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Review Article | DOI: https://doi.org/10.31579/2640-1053/262
Department of Oral and Maxillofacial Surgery, Anandaban tertiary Hospital, Head of Department, Position-Level 11th, Nepal.
*Corresponding Author: Bikash Desar., Department of Oral and Maxillofacial Surgery, Anandaban tertiary Hospital, Head of Department, Position-Level 11th, Nepal.
Citation: © 2026, Bikash Desar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright: © 2026, Bikash Desar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 10 March 2026 | Accepted: 25 March 2026 | Published: 01 April 2026
Keywords: dietary assessment; dietary protein; impacted third molar; nutritional status; oral surgery; oral health–related quality of life; wound healing
Background: This pilot study aimed to evaluate the effect of protein intake on early wound healing following the surgical removal of impacted mandibular third molars and to investigate its association with postoperative outcomes, including trismus, edema, pain, and oral health–related quality of life.
Methods:
Patients presenting with asymptomatic impacted mandibular third molars classified as easy or moderate difficulty according to the Pernambuco index were included. Dietary protein intake over the preceding month was assessed using a food frequency questionnaire and a 24-hour dietary recall. Early wound healing was evaluated using the Early Wound Healing Index (EHI). Trismus was assessed by measuring maximum interincisal opening, facial swelling by linear facial measurements, and pain using a visual analog scale (VAS). Oral health–related quality of life was measured using the OHIP-14 questionnaire.
Results: A total of 25 patients (16 females and 9 males), aged 19–33 years (mean 23.3 ± 2.88 years), were analyzed. No significant differences were observed between the protein intake groups with respect to age, sex, body mass index, surgical difficulty, or duration of surgery. Patients with high protein intake exhibited a significantly greater reduction in mouth opening on postoperative day 3 (p = 0.004). Facial swelling on day 3 was also significantly greater in the high protein intake group compared with the low and normal intake groups (p = 0.023), whereas pain scores on postoperative day 1 were significantly lower (p = 0.009). Protein intake showed a positive association with EHI scores on postoperative day 7 (p = 0.019), indicating improved early wound healing; however, no significant association was observed on day 1 (p = 0.081). No significant relationship was found between protein intake and OHIP-14 scores at any time point (p = 0.211, p = 0.462, and p = 0.704).
Conclusions
Higher protein intake was associated with improved early wound healing and favorable modulation of postoperative outcomes, including reduced pain severity and improved functional recovery following impacted mandibular third molar surgery. These findings highlight the potential importance of nutritional assessment and dietary support as integral components of postoperative care. Further large-scale studies are needed to confirm these results and to elucidate the underlying biological mechanisms.
Protein is a crucial macronutrient that plays a significant role in immune function and wound healing [1]. The current recommended dietary allowance (RDA) for protein intake in healthy adults with minimal physical activity is 0.8–1.0 g/kg body weight per day. In catabolic or stress conditions, such as acute burn injuries, protein requirements may increase to approximately 1.5 g/kg body weight per day [2,3]. However, the precise amount of protein required to optimize wound healing—particularly following oral surgical procedures—remains unclear. Surgical removal of impacted mandibular third molars (SRM3s) is one of the most frequently performed procedures in oral surgery [4]. The acute inflammatory response that follows surgical trauma represents a physiological and necessary phase of the healing process. However, an exaggerated or prolonged inflammatory response may result in increased postoperative discomfort and complications. Therefore, controlling excessive inflammation is essential for optimizing surgical outcomes [5]. Delayed or impaired wound healing in the postoperative period may also negatively affect patients’ quality of life (QoL) [1]. Although QoL during the recovery period after SRM3 has been widely investigated [6–8], the potential role of dietary protein intake in this context remains unclear. Previous clinical studies have evaluated the impact of nutritional status on postoperative healing in oral and maxillofacial surgery [1,9,10]. However, to the best of the authors’ knowledge, no study has specifically examined the association between protein intake and early wound healing, oral health–related quality of life (OHRQoL), and postoperative outcomes following SRM3. Accordingly, this prospective observational study was designed to assess the influence of dietary protein intake on early postoperative wound healing and to explore its relationship with postoperative clinical outcomes and OHRQoL. We hypothesized that higher protein intake would be associated with enhanced wound healing and a smaller decline in OHRQoL during the recovery period.
Study Population
Patients aged 18–35 years who presented to Biruni University Faculty of Dentistry between January 2023 and November 2023 with asymptomatic impacted mandibular third molars were screened for eligibility. Only teeth classified as easy or moderate difficulty according to the Pernambuco index [11] were included. Exclusion criteria comprised pregnancy or breastfeeding; systemic conditions known to impair wound healing (e.g., diabetes mellitus, severe anemia, or malignancy); immunodeficiency states (including steroid therapy); preoperative use of antimicrobial or anti-inflammatory medications; local inflammatory conditions such as pericoronitis; and smoking or other nicotine use, as these factors may adversely influence postoperative healing.
Assessment of Protein Intake
A food frequency questionnaire (FFQ) was administered to evaluate participants’ dietary habits and nutritional status over the preceding month. FFQs are widely used to assess habitual dietary patterns. The questionnaire categorized the frequency of consumption of fixed food portions as follows: never or rarely; one to three times per month; once per week; two to four times per week; five to six times per week; once per day; two to three times per day; and four or more times per day [12]. The FFQ served as the primary tool for assessing habitual protein intake and enabled classification of participants according to their typical protein consumption. In addition to the FFQ, a single 24-hour dietary recall was conducted to obtain detailed information on protein intake for a specific day. The combined use of these two methods allowed for a more comprehensive evaluation of both long-term and short-term dietary intake [13,14]. Food consumption was recorded by M.S.A. using portion size models (e.g., water glass, tea glass, and tablespoon) and known net weights. When participants were unable to specify portion sizes, the Standard Recipes book [15] was consulted. Reported food and beverage amounts were converted into standardized quantities. Daily energy and nutrient intake were analyzed using the Computer-Aided Nutrition Program, Nutrition Information Systems Package Program (BEBIS), developed for use in Turkey. Protein intake was evaluated according to the recommended dietary allowance (RDA) values provided in the Nutrition Guide Specific to Turkey [16]. Participants were categorized into three groups: low protein intake (< 0> 1.0 g/kg/day)
Study Population
Patients aged 18–35 years who presented to the Biruni University Faculty of Dentistry between January 2023 and November 2023 with asymptomatic impacted mandibular third molars were screened for eligibility. Only teeth classified as easy or moderate difficulty according to the Pernambuco index [11] were included in the study. Exclusion criteria comprised pregnancy or breastfeeding; systemic conditions known to impair wound healing (e.g., diabetes mellitus, severe anemia, or malignancy); immunodeficiency states (including steroid therapy); preoperative use of antimicrobial or anti-inflammatory medications; local inflammatory conditions such as pericoronitis; and smoking or other nicotine use, as these factors may adversely affect postoperative healing.
Trismus:
Trismus was evaluated by measuring the maximum interincisal distance between the mesioincisal angles of the maxillary and mandibular right central incisors during maximal mouth opening. Measurements were recorded preoperatively and repeated on postoperative days 3 and 7. Changes from baseline values were calculated to determine the degree of trismus.
Facial Swelling:
Facial swelling was assessed using a modified tape measurement technique [17], originally described by Gabka and Matsumura [18]. Measurements were obtained preoperatively and on postoperative days 3 and 7 using five anatomical landmarks: the tragus, soft tissue pogonion, lateral canthus of the eye, mandibular angle (gonion), and oral commissure. At each time point, three linear distances were recorded: tragus to oral commissure, tragus to soft tissue pogonion, and gonion to lateral canthus of the eye. The sum of these three measurements obtained preoperatively was considered the baseline value for the operated side. Postoperative swelling was calculated as the difference between the sum of the linear measurements recorded on each postoperative day and the corresponding preoperative baseline value. Postoperative pain was assessed using a 10-mm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst imaginable pain), on postoperative days 1, 3, and 7. The total number of analgesic tablets consumed during the postoperative period was also recorded. Early wound healing was evaluated using the Early Wound Healing Index (EHI) [4]. The EHI assesses clinical signs of re-epithelialization (CSR), hemostasis (CSH), and inflammation (CSI) according to predefined scoring criteria. Detailed descriptions and interpretations of the EHI scores are presented in Table 1.
Assessment of Quality of Life
Oral health–related quality of life (OHRQoL) was evaluated using the Turkish version of the Oral Health Impact Profile-14 (OHIP-14) questionnaire. OHIP-14 scores range from 0 to 56, with higher scores indicating poorer OHRQoL [19].
Surgical Protocol
All surgeries were performed by two experienced surgeons, O.S. and A.V., under inferior alveolar nerve block and buccal infiltration anesthesia using 40 mg/mL articaine HCl with 0.012 mg/mL epinephrine HCl (Ultracaine D-S Forte 2 mL/Ampul; Sanofi Aventis). A full-thickness triangular flap with a mesial vertical releasing incision at the mandibular second molar was raised to provide adequate surgical exposure [20]. Osteotomy, and odontotomy when necessary, was performed using a high-speed surgical handpiece (NSK Surgic Pro, Japan) at 40,000 rpm with a 1.6 mm round bur under copious sterile saline irrigation. Following tooth extraction, the socket was curetted and irrigated with sterile saline. The flap was then repositioned and sutured with 3/0 silk sutures (Dogsan). Postoperative medications included Augmentin 1 g (875 mg amoxicillin + 125 mg clavulanic acid) administered orally twice daily for 7 days, Parol 500 mg (paracetamol) as needed with a maximum of four doses per day, and Kloroben mouth rinse (0.12% chlorhexidine). Postoperative care included the use of Kloroben mouth rinse containing 0.12% chlorhexidine gluconate and 0.15?nzidamine hydrochloride, administered three times daily for one week. Patients were provided with standard postoperative instructions: bite on sterile gauze for the first 30 minutes, apply intermittent ice packs (10 minutes on, 10 minutes off) during the first six hours, and maintain oral hygiene by brushing teeth twice daily. Mouth rinsing was advised to begin 24 hours after surgery. Patients were also instructed to avoid foods with small grains or particulate texture for one week to prevent adherence to sutures or the surgical site. Sutures were removed during the follow-up visit on postoperative day 7.
A priori power analysis was performed using G*Power version 3.1.9.4, which indicated that a minimum sample size of 25 participants was required to achieve 80% power, assuming an effect size of 0.5897 and a standard deviation of 0.97 for wound healing, at a significance level of α = 0.05. Given the prospective design and short follow-up period, the risk of patient dropout was considered minimal, and no adjustment for attrition was made. The study continued until the target sample size with complete data sets was achieved. All statistical analyses were conducted using IBM SPSS Statistics version 22.0. Data were summarized using descriptive statistics. Group comparisons were performed using Student’s t-test or the Mann–Whitney U test, as appropriate. Repeated-measures ANOVA with post hoc Bonferroni correction and the Friedman test with post hoc Wilcoxon signed-rank test were used to analyze changes over time. Categorical data were analyzed using the chi-square test. Statistical significance was set at p < 0>
A total of 25 patients (16 females and 9 males) aged 19–33 years (mean 23.3 ± 2.88 years) were included in the analysis. There were no significant differences between the protein intake groups with respect to age, sex, body mass index (BMI), surgical difficulty, or duration of the operation. Detailed demographic and clinical characteristics of the study population are summarized in Table 2.
| Parameter | Description | Points |
| CSR | Visible distance between incision margins | 0 |
| Incision margins in contact | 3 | |
| Merged incision margins | 6 | |
| CSH | Bleeding at the incision margins | 0 |
| Presence of fibrin onthe incision margins | 1 | |
| Absence of fibrin on the incision margins | 2 | |
| CSI | Redness involving more than50% of the incision lengthand/or significant swelling | 0 |
| Redness involving less than 50% of the incision length | 1 | |
| Absence of redness alongthe incision length | 2 | |
| In the presence of suppuration, the EHI score was recorded as 0 | ||
Table 1: Early wound healingindex scoring.
Gender |
Female | n | % |
| 16 | 64 | ||
| Male | 9 | 36 | |
| BMI (kg/m2) | Underweight | 2 | 8 |
| Normal weight | 15 | 60 | |
| Overweight | 7 | 28 | |
| Obese | 1 | 4 | |
| Surgical Difficulty | Easy | 6 | 24 |
| Medium | 19 | 76 | |
| Operation Duration | 10–19 min | 8 | 32 |
| 20–29 min | 7 | 28 | |
| > 30 min | 10 | 40 | |
| Protein Intake | Low | 10 | 40 |
| Normal | 6 | 24 | |
| High | 9 | 36 |
Table 2: Description of the subjects.
| Time | Min-Max | Mean ± sd | P | |
| Trismus (mm) | Day 3 | 30 − 0 | 12.52 ± 10.21 | 0.001* |
| Day 7 | 27 − 0 | 6.68 ± 8.06 | ||
| Facial swelling (mm) | Day 3 | 0–10 | 2.1 ± 2.95 | 0.001* |
| Day 7 | 0-17.5 | 1.7 ± 4.66 | ||
| Pain | Day 1 | 0–10 | 3.88 ± 3.36 | 0.001* |
| Day 3 | 0–10 | 3.2 ± 3.1 | ||
| Day 7 | 0–8 | 1.28 ± 2.34 | ||
| Early Healing Index | Day 1 | 0–9 | 5.04 ± 2.05 | 0.001* |
| Day 7 | 4–10 | 8.56 ± 1.83 | ||
| Day 14 | 10–10 | 10 ± 0 | ||
| OHIP-14 | Preop | 0–44 | 13.2 ± 10.63 | 0.004* |
| Day 3 | 3–40 | 20.88 ± 10.16 | ||
| Day 7 | 1–29 | 13.36 ± 9.21 |
Table 3 Comparison of preoperative and postoperative parameters. *p < 0.05.
| Protein intake | ||||||
| Time | Low | Normal | High | p | ||
| Trismus (mm) | Day 3 | 13.2 ± 9.15ab | 6.17 ± 5.85a | 16 ± 12.36b | 0.004* | |
| Day 7 | 5.5 ± 7.07 | 3.83 ± 5.85 | 9.89 ± 9.88 | 0.255 | ||
| Facial swelling (mm) | Day 3 | 1.75 ± 3.34a | 1.67 ± 3.03a | 2.78 ± 2.64b | 0.023* | |
| Day 7 | 0.75 ± 4.26 | 0 ± 0 | 3.89 ± 6.01 | 0.58 | ||
| Pain | Day 1 | 4.1 ± 3.36a | 4 ± 3.35a | 3.6 ± 3.01b | 0.009* | |
| (VAS - | Day 3 | 3.9 ± 3.1 | 2.17 ± 3.49 | 3.1 ± 2.85 | 0.208 | |
| 10 mm) | Day 7 | 1.3 ± 2.34 | 2 ± 3.16 | 0.8 ± 1.39 | 0.849 | |
| Analgesic consumption (Total) | - | 7.1 ± 7.12a | 13 + 9.19b | 8.4 ± 8.47a | < 0.001* | |
| EHI | Day 1 | 4.3 ± 2.05 | 5.29 ± 1.86 | 6.2 + 1.93 | 0.081 | |
| Day 7 | 7.7 ± 1.83a | 8.14 ± 1.61ab | 9.8 ± 1.71b | 0.019* | ||
| OHIP-14 | Preop | 12.9 ± 10.63 | 11.71 ± 10.54 | 12.7 ± 11.08 | 0.211 | |
| Day 3 | 20.3 ± 10.16 | 21.57 ± 10.93 | 20.2 ± 9.95 | 0.462 | ||
| Day 7 | 13 ± 9.21 | 12.43 ± 9.74 | 11.9 ± 10.09 | 0.704 | ||
Malnutrition is a well-established risk factor that can negatively influence wound healing [21]. Despite extensive research on postoperative recovery following surgical removal of impacted mandibular third molars (SRM3), few studies have specifically investigated the role of dietary protein intake in this context. This study aimed to evaluate the effect of protein consumption on early wound healing, as well as on postoperative outcomes such as trismus, facial swelling, and pain. Our findings suggest that higher protein intake is associated with improved early wound healing, as reflected by higher EHI scores on postoperative day 7. Additionally, protein intake appeared to modulate postoperative outcomes: patients with higher protein intake experienced lower pain scores on day 1, although they showed greater trismus and facial swelling on day 3. These results indicate that while early inflammatory responses (manifested as swelling and limited mouth opening) may be more pronounced in patients with higher protein intake, overall wound healing is enhanced in the first week postoperatively. No significant relationship was observed between protein intake and OHRQoL (OHIP-14 scores), suggesting that short-term variations in protein consumption may not substantially impact patients’ perceived oral health-related quality of life during the first week of recovery. Gender differences were noted on day 7, with females showing improved OHRQoL compared with males, while surgical variables such as difficulty level and operation duration did not significantly influence postoperative outcomes. These findings underscore the potential importance of nutritional assessment and dietary support as part of postoperative care in oral surgery. Few clinical studies have specifically explored the relationship between protein intake and wound healing in oral and maxillofacial surgery, and most of these have been observational, consistent with our findings. For example, Laimer et al. reported that better nutritional status was associated with improved wound healing in patients with medication-related osteonecrosis of the jaw (MRONJ) undergoing intraoral soft tissue closure [9]. Similarly, Dodington et al. observed enhanced healing outcomes with higher protein intake following nonsurgical periodontal therapy [1]. Lee et al. conducted the first interventional study examining the effects of nutritional supplementation on healing after periodontal surgery, reporting improvements in early periodontal wound repair [10]. In our study, a significant positive correlation was observed between protein intake and Early Wound Healing Index (EHI) scores on postoperative day 7, suggesting that greater protein consumption may accelerate early wound healing, particularly during the inflammatory and early proliferative phases. No significant correlation was observed on day 1, and by day 14, all patients had achieved maximum EHI scores, rendering further assessment unnecessary. Surgical trauma disrupts protein metabolism, leading to rapid mobilization of amino acids from skeletal muscle. Some studies suggest that muscle protein breakdown provides essential precursors for wound protein synthesis, yet this catabolic-anabolic interplay may sometimes delay healing [22]. Conversely, reduced lean body mass has been shown to impair immune function and prolong wound repair [21,23,24]. Anabolic steroids have been reported to accelerate wound healing [25]. Gore et al. highlighted the phenomenon of net muscle protein catabolism alongside net wound protein anabolism following trauma, challenging the assumption that amino acids released from muscle are insufficient for tissue repair. These findings collectively emphasize the critical role of adequate protein intake in supporting early postoperative healing after oral surgical procedures.
This study demonstrates a clear association between higher protein intake and improved early postoperative outcomes following impacted mandibular third molar surgery. These findings suggest that dental professionals should consider assessing patients’ dietary habits preoperatively and provide guidance on adequate protein intake during the perioperative period. Simple strategies, such as encouraging protein-rich foods or short-term supplementation, may promote faster recovery, reduce pain, and enhance quality of life.
SRM3: Surgical removal of impacted mandibular third molars
RDA: Recommended dietary allowance
FFQ: Food frequency questionnaire
VAS: Visual Analog Scale
EHI: Early Wound Healing Index
OHRQoL: Oral health–related quality of life
OHIP-14: Oral Health Impact Profile-14
BMI: Body mass index
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Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).
