AUCTORES
Globalize your Research
Research Article | DOI: https://doi.org/10.31579/2690-4861/388
Department of Otolaryngology, 988th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China, Zhengzhou 450042, Henan.
*Corresponding Author: Li Yi, Department of Otolaryngology, 988th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China, Zhengzhou 450042, Henan.
Citation: Li Yi, Wen Xiaomei, Yue Wei, Zhang Yage, Hu Haolei, Xing Peimei, et al, (2024), The Clinical Effect of External Application of Scorzonera Glabra Herpes Ointment on the Treatment of Herpes Zoster in the Ear, International Journal of Clinical Case Reports and Reviews, 16(3); DOI:10.31579/2690-4861/388
Copyright: © 2024, Li Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 22 January 2024 | Accepted: 19 February 2024 | Published: 29 February 2024
Keywords: herpes zoster; scorzonera glabra herpes ointment; acyclovir ointment; pure tone electrical audiometry; visual simulation scoring method
Objective to Exploring the effect of external application of scorzonera glabra Herpes Ointment on the treatment of Herpes zoster of the ear (HZE). Methods Select 100 HZE patients who met the inclusion criteria and were treated at the 988th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from January 2021 to June 2023. Divide into a treatment group and a control group using a random number table method, with 50 cases in each group. The treatment group was treated with external application of crow onion herpes ointment, while the control group was treated with external application of acyclovir ointment. After 10 days of treatment, the therapeutic effect was evaluated, and the HZE comprehensive symptom and sign efficacy score and visual analogue scale (VAS) were observed and compared between the two groups on the 10th day. The time for erythema reduction, blister stop, nodulation, and detachment were observed throughout the treatment process; Compare the difference in air conduction and air bone conduction between two groups before and after treatment (1 month after treatment); Observe and compare the incidence of postherpetic neuralgia (PHN) between two groups one month after treatment. Results The difference between the two groups was statistically significant (P<0.05), and the clinical effect of the treatment group was significantly better than that of the control group. Compared with the control group, the total score of HZE symptoms and signs in the treatment group was lower, and the difference was statistically significant (P<0.05). The comparison of air conductance between the treatment group and the control group before and after treatment (1 month after treatment) showed that the average air conductance was (35.5 ± 4.5), (35.9 ± 4.7), (15.6 ± 2.2), and (21.0 ± 3.1) dBHL, respectively; The air bone conduction differences were (10.1 ± 2.7), (10.5 ± 2.8), (5.1 ± 0.3), and (10.0 ± 2.4) dBHL, respectively. The differences in air conduction between the two groups before and after treatment (1 month after treatment) were statistically significant (P<0.05); The difference in air bone conduction between the two groups before and after treatment (1 month after treatment) was statistically significant (P<0.05); However, there was no statistically significant difference in air bone conduction difference between the control group before and after treatment (P>0.05). The incidence of PHN in the treatment group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).
Conclusion
The external application of scorzonera glabra Herpes Ointment has a significant effect on treating HZE, and can shorten the course of the disease, improve hearing, restore the function of the auditory nerve, and effectively prevent PHN.
The herpes zoster virus in the ear often invades the geniculate ganglia of the auditory and facial nerves, causing severe discomfort such as ear pain, deafness, and postherpetic neuralgia (PHN) [1-3]. Early active treatment of herpes zoster and peripheral neuropathic pain in the ear [4-6] can protect hearing and reduce the incidence of PHN [7]. At present, Western medicine mainly relies on antiviral drugs such as acyclovir orally or externally for the treatment of HZE, but the effect is not satisfactory. Traditional Chinese medicine treatment for HZE has the characteristics of good efficacy, short duration, and no toxic side effects. Especially in recent years, we have achieved good clinical results in the treatment of HZE with the internal preparation of scorzonera glabra herpes ointment applied externally. The specific situation is reported as follows.
1.1 General information
Select 100 HZE patients who met the inclusion criteria and were treated at the 988th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from January 2021 to June 2023. Divide into a treatment group and a control group using a random number table method, with 50 cases in each group. There was no statistically significant difference in the course, gender, age, and degree of pain between the two groups (P>0.05), indicating comparability. See Table 1. This study was approved by the Medical Ethics Committee of our hospital (SP20001 V2.0).
1.2 Diagnostic criteria
According to the "Clinical Diagnosis and Treatment Guidelines - Dermatology and Sexually Transmitted Diseases", the diagnosis of HZE is based on the fact that the rash is caused by a single ear, with visible blisters on the auricle, external ear canal, and tympanic membrane surface, as well as band like erythema and clustered herpes, accompanied by peripheral nerve pain.
1.3 Inclusion criteria
① Meets HZE diagnostic criteria; ② The appearance time of the skin lesion is less than 3 days, and no medication or method has been used before the visit; ③ Age 13y-60y; ④ The principle of voluntariness, understanding and reasoning, and signing an informed consent form.
1.4 Exclusion criteria
① Individuals who are allergic to acyclovir; ② Long term suffering from severe cardiovascular and cerebrovascular diseases and difficulty in controlling blood sugar; ③ Pregnant or lactating women; ④ Long term use of corticosteroids or immunosuppressants.
1.5 Dosage method
The treatment group applied graffiti scallion herpes ointment (The 988th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China.batch number: 20200310, specification: 30g/box) on the affected area, with a thickness of about 0.1mm, 5 times a day, covered with sterile gauze for 3 hours before removal. The control group applied acyclovir ointment externally to the affected area [Jiangsu Yongda Pharmaceutical Co., Ltd., National Medical Standard H19993851, specification: 10g, 300mg (3%)], with a thickness of approximately 0.1mm, 5 times a day. All patients were treated continuously for 10 days. At the same time, both groups were treated with methylprednisolone injection (Pfizer Pharmaceuticals, National Medical Standard HJ20170197, specification: 40mg) 500mg+0.9% physiological saline 250ml pulse therapy, intravenous infusion, and discontinuation for 3 consecutive days.
Table 1 Comparison of baseline data between two groups
1.6 Observation of therapeutic effects
1.6.1 Observation indicators: Observe and record the patient's symptoms and signs before treatment and on the 10th day after treatment. Evaluate the degree of pain using the Visual Analog Score (VAS) method (see Table 2). The specific method is to draw a horizontal line (10cm in length) on the paper, with the two ends of the line being 0 and 10 respectively, where 0 represents painlessness; 10 represents severe pain; The pain gradually intensifies from 0 to 10. Patients can mark their pain levels online based on their own feelings. The average value of mild pain is (2.57 ± 1.04); The average value of moderate pain is (5.18 ± 1.41); The average value of severe pain is (8.41 ± 1.35). Significant effect, that is, the patient's
pain symptoms completely disappear, and the VAS score decreases by more than 70%; Effective, that is, after treatment, the patient's neurological pain symptoms have improved, and the VAS score has decreased by 45% -70%; Invalid, meaning that the patient's neuralgia symptoms have not improved after treatment, and the VAS score has decreased by less than 45%. The total effective rate is the sum of apparent efficiency and effective rate. Observe and record the time for erythema reduction, blister arrest, scab formation, scab removal, and adverse reactions in two groups. Follow up of PHN occurrence one month after the healing of herpes zoster in the ear.
Table 2 Visual Simulation Rating Scale
1.6.2 Evaluation criteria for efficacy refer to the efficacy evaluation criteria formulated in the 2023 version of the Diagnosis and Efficacy Criteria for Traditional Chinese Medicine Diseases [8]. Cure: The rash subsides, clinical signs disappear, and there are no painful sequelae. Improvement: The rash has subsided by about 30%, and the pain has significantly decreased. Not cured: The rash has subsided by less than 30% and there is still pain.
1.7 Statistical methods
Statistical analysis was conducted on the obtained data using SPSS 26.0 software. Quantitative data that conform to a normal distribution are expressed as mean ± standard deviation (x soil s) using t-test. Measurement data that do not conform to a normal distribution are represented as median or quartile [M (P25, P75)], using Mann Whitney U test. Count data expressed in examples or percentages, using Χ 2 Inspection. Before and after treatment, t-tests were used for hearing (pre - and post-treatment air conduction, and pre - and post-treatment air bone conduction difference), and the results were statistically analyzed. The difference is statistically significant with P<0>
2.1 Comparison of treatment effects between two groups
After 10 days of treatment, the total effective rate of the treatment group was 98.00%, while the total effective rate of the control group was 84.00%. Both rows Χ Two tests showed that the treatment group had better therapeutic effects than the control group, and the difference was statistically significant (P<0>groups n cure Better healed Treatment 50 33(66.00) 16(32.00) 1(2.00) Control 50 26(52.00) 16(32.00) 8(16.00) Χ2 5.983 P 0.015
Table 3: Comparison of treatment effects between two groups, ％）
2.2 Comparison of total scores of HZE symptoms and signs before and after treatment between two groups
After repeated measures analysis of variance, there was a statistically significant difference (P<0>groups n before On the 10th day after treatment Treatment 50 21.18 ±5.89a 4.04±1.97 a Control 50 20.97±5.01b 7.76±2.12b t组间/P组间 0.252/＞0.05 -13.350/<0> ta/Pa 20.574/<0> tb/Pb 18.642/<0>
Table 4 Comparison of total scores of HZE symptoms and signs between two groups before and after treatment score, (x土s）
Note: Compared with before treatment in this group, P<0>
2.3 Comparison of Erythema Reduction Time, Scar Stopping Time, Scab Formation Time, and Scab Removal Time between Two Groups
The time for erythema reduction, blister arrest, scab formation, and scab removal in the treatment group was shorter than that in the control group, and the difference was statistically significant (P<0> groups n Reduce time Stop blister time Scabbing time Scab shedding time Treatment 50 3.34±1.78 4.46±2.13 5.87±1.67 9.02±2.45 Control 50 3.98±1.87 5.41±2.34 7.67±1.84 12.23±3.23 t 2.420 2.870 6.686 7.026 P 0.019 0.006 <0> <0>
Table 5 Comparison of time for erythema reduction, blister arrest, scab formation, and scab removal between two groups (d,x土s）
2.4 Comparison of VAS scores between two groups before and after treatment
After repeated measurements, there was a statistically significant difference (P<0> Groups treatmentn before On the 10th day after Treatment 50 8.64±1.84a 2.81±0.87a Control 50 8.56±1.81 3.98±1.12 tInter group/P Inter group 0.307/＞0.05 9.508/<0> ta/Pa 22.401/<0> tb/Pb 17.890/<0>
Table 6 Comparison of VAS scores between two groups before and after treatment (scorex土）
Note: Compared with before treatment in this group, P<0>
2.5 Comparison of incidence rates of PHN between two groups
There was no occurrence of PHN in the treatment group, while there were 12 cases in the control group, with an incidence rate of 24.00%. The incidence of PHN in the treatment group was significantly lower than that in the control group, and the difference was statistically significant（ Χ 2 values=13.636, P<0>
2.6 Comparison of air conduction and air bone conduction differences between two groups before and after treatment (1 month after treatment)
The difference in air conduction between the two groups before and after treatment (1 month after treatment) was statistically significant (P<0>0.05). See Table 7.
| Treatment group | control group | Air conduction |
| before | 35.5±4.5 | 35.9±4.7 |
| One month after treatment | 15.6±2.2 | 21.0±3.1 |
| t | 31.265 | 22.413 |
| P | <0> | <0> |
| Air bone conduction differencebefore | 10.1±2.7 | 10.5±2.8 |
| One month after treatment | 5.1±0.3 | 10.0±2.4 |
| t | 13.093 | 1.262 |
| P | <0> | 0.219 |
Table 7 Comparison of air conduction and air bone conduction differences between two groups before and after treatment (1 month after treatment) (dBHL）
2.7 Comparison of incidence rates of adverse reactions between two groups
During the treatment period, no adverse reactions occurred in the treatment group; There were 6 cases of adverse reactions in the control group, including 4 cases of nausea, vomiting, and poor appetite, and 2 cases of abdominal pain and diarrhea. The incidence of adverse reactions was 12.00%. There is a statistically significant difference in the incidence of adverse reactions between the two groups（ Χ 2 values=6.383, P<0>
HZE is a common skin disease in clinical practice. After infection with herpes zoster virus, the virus can lurk in the posterior root of the spinal cord and cranial ganglion cells. When the body's resistance/immunity decreases, the herpes zoster virus will be reactivated, causing a series of symptoms and signs, such as burning, stabbing, and other symptoms [9]. Some patients have left behind PHN in the long term [10], often manifested as burning like, needle like pain [11-13], Seriously affecting the work and daily life of patients [14-15]. The auricle and external ear canal belong to the distribution area of the sensory branch of the facial nerve, with visible blisters on their surface, as well as band like erythema, clustered herpes, and peripheral nerve pain. The herpes zoster virus in the ear often affects other brain nerves and often causes symptoms of meningitis to a certain extent. After the herpes zoster virus invades the auditory nerve and its ganglia, it can lead to permanent deafness. Facial paralysis caused by the herpes zoster virus in the ears can be temporary, but if not treated promptly, it may also lead to permanent facial paralysis.
Western medicine treatment for HZE is currently mainly antiviral therapy [16], commonly used being acyclovir. Although this drug has the effect of inhibiting virus replication, it cannot reduce the incidence of PHN [17], and acyclovir has significant side effects, often including nausea, poor appetite, dizziness, bloating, and renal function damage.
In clinical treatment of HZE, corticosteroid drugs are often used in addition to antiviral therapy. But it is usually used in the early stages of the disease, and commonly used methods such as methylprednisolone injection combined with physiological saline for 3D shock therapy have significant clinical effects. As this drug is an immunosuppressive agent and belongs to the hormone class, it has anti-inflammatory and anti-allergic effects, and can also inhibit the growth of viruses. But this medicine cannot be used for a long time. Long term use can cause metabolic disorders of fat and protein, as well as drug-induced liver damage.
scorzonera glabra herpes ointment is a traditional Chinese medicine topical ointment developed by our hospital. When applied to the affected area, it can directly act on the affected area and kill the virus without the need for liver and kidney metabolism. It can regulate the function of the organs through the meridian system and promote the recovery of herpes. The main ingredient of scorzonera glabra herpes ointment is scorzonera, which has a bitter and spicy taste, a cold nature, and has the effects of clearing heat, detoxifying, treating sores, and dispersing nodules. There are literature reports that scorzonera has antiviral, analgesic, immunomodulatory, and antidepressant effects [17-20].
After 10 days of treatment in both groups, the total effective rate of the treatment group was 98.00%, while the total effective rate of the control group was 84.00%. The treatment effect of the treatment group was better than that of the control group, and the difference was statistically significant (P<0>
The incidence of PHN between the two groups was compared, with no PHN occurring in the treatment group and 12 cases in the control group, with an incidence rate of 24.00%. The incidence of PHN in the treatment group was significantly lower than that in the control group, and the difference was statistically significant. This indicates that external application of scorzonera glabra herpes ointment can indeed alleviate or eliminate postherpetic neuralgia (PHN) in the treatment of herpes zoster in the ear.
The external application of Ya Cong Herpes Ointment to treat ear herpes zoster not only reduces symptoms but also relieves pain, which is related to an important substance contained in Ya Cong itself. Their research found that the extracts from the ground and roots of Ya Cong have anti-inflammatory and analgesic effects [22]; Some scholars have studied [19] and found that extracts C, glucosylflavones, and 7-methylisochlorohydrin have analgesic and anti-inflammatory effects. Therefore, scorzonera glabra herpes ointment can improve the symptoms and signs of HZE and alleviate the pain of patients.
Scorzonera glabra herpes ointment can not only improve the symptoms and signs of HZE, alleviate the pain of patients, but also shorten the course of the disease. Comparison of the time for erythema reduction, scar arrest, scab formation, and scab removal between the two groups showed that the treatment group had shorter time for erythema reduction, blister arrest, scab formation, and scab removal compared to the control group, and the difference was statistically significant (P<0>
Comparison of the incidence of adverse reactions between the two groups, during the treatment period, no adverse reactions occurred in the treatment group; There were 6 cases of adverse reactions in the control group, including 4 cases of nausea, vomiting, and poor appetite, and 2 cases of abdominal pain and diarrhea. The incidence of adverse reactions was 12.00%. There is a statistically significant difference in the incidence of adverse reactions between the two groups. This indicates that the incidence of adverse reactions is low when treated with external application of scorzonera glabra herpes ointment.
The difference in air conduction between the two groups before and after treatment (1 month after treatment) was statistically significant (P<0>0.05). This indicates that external application of scorzonera glabra Herpes Ointment in the treatment of ear herpes zoster can not only improve the patient's air conduction hearing, but also effectively enhance bone conduction hearing. At the same time, it also indicates that the crow onion herpes ointment can better promote the recovery of auditory nerve function.
In summary, the external application of scorzonera glabra Herpes Ointment has a significant effect on the treatment of HZE, and can shorten the course of the disease, improve hearing, and effectively prevent PHN. The clinical application has minimal toxic side effects and is worthy of clinical promotion and application.
All authors have no conflict of interest.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
