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Review Article | DOI: https://doi.org/10.31579/2690-4861/1059
Medical Oncologist (Diploma in Cancer Biology), Oncology course: Tumors and Cancers, Certification in Cancer Nutrition, PG (Electro Homeopathy), BASM (Alternative Medicine), RMP (Alt Medicine and Electro Homeopathy), M.A (Clinical Psychology), M.A (English), India.
*Corresponding Author: Sabita Sinha., Medical Oncologist (Diploma in Cancer Biology), Oncology course: Tumors and Cancers, Certification in Cancer Nutrition, PG (Electro Homeopathy), BASM (Alternative Medicine), RMP (Alt Medicine and Electro Homeopathy), M.A (Clinical Psycholog
Citation: Sabita Sinha, (2026), The Gut Micro biome: The Hidden Driver of Human Health and its Scientific Foundations, International Journal of Clinical Case Reports and Reviews, 34(4); DOI:10.31579/2690-4861/1059
Copyright: © 2026, Sabita Sinha. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 27 February 2026 | Accepted: 04 March 2026 | Published: 13 March 2026
Keywords: antioxidants; oxidative stress; free radicals; urolithihin A; and Akkermansia Muciniphila
Gut micro biome serves as a strong indicator to asses our health. It plays a vital role in our overall health. What does the gut micro biome define? It is the community for trillions of micro-organisms like virus, bacteria, fungi, and protozoa- that live in the digestive tract specifically the colon. Their daily activities influence overall health. It seems to be pretty silly, but they are the main contributing factor or determinant of almost all diseases. It can influence our overall health in positive and negative way. If we have good bacteria, it has positive impact in our body. It gives us negative impact in our health, when we are lack of good bacteria’s. We can predict about good bacteria just seeing our overall health. If we have good bacteria loaded in our gut micro biome, we are energetic, enthusiastic, and active, in good mood and fall sick less often. Reverse is also observable, when we have harmful bacteria’s, we have parasite infection, lethargic, brain fog, mood swing, falling sick frequently is the key note of it. So, we can enjoy good health if we just figure out this gut micro-biome dysbiosis and fix it. In this article we will discuss about gut micro biome in depth and discover hidden contribution of gut micro biome in almost all diseases.
When we were little kid and whenever we were getting sick - our grandparents use to tell that something is wrong with stomach. They might not be aware of scientific name; however, their diagnosis was so correct. They were talking about gut micro biome, which we came to know little late. So what is this gut micro biome in real? Gut micro-biome plays crucial role in human health. It is the eco-system for trillions of micro-organisms like virus, bacteria, fungi, protozoa-which lives in our digestive tract especially colon. Their daily activities have influence in every aspect of human physiology. We have so many tiny guests in our gut micro-biome and their temper reflects in our overall health and behavior. If we feed them daily basis with healthy fiber rich food, they grow. Again, they do not prefer same kind of food every day. Varieties of plant-based food make them happy and grow. When we hit them knowingly or unknowingly with different kind of chemicals, processed and junk food, it hurts them and kills. However, it is favorable micro environment for harmful antigen to grow. Neuro specialist Dr. Sweta Adatia has conducted an experiment on her. Every day she was taking same kind of food. After 1 month, when she performed gut micro biome test, it was shocking for her. Her good bacteria didn’t grow at all. However, she took variety of fiber rich food and performed gut micro biome test, she found her good bacteria had movement and it grew in number. Gut bacteria are also like human being. They do not prefer to have same kind of food every day. Important things to be noted, most of us do not have beneficial bacteria’s and this is the important factor contributed in disease development.
1. Digestive and metabolic function:
i) B12 production in gut......> whatever we eat, not all food gets digested. Undigested food reaches in colon (large intestine). Bacteria take part to make basic building block. They use amino acids+ sugars+ cobalt (Co). With the help of multiple enzyme reactions, bacteria build a complex ring structure, which is called corrin ring. Trace mineral cobalt is embedded into the center of the ring. Substitute groups are introduced and active vitamin B12 is produced (cobalamin).
ii) Folate (B9) production in gut......>Undigested food
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Bacteria use
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Glucose+ amino acid
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Form molecule
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PABA (para-aminobenzoic acid + Added glutamate component
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Active form of Folate (Tetra hydrofolate)
iii) Biotin (B7) formation in gut......>Undigested food
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Bacteria use
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Fatty acid pre-cursors
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Form ring structure (pimeloyal-ACP) + added sulfur atoms
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Multiple enzyme reaction modifies the structure
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Final version is Biotin (B7)
iv) Vitamin K production in gut......>Undigested food
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Bacteria use
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Amino acid (chorismate)
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Converted into menadione nucleus + added Isoprenoid side chain
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Final version is Vitamin K2 (menaquinone)
c). Energy regulation: It ferments fiber into short chain fatty acid (SCFAs) like acetate, propionate, butyrate, which strengthen colon cells and regulate metabolism. Function of these 3 short chain fatty acids:
i) Acetate...........> helps........>energy metabolism
ii) Propionate....>promote....> Liver glucose metabolism
iii) Butyrate......>major energy source for colon cells
They strengthen gut lining, reduce inflammation and play crucial rule to support overall metabolic health.
d). Bile metabolism: It modifies bile acid.
/
Liver produces
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Cholic acid + chenodioxycholic acid
\ /
Stored
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Gall bladder
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Released
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Small intestine
\ \
Digest \
\ \
Fat \
\
Bile acid fails to reabsorb
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Reach in colon
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Bacteria act on it
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Produce enzyme
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Bile salt hydrolase (BSH)
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Removes glycine from bile acid
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Process
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Deconjugation
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Bacteria further modify them through
/ \ \
Dehydroxylation oxidation epimerization
\ \ \
Converts primary bile acid into secondary bile acids
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i) Deoxycolic acid
ii) Lithocholic acid
Secondary bile acids are excellent in regulating metabolism, help in fat absorption, reduce inflammation, they can send signal through receptors like FXR and TGR5. Their activities influence diabetes, obesity, and liver health and balance cholesterol.
3) Metabolic and Systematic Health:
i) Weight regulation: Whatever we eat is not completely getting digested. Undigested food breaks down by certain bacteria. They produce short chain fatty acid. These short chain fatty acids provide extra energy and calorie to body. Well, some micro biome draws out extra energy and calorie to body, which contributes to weight gain. Moreover, activities of gut micro biome influence appetite and hunger. They influence hormones like-GLP-1(glucagon like peptide 1, PYY (Peptide YY), Ghrelin (hunger hormone). When we have large number unhealthy gut micro biome, it increases hunger, no control over appetite and the result is weight gain.
ii) Strong bond between fat storage and metabolism: Few micro biomes affect fat storage in body. When we have slow metabolism, body burn fewer calories and rest will go and deposit as fat in fat prone areas like arms, thighs, abdomens. Mostly slow metabolism is observed in case of metabolism related disorders like hyperglycemia, hypothyroidism, and obesity. It happens due to insulin sensitivity, inflammation, and dysbiosis in micro biome. Harmful bacteria cause inflammation- more visceral fat in body for prolonged period, lack of few beneficial bacteria may cause imbalance in gut micro biome. So, we can see how gut micro biome influences fat storage and slows down metabolism.
iii) Cardio vascular health: when we eat food like egg and meat, it reaches in our gut. Certain bacteria convert choline (egg) and carnitine (meat) into TMA (tri methylamine). Then liver enzyme (FMO3) converts TMA into TMAO (Trimethylamine N-Oxide).
Choline + Carnitine….>reaches....>gut….>certain bacteria....> converts into....>TMA
TMA (certain gut bacteria) + FMO3 (Liver enzyme)......TMAO
What happens when TMAO level is elevated?
i) It causes heart disease
ii) Increases tendendency of blood clotting
iii) Plaque buildup tendency
iv) Kidney failure issue
v) Inflammation
vi) Increases oxidative stress
How can we reduce TMAO level?
i) Plant based foods
ii) Fiber rich foods
iii) Physical exercise
iv) Kidney function optimization
v) Reducing red meat consumption
What is this oxidative stress?
Oxidative stress is a condition caused in body when we have no control over free radicals and it exceeds antioxidants.
| Oxidative stress= | Free Radicals > | Antioxidants |
| Normal Metabolism | i)Normal Energy production (ATP) I mitochondria | i) Vitamin C |
| + | ii) Chronic inflammation | ii) Vitamin E |
| Environmental | iii) UV radiation | iii) Glutathione |
| Exposure | iv) Radiation (mobile, cancer treatment) | iv) Antioxidants found in vegetables and fruits |
| v)Smoking | ||
| vi) Pesticides and chemicals | ||
| vii) Heavy metals | ||
| viii) Fried and processed foods |
How can we minimize oxidative stress?
We cannot totally stop producing oxidative stress or free radicals in the body. Everyday body produces little amount of free radicals, while processing normal metabolism. However, we can have control over free radicals with healthy life style, diet and physical activity. Physical activity is such a powerful weapon to stay healthy and fit. As a Medical Oncologist, I have observed that cancer treatment outcome is successful in any medical system like conventional, holistic - Ayurveda, Homeopathy, Ayurveda, Unani, and Siddha and in naturopathy, when we include physical exercise as rehabilitation during treatment and after post treatment. Well, consistency does matter a lot with life style change, medication and proper diet.
We will try to explain how physical exercise influences mitochondria in energy (ATP) production:
Physical Exercise
\
Activates mitochondria
\
Through Energy demanding signal
Muscle contraction....>demands more ATP...>up regulate several powerful cellular pathways
i) Elevated ATP--Demands....>AMPK activation [AMP-Activated Protein Kinase]…..>energy sensor....>cell
AMPK (Adenosine Monophosphate-Activated Protein Kinase)
\
Commands to cell
/ \
Produce utilize energy substrates
More
Mitochondria
ii) PGC-1a activation (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha)
When we do exercise, following changes happens inside cell....
Exercise....>muscle contraction....> increases.....>calcium level.....>calcium activates....>signaling protein.....>switch on PGC-1a (master regulator of mitochondrial biogenesis)
\
Functions
a) Activates NRF1+NRF2 pathway (proteins which have the ability to switch on or switch off genes involved in mitochondrial function and antioxidant
b) Enhances mitochondrial enzymes
c) Promotes oxidative phosphorylation
What is oxidative phosphorylation?
Oxidative phosphorylation
/
Process
/
Mitochondria
/
Use
/
Oxygen
/
Produce
/
ATP
/
Through Electron Transport Chain
iii) ROS (Reactive Oxygen Spices)…..>works as signal controller
Exercise
\
Produces
\
ROS (mild level)
/ \
High Low
/ \
Oxidative stress Protective signal
\
a) Activates NRF1+NRF2 pathway (proteins which have the ability to switch on or switch off genes involved in mitochondrial function and antioxidant
b) mtDNA replication (mitochondrial DNA)
c) Activates antioxidant enzymes (SOD +Catalase+ glutathione peroxidase)
iv) Enhanced Oxygen Utilization:
Exercise-àenhances--àcapillary density
\
Myoglobin content (protein found in muscle cell.....stores +carries Oxygen
It increases oxygen utilization and produces more ATP
Hypoxia is the one major cause of death in cancer in advanced stage. Most of the cancer patients feel difficulty in advanced metastasis stage and struggle to manage O2 level.
v) Mitophagy activation (Removing damaged mitochondria):
Exercise....>activates...>autophagy+mithophagy pathway...>damaged mitochondria would be removed
\
Good and healthy mitochondria will remain same and multiply
How antioxidants neutralize free radicals and reduce oxidative stress?
Here is the simple model to explain the above scenario in an understanding way.
Free radicals
/
Nature
/
Missing paired electron
/
Example
/
a) Superoxide radical
b) Ozonize radical
Remarkable point is that, when they are impaired, they are highly reactive free radicals and they can damage DNA, protein and lipid. However, they have tendency to be paired. On the other hand, antioxidants are such a molecule that neutralizes free radicals transferring one electron and sheiled the body from oxidative damage.
Where can we get Antioxidants?
We get antioxidant from colorful vegetables, seeds, nuts, beverages and our body also produces it. Cruciferace vegetables: Broccoli, cauliflower, cabbage- have sulferophane as in-active form. It has in -active glucoraphanin. We chop it and keep it for 40 min; one enzyme called myrosinase, come in contact with glucoraphanin and activates sulferophane. Myrosinase is heat sensitive and gets damaged in high heat. So, we have to prepare in low steam to get maximum benefit of activation of sulferophane.
Green banana (high amount of resistance starch), green peas (moderate level), sweet potato and normal potatoes have small amount of resitance startch. It depends upon, how do we prepare and activate it. Resistance starch is a healthy carbohydrate, which will go to our gut and gets fermented in large intestine. It feeds gut bacteria and assists to grow good bacteria.
Green leafy vegetables and fruits are loaded with vitamins and minerals and antioxidants. Fruits like blueberry, strawberry, Kiwi, Pomegranate, avocado and green leafy vegetables such as spinach, amaranth, Malabar spinach, kale- all are good sources of antioxidants.
Urolithin A: It is a natural compound produced in our gut. When we eat food like pomegranate, strawberry, walnut-polyphenols in these fruits like ellagic acid and ellagitannis breaks down in gut with the help of special bacteria called gordonibacter Urolethinfaciens and produce Urolithin A. It reduces inflammation and strengthens intestinal lining. It enhances mitochondrial function, boosts immune system and empowers memory function. Everyone cannot produce Urolithin A. However, they can have the same benefit with Urolithin A supplement.
Akkermansia Muciniphila: It is a beneficial bacterium found in our large intestine. It feed on mucin and assist to maintain integrity of gut lining. More the akkermansia in our gut indicates strong metabolic function. It plays crucial role in metabolism. So, it prevents the risk of diabetes and obesity. Scientists are working on it for further therapeutic purpose. Renowned cancer researcher Dr. William Li’s mother got diagnosed with endometrial cancer 4th stage at the age of 84 years. Her Oncologist informed Dr. Li that at this age, chemo and radiation would be more devastative than the cancer. So better to shift her in palliative care, where she can have good time until she survives. He introduced his mom to brand new Immunotherapy. They checked her akkermansia level and boosted it with food like pomegranate, green tea, and cranberry. When her akkermansia Level was up, it did wonder with immunotherapy. With little radiation and Immunotherapy, she reversed her 4-stage cancer to Zero (0) stage.
Even Dr. Lawrence Zigvitol, French Oncologist and Immunotherapist also proved that akkermansia is a powerful tool for immunotherapy. She conducted an experiment upon 249 cancer patients who were going through immunotherapy. Again, she separated 249 patients into 2 groups, who were giving response towards immuno therapy and who were not responding towards immuno therapy. What she found was quite shocking. People who were responding towards immuno therapy had high level of akkermansia, whereas who were not responding towards immuno therapy, had low level of akkermansia. Unfortunately, very few people have this beneficial bacterium in their gut. We can increase the level with food and supplement. I do prescribe Urolithin A and Akkermensia supplements to almost all patients as well as cancer patients. It has an excellent result in overall health.
How to support gut micro biome?
We can sum up gut micro biome as hidden organ. It has control over digestion, immune function; cardio vascular health and even brain function as well. Gut micro biome is called as second brain. If we want to stay healthy, we must take care of gut micro biome. Almost all diseases are linked with gut micro biome. We can follow healthy life style and grow good bacteria to support our overall health. One simple fix in gut micro biome is the key to enjoy healthy life. So, we can leave a healthy life with proper food, exercise, hydration, taking proper antioxidants from fruits and vegetable and prepare our body to produce anti-oxidants. When we know how to figure out our health issues, why do we stay back and act carelessly? We can maintain its balance which is essential for overall health and disease prevention. A healthy and balanced gut micro biome is the door towards healthy life.
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Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
