Short Communication | DOI: https://doi.org/10.31579/2692-9406/152
1 Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science & Technology, Jordan.
2 International Mariinskaya Academy, department of medicine and critical care, department of philosophy, Academician secretary of department of Sociology.
3 Cypress International Institute University, Texas, USA.
*Corresponding Author: Mostafa Norizadeh, Department of Public Health, University of Namibia, Oshakati, Namibia, School of Health Sciences, Cardiff University, Wales, UK.
Citation: Ghazal Zarei, Mostafa Norizadeh, (2023), The Importance of Rotavirus Vaccination in Children, J. Biomedical Research and Clinical Reviews. 8(2); DOI:10.31579/2692-9406/152
Copyright: © 2023, Mostafa Norizadeh. this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 09 May 2023 | Accepted: 16 May 2023 | Published: 23 May 2023
Keywords: .
.
The major reason of severe and dehydrating gastroenteritis in children is Rotavirus, especially in children under 5 years old. The virus first infects enterocytes and induces diarrhea by the destruction of absorptive enterocytes, intestinal secretion stimulated through rotavirus non-structural protein, and activation of the enteric nervous system [1]. The symptoms of Rotavirus infection appear after a period of 1 to 3 days. It is noticeable that the symptoms of this disease are almost the same as other gastrointestinal infections. However, rotavirus infections are expected to be more severe diarrhea, fever, and vomiting are the most common presenting symptoms [2].
Currently, the most effective way to prevent this disease is to use a more effective vaccine. Rota Teq (RV5) and Rotarix (RV1) are the most used vaccines for rotavirus prevention. Rotarix is an oral monovalent vaccine consisting of a live-attenuated human rotavirus G1P genotype.
RV1 is a product of GlaxoSmithKline Biologicals, Belgium, and was launched into the market in 2006. Since then, the use of RV1 is extensively characterized by post-marketing surveillance studies in different settings to establish safety, effectiveness, and impact. The data from the developed countries have shown that RV1 prevents 82% of severe diarrhea cases attributed to Rotavirus and approximately 37% of severe all-cause childhood diarrhea. [3-6]. RotaTeq is an oral pentavalent live attenuated reassorted bovine-human rotavirus vaccine that contains one common human VP4 type and four common human VP7 (G) type rotaviruses (G1, G2, G3, and G4). RotaTeq was created by Merck and Co. Inc. in the United States and released on the market concurrently with RV1. RV5 has been demonstrated to prevent 82% of severe rotavirus-associated children’s diarrhea in affluent nations with low mortality. Similar to R1, its efficacy is diminished in developing nations with notably high birth cohorts since it only stops 41% of severe rotavirus-associated children’s diarrhea and 15% of severe all-cause diarrhea episodes. One justification for rotavirus vaccination is that it triggers an immune response to both the heterologous serotypes and the vaccine's serotype [4,6]. Although rotavirus infections of the gastrointestinal system still cause serious illness, new vaccinations provide hope for lowering the high morbidity seen in developing nations. Hopefully, continuing vaccine studies in developing nations may reduce child mortality from rotavirus globally. The fight against this virus must be taken more seriously, and vaccination must be utilized widely. Because this virus has an RNA genome, it has a high degree of mutability and this issue could become a severe problem.
Dear Editorial Team, Clinical Medical Reviews and Reports. My experience with the journal was highly positive. The peer-review process was rigorous, constructive, and completed in a timely manner. The reviewers provided valuable comments that helped improve the quality and clarity of our manuscript. The editorial office was professional, responsive, and supportive throughout all stages of the publication process. Communication was clear and efficient, and any questions were addressed promptly. Overall, I found the journal to maintain high scientific standards and an excellent publication workflow. I would be pleased to consider submitting future work to this journal. Best wishes from, Elena Popa.
It was my pleasure to submit my testimonial concerning the Reviewer Board of our Scientific Journal “Brain and Neurological Disorders”. The Reviewers focused on some modifications and their contribution was helpful. The ladies of our Editorial Office were also supported my efforts. It was my honor to have such a co-operation and I am looking forward for more collaboration.
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Thank you for the speedy and efficient peer review process. I appreciate the fact that your peer reviewers do not take months to respond like with some other journals. I would also like to thank the editorial office for responding quickly to my questions. It is an excellent journal. I plan to submit more manuscripts in the future. Best wishes from, Robert W. McGee
Dear Grace Pierce, Editorial Coordinator of Journal of Clinical Research and Reports, Working with you and your team on our recent publication in JCRR has been a truly wonderful and enjoyable experience. The responses were prompt, and the reviewers were patient, constructive, and highly professional. One reviewer in particular gave me the feeling that a professor was carefully reading and commenting on my coursework, which was deeply touching. The entire process was straightforward and hassle‑free, with no tedious online forms to complete. I highly recommend this journal. Best wishes from, DR Aibing Rao, Head of R&D
I Appreciate the Opportunity to Share my Experience with the Journal of Clinical Research and Reports. The peer review process was timely and constructive, and the feedback provided helped improve the quality of our manuscript. The editorial office was professional, responsive, and supportive throughout the process, ensuring smooth communication and efficient handling of the submission. Overall, it was a positive experience collaborating with your team.
Dear Mercy Grace, Editorial Coordinator of Obstetrics Gynecology and Reproductive Sciences, We would like to express our gratitude for your help at all stages of publishing and editing the article. The editors of the magazine answer all the necessary questions and help at every stage. We will definitely continue to cooperate and publish other works in the Obstetrics Gynecology and Reproductive Sciences! Best wishes from, Alla Konstantinovna Politova,
