (3, 4, 5, 6) (Figure 1 and Figure 3). The considerably increased Lactic Acids, as the marker of Glycolysis, and prevailing Aerobic catabolic exergonic oxida-tive processes determine “Aerobic Glycolysis” of Warburg effect in cancer metabolism (3, 4, 5, 6) (Figure 3). The Pasteur effect exhibits “Incompatibility Glycolysis with Aerobic Oxida-tion” in normal tissue, Warburg effect exhibits Aerobic Glycolysis in cancer tissue metabolism, i.e. combination Aerobic Oxidation with Glycolysis which is defined by increase Lactic acids as crucial marker of Glycolysis. Hence there are targets of cancer stem cells which use much energy for their development in cancer cellular cycle with increasing anabolic processes in dis-balance anabolic biosynthetic processes & catabolic oxidative processes (Figure 4). 

Figure 4: Influences of energy flow on interaction catabolic processes and anabolic processes in norm and in cancer pathology.

The partial suppression catabolic anaerobic exergonic processes of oxidative phosphorilation in Krebs tricarbonic acids cycle [TCA] are exerted by considerably expression catabolic aerobic exergonic oxidative processes which induce expression oxidative processes in targets new method and modern methods of  cancer diseases treatments [6] (Figure 5). 

Figure 5: The targets of both the new methods cancer treatment and modern method of cancer treatment.

Just mitochondria aerobic catabolic oxidative function is acted in norm. There are occurred the operation electron transport chain through Five Complexes includes cytochrome system [cyto-chrom C, cytochrom-c-oxidase, cytochrom P450 etc.] in cancer cells that receives stabile quan-tity Oxygen (O2) being delivered by Hemoglobin system corresponding to stabile constant Respiratory Index [CO2/O2 = 0,8 – 1,0] of an organism (Figure 5). The shift balance Aerobic oxidative processes & Anaerobic processes of oxidative phosphorilation into expression Aero-bic oxidative processes, owing to partial suppression of Anaerobic processes of oxidative phosphorilation in mitochondria of cancer cells are forming the excessive quantity of mito-chondrial superoxide [O2*]. The forming of excessive quantity of mitochondrial superoxide [O2*] are occurred by supply sufficient quantity ions of Hydrogen (H+) for production H2O via oxidation of Hydrogen ions, and Oxygen (O2) adds electrons (e-) forming mitochondrial Su-peroxide (O2*): O2 + e- = O2*(5, 6). The superoxide [O2*-] reduces Ferric iron [Fe3+] into Fer-rous iron [Fe2+] with oxygen through following reaction: O2*- + Fe3+ → Fe2+ + O2 (Figure 3 and Figure 5). Then superoxide anion is subjected to dismutation by manganese superoxide dismutase (MnSOD) and copper, zinc superoxide dismutase (Cu, ZnSOD) converting into hydrogen peroxide:  2O2*- + 2H+ = H2O2 + O2. Thus Krebs tricarbonic acid cycle (TCA) reac-tion leads to forming increased quantity of Reactive Oxygen Species (ROS) [5, 6] (Figure 6). 

Figure 6: The influences general regulations biochemical processes on internal energy determining stability internal chemical potentials of an organism(μ), normal cells(μ) and cancer cells(μ*).

The excessive quantity of mitochondrial superoxide [O2*] does not support processes of anaer-obic oxidative phosphorilation and does not lead to final products CO2 and H2O. The normal steady concentration of superoxide [O2*] is higher in mitochondrial matrix than in cytoplasm and nucleus. Subsequently it is happened Haber –Weiss reaction of iron catalyzed by superox-ide transformations which is passed into Fenton reaction [7, 8, 9, 10, 11, 12]. 

1.Fe3+ + O2*- → Fe2+ + O2 

2. Fe2+ + H2O2 → Fe3+ + −OH + *OH 

3. O2*- + H2O2 → −OH + *OH + O2 + Fe3 

The formed complex ROS/H2O2 pass through mitochondrial membranes and cytoplasm into nucleus and generates superoxide [O2*] inducing free radicals (*OH). Free radicals (*OH) react on nuclear DNA [nDNA] and induce process replication via realizing of 2nDNA reaction [11, 12].

1. *OH + H2-nDNA-DNA ––> H2O + H•-nDNA-DNA; 

2. O*+ 2H2O ––> 2H• + 2OH¯; 

3. 2H•-nDNA-DNA + 2H• ––> 2nDNA-H• + 2nDNA-H•; 

4. 2nDNA-H• + 2*OH ––> 2nDNA + H2O

Thus the free radicals (*OH and H•) induce nDNA replication, and free radicals are neutralized in final S and G2 phases of cellular cycle via nDNA replication which occurs as in cancer cells as well as in normal cells [4, 6. 7]. However 2nDNA reactions for cells’ replications occur more often in cancer cells than in normal cells because cancer stem cells use more energy for excessive anaerobic endergonic biosynthetic processes and for 2nDNA reactions creating can-cer cells’ replications than energy for normal balance anabolic processes & catabolic processes and for 2nDNA reactions creating normal cells’ replications. Therefore the excessive energy more exerts activity of 2nDNA reactions for the cancer stem cells replications as opposed to normal quantity energy for 2nDNA reactions for normal cells replication. Hence cancer cells consume more organism’s energy than normal cells which leads to as grow cancer tumors as well as lose energy for cancer cells development. Therefore the loss energy of cancer cells leads to transit some oncologic viruses into normal cells of an organism with enough of level energy for 2nDNA replication obtained from Basic Internal Energy causing mechanisms of Metastasis (see below, part 4). Highlight of Warburg effect mechanism of the huge anabolic processes in cancer processes in which viral oncogenes operation cause huge consumption en-ergy and Acetyl-CoA with partial suppress catabolic anaerobic processes in cancer tissue. Hence the shift balance anabolic processes & catabolic processes into excessive anabolic pro-cesses leading to lack Acetyl-CoA for anaerobic processes in cancer metabolism that causes shift balance Aerobic oxidative processes & Anaerobic processes of oxidative phosphorilation into expression of Aerobic oxidative processes, owing to partial suppression of Anaerobic pro-cesses of oxidative phosphorilation, in mitochondria of cancer cells. These processes induce increased ROS/H2O2/Free radicals which exert cancer cells’ irrepressible proliferative process-es for cancer tumor growth and Metastasis [7, 8, 9, 10]. 

3a. The detailed description of the used Herbal Extracts in cancer treatment by “Pro-longed Medical Starvation for 42 – 45 days”. 

New method cancer treatment uses “Prologed medical Starvation” which is supplemented with considerably decreased dosage cytotoxic substances [13, 14, 15]. “Prolonged medical Starvation during 42 - 45 days” of an organism is supported with herb extracts [sage, haw-thorn, horse-tail, (stinging-)nettle, ninety-knot, hypericum, ergot, St.John’s wort, etc.] provid-ing with small dosage of cytotoxic activity of red cranesbill (Geranium robertianum) and used abundant liquid drink including water up to 1,5 – 2,0 liter per day [13, 14, 15, 16]. The herbal extracts should be filtered through a triple gauze layer in order that any fibre must not remain in the extract. The herbal extracts fill the organism during “Prolonged medical Starvation 42 – 45 days” for supplementing with necessary microelements and vitamins, especially folic acid, that is necessary for hemopoiesis and decreases also acidification in the blood of the or-ganism by “Prolonged medical Starvation”. During the “Prolonged medical Starvation” it’s necessary to look after the common health state of the person and especially state of gastroin-testinal tract that it occurs the bowels open /timely evacuation of excrements/, that there will not be constipation /retention of feces/. The disturbance of gastrointestinal activity should be healed with vegetable laxatives, activated charcoal, medicaments and use an enema if it’s nec-essary. The starvation leaving should been taken place during 7 days with gradual addi-tion of products: juices, then watery decoctions and gels, then vegetable pulps, then baked fruits and vegetables, then liquid kasha (dish of cooked grain), then mashed potatoes, then pair of cutlets – and up to the usual nutrition [14, 15]. The diet shouldn’t be salted during leaving starvation [14, 15].

3b. The Healing Mechanism of “Prolonged Medical Starvation 42–45 Days with very Small Dosage and Weak Cytotoxic Substances”. Cancer tumor is situated inside the human organism using the organism as environment, and obtains the substances from depot of an organism for its metabolism (fat depots, carbohydrate depots, etc.). Also, an organism obtains substances from depots of an organism for its metabo-lism in condition depressive organism via treatment by “Prolonged medical Starvation (during 42–45 days)” [13, 14, 15, 16, 17]. The treatment by “Prolonged medical Starvation (during 42–45 days)” is providing with small dosage of cytotoxic activity of red cranesbill (Geranium robertianum) and used abundant liquid drink including water up to 1,5 – 2,0 liter per day (14, 15) causing considerable decrease almost of all depots of an organism exhausting organism’s fat and hydrocarbonic depots, that leads to competition between cancer tissue and an organ-ism for the use of remained decreased depot for maintenance stability Internal Energy of a depressive organism (U org) (normal temperature 36.0°C–37.0°C by which all enzymes oper-ate and other indices). Thus, this competition between the organism and the cancer must lead to the win for most strong one. But the protective forces of the depressive organism become stronger due to support with herbal extracts including also small dosage of cytotoxic activity of red cranesbill (Geranium robertianum), delivering vitamins and microelements into the or-ganism [14, 15]. Besides increase of fat metabolism from fat depot leads to augmentation glu-tation peroxide GPX and phospholipid hydroperoxide glutathione peroxide (PHGPX) in all cells of an organism which neutralize redundant superoxide [O*] and ROS/H2O2/free radicals in G1/S phases cellular cycle of cancer cells cycle suppressing excessive proliferative processes of cancer cells [6, 14, 15]. Suppression accelerating cellular cycle in cancer cellular cycle leads to decrease anabolic processes in condition of “Prolonged medical Starvation” with small dos-age of cytotoxic activity of red cranesbill (Geranium robertianum) which is exerting normal nuclear DNA [nDNA] work, decreased replication via prevailing Mitosis over Meiosis in com-plex Mitosis-Meiosis phase [6, 13]. Eliminating partial suppression of Anaerobic processes of oxidative phosphorylation by “Prolonged medical Starvation” restores normal balance Aerobic oxidative processes & Anaerobic processes of oxidative phosphorylation. But suppressed some Aerobic processes in mitochondria of cancer cells create decreasing ROS in mitochon-dria of cancer cells causing suppression of excessive nucleus DNA replication with normaliza-tion of cellular cycle and elimination irrepressible proliferative processes of cancer growth [3, 4, 15, 16, 17]. Also, complex Meiosis-Mitosis phase of cancer cellular cycle is broken into sep-arate Mitosis and Meiosis where haploid Meiosis phase of viral cellular cycle is deprived due to prevailing state over diploid Mitosis phase normal cellular cycle [15, 16, 17]. Besides bro-ken covalent bonds between Mitosis and Meiosis deprive barriering defense of viral pluripo-tent stem cells function causing normal cellular cycle with activity of diploid Mitosis phase in cancer cells [14, 15, 16, 17]. Expression Mitosis in normal cellular cycles of all cells incite T cells [T lymphocytes] with appearance produced immunoglobulins CTLA-4 and PD-1. The resonance waves of cellular capacitors T memory cells learn and remember through waves function of viral molecular build substances into 21 containing separated haploid Meiosis phase. Then T memory cells exert with remembered viral substances of T helper cells, and T helper cells stimulate T killer cells’ phagocytes as well as B cells for production antibodies against cancer viral substances with their haploid Meiosis phase. Thus it is deprived barriering defense of covalent bonds between Mitosis and Meiosis causing loss viral pluripotent stem cells function. Thus, such basic phenomena of the cancer metabolism are inhibited by follow-ing datum [14, 15, 17].

1. Mechanism of “Warburg effect.” 

2. Biochemical and biophysical mechanisms of metastases and non-healing tumor ulcers. 

3. Inhibition of Warburg effect by “Prolonged medical Starvation” with weak small dose cy-totoxic substances leads to cancer cells’ depressions which are determined by the following changes: 

3a. Expression normal cellular cycle and inhibition accelerated cancer cellular cycle. 

3b. Activated diploid Mitosis phase cellular cycle and suppression haploid Meiosis phase of viral cellular cycle.

3c. Stimulated immune phagocytosis of T memory cells – T helper cells – T killer cells and B cells to produce antibodies against the autoantigen IgE substances causing suppression haploid Meiosis phase of viral cellular cycle. Simultaneously the very small dosage and weak cytotoxic substances damage only depressed cancer cells but don’t influence on singles survived cancer viruses. The singles survived cancer viruses are damaged by immune antibodies of an organism as well as immune phagocytosis of T-cells. Thus influences these very small dosage and weak cytotoxic substances on depressed cancer cells promote penetration through cellular walls by the anticancer antibodies against viral substances which ruin as viral substances as well as hap-loid Meiosis phase of cancer cells promoting cured an organism. Benefits “Prolonged medical Starvation” with decreased dosage cytotoxic substances contributes to depression of cancer tumor metabolism that helps for efficient anticancer therapy. Such anticancer chemotherapy prevents damage Internal Energy (U) and Internal Medium both an organism and cells of an organism, Besides “Prolonged medical Starvation” with decreased dosage cytotoxic substanc-es prevent damage of immune and hormonal systems as the links of defensive mechanisms an organism. 

4a. The Mechanisms of Cancer Tumor Metastases in neglected state of an organism. 

The overload of “nodal point of bifurcation anabolic and catabolic processes” [NPBac] with partial suppression catabolic exergonic anaerobic processes occurs due to shift balance anabol-ic endergonic processes & catabolic exergonic anaerobic processes into excessive anabolic en-dergonic processes in cancer metabolism [4, 18, 19, 20, 21, 22] (Figure 3). Thus increased the anabolic endergonic processes in cancer tissues of neglected organism leads to deep loses of considerable decrease almost of all depots of an organism especially exhausting organism’s fat and hydrocarbonic depots via their substances because of increased anabolic endergonic pro-cesses of cancer tumor in neglected state of a human organism due to becoming lean [4, 18, 19, 20, 21, 22]. Besides this violated balance anabolic biosynthetic processes & catabolic an-aerobic oxidative processes cause violation balance catabolic aerobic processes & catabolic an-aerobic processes into prevalence aerobic processes of respiratory oxidation over partial sup-pressed anaerobic processes of oxidative phosphorilation in cancer metabolism [4, 6, 18, 19, 20, 21, 22]. The prevalence aerobic processes of respiratory aerobic oxidation over anaerobic processes of oxidative phosphorilation leads to disbalance between mitochondrial aerobic res-piratory oxidative function and anaerobic oxidative phosphorilation of link Glycolysis – Krebs Tricarboxylic Acids Cycle (TCA) in which it is created disbalance anabolic processes & catabolic processes by violation stability Internal Energy and chemical potentials (µ*) of cancedr tissue and cells in opposed to chemical potentials (µ) of normal organism tissues and cells stable Inrenal Energy  [4, 5, 6, 18 – 22] (Figure 6). As concerning to the absence the respiratory electron transport chain with five Complexes in oncologic viruses (v-oncogenes), the prevalence aerobic processes of respiratory oxidation in cancer cells is provided by respiratory electron transport chain with five Complexes from cel-lular mitochondrial respiratory electron transport chain. However the oncologic viruses (v-oncogenes) are intensive replicated and find respiratory activity in cancer cells’ mitochondrial respiratory electron transport chain with five Complexes which can provide only specified quantity Oxygen (O2). Therefore the intensive replication oncologic viruses (v-oncogenes) in cancer cells need more respiratory electrons transport chain with five Complexes than speci-fied quantity of respiratory electrons transport chains with five Complexes that are compelled to receive supplemented respiratory electrons transport chains with five Complexes in new normal heathy cells which are affected by oncologic viruses of cancer cells causing transmuta-tion normal healthy cells of other organs into the new cancer calls of metastasis in new organs of an organism. Hence the balance chemical potentials (µ) of the Internal Energy both healthy cells and the healthy organism promote operation resonance waves of cellular ca-pasitors but the disbalance chemical potentials (µ*)  of violationg Internal Energy of Cancer Cells (Figure 7). 

Figure 7: Balance internal energy both cells and an organism due to their chemical potentials (μ) promoting operation resonance waves of cellular capacitors and dis balance of chemical potentials (μ*) cancer cells.

Thus increased quantity metastases create neglected state of cancer ill organism. Just cells’ mi-tochondrial aerobic oxidative function produces stable quantity Oxygen ions [O-2] via opera-tion of cytochrome system [cytochrom C, cytochrom-c-oxidase, cytochrom P450 etc.] in cells because of delivering stable quantity Oxygen (O2) by Hemoglobin system in blood corre-sponding to stable Respiratory Index [CO2 /O2 = 0,8 - 1,0] in an organism. Produced in Krebs tricarboxylic acids cycle (TCA) Hydrogen ions (H+) react with Oxygen (O2 ) and form Water (H2O) that must eliminate Oxygen from liquids of an organism tissue and cells of an organism [4, 6, 9, 10, 18 – 22] (Figure 5 and Figure 6). However the supplementary Oxygen (O2) does not find sufficiently Hydrogen ion (H+) to react with Oxygen (O2) and does not produce sup-plementary Water (H2O) [4, 6, 9, 10, 17 – 22]. Therefore this supplementary Oxygen (O2 ) adds electron, due to Reactive Oxygen Species (ROS) operation, and is transformed into su-peroxide (O2 *) which generates free radicals in norm. The many free radicals exert DNA rep-lications in G2 phase of cellular cycle via inducing great reactions 2nDNA of oncologic accel-erated replication [5, 6]. Partial suppression catabolic processes of Krebs tricarboxylic acids cycle (TCA) decrease quantity of Hydrogen ions (H+) production in cancer metabolism. The insufficiency of Hydrogen ions (H+) production causes abundance superoxide (O2 *) inducing excessive quantity of ROS/ H2O2 /free radicals which exert accelerative DNA replications via inducing accelerative reaction 2nDNA reactions in cancer cells [4, 5, 6, 11, 12, 18 – 22].   

1. *OH + H2-nDNA-DNA ––> H2O + H•-nDNA-DNA; 

2. O*+ 2H2O ––> 2H• + 2OH¯; 

3. 2H•-nDNA-DNA + 2H• ––> 2nDNA-H• + 2nDNA-H•; 

4. 2nDNA-H• + 2*OH ––> 2nDNA + H2O 

The induce nDNA replication in G2 phase cellular cycle, and also the free radicals (*OH and H•) are neutralized in final G2 phase of nDNA replication as in cancer cells as well as in nor-mal cells [5, 6, 11, 12, 18 – 22]. Then it occurs M phase of cellular cycle, i.e. Mitosis in cell division. Thus moderate cellular replication occurs in norm due to production moderate quanti-ty ROS/H2O2/free radicals in able-bodied cells and occurs via G○, G1/S, G2, M phases cellular cycle. The accelerated cycle of cancer cell is induced by accelerated cycle of v-oncogene ini-tially and then is continued via affecting cancer nuclei by excessive quantity ROS/H2O2 /free radicals produced in cancer cells’ mitochondria. The accelerated cellular cycle of cancer cells leads to shortening cancer cellular cycle without G○ and G1 phases cellular cycle that creates excessive cellular replication of cancer cells. The perpetual affecting cancer cells by excessive quantity of ROS/H2O2 /free radicals cause irrepressible cancer tumor growth which also sup-ports by some growth factors as EGF, FGFs, HGF, HDGF, GDF9, IGFs and so on [5, 6, 11, 12, 18 – 22].                                                         

4b. The cancer metastases in neglected state of an organism are destructed via creating efficient treatment of cancer disease by mechanisms of new method cancer treatment. 

The state of “Prolonged medical Starvation (during 42–45 days)” bereave of some substances for anabolic biosynthetic processes that prevent affected normal cells by v-oncogenes via im-peding of shift balance anabolic endergonic processes & catabolic exergonic processes into excessive anabolic endergonic processes [4, 14, 15, 23, 24, 25]. Hence absents of excessive anabolic endergonic processes of cancer tissue and excessive quantity of mitochondria cata-bolic aerobic oxidative processes are creating by exerting electrons transport chain with five Complexes that lead to absence mechanism forming metastases and development of cancer cells [11, 12, 15, 23, 24, 25]. Thus overloaded “nodal point of bifurcation anabolic and cata-bolic processes” [NPBac] with consumption great quantity energy and Acetyl-CoA is dam-aged in “Prolonged medical Starvation (during 42–45 days)” that leads to depression of can-cer development [4, 15, 19, 23, 24, 25]. Besides it prevents of forming Warburg effect as mechanism of cancer development.  Also the new method cancer treatment use “Prolonged medical Starvation (during 42–45 days)” for depression cancer activity of forming metastases, and use very small dosage of cytotoxic substances which destruct depressed cancer cells without suppression activity of immune systems and hormonal systems of an organism. Hor-mones how cofactors of an organism’s metabolic chemical processes promote maintenance stability Internal Energy (Uorg) of an organism in state of “Prolonged medical Starvation (dur-ing 42–45 days)” that supports stability as balance anabolic biosynthetic processes & catabolic anaerobic phosphorilation of oxidative processes as well as catabolic aerobic oxidative pro-cesses & catabolic anaerobic phosphorilation of oxidative processes. Also very small dosage of cytotoxic substances destruct of some depressed mechanism of cancer development, and then immune T cells phagocytosis with B cells‘ antibodies creates complete destruction of oncolog-ic mechanisms leading to recovery of the organism. However there are the some incurable state in neglected state of cancer disease which cannot be to cure ever by new method cancer treatment. Therefore a doctor must determine following queries: 1) Have oncological patient cachectic state of Health entirely? 2) Have the oncological organism many inoperable metasta-ses into life support organs how the brain, the lungs, the hepar etc. 3) Have the oncological organism very bad state of Health due to excruciating common pain or local pain in life sup-port organs? c) Had oncological organism losing common activity? The oncologic Doctor must treat only symptoms or syndrome of such neglected oncological disease. 

4c. The cancer metastases in neglected state of an organism are appeared in all organs of an organism including in living organs which create impossible to treatment of cancer disease by modern method cancer therapy with large dosage cytotoxic drugs. 

As concerning to modern methods of cancer treatment with large doses of cytotoxic drugs, the both immune system and hormonal system of an organism are suppressed by large dosage cytotoxic drug that reduce possibility of efficient cancer treatment especially of cancer many metastases [6, 26 – 37]. First of all, chemotherapeutic modern methods cancer therapy use large dosage cytotoxic drugs which create destruction as great quantity of cancer cells with oncologic viruses (v-oncogenes) in them as well as suppressed both Hormonal processes of an organism’s maintenance stability Internal Energy and Immune processes of T cells phagocyto-sis and B cells’ antibodies again internal viral oncogenes (v-oncogenes) [6, 26 – 37]. Secondly, the modern methods cancer therapy with large dosage cytotoxic drugs can destruct great quantity of cancer cells with oncologic viruses (v-oncogenes) in them or only some single quantity of cancer cells with oncologic viruses (v-oncogenes) in the beginning cancer disease without multiple cancer metastases [6, 26 – 37]. Hence the forming multiple cancer metastases in neglected state of an organism are occurred through overload of “nodal point of bifurcation anabolic and catabolic processes” [NPBac] with partial suppressed catabolic exergonic anaero-bic oxidative processes also shift balance anabolic endergonic processes & catabolic exergonic anaerobic oxidative processes into excessive anabolic endergonic biosynthetic processes ac-cording to Warburg Effect. Therefore the multiple cancer metastases consume great quantity substances from fat and hydrocarbonic depots creating exhausting of an organism. Besides the great consume of depots’ substances by cancer metastases lead to use of the increased catabol-ic exergonic aerobic oxidative processes for its respiratory activity. The excessive respiratory activity demands excessive catabolic aerobic oxidative processes for cancer cells and for nor-mal organism’s cells processes. Thus excessive catabolic aerobic oxidative processes induce accelerating reaction 2nDNA replication via exerting accelerative DNA replications by cancer cells [6, 26 – 37]. The accelerating state of cancer cells are supported by oncologic viruses (v-oncogenes) activity which form supplemental metastasis by exerting affected healthy cells into cancer cells [6, 26 – 37]. These activities of cancer development form many new cancer cells which cannot be destructed all of them even by large quantity of cytotoxic drugs that make neglected state of cancer disease via creating incurable organism. This activity of cancer de-velopment can be ceased by creating depressed activities of cancer cells development. Just the depressed activities of cancer cells development are made by “Prolonged medical Starvation (during 42–45 days) with very small dose of weak cytotoxic substance which give opportunity of efficient treatment by immune therapy of T cells phagocytosis and B cells Antibodies in new method cancer treatment. 

5. The mechanism of forming either resistance cytotoxic drugs or relapse cancer disease in event to cease of treatment after modern methods of therapy with large dosage cyto-toxic drugs and the mechanism of preventing as forming resistance cytotoxic drugs as well as appearance relapse cancer disease by new method cancer treatment. 

Immune system and hormonal system are the links of system maintenance stability Internal Energy and Internal Medium via determining stability chemical potential Internal Energy (Uµ) of an organism. Therefore suppressed immune system and hormonal system after long anti-cancer modern chemotherapy with large dosage of cytotoxic drugs don’t prevent both relapse of cancer disease and resistance of anticancer cytotoxic drugs which are occurred due to viola-tion stability Internal Energy of chemical potential (Uµ*) of an organism [38, 39, 40, 41] (Figure 7). 

5a. The mechanism of forming either resistance cytotoxic drugs or relapse cancer disease in event of the cease after treatment by modern methods of therapy with large dosage cytotoxic drugs.  Cancer tumor is situated inside the human organism using the organism as environment, and obtains the substances from depot of an organism (fat depots, carbohydrate depots, etc.) for its metabolism [42, 43] (Figure 8). 

Figure 8: The mechanisms of relapse oncologic viruses in cancer diseases.

 The modern chemotherapy with large dosage cytotoxic drugs leads to complete destruction of some cancer cells with oncologic viruses within them, and also it makes some suppression of defensive mechanisms both immune and hormonal systems [44, 45]. Just the normal develop-ment of cellular cycle demand energy for the supplemental anabolic biosynthetic endergonic processes which energy is received from Basic Internal Energy (Ebasic) through Basic stem cells (neurons) → Totipotent stem cells → Pluripotent stem cells → Multipotent stem cells → Oli-gopotent stem cells → Unipotent stem cells → type healthy cells in norm of an organism. There are occurred oncogenesis also through Basic stem cells (neurons) → Totipotent stem cells → Pluripotent stem cells → Multipotent stem cells → Oligopotent stem cells → then Unipotent stem cells are affected by oncologic viruses (v-oncogene), and normal Unipotent stem cells turn into Unipotent cancer stem cells. Thus the modern method cancer treatment with large dose cytotoxic drugs suppressed defensive mechanisms of immune and hormonal systems of an organism that leads to exerting of some survived oncologic viruses after pause of intensive chemotherapy making relapsed cancer cells of appearance cancer disease [6, 44, 45] (Figure 9). 

Figure 9: T cell disordered resonance waves on strange drugs substances causing resistance to cytotoxic  drug.

As opposed to the relapsed cancer disease, the resistance cytotoxic drugs after pause from in-tensive modern Chemotherapy is occurred via following reasons: Firstly, normal chemical po-tentials (µ) of relative G1 → S → G2 phases cellular cycle of T cells phagocytes being affect-ed by survived oncologic viruses create transition normal chemical potentials (µ) of T cells phagocytes via relative G1 → S → G2 phases cellular cycle into cancer pathology chemical potential (µ*) via cancer prokaryotic cellular cycle. Just relative G1 → S → G2 phases of T cells phagocytes via eukaryotic cellular cycle are the mechanisms in which there are realized as driving mechanisms of eukaryotic cellular cycle in norm (µ) as well as driving mechanisms of prokaryotic cellular cycle in cancer pathologic chemical potential (µ*) (Figure 7). Also it is reflected positive fluctuations entropy (+Δxβ) and negative fluctuation entropy (-Δxβ) showing cellular cycle as via G0/G1/S/G2/Mitosis in normal phases of eukaryotic cellular cycle as well as through G0/G1/S/G2/Mitosis-Meiosis in oncologic phases of prokaryotic cellular cycle according Glansdorff-Prigogine theory [1, 2], (Figure 1). This mechanism exerts operation Meiosis-Mitosis prokaryotic cancer cellular cycle because of affected both nuclear DNA and mitochondria of an organism’s cells [44, 45]. Modern methods cancer therapy affects follow-ing targets: cancer tumors, cancer cells, cancer cells’ nucleus and its DNA, cancer cells’ mito-chondria, cancer cells’ organelle as well as links between them [46, 47]. Thus, secondly, there are occurred pause after intensive influence by large 

dosage cytotoxic drugs on cancer cellular cycles in modern methods cancer therapy [44, 46, 47]. Hence there are subjected the strange DNA of dead cells by large dosage cytotoxic drugs as DNA of dead cancer cells as well as DNA in the glands of immune cells and of hormonal cells of an organism [44, 48, 49]. There-fore some survived Immune T cells of phagocytosis and B cells of antibodies are found anti-gens via sensitive factors in pause after intensive Chemotherapy as antigens of the decom-posed substances of dead cancer cells within the received antigens of cytotoxic drugs [44 – 49]. The some survived immune T cells phagocytosis and B cells of antibodies don’t react on the decomposed substances of dead cancer cells but react on antigens of cytotoxic drugs caus-ing phagocytosis of destruction these cytotoxic drugs [44 – 49]. Thus resistance to cytotoxic drugs creates destruction cytotoxic drugs which repeat exertion of cancer disease [44 -49] (Figure 9). Therefore DNA minor grooves of immune cells and DNA minor grooves of hor-monal cells are also connected by Brostallicin (PNU-166196) although normal cells are less exertion than cancer cells [50]. Thus violation immune and hormonal functions of an organism causes common disbalance anabolic endergonic processes & catabolic anaerobic exergonic processes & catabolic aerobic exergonic processes of Quasi-stationary pathologic State of an organism via accelerating cancer cellular cycle supplementally. Besides, thirdly, influencing of cancer cells by large dosage cytotoxic drugs can suppress also immune T cells and hormonal cells which are remained on immune sensitive condition to chemical structure of cytotoxic drugs in dead cancer cells. That condition of survived immune T cells leads to resistance of cytotoxic anticancer drugs after recovery from suppressed their states in pause of Chemotherapy. Hence the survived immune T cells create resistance of cytotoxic drugs transit-ing to relapsed cancer disease after intensive suppressed Chemotherapy with resistance cyto-toxic drugs [44 – 49] (Figure 9). Thus resistance to cytotoxic anticancer drugs and relapsed cancer disease are occurred after some times of pause intensive chemotherapeutic treatment with large cytotoxic drugs that can affect by survived some cancer cells [v-oncogenes] of nuclear DNA (nDNA) exerting G1/S/G2 phases prokaryotic cancer cellular cycle of Meiosis-Mitosis phase. The suppression of Meiosis-Mitosis phase cancer cellular cycle by large dosage cytotoxic drugs touch on exerting human eukaryotic genome of normal cellular cycle. Just it is occurred resistance antiviral force of cytotoxic drugs over oncologic viral force which can transit Meiosis-Mitosis into Mitosis-Meiosis reflecting prevalence antiviral force of cytotoxic drugs. But retaining Meiosis-Mitosis reflects prevalence oncologic viral force over antiviral force of cytotoxic drugs in which viruses [v-oncogenes] use energy for cancer cells development via accelerating cancer cellular cycle [2, 4]. Just the transition Meiosis-Mitosis into Mitosis-Meiosis reflects prevalence antiviral force of cytotoxic drugs in which rest some hormones activity of hormonal glands and immune T memory cells, T helper cells, T killer cells with B cells are restored activity after some time of intensive cytotoxic drugs treatment [44 – 49]. Thus also hormones activity restore immune T memory cells, T helper cells, T killer cells. Then T memory cells transmit these data to T helper cells and further to T killer cells. Thus either immune T killer cells and antibodies of B cells destruct cancer cells together with cytotoxic drugs activity or these immune T cells causing resistance to these anticancer drugs (44 - 49). Hence retaining Meiosis-Mitosis cancer cellular cycle of survived oncologic viruses [v-oncogenes] retains accelerating cancer cellular cycle which is supported by activity of mis-taken survived immune T cells after some time of intensive large dosage of cytotoxic drugs treatment [44 – 49] (Figure  9). Then it gives possibility some survived oncologic viruses [v-oncogenes] to create relapsed cancer disease after some time pause of intensive cytotoxic drug therapy [6, 44 – 49] (Figure 9). As concerning to using some hormone activity by survived rest oncologic viruses, it must be explained the following example: In breast cancer cells after intensive cytotoxic therapy are occurred either resistance to cytotoxic drugs or relapse cancer disease because cytotoxic drugs suppress cancer Meiosis-Mitosis cellular cycle and simultaneously suppress as immune T memory cells, T helper cells, T killer cells as well as activity female hormones Estrogens [estrone, estradiol, estriol] and Progesterone hormones. After some time from intensive chemotherapy, it is begun to restore as suppressed immune T memory cells, T helper cells, T killer cells as well as suppressed activity female hormones es-trogens [estrone, estradiol, estriol] and Progesterone hormones in which the restored activity of both survived immune cells and hormonal estrogens can make mistakes which lead to either resistance to cytotoxic drugs or to relapse cancer disease (see above). 

5b. The mechanism prevents of forming either resistance cytotoxic drugs or relapse can-cer disease in new method cancer treatment. 

Cancer tumor is situated inside the human organism using the organism as environment, and obtains the substances from depot of an organism for its metabolism (fat depots, carbohydrate depots, etc.) as in normal organism as well as in cancer disease organism (Figure 8). As op-posed to modern methods chemotherapy with large dosage of cytotoxic drugs, the new meth-od cancer treatment uses combination “Prolonged medical starvation (during 42 – 45 days)” with considerably decreased dosage of cytotoxic drugs which don’t suppress immune and hormonal systems by small dosage of cytotoxic drugs [51 – 55]. Thus “Prolonged medical starvation 42 – 45 days” leads to bereave of the substances which are used for anabolic bio-synthetic processes in oncogenesis. Thus it is occurred suppression activity of cancer cells due to violation mechanism of Warburg effect. As opposite stability Internal Energy (µ) and Inter-nal Medium in normal stability state of an organism and organism’s normal cells, there are oc-curred violation stability Internal Energy in cancer cells (µ°) of an organism. Besides violation stability Internal Energy of cancer cells (µ°) are more stronger than normal cells stability of Internal Energy (µ) because large dosage of cytotoxic drugs suppress immune system and hormonal system after anticancer modern chemotherapy with large dosage of cytotoxic drugs. Just these large dosage cytotoxic drugs cannot cure the neglected state of the cancer disease organism (see above). Besides these large dosage cytotoxic drugs don’t prevent both relapse of cancer disease and resistance anticancer cytotoxic drugs. The therapeutic targets Warburg effect by new method cancer treatment using “Prolonged medical Starvation (during 42 – 45 days)“ and immunotherapy combination with very small dosage weak cytotoxic substances is more efficient method of cancer treatment than modern methods cancer treatments with large dosage cytotoxic drugs [51 – 55]. As opposed to modern method Chemotherapy with target-ing for destruction cancer cells and suppression of defensive systems immune cells and hor-monal cells causing by large dosage cytotoxic drugs, the new method cancer treatment dis-plays combination “Prolonged medical starvation 42 – 45 days” with considerably decreased dosage of cytotoxic drugs that leads to destroy mechanism of Warburg effect which is the mechanism again oncogenesis and activity of viral oncogenes (v-oncogene). Just the depressed activity oncologic viruses (v-oncogenes) via depressed cancer cells are arisen by “Prolonged medical starvation 42 – 45 days” that targets Warburg effect creating violating “aerobic oxida-tion in Glycolysis” for destructed Warburg effect. The considerably decreased dosage of cyto-toxic drugs exerts activities of immune system of an organism. Hence “Prolonged medical starvation 42 – 45 days” creates depressed state of metabolic processes in the organism’s cells and in the cancer cells because of bereaves of the substances for decreasing anabolic biosyn-thetic processes. Therefore decreased anabolic biosynthetic processes prevent to affect an or-ganism’s cells by v-oncogenes impeding shift into excessive anabolic endergonic processes of balance anabolic endergonic processes & catabolic exergonic processes. The absent of exces-sive anabolic endergonic processes of cancer tissue and excessive quantity of mitochondria catabolic aerobic electron transport chain processes lead to absent mechanism forming metas-tases and development of cancer cells. Thus overloaded “nodal point of bifurcation anabolic and catabolic processes” [NPBac] with consumption great quantity energy and Acetyl-CoA in “Prolonged medical Starvation (during 42–45 days)” leads to depression cancer development [4, 5]. Besides it prevents of forming Warburg effect as mechanism of cancer development. Also the new method cancer treatment use “Prolonged medical Starvation (during 42–45 days)” for depression cancer activity of forming metastases, and use very small dosage of cy-totoxic substances which don‘t suppress activity of immune systems and hormonal systems. Therefore hormones how cofactors of an organism’s metabolic chemical processes promote maintenance stability Internal Energy (Uorg) of an organism in state of “Prolonged medical Starvation 42–45 days” via supporting extracts of vegetable herbs for delivering Vitamins, as biochemical cofactors. The chemical cofactors supports an organism metabolism creating sta-bility as balance anabolic biosynthetic processes & catabolic anaerobic phosphorilation of oxi-dative processes as well as balance catabolic aerobic oxidative processes & catabolic anaerobic phosphorilation of oxidative processes. Also very small dosage of cytotoxic substances de-struct depressed mechanism of cancer cells development, and immune T cells with B cells an-tibodies creates complete destruction of oncologic mechanisms leading to recovery of the normal organism. Thus as opposed to modern methods chemotherapy with large dosage of cytotoxic drugs, the depressed state of the organism causing by “Prolonged medical Starva-tion 42 – 45 days” creates depressed the mechanism increased anabolic endergonic biosynthet-ic processes that promotes exerting decreased dosage of cytotoxic drugs with activity of im-mune and hormonal systems. It causes decreased catabolic aerobic electron transport chain processes and restored balance anabolic biosynthetic processes & catabolic anaerobic oxidative phosphorilation processes of creating destruction Warburg effect by new method cancer treatment and appear Pasteur effect of defensive activity by immune and hormonal systems which resonance waves maintain stability Internal Energy of all organism’s cells and an organ-ism [51 – 55].

This article is dedicated to the memory of my daughter T.M. Ponisovska.