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Research Article | DOI: https://doi.org/10.31579/2690-8816/159
Department of Propaedeutics of Internal Medicine, dep. Pathophysiology Grodno State Medical University, Grodno, Belarus.
*Corresponding Author: Maksimovich Nataliya Ye, Department of Propaedeutics of Internal Medicine, dep. Pathophysiology Grodno State Medical University, Grodno, Belarus.
Citation: Maksimovich Nataliya Y., Maksimovich Yelizaveta N., (2025), The Relationship Between the Development of Arrhythmias and Changes in Free Hemoglobin Levels During Coronary Artery Bypass Grafting, J Clinical Research Notes, 6(2); DOI:10.31579/2690-8816/159
Copyright: © 2025, Maksimovich Nataliya Ye. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 19 February 2025 | Accepted: 27 February 2025 | Published: 05 March 2025
Keywords: coronary artery bypass grafting; hemolysis; arrhythmias
Introduction The operation of coronary shunting in patients with coronary heart disease leads to the development of various complications in the postoperative period, the most frequent are heart rhythm disturbances.
Purpose. To establish the connection of intraoperative hemolysis (IOH) with the development of cardiac rhythm disturbances in patients with coronary artery disease after coronary shunting in conditions of cardiopulmonary bypass (CB).
Material and research methods. The assessment of the degree of IOH was made by the level of free hemoglobin [Hb] In the blood plasma at the beginning of the operation, immediately after the patient was connected to the CB device and 15 minutes before removal from the CB, using the HemoCue Plasma / Low Hb analyzer. According to the degree of IOH, patients (n = 123) are divided into 3 groups (gr.) in accordance with free [Hb]: gr.1 – ≤0,1 g/l; gr.2 > 0.1 g/l and <0,5 g/ l; gr.3 – ≥0,5g/l. Were used the following instrumental methods of investigation: electrocardiography, 24-hour ECG monitoring. Was analyzed the frequency of heart rhythm disturbances in patients after coronary shunting with various levels of IOH in the early (up to 1 month) periods.
Results. Arrhythmias were observed in 2.3% of patients of the 1st group, in 11.9% - the 2nd group, in 52.6% - the 3rd group. Associations were noted between [Hb]. In plasma at the end of cardiopulmonary bypass and the frequency of arrhythmias (rs=0,70, p<0.001). The share of life-threatening and hemodynamically significant arrhythmias in the study period in the group with a high degree of IOH accounted for about half of all arrhythmias that occur, which is significantly more than in the group without IOH and with low IOH, p <0.001.
Conclusion The operation of coronary artery bypass surgery in conditions of artificial blood circulation leads to the development of arrhythmias in the postoperative period in 22% of patients with ischemic heart disease. A significant proportion of these are arrhythmias that pose a threat to the patient’s life and arrhythmias, causing hemodynamic disturbances and hypoperfusion of vital organs.
The largest number of patients with cardiac rhythm disturbances after coronary artery bypass grafting was observed in the group with the level of free hemoglobin in the blood plasma of 0.5 g / l or more (p <0.001), which indicates the relationship between the occurrence of arrhythmias and the degree of intraoperative hemolysis. The high risk of arrhythmias in patients with coronary heart disease after coronary artery bypass surgery is determined when the content of free hemoglobin is more than 0.85 g / l.
One of the ways to assess the risk of heart rhythm disturbances should be to determine the level of free hemoglobin in the blood plasma of patients in the intraoperative period of coronary artery bypass grafting, which is necessary for the timely prevention and correction of possible hemodynamic disorders.
Coronary artery bypass surgery in patients with coronary heart disease (CHD) is frequently associated with postoperative complications, with arrhythmias being a significant concern [1, 2]. Potentially life-threatening arrhythmias, such as ventricular fibrillation and tachycardia, and third-degree atrioventricular block, as well as hemodynamically significant arrhythmias like atrial fibrillation (AF), severe bradycardia, and severe sinus tachycardia, are common. AF, a highly prevalent and dangerous postoperative arrhythmia, is frequently observed (25-65% of cases) [3] and is associated with adverse outcomes, including increased risk of heart failure progression, thromboembolism, prolonged hospitalization, and mortality [4]. Patients experiencing AF after CABG have a higher risk of mortality related to cerebrovascular accidents and myocardial infarction [4]. The pathogenesis of CABG-related arrhythmias is complex and not fully understood. Perioperative and early postoperative arrhythmias likely represent a reaction of the conduction system to the altered blood flow during the surgery, including the transition from cold cardioplegia to reperfusion [5-11]. Reoxygenation following the restoration of coronary blood flow can induce oxidative stress, metabolic disturbances, and electrical heterogeneity in the myocardium [5]. Further, the use of cardiopulmonary bypass (CPB) during CABG, necessary for maintaining blood circulation during the operation, is associated with potential red blood cell damage. This hemolysis may contribute to the development of cardiovascular complications in the postoperative period [12]. However, the specific relationship between intraoperative hemolysis (IOH) and the development of arrhythmias following CABG remains unclear in the existing literature.
Purpose of the study.
To establish the connection of intraoperative hemolysis (IOH) with the development of cardiac rhythm disturbances in patients with coronary artery disease after coronary shunting in conditions of cardiopulmonary bypass (CB).
It was performed a prospective study of 123 patients with coronary heart disease undergoing CABG. The study was consistent with the Helsinki Declaration of the World Medical Association «Ethical Principles for Conducting Scientific Medical Research with Human Participation» and was approved by the ethics committees of the Grodno State Medical University and the Grodno Regional Clinical Cardiology Center healthcare institution. All patients underwent CB surgery in a planned manner under IR conditions. According to the level of free hemoglobin [Hb] in blood plasma, which is a marker of the degree of IOH, patients are divided into three groups: group 1 – without IOH (Hb≤ 0.1 g/l), n=43, group 2 - with low IOH (lIOH) - with [Hb]>0.1g/l and <0 n=42, n=38.>
Figure 1: Diagram of the coronary bypass surgery operation
CB – cardiopulmonary bypass
CB – cardiopulmonary bypass start
CB – cardiopulmonary bypass completion
KP – cardioplegia
OS – operation start
OC – operation completion
1st BT – first blood test
2nd BT – second blood test
Patients of all groups are comparable by age and gender (Table 1).
Indicator
| Group 1 n=43 | Group 2 n=42 | Group 3 n=38 |
| Age, years | 60 (56; 63) | 64 (58; 66) | 66 (60; 68) |
| Gender (male), % | 36 (87,8%) | 32 (78,0%) | 31 (78,0%) |
| BWI (kg / m2) | 27,8(24,7; 29,2) | 27,7 (24,8; 29,2) | 29,1(25,9; 32,2) |
| Total protein (g / l) | 69 (62; 71) | 69(58; 68) | 66(57; 67) |
| Glucose, mmol /L | 5,0(4,5; 5,6) | 5,2(4,4; 6,1) | 5,3(4,5; 6,2) |
| Cholesterol, mmol /L | 4,1(3,3; 5,0) | 4,6(3,2; 5,7) | 5,0(4,6; 5,6) |
| Urea, mmol /L | 5,3(4,8; 5,6) | 6,0(5,5; 7,6) | 6,4(5,5; 7,2) |
| Creatinine, mmol /l | 99(89; 104) | 105(98; 110) | 106(99; 112) |
| CRP (mg / ml) | 1,2(0,8; 1,4) | 1,1(0,8; 1,3) | 1,0(0,6; 1,2) |
Table 1: Clinical characteristics of the subjects
Notes: data are presented as Me [Q25; Q75], where Me is the median, Q25 is the value of the lower quartile; Q75 is the value of the upper quartile;
All patients underwent surgical intervention using a standard anesthetic protocol under normothermic artificial sirculation conditions with a hemodilution level of hematocrit of 25-30%.
The groups did not differ in the duration of artificial sirculation and the time of myocardial ischemia (p> 0.05), Table 2.
Indicator
| Group 1 n=43 | Group 2 n=42 | Group 3 n=38 |
| Ischemia-reperfusion time (min) | 69(65; 89) | 74 (68; 78) | 80 (75; 94) |
| Ischemia time (min) | 46(39; 64) | 58(56; 62) | 59(51; 68) |
Table 2. Duration of cardiopulmonary bypass (CB) and myocardial ischemia in patients with varying degrees of IOH during coronary artery bypass grafting
Note: the data are presented in the form Me (Q25; Q75), where Me is the median of the indicator; Q25 - value of the lower quartile; Q75 is the value of the upper quartile.
Most patients (85%) underwent mammary-coronary bypass surgery in combination with aortic-coronary bypass surgery. Mammary-coronary bypass surgery was performed in 4% of patients (p <0> 0.05). More often, lesions of three or more coronary arteries, CA (63.1%) and significantly less often than one CA (7.1%) were revealed, Table 3.
| Number of shunts | Group 1 n=43 | Group 2 n=42 | Group 3 n=38 | p1-2 | p1-3 | p2-3 |
| 1 | 9,9 | 7,5 | 10,8 | 0,412 | 0,510 | 0,314 |
| 2 | 31,0 | 26,8 | 39,2 | 0,510 | 0,610 | 0,094 |
| 3 and more | 59,1 | 65,7 | 50,0 | 0,462 | 0,130 | 0,318 |
| Left anterior interventricular coronary artery | 87,8 | 100 | 100 | 0,21 | 0,31 | 0,31 |
| Left circumflex artery | 4,9 | 7,3 | 19,5 | 0,644 | 0,420 | 0,105 |
| Posterior interventricular branch of left circumflex artery | 14,6 | 39,0 | 61,0 | 0,210 | 0,310 | 0,406 |
| Left marginal artery | 56,1 | 65,9 | 80,5 | 0,172 | 0,22 | 0,324 |
| Right coronary artery | 24,4 | 58,5 | 61,0 | 0,231 | 0,341 | 0,821 |
| Right interventricular branch artery | 17,07 | 34,15 | 26,8 | 0,706 | 0,285 | 0,471 |
Table 3: Characterization of shunts in patients with coronary heart disease in groups with different levels of IOH
Note: Accordingly, with myocardial revascularization, three or more coronary arteries (CA) were shunted more often - 56.9% of patients.
The most common lesions were observed in the anterior interventricular branch of left coronary artery (p<0>
the of left circumflex artery (p<0>
Indicator
| Gr 1 n=43 | Gr 2 n=42 | Gr 3 n=38 |
| Ischemic heart disease duration | 8,5 (4,2; 11,4) | 8,9 (4,6; 10,8) | 9,5 (6,2; 12,1) |
| Duration of hypertension | 10 (6; 11) | 8 (5; 10) | 11,5 (9; 15) |
| Functional class II | 9 (20,1%) | 11 (26,2%) | 6 (15,8%) |
| Functional class III | 34 (79,9%) | 31(73,8%) | 32 (84,2%) |
| Postinfarction cardiosclerosis | 37 (86,1%) | 36 (85,7%) | 33 (86,8%) |
| The number of myocardial infarction (2 MI) in the history | 16(37,2%) | 18(42,8%) | 13(34,2%) |
| NYHAII | 36(83,7%) | 31(73,8%) | 33(86,8%) |
| NYHAIII | 7(16,3%) | 11(26,2%) | 5(13,2%) |
| Ischemic cardiomyopathy | 2 (0,86%) | 3 (1,26%) | 2 (0,76%) |
| History of arrhythmias | 7(16,3%) | 7(16,6%) | 6(15,4%) |
| Paroxysm of atrial fibrillation | 0 (9%) | 1(0,42) | 1 (0,38%) |
| supraventricular extrasystole | 4(1,72%) | 2 (0,84) | 2(0,76%) |
| ventricular extrasystole | 1(0,43%) | 1 (0,42%) | 1(0,38%) |
| right His bundle branch block | 1(0,43%) | 1 (0,42%) | 1(0,38%) |
| left His bundle branch block | 1(0,43%) | 2 (0,42%) | 2(0,76%) |
| blood hypertension | 36 (87,8%) | 38(90,2%) | 38(92,7%) |
| chronic bronchitis without exacerbation | 7(16,3%) | 9(21,4%) | 12(31,6%) |
| gastropathy | 18(41,9%) | 17(40,5%) | 20(52,6%) |
| urolithiasis | 6(13,9%) | 9(21,4%) | 7(18,4%) |
| osteoarthritis | 0(0%) | 3(7,1%) | 1(2,6%) |
| excess BWI and obesity | 36(83,7%) | 31(73,8%) | 33(86,8%) |
| excess BWI | 22(51,2%) | 18(42,9%) | 18(47,4%) |
| obesity | 14(32,6%) | 13(31%) | 15(39,5%) |
Table 4: Nosological characteristics of patients with coronary artery disease before coronary bypass surgery with varying degrees of intraoperative hemolysis (IOH)
Note: quantitative data are presented in the form Me [LQ; UQ], where Me is the median, LQ is the value of the lower quartile; UQ is the value of the upper quartile, and categorical – in the form of absolute and relative frequencies of signs; for all presented indicators, differences between the studied groups were absent (p> 0.05).
Most patients had one previously suffered myocardial infarction, MI. Patient groups were comparable in the number of MI (p> 0.05), the presence of ischemic cardiomyopathy (p> 0.05) and a history of cardiac arrhythmias (A), p> 0.05. Table 4 presents the frequency and structure of cardiac arrhythmias in patients with varying degrees of intraoperative hemolysis before coronary artery bypass surgery. As you can see, before surgery, cardiac arrhythmias were found in 22 people (17.89%). Among cardiac arrhythmias, AF paroxysms, supraventricular and ventricular extrasystoles, as well as blockade of the right and left legs of the bundle of His were found. At the same time, AF paroxysms were observed in 2 (1.63%) patients, extrasystoles were found in 11 (8.94%), including supraventricular extrasystoles, and in 3 (2,44%) – ventricular extrasystoles were noted. Dysfunction of the conduction function was noted in 8 people (6.5%), including blockade of the left leg of the bundle of His was noted in 5 people (4.07%), blockade of the right leg of the bundle of His - in 3 people (2.44%). The groups were comparable in the frequency and nature of cardiac arrhythmias in the anamnesis (p>0.05).
Patients before CB (1-5 days) and after surgery (within 1-5 days) underwent daily ECG monitoring, as well as standard electrocardiography (ECG). In order to clarify the role of hemolysis in the development of postoperative arrhythmias in the studied groups of patients with different levels of IOH, we analyzed the incidence of cardiac arrhythmias in the perioperative (during the operation and during the first day after it) and in the early period (up to 1 month) and their structure.
The examined patients received standard therapy consisting of antiplatelet agents (79.7%), statins (76.4%), beta-blockers (84.6%), angiotensin-converting enzyme inhibitors (76.4%), antianginal drugs (79.7%), table 5.
The drug treatment among patients of the studied groups did not differ in the administration of clopidogrel (χ2 = 5.35; p = 0.069), β-blockers (χ2 = 3.18; p = 0.204), but it differed in the reception of statins (χ2 = 12.2; p = 0.006), inhibitors of the angiotensin-converting enzyme, ACE inhibitors (χ2 = 7.13; p = 0.028) and antianginal drugs (χ2 = 13.7; p<0>
| Index (%) | Gr 1 n=43 | Gr 2 n=42 | Gr 3 n=38 | Gr 1-3 n=123 | χ2 | p |
| beta blockers | 86,0 | 90,5 | 76,3 | 84,6 | 3,18 | 0,204 |
| ACE inhibitors | 88,4 | 76,2 | 63,2° | 76,4 | 7,13 | 0,028 |
| statins | 90,7 | 78,6 | 57,9°• | 76,4 | 12,2 | 0,006 |
| antianginal | 93,0 | 83,3 | 60,5°• | 79,7 | 13,7 | 0,0001 |
| antiplatelet agents | 88,4 | 81,0 | 68,4 | 79,7 | 5,35 | 0,069 |
Table 5: Characterization of drug therapy for examined patients with coronary artery disease before coronary artery bypass surgery with varying degrees of IOH
Note: ° - p <0> • - p <0>
To prevent arrhythmias during the operation, lidocaine was infused in a cardioplegic solution (1-1.5 mg / kg /min). After the operation, antiarrhythmic drugs were administered to arrest AF paroxysm (AF - 5 mg /kg intravenously dropwise for 60 min). Patients after CB took β-blockers (atenolol 25-50 mg / day, metoprolol at a dose of 25-50 mg / day, bisoprolol at a dose of 2.5-5 mg / day) depending on the level of blood pressure. In patients with atrial flutter and ventricular tachycardia in the perioperative period, temporary atrial pacemaker was performed, which was maintained for 72 hours with a frequency of 10 beats / min more than their own heart rate. Statistical data processing was carried out using the program Statistica 10.0 for Windows (StatSoft, Inc., USA). Given the abnormality of the distribution of attributes, nonparametric methods of descriptive statistics were used for processing: quantitative data are presented in the form Me [LQ; UQ], where Me is the median, LQ is the value of the lower quartile; UQ is the value of the upper quartile; categorical data are presented in the form of absolute and relative frequencies. When comparing the medians of quantitative variables of several independent groups, the Kruskell-Wallis test was used, to compare categorical data, the exact Fisher test, the χ2 criterion, with the Yeats correction at low frequencies were used. The strength of the relationship between the indicators was estimated using a correlation analysis based on the association coefficient (Kendall criterion) by its value (rs ≤0.25 - weak; 0.25
Of the 123 examined with CB, 29 (23.6%; p<0> 0.05), in the early period - in 13 people (10.6%, p> 0.05). More often, in the operated patients, arrhythmias were revealed in 27 patients (21.95%, p <0 xss=removed xss=removed>
The most common complications of CB during myocardial revascularization in patients with coronary artery disease were various types of arrhythmias, which were observed both in the perioperative period and during the month of observation - an early period (Table 6).
| Types of complications | Group 1 n=43 | Group 2 n=42 | Group 3 n=38 | All n=123 | χ2 | p | ||||
| n | % | n | % | n | % | n | % | |||
| Arrhythmias | 2 | 4,7 | 5 | 11,9 | 20 | 52,6 | 27 | 22,0 | 21,95 | 0,000 |
Table 6: The frequency of arrhythmias in patients with coronary heart disease after CB surgery with varying degrees of intraoperative hemolysis (IOH)
After surgery, arrhythmias developed in 27 (21.95%) patients. At the same time, 5 (4.9%) patients had life-threatening arrhythmias (ventricular fibrillation, ventricular tachycardia), 7 (5.7%) patients had hemodynamically significant arrhythmias – atrial fibrillation and flutter, supraventricular tachycardia. Atrial fibrillation was the most common type of postoperative arrhythmias (5.7%, p<0>
classification of Myerburg RJ, 1984), as well as AV blockade of the 1st or 2nd degree) were observed, accounting for about half of the occurring during and after surgery arrhythmias. Most often, arrhythmias were observed in patients with a high degree of IOH (Table 7).
In the group with high IOH, the frequency of arrhythmias was 52.6%, which is higher than in the group with low IOH - 11.9%, p <0>
Types of arrhythmias | n | Group 1 n=43 without IOH | n | Group 2 n=42 | n | Group 3 n=38 | χ2 | p |
| Total arrhythmias | 2 | 4,65 | 5 | 11,9°°°••• | 20 | 52,6°°°••• | 28,75 | 0,0000 |
| ventricular fibrillation | - | - | 1 | 2,38 | 2 | 5,26 | 4,547 | 0,1020 |
| ventricular tachycardia | - | - | - | - | 3 | 7,89 | 6,878 | 0,032 |
| atrial fibrillation | 2 | 2,32 | 3 | 7,18 | 13 | 34,20°°°••• | 14,132 | 0,132660 |
| atrial flutter | - | - | 1 | 2,38 | 1 | 2,63 | 1,100 | 0,5760 |
| supraventricular tachycardia | - | - | - | - | 1 | 2,63 | 2,255 | 0,3238 |
Table 7: Frequency and structure of arrhythmias in patients with coronary artery disease after CB with different degree in intraoperative hemolysis (IOH)
Note: data are presented in the form of absolute and relative frequencies of signs;
l IOH – low IOH; hIOH – high IOH;
# – p<0>
° – p<0>
• – p<0>
As can be seen from the table, in patients of the second (lIOH) and third (hIOH) groups, arrhythmias were more common than in the first group (without IOH), p<0>
(26.3%) patients, in the group with lIOH – in 3 people (7.14%, p<0 xss=removed xss=removed xss=removed Rs=0.4167, p=0.000003). xss=removed xss=removed xss=removed xss=removed>
Figure 2: ROC curve characterizing the sensitivity and specificity of the method for assessing the likelihood of developing postoperative arrhythmias by the concentration of free hemoglobin in blood plasma.
A high risk of developing arrhythmias in patients with coronary heart disease after CB was determined with a value of [Hb]>0.85 g/l (sensitivity - 86.4%, specificity - 92.7%, PPV (predictive value of a positive result) = 96.9 %, NPV (predictive value of a negative result) = 70.4%, area under the ROC-curve (AUC) = 0.892 (0.803-0.981), 95% confidence interval.
Discussion. As noted earlier, before the operation, cardiac arrhythmias occurred in 22 people (17.89%). Among arrhythmias, AF paroxysms, supraventricular and ventricular extrasystoles, as well as blockade of the right and left legs of the bundle of His were found. AF paroxysms were observed in 2 people (in 1 – in groups with lIOH and in 1 – in group with hIOH. The groups were comparable in history and frequency of arrhythmias in history (p>0.05). However, the incidence of arrhythmias in postoperative the period was highest in the third group with hIOH, and in the second group with lIOH it was greater than in the group without IOH According to the literature, the occurrence of arrhythmias associated with CB is caused by the restoration of blood flow in the ischemic zone, as a result of which the resumption of oxygenation initiates the development of oxidative stress. Action a reactive forms of oxygen and nitrogen leads to structural and metabolic disturbances, manifested by damage to cell membranes, electrolyte imbalance, forming a state of electrical myocardial heterogeneity, impaired excitability, pulse generation and conduction in the heart. Post-traumatic remodeling of heart chambers can contribute to the development of arrhythmias [6,7,9].
It was shown that not only the frequency of arrhythmias in groups after CB has changed, but also the structure. Transformation of less life-threatening arrhythmias (extrasystole, blockade of the bundle of His) into arrhythmias was noted, which had more serious consequences for hemodynamics and posed a greater threat to the lives of patients (atrioventricular block of the 1st degree, atrial fibrillation and flutter, paroxysmal ventricular and supraventricular ventricles).
Some authors have identified the relationship between arrhythmias and the features of surgical treatment (inadequate myocardial protection during surgery, due to the composition of the cardioplegic solution used, the direction of its administration, temperature, and the duration of cardioplegia). A positive correlation was revealed between the occurrence of arrhythmias and the duration of IR, the intensity of inotropic support, blood transfusion, and the level of leukocytosis after surgery. Other authors have not found such a dependence on the duration of artificial circulation.
CB has been shown to be most conducive to the development of arrhythmias in patients who had morphological changes in the heart (post-infarction cardiosclerosis) and a history of arrhythmias.
Studies on the study of arrhythmias after CB using correlation, as well as logistic and ROC analysis revealed the dependence of the frequency of arrhythmias on the level of free hemoglobin as an indicator of the degree of intraoperative hemolysis. The destruction of red blood cells due to their mechanical damage in the artificial circuits of the exerts a pathogenic effect on the state of the rhythmogenic function of the cardiac conduction system and myocardial excitability, predisposing to the development of arrhythmias. The largest number of arrhythmias in the group with a high level of free hemoglobin, as well as the presence of correlation between the frequency of arrhythmias and [Hb] In the blood plasma at the end of the operation, as well as the results of the logistic and ROC analysis, indicate the important role of intraoperative hemolysis in their occurrence in perioperative and early periods. The pathogenetic role of free hemoglobin in the development of rhythm disturbances in CB, it is advisable to develop a set of perioperative preventive measures aimed at chelation of free iron, which reduce the activity of oxidative processes. Elimination of patient-dependent risk factors for increased hemolysis (smoking, alcohol consumption, normalization of blood pressure, body weight and cholesterol) is also important for the prevention of cardiac arrhythmias, as one of the most common complications of coronary artery bypass surgery.
1. Postoperative arrhythmias occur in approximately 22% of patients undergoing CABG with cardiopulmonary bypass. A substantial portion of these arrhythmias are life-threatening or cause significant hemodynamic compromise and organ hypoperfusion.
2. Analysis demonstrated a strong correlation (p<0>
3. These findings suggest that monitoring free plasma hemoglobin levels during CABG procedures may serve as a crucial indicator for predicting and preventing postoperative arrhythmias, and potentially guiding interventions to correct any hemodynamic complications.
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