The First Ten Cardiac Stimulations Performed in Guinea by a Local Team: a Historic Turning Point for Guinean Cardiology

Research Article | DOI: https://doi.org/10.31579/2641-0419/548

The First Ten Cardiac Stimulations Performed in Guinea by a Local Team: a Historic Turning Point for Guinean Cardiology

  • Baladé EY *
  • Bah MB 1
  • Bah A 1
  • Diallo M 1
  • Koné A 1,2
  • Baldé TS 1
  • Camara A 1
  • Diallo H 1
  • Keita M 1
  • Barry A 1
  • Samoura S 1,2
  • Soumaoro M 1
  • Bah MD 1
  • Barry IS 1
  • Baldé MD 1

1Department of cardiology national hospital of Ignace Deen UH of Conakry

2Department of cardiology friendship siono-guineene hospital

*Corresponding Author: Baladé EY, Department of cardiology national hospital of Ignace Deen UH of Conakry.

Citation: Baladé EY, Bah MB, Bah A, Diallo M., Koné A, et al, (2026), The First Ten Cardiac Stimulations Performed in Guinea by a Local Team: a Historic Turning Point for Guinean Cardiology, J Clinical Cardiology and Cardiovascular Interventions, 9(5); DOI:10.31579/2641-0419/548

Copyright: © 2026, Baladé EY. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 16 January 2026 | Accepted: 09 March 2026 | Published: 31 March 2026

Keywords: atrioventricular block; cardiac stimulation; guinea

Abstract

Introduction : The atrioventricular block (AV Block) is a normal loss of function of the cardiac conduction pathway between the atrium and the ventricle. It is a serious pathology encountered throughout the world, whose management mainly involves cardiac stimulation. This study aimed to describe the practice of cardiac stimulation in Guinea. Methodology: It was a cross-sectional descriptive study lasting 22 months from November 1, 2023, to August 30, 2025. We included in the study all patients with AV block who were received at the CEMECO clinic during the study period and who benefited from the insertion of a cardiac pacemaker.

Result : We have identified 36 cases of AV Blockk out of 953 patients, 10 of whom benefited from the implantation of a pacemaker, representing an implantation rate of 27.78%. A male predominance was noted at 7/10 (70%) and the patients were aged 68 to 87 years. The symptomatology was marked by syncope 9/10 (90%) followed by exertional dyspnea 7/10 (70%). 9/10 (90%) of the cases were 3rd degree AV Blocks. The cephalic vein was the preferred route of access for 7/10 (70%) of our patients. Double chamber stimulation was the most practiced (8/10 cases, or 80%). All our patients had their clinical condition stabilized. In terms of complications, we noted a case of 1/10 (10%) of displacement of the atrial catheter, a case of 1/10 (10%) of pericardial tamponade that was well managed. 

Conclusion : The development of cardiac stimulation offers better prospects in the management of conductive disorders in our context. Measures to promote its accessibility should be considered.atrioventricular block; cardiac stimulation;  guinea

Introduction

The auriculoventricular block (AV Block) refers to the existence of a disruption in the transmission of electrical impulses from the atria to the ventricles, through the atrioventricular node, the bundle of His or simultaneously in both branches of this bundle [1]. It is a serious pathology encountered throughout the world whose treatment by excellence remains cardiac stimulation [2]. The development of cardiac stimulation represents a curative treatment [3]. His practice in sub-Saharan Africa is booming with rates of first implantation increasing [2;4;5]. The practice of cardiac stimulation in Guinea was once a punctual and sporadic activity because it was reserved for health missions. However, since 2024, the installation of cardiac pacemakers has been made possible and accessible, which constitutes a major advance that revolutionizes the management of AV Blocks in our context. Thus, the present study was initiated in order to assess cardiac stimulation in Guinea.

Methodology

Framework and type of study: The CEMECO clinic in Kipé served as the setting for our study. It was a cross-sectional descriptive study lasting 22 months from November 1, 2023, to August 30, 2025.  study process : This study focused on all the records of patients admitted for BAV at the clinic during the study period who had benefited from the placement of a pacemaker. We have conducted an exhaustive recruitment of all patients meeting our inclusion criteria. We included in the study all patients with a AV Block received in our department during the study period and who benefited from the installation of a cardiac pacemaker. However, we excluded from the study all patients received for AV Block during the study period but who did not benefit from a pacemaker installation. Thus, we noted the sociodemographic characteristics of the patients, then described the clinical and paraclinical data, the associated risk factors, the etiologies as well as the practical data of the implantation.

Ethics : The data were collected anonymously and used only for this study.

Results

We have identified 36 cases of AV Block, 10 of which benefited from the implantation of a pacemaker, representing an implantation rate of 27.78%. The average age of patients at the time of cardiac stimulation was 75.4 years, with extremes of 68 and 87 years. A predominance of the male sex was noted at 7/10. The main symptom was syncope (9/10), followed by dyspnea (7/10). The 3rd degree AV Block was present in 9/10 of our patients compared to 10% of 2nd degree AV Block. Regarding the etiology, the degenerative origin was suspected in all our patients, ie 10/10. The preferred route in our patients for implantation was the cephalic vein (7/10), followed by the subclavian vein (2/10). Regarding the type of pacemaker, 9/10 of our patients had benefited from a double chamber case compared to 2/10 of a single chamber case. Furthermore, we proceeded with the placement of a temporary probe in a single patient before his recovery the next day for definitive stimulation. The ventricular lead was positioned at the apex in 8/10 patients, at the septal level in 1/10 as well as at the apex and then repositioned at the septal in 1/10 patients. The parameters at the output of the block varied between 0.5-1.5 V for the atrial threshold, 0.5-0.7 V for the ventricular threshold, between 490-630 ohms for the atrial impedance and 330-950 ohms for the ventricular impedance. The average duration of the stimulation procedure in our patients was 190 min. In terms of complications, we noted 1/10 cases of atrial probe displacement and 1/10 cases of pericardial tamponade.

 NumbersPercentage
Age range  
< 80>880%
≥ 80 years220%
Average age = 75,4 ans                    Extreme = 68 - 87 
History and Cardiovascular Risk Factors 
Diabetes220%
HBP10100%
Tabacco110%
Functional symptoms  
Dyspnoea770%
Physical asthenia110%
fainting fit890%
Physical signs  
Bradycardia10100%
Crackles220%
Edema of the lower limbs110%
Hepatomegalia110%
Biology  
TSH normal770%
Normal blood ionogram990%
Creatinine concentrations220%
Dyslipidemia110%
Type de AV Block  
Type II110%
Type III990%
Type of pace  
Mono Chamber220%
Double chamber880%
intravenous access  
Cephalic vein770%
Subclavian Vein220%
Mixed110%
Ventricular lead insertion site 
Septal110%
Apex880%
Apex then reposition in septal110%
Favourable trend880%
Complications220%
Displacement of the atrial probe880%
Pericardial tamponade110%

Discussion

In developed countries, the practice of cardiac stimulation is very advanced compared to developing countries.  In sub-Saharan Africa, more and more countries are now performing cardiac stimulation. As part of our study, we identified 36 cases of AV Block of which only 10 were implanted, representing an implantation rate of 27.78%. Our results are lower than those of Camara Y et al [2] in Mali in 2021, which had reported a primo-implantation rate of 68.3%. Moreover, our result is similar to that obtained by Baldé E et al [5] in a previous study conducted in Guinea, which had reported 14 stimulated patients out of 64 cases of AV Block collected, representing an implantation rate of 21.86%. This low rate of stimulation in our study could be explained by the fact that cardiac stimulation is recent in our context, but also the lack of patient care in a context marked by a weak development of insurance system.

In our study, the age of patients at the time of cardiac stimulation ranged from 71 to 87 years, with a mean age of 75.4 years. Our data are consistent with those found in the African literature [6, 7, 8]. In the study by Rahma K et al. [9], the average age of patients was 72 15 years. The predominance of AV Blocks at this age is explained by the degeneration of conduction pathways related to physiological aging.

In general, AV Blocks are more common among women due to their reduced mobility, unlike men who are more active. However, our sample had 70% men against 30% women. Moreover, the predominance of the female sex is often found in the literature with Tabane A et al. [10] (52%) and Tuomas K. et al. [11] (56.1%). In our study, syncope was the master symptom (9/10), followed by exertional dyspnea (7/10). This symptom remains the main manifestation encountered in African series, with prevalences ranging between 60 and 88.6%. Dyspnea was present in 67.4?cording to Camara Y et al [2]. According to Lévesque K et al [12], syncope was present in 88.6% of cases. This would probably suggest the gradual installation of conduction disorder, thus evoking the degenerative origin we had suspected. The 3rd degree BAV was present in 9/10 patients. Our result is similar to that of Camara Y et al [2] who had reported a rate of 83.7%. Ramiandrisoa L et al [1] had found 72.5% of 3rd degree BAV. From an etiological point of view, the degenerative origin was the most suspected in all our patients, i.e. 10/10. Ce résultat corrobore les données de la littérature (88.3?ns la série de  Camara Y et al.) [2]. This would be due to fibrous degeneration of the branches of the His bundle, sometimes to sclerocalciferous lesions of the trunk and the bifurcation of this bundle. The extension of indications to definitive stimulation by pacemaker or implantable automatic defibrillator is at the origin of the expansion of implantation procedures [13; 14]. From a technical point of view, the cephalic vein was the preferred route for all our patients, which is 10/10. In the study by Brignole M. et al. [14], the cephalic approach was practiced in 56.8% of cases, ahead of the subclavian (23.9%) and axillary (8%) approaches. In the study by Khadidiatou D et al. [15], the cephalic approach was mostly used in 68.3% of cases, followed by the subkeyboard approach in 31.5% of cases and the axillary approach in 0.3% of cases. This deviation from our result is explained by the scheduled nature of most procedures and the small sample of patients stimulated in our context. Regarding the type of cardiac pacemaker, 8/10 patients had benefited from a double chamber case compared to 2/10 single chamber cases. This predominance of double-chamber housing was also observed by Rahma K et al. [9] who had reported that the devices were of the single-chamber type (51.2%), double-chamber (43.2%) and triple-chamber (5.6%). However, some authors report a preference for single-chamber enclosures [6,8]. Adoubi K et al. [16] had reported the use of simple chamber ventricular pacemakers in 66.6% of cases. The preferential use of double chamber housings in our patients could be explained by its more physiological functioning and on the other hand by the predominance of AV Block 3 which constitute a preferred indication of double chamber stimulators. In our study, the ventricular probe was positioned at the apex in 8/10 patients and at the septal level in 2 patients. Furthermore, Khadidiatou D et al. [15] had reported in their study that right ventricular probes were most often implanted in the apical position (98.3%) and in the septal position in 1.7% of cases. The right ear probes were implanted on the side wall of the right atrium (88.2%) and in the right atrium pavilion (11.8%). The parameters at the output of the block ranged from 0.5 - 1.5 V for atrial threshold, 0.5 - 0.7 V for ventricular threshold, between 490 - 630 ohms for atrial impedance and 330 - 950 ohms for ventricular impedance. In the study by Yves N. et al. [17], the median detection at implantation was 3.4 mV and 6.8 mV in the atrium and right ventricle, respectively, with extremes ranging from 0.8 to 8 mV for the right atrium and 1.6 to 15 mV for the right ventricle. The median stimulation threshold was 0.85 V and 0.80 V respectively, at the atrial and right ventricular levels. The median impedances were 569 and 716 ohms respectively at the atrial and right ventricular level. The average duration of stimulation in our patients was 190 min. Our result was higher than that of Yves N. et al. [17], who reported an average duration of 90 minutes. This difference could be explained by the strong predominance of double chamber devices in our context, as well as the learning curve of the team. The short-term evolution was marked clinically by the disappearance of symptoms that led to implantation in all our patients (10/10), in agreement with the literature [6,18]. It was favorable in 95.3% of the cases in the study by Camara Y et al [2]. Infectious complications are to be avoided in the case of definitive stimulation because it is associated with an excess mortality [19; 20]. The incidence of infectious complications varies greatly according to the studies. Infectious complications accounted for 1.96% in the study by Rahma K et al. [9]. In the case of our series, we did not note any complications, notably infectious, respiratory (pneumothorax) or hemorrhage (bleeding from the surgical site). On the other hand, in terms of the device, we noted 1/10 cases of displacement of the atrial probe and 1/10 cases of pericardial tamponade, or 10%. Our results are lower than some authors such as Udo E et al [21] who had found a complication rate of 12.4%, compared to 17.4% for Millogo G et al [6]. In the study by Camara Y et al [2], complications were mainly dominated by probe displacement with 3 cases, 3 hematomas and 1 case of wound infection. This difference could be explained by the small sample size. In the study by Khadidiatou D et al. [15], complications occurred in 4.53% of patients, mainly probe displacement (1.94%), infections (1.29%), pocket hematomas (0.65%) and pneumothorax (0.65%).

Conclusion

The implementation rate in our series was relatively low. The cephalic vein was the preferred route for all our patients and they had mainly benefited from double chamber stimulation. The clinical course was favorable in all our patients. Furthermore, appropriate measures would make it possible to better develop this technique in our environment.

References

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub

International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.

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Joel Yat Seng Wong

Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.

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Dr Perlat Kapisyzi

Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.

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Dr Ted Christopher

Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).

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Dr SABITA SINHA

Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.

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Dr Efstratios Troganis

Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).

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Dr Gary Merrill