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Research Article | DOI: https://doi.org/10.31579/2690-4861/1031
1Department of Bioinformatics, Africa City of Technology, Sudan.
2Faculty of Medicine Al Neelain University, Sudan.
3Oculoplastics and Ocular Oncology Department, Makkah Eye Complex, Sudan.
4Nile College, Hematology and Immunohematology Department, Sudan.
*Corresponding Author: Nada O. Ibrahim, Department of Bioinformatics, Africa City of Technology, Sudan.
Citation: Nada O. Ibrahim, Mahgoub Saleem, Entesar Eltayeb, Salwa O Mekki, Elteleb G. Elnaim, et al., (2026), Targeted Screening of RB1 Exon 18 in Sudanese Children with Retinoblastoma: A Molecular and Bioinformatics Study, International Journal of Clinical Case Reports and Reviews, 33(4); DOI:10.31579/2690-4861/1031
Copyright: © 2026, Nada O. Ibrahim. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 08 January 2026 | Accepted: 16 January 2026 | Published: 23 January 2026
Keywords: molecular genetics; retinoblastoma; PCR, exon 18; sequencing; single nucleotide polymorphisms (snp); bioinformatics; sift; polyphen-2; i-mutant and project hope
Background: Retinoblastoma (RB) is the most common intraocular malignancy in early childhood. It is most often related to mutations in the RB1 gene, with an incidence of 3% of all pediatric tumors.
Methods: Thirty-one (n=31) clinically and histopathological diagnosed cases of RB attending Makkah Eye Complex Orbit clinic (Khartoum, Sudan) were included in this Molecular Genetic RB Analysis. Fresh blood samples were collected, from seven RB patients and 15 close families, for DNA extraction and PCR products were sent for Genetic Sequencing and Bioinformatics approach for “Exon 18 mutations” which is a known mutational hotspot globally.
Results: Most patients (41.9%) were under five years old. Females were 58.1% and males were 41.9%. Leukocoria was the most common sign at presentation (41.9%). RB unilaterality was 77.4% while bilaterality was 19.4%. Both eyes were equally affected (50% each). The age at the time of diagnosis ranged from seven days to five years old. Consanguinity of parents was very high (85.7%); 1st degree cousins were much lower (28.6%) than 2nd degree cousins (57.1%). The patients’ ethnic background and geographical area were from seven different tribes; all belong to Western Sudan. The Functional Analysis and Single Nucleotide Polymorphisms (SNPs) prediction study of exon 18 from NCBI data base showed that the various computational approaches used (SIFT, PolyPhen-2, I-mutant and Project hope) identified 16 reported mutations worldwide, three of which (rs137853292, rs375645171 and rs772068738) are major nsSNPs (non-synonymous) which might contribute to native RB1 protein malfunction and ultimately causing carcinoma (Additional file 2). Our molecular genetic study showed that no mutations were detected in exon 18 among the Sudanese RB patients and their relatives
Conclusion: RB mainly affected children under five years of age, and both sexes were equally affected. Unilaterality was predominant. Consanguinity plays a role in inheritance and most patients were from Western Sudan. The most detected deleterious mutations worldwide in exon 18 were not found in the Sudanese studies samples. Further studies targeting other frequently mutated exons (e.g., exons 8, 10, and 14) or employing next-generation sequencing (NGS) are recommended. Bioinformatics tools are useful in studying the functional analysis of SNPs.
Retinoblastoma (RB) is a rare embryonal tumor of retinal origin and represents the most common intraocular tumor in children, with a 3% incidence of all pediatric tumors and a frequency averaging 1:20,000 live born in different populations (Nag and Khetan, 2024, Gu et al., 2021). It is estimated that 8,000 worldwide new cases of RB of the developing retina are diagnosed each year (Lukamba et al., 2018). Approximately 28% of the global RB population is found in sub-Saharan Africa. It has a favorable prognosis if diagnosed early as in some developed countries as in USA and Canada, however, delayed diagnosis significantly increases mortality risk as in African countries. This is due to a lack of awareness of the clinical outcomes and severity of the disease, preference to seek alternative medicine by some parents, difficulty in accessing referral centers and financial burden (Essuman et al., 2023, Beukman, 2024). Since the condition is lethal, there is a global survival rate of less than 30% if left untreated (Rathore et al., 2023). The most common presenting sign is Leukocoria, followed by strabismus (squint) (Fabian et al., 2020). There are large populations and high birth rates in Asia and Africa. Thus, both bear the most significant burden of RB as well as carry the highest mortality rate of 40 to 70%, compared to 3-5% in the USA, Europe, and Canada (Gu et al., 2021).The RB1 gene (OMIM 614041/ OMIM 180200), located on chromosome 13q14 (Retinoblastoma - GeneReviews® - NCBI Bookshelf, Entry - #180200 - RETINOBLASTOMA; RB1 - OMIM - (OMIM.ORG), consists of 27 exons (Byroju et al., 2023). It is the first tumor suppressor gene to be discovered. The lack of functional RB protein (pRB) in RB1 mutation results in uncontrolled cell division (Nag and Khetan, 2024, Gu et al., 2021). About one-third of RB tumors are hereditary and bilateral, with a median age of one year at diagnosis. It is caused by an RB1 constitutional mutation (M1) on one allele followed by a somatic RB1 mutation on the other allele (M2), leading to loss of function of the RB protein and tumor initiation. Knudson first hypothesized this ‘two-hit’ mechanism in 1971 (Norrie et al., 2021, Soliman et al., 2017). The other two-thirds of these tumors are unilateral, mostly nonhereditary (85%), and have somatic inactivation of both RB1 alleles with a median age of two years at diagnosis. The remaining 15?rry a germlineRB1 mutation and are heritable RB. Heritable tumors have autosomal dominant inheritance, and these patients can transmit the mutation to their offspring and are at increased risk for secondary tumor development (Nag and Khetan, 2024, Gu et al., 2021). Precise identification of RB1mutations in affected families can significantly improve the quality of clinical management of the affected patient and relatives at risk (Soliman et al., 2017). Children at risk undergo series of clinical examinations, including examination under anesthetic (EUA), to early diagnose and treat tumors (Nag and Khetan, 2024, Gu et al., 2021). Siblings of an individual with heritable retinoblastoma should be tested for germline mutation, its presence or absence would determine the future risk which is very similar to the general population if no mutation is found. Whereas those with mutations are considered at high risk and this necessitates periodic surveillance (Byroju et al., 2023, Nag and Khetan, 2024). Thus, cost-effective and sensitive genetic testing is essential to determine the presence of a germline mutation before routine implementation in clinical practice (Gudiseva et al., 2019). Genetic counseling and prenatal testing for pregnancies at risk are thus necessary (Nag and Khetan, 2024, Gu et al., 2021). Therefore, a good understanding of RB genetics is important to support optimal care for children with RB and their families (Soliman et al., 2017). Next-generation sequencing (NGS) strategies are becoming essential in the management and counseling of these patients (Lukamba et al., 2018). In Africa, much research has been conducted regarding incidence, inheritance pattern, treatment outcomes and associated cancers with RB (Hill et al., 2016, Parkin and Stefan, 2017, Essuman et al., 2023). Fewer research has been conducted regarding mutational analysis of the RB1 gene in Arabian African countries (El Amrani et al., 2022). Very few research has been published in Sudan regarding RB from the year 2006 to 2024. A recent study conducted by Abdalla and Mohammed showed that RB has been ranked 4th (n = 410; 9.4%) among the most common cancers and the 2nd most frequent solid tumor in a 15-year retrospective study in Khartoum Oncology hospital, Sudan, from the year 2005 to 2019. The patients were mostly from central Sudan (Khartoum and Al Jazeera) while one third originated from Western Sudan (Kordofan and Darfur). There was no significant difference between boys and girls (Abdalla and Mohammed, 2024). Retinoblastoma incidence in Sudan is not well known and is believed to be underestimated. It is estimated to be around 40-50 cases per year (unpublished data by other colleagues). No complementary updated follow up research was conducted by the Institute of Nuclear Medicine in Gezira regarding the incidence of retinoblastoma and other childhood cancers. To date, no study regarding molecular analysis of RB1 gene mutations in patients with Retinoblastoma has been published in Sudan. By searching the database, there are couple of papers published regarding molecular studies of RB1 gene in tumors other than RB, the recent one was conducted by Elagali et al, 2021 regarding breast cancer patients in Sudan. (Elagali et al., 2021). RB1 gene is well known for its CpG islands dispersed across several exons, exon [8, 10, 11, 14, 15, 17, 18 and 23]. Recurrent mutations in these locations represent mutational hotspots (Marković et al., 2023). Therefore, this study aims at screening for the most deleterious mutations reported worldwide in exon 18 (rs137853292, rs375645171, and rs772068738) (Additional files) in Sudanese families with positive RB member/s from the same ethnic background. To our knowledge, this study is the first to screen RB1 exon 18 in Sudanese RB cases.
Editorial Policies and Ethical Considerations
Demographic data and the clinical information about each child and his family were collected through a close ended Questionnaire. A family pedigree was constructed for each family and was included in the questionnaire (Additional file 1). All patients’ guardians were informed and consented in writing to participate in the study before collecting the samples for publication. Ethical approval was obtained from the ethics committee of Makkah Eye Complex.
Study area
This study was carried out in Khartoum state at Makkah Eye Complex, the largest hospital in Khartoum that provides eye care services for people from all parts of Sudan.
Sampling
Out of all Sudanese patients diagnosed with RB (31 patients) attending Makkah Eye Complex during the year 2017, seven patients were selected randomly for genetic sequencing and analysis according to budget limitations. Three healthy family members with no RB have been added as controls. Blood specimens were collected using EDTA-vacutainer tubes from the selected patients and controls. The specimens were preserved at −20 °C.
DNA extraction
DNA extraction was carried out using a kit from iNtRON Biotechnology for both patients and controls. Genomic DNA extraction was confirmed by agarose gel electrophoresis, and the DNA was kept at −20 °C until use.
PCR amplification
Samples from seven patients and 15 relatives were amplified using the primer set in (Table 1) targeting RB1 gene exon 18. Primers were synthesized and purchased from Macrogen Incorporation (Seoul, South Korea). The annealing temperature was adjusted using Maxime PCR PreMix Kit (i-Taq) 20μl (INTRON Biotechnology, South Korea) on several runs of PCR. The adjusted temperatures are described in (Table 1). Amplification for the targeted region was done after the addition of 14ul distilled water, 1ul DMSO, 3ul DNA sample, and 1ul of each of the forward and reverse primers to the ready-to-use master mix volume. The PCR mixture was subjected to an initial denaturation step at 95°C for 3 min, followed by 40 cycles of denaturation at 95 °C for 45 s, primer annealing at 55.6 °C for 60 s, followed by a step of elongation at 72 °C for 60 s, and the final extension was at 72 °C for 7 min (Elimam et al., 2017). PCR was repeated twice to yield enough DNA samples. The PCR products were checked and analyzed by 2% agarose gel electrophoresis at 100 V for 30 to 45 min, then, an automated gel photo documentation system visualized the bands. [Figure 1] The seven patients and the three controls were subsequently selected for sequencing by the Sanger sequencing technique.
| Primer’s nucleotide sequence | PL* | AT* | Am* |
| F: 5' dTGACTTTATTTGGGTCATGTACCTT 3' | 25 | 55.6 | 360 |
| R: 5’ dGCCACTGTCAATTGTGCCTA 3’ | 20 | 55.6 |
Table 1: Primers used to amplify RB1geneexon 18.
PL* Primer length in base pair, AT* Annealing Temp, Am* Amplicon size (bp)
Sequencing of RB1 gene exon 18
Sanger sequencing was performed for the selected PCR products. Both DNA strands were sequenced by Macrogen Company (Seoul, South Korea).
Bioinformatics analysis
FinchTV program version 1.4.0 was used to view and check the quality of each sample's two purified chromatogram (forward and reverse) nucleotide sequences. NCBI offers the BLAST (Basic Local Alignment Search Tool) family of programs (blast.ncbi.nlm.nih.gov) to detect similarities between the database sequences and a query sequence (Sayers et al., 2019). Thus, NCBI Nucleotide database was searched for reference sequences for Retinoblastoma gene. The RB1 nucleotide sequence (gene ref_ NG 009009.1) was obtained (Homo sapiens RB transcriptional corepressor 1 (RB1), RefSeqGene (LRG_5 - Nucleotide - NCBI) and exon 18 was analyzed accordingly using nucleotide BLAST. BioEdit software was used to find any apparent changes within the tested sequences through multiple sequence alignment. It is available for download at https://bioedit.software.informer.com/7.2/.
Study population characteristics
Patient characteristics & clinical parameters
Thirty-one patients (n=31) diagnosed with RB attended Makkah eye complex (MEC) for the year 2017. The majority of patients (41.9%), when attended the Orbit clinic and diagnosed with RB, were below the age of 5 years (2-5 years), next age group were 1-2 years old (29.0%), followed by below 1 year old group (19.4%) and only 3 patients (9.7%) were above the age of 5 years. [Table 2] Females (58.1%) slightly dominating males (41.9%). [Table 3] Despite the incomplete records for all patients (n=15), Leukocoria seems to be the most common sign at presentation (41.9%), while Phthisis, Enophthalmos and Retinal detachment were one case each. [Table 4] Unilaterality of RB (n=30) were described in 77.4% of patients while Bilaterality in 19.4% (one missing record). [Table 5] Right and left eyes were equally affected, 50% each. [Table 5]. Regarding the seven RB cases, the demographic, characteristics and clinical features are summarized in Table 6. Their age at the time of diagnosis ranged between seven days (0.02 year) to five years (mean age of 2 years ± 0.71 years). Again, most patients (six patients) were below the age of five years, only one patient (14.3%) was above the age of five years. There were two males (28.6%) compared to five females (71.4%). Leukocoria was found in most patients (5 females/ 71.4%). Regarding tumor site, unilaterality was found in85.7% of patients. Five patients have a unilateral sporadic tumor (i.e. no family history), one patient with unilateral familial tumor (affected cousin) and one patient (14.3%) with bilateral sporadic tumor (no family history at that time). The patient with the unilateral familial RB had a family history of a cousin diagnosed with an eye tumor at the age of seven months and died shortly at the age of 10 months. [Figure 2] Regarding consanguinity of parents, it was very high. It was found in six out of seven cases (85.7%), in which two patients (28.6%) have parents who are 1st degree cousins, whereas four patients (57.1%) have parents who are 2nd degree cousins. Only one patient (14.3%), his parents are not relatives. [Table 6] No distant metastasis was reported in our samples but there were four female recurrences out of the seven samples (57.14%). Regarding ethnic background and geographical area, patients were from seven different tribes, all of them (100%) belong to Western Sudan [Baramka (Kurdofan/Darfor), Rezaigat (Kurdofan/Darfor), Jammoeyya (Central/Kurdofan),Zaghawa (Darfor), Fallata (Darfor and Western Africa), Mesaireya (Kurdofan/Darfor) and Kawahla (Kurdofan), [Table 6] Geographical area is not definite as most of these tribes are nomadic with known habits of moving across the country with their animals. [Table 6]
PCR products of exon 18
The PCR products (360 nucleotides long) of the seven afflicted children with RB (P1, 5, 7, 9, 12, 15, 20) and their relatives as Controls (C2-C22) are shown in figure 1A. All 22 samples yielded sufficient quality bands (sample #19 did not show a PCR product in this gel picture but gave a clear band in another run. Picture is not shown).
Bioinformatics result analysis
The sequencing data was checked for consistency and quality by FinchTV as shown in figure 1B. Our result showed consistency and good quality for all 10 sequences. By using the multiple sequence alignment tool BioEdit, the analysis of seven tested patients and three family controls compared to NCBI reference sequence RefSeq (NG 009009.1) revealed no nucleotide change as shown in figure 1C.
| Age at diagnosis (years) | No. of patients | % |
| 0-1 | 6 | 19.4 |
| >1-2 | 9 | 29 |
| >2-5 | 13 | 41.9 |
| >5 | 3 | 9.7 |
| Total | 31 | 100% |
Table 2: Age distribution at first RB diagnosis in MEC (n=31).
Note: RB: Retinoblastoma; MEC: Makkah Eye Complex.
| Sex | No. of patients | % |
| M | 13 | 41.9 |
| F | 18 | 58.1 |
| Total | 31 | 100% |
Table 3: Gender of RB patients attended MEC.
Note: RB: Retinoblastoma; MEC: Makkah Complex Eye.
| First signs at diagnosis | No. |
| Leukocoria | 13 |
| Phthisis eye diagnosed as Enophthalmos | 1 |
| Retinal detachment | 1 |
| Total | 15 |
Table 4: Distribution of RB First sign at diagnosis in MEC (n=15).
Note: RB: Retinoblastoma; MEC: Makkah Eye Complex
| Laterality | No. | % | OD | % | OS | % | |
| Unilateral | 24 | 77.4 | 12 | 50 | 12 | 50 | |
| Bilateral | 6 | 19.4 | - | - | - | - | |
| Total | 30 | 96.8% |
Table 5: Laterality Distribution of RB in MEC (n=30).
Note: RB: Retinoblastoma; MEC: Makkah Eye Complex
OD: Oculus Dextrus (right eye); OS: Oculus Sinister (left eye)
| Variable | Frequency (%) | |
| Onset | ⋜1 year 1-2 years 2-5 years >5 | 4 (57.1%) 1 (14.3%) 1 (14.3%) 1 (14.3%) |
| Sex/Gender | Males | 2 (28.6%) |
| Females | 5 (71.4%) | |
| Leukocoria | Males | 2 (28.6%) |
| Females | 5 (71.4%) | |
| Tumor site | Unilateral | 6 (85.7%) |
| Bilateral | 1 (14.3%) | |
| Family history | Ocular cancer Other cancer | 1 (14.3%) 0 (0%) |
| Consanguinity of parents | 1st degree cousins | 2 (28.6%) |
| 2nd degree cousins | 4 (57.1%) | |
| None | 1 (14.3%) | |
| Recurrence | Male | 0 (0%) |
| Female | 4 (57.1%) | |
| Tribe | Baramka (Kurdofan/Darfor) | 1 (14.3%) |
| Rezaigat (Kurdofan/Darfor) | 1 (14.3%) | |
| Jammoeyya (Central/Kurdofan) | 1 (14.3%) | |
| Zaghawa (Darfor) | 1 (14.3%) | |
| Fallata (Darforand Western Africa) | 1 (14.3%) | |
| Mesaireya (Kurdofan/Darfor) | 1 (14.3%) | |
| Kawahla (Kurdofan) | 1 (14.3%) | |
| Geographical region | Central Sudan [1] | 0 |
| Western Sudan | 7 (100%) | |
| Northern Sudan | 0 | |
| Eastern Sudan | 0 |
Table 6: The demographic, characteristics and clinical features of the seven RB patients attended MEC (2017).
Note: RB: Retinoblastoma; MEC: Makkah Eye Complex [1] Comprising both Khartoum and Al Gezira.
Figure 1: A-C: Results of the seven affected patients with RB. D: Reported mutations worldwide in exon 18.
A: PCR amplification products (360 bp) of the seven afflicted children with Retinoblastoma (P1,5,7,9,12,15,20) and their relatives as Controls (C2-C22). The band of C19 appeared in the second gel (data not shown). DNA ladder of 100 bp was used.
B: FinchTV result showing good DNA quality of exon 18 coding sequence.
C: BioEdit result showing alignment of the seven patients with their family controls compared to NCBI control. F: forward sequence. NG: genomic nucleotide reference sequence. No SNPs are found.
D: Identification of 16 reported mutations world-wide, three of which (red color) are major nsSNPs (non-synonymous) which contribute to native RB1 protein malfunction.
Figure 2: Pedigree of an 8-month-old RB patient with a unilateral familial RB who has a cousin that is diagnosed with an eye tumor at the age of seven months and died shortly after three months at the age of 10 months.
In our study, the number of RB patients attending Makkah Eye complex in 2017 was 31. Most of our patients were below the age of five years, and there is a slight predilection for the female gender with a male-to-female ratio of 1:1.4. Although some records were incomplete, leukocoria remained the most frequently reported presenting sign (13 patients). This finding is consistent with the result reported by K Shahraki et al. in Iran that Leukocoria represents the most significant complaint in RB patients (Shahraki et al., 2017). Regarding the laterality of the disease, our findings slightly diverge from global trends reported in the literature, where unilateral tumors occupied 77.4% and bilateral tumors 19.4% compared to ~ 60% unilateral and 40% bilateral worldwide (Nag and Khetan, 2024). For unilateral tumors, the right and left eyes are equally affected and have no preference to one side. Although most of our patients had unilateral sporadic disease (five out of seven), family history of an eye tumor was found in one case with a unilateral RB and whose parents are 2nd degree cousins. The patient has a cousin who had an eye tumor at the age of seven months and died shortly at the age of 10 months old (Figure 2). This supports the literature in that familial RB can presents as unilateral disease (Nag and Khetan, 2024). The other patient (two years old) with a bilateral sporadic tumor and whose parents are not relatives had a younger sibling who was one month old at the time of study, and thus, no family history was demonstrated at that time. This family needs follow-up for possible sibling affection with RB. Regarding consanguinity, our results showed that RB could occur in 2nd degree relatives as well as in non-relatives. This demonstrates that RB has no predilection to close relatives; it can occur in any family relationship. Regarding ethnic background and geographical area, all seven studied families were from Western Sudan. Although this is a small sample number, it is comparable with a study performed by a colleague (unpublished), which demonstrated that RB is present in Western Sudan (Kurdofan and Darfor) in a slightly higher percentage (40.6%) than in Central Sudan (Khartoum and Al Gezira) (34.4%). Recurrences occurred in four patients either immediately after six months of chemotherapy or later, indicating late presentation and spread of the disease or ineffectiveness of the chemotherapy. Due to budget constraints, only seven patients under active treatment and follow-up were selected for molecular analysis. Mutations in exon 18 in this study is one of the hotspots reported world-wide (Marković et al., 2023, Nguyen et al., 2018, Parma et al., 2017, Tomar et al., 2017). The various computational approaches used (SIFT, PolyPhen-2, I-mutant and Project hope) identified 16 reported mutations worldwide, three of which (rs137853292, rs375645171 and rs772068738) are major ns SNPs (non-synonymous) which might contribute to native RB1 protein malfunction and ultimately causing carcinoma (Figure 1D). In this study, these targeted mutations were absent in exon 18 of the RB1 gene among the Sudanese study sample. However, mutations in RB1 gene are random and could be found in other exons as well due to heterogeneity of the disease, and thus comprehensive screening of all RB1 exons is recommended. In addition, several previous studies from different countries agreed with our finding in which they revealed numerous mutations across RB1 gene of RB patients, but not in exon 18 (unilateral, bilateral, trilateral, sporadic and familial RB cases) (Kalsoom et al., 2015). Further investigations should focus on recurrent mutations in exons 8, 10, and 14 or employ next-generation sequencing (e.g. Gene Panel, whole-exome sequencing) to capture broader mutational landscapes. To our knowledge, this is the first published study to screen RB1 exon 18 in Sudanese patients affected with RB.
This study reveals that retinoblastoma mostly affects Sudanese children under the age of five, with most cases being unilateral. A high rate of parental consanguinity was observed, specifically among diverse tribes in western Sudan, suggesting possible contribution to genetic predisposition. Notably, none of the widely known harmful variants in exon 18 of the RB1 gene were found in the Sudanese study sample. Further screening for the highly reported mutations in exons 8, 10 and 14 or NGS (whole-Exom sequencing) are recommended, ideally with a larger sample size and complete family trios (child, parents, and siblings). Clinically, the use of tailored molecular genetics diagnostics could improve early detection, facilitate family counseling, and optimize surveillance techniques for at-risk families. To our knowledge, this is the first study performed to screen exon 18 in Sudanese patients.
DNA: Deoxyribonucleic acid
MEC: Makkah Eye Complex
NCBI: National Center for Biotechnology Information
NGS: Next Generation Sequencing
nsSNPs: non-synonymous Single Nucleotide Polymorphisms
PCR: Polymerase Chain Reaction
RB: Retinoblastoma
Rs: reference SNP ID number or (“rs#”; "refSNP cluster")
SIFT: Sorting Intolerant from Tolerant
SNPs: Single Nucleotide Polymorphisms
Special thanks to Makkah Eye Complex authorities for allowing this research to be conducted at their premises and I would like to thank the laboratory and anesthesiology staff for their kind assistance in collecting blood samples from our patients and their families.
Additional file 1
Questionnaire (Closed-Ended) _Template.
This questionnaire used to collect demographic data, pedigree, and clinical information from each family.
Additional file 2
The sixteen nsSNPs of exon 18 Polyphen, and I-Mutant software were also identified.
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I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
Dear Grace Pierce, Editorial Coordinator of the journal IJCCR, I had a very positive experience with Auctores - Journal throughout the publication process. The Editorial Team was highly responsive, professional, and supportive at every stage. I would like to extend my sincere thanks to the Editor: Grace Pierce, for her guidance and assistance. The peer-review process was smooth and constructive, helping improve the quality of my work. I would gladly recommend Auctores Journal to fellow researchers and authors. Dr. SABITA SINHA, Medical Oncologist, MD (Electro Homeopathy).
Dear Maria Emerson, Editorial Coordinator of - Journal of Clinical Research and Reports. ''I am pleased to provide this testimonial following the publication of our recent case report in this journal. The peer review process was rigorous, constructive, thorough, and conducted in a timely manner. The reviewers’ comments were thoughtful, detailed, and highly constructive, contributing substantially to the refinement, clarity, and scientific robustness of our manuscript. The process was conducted with professionalism and academic integrity throughout. The support provided by the editorial office was exemplary. Communication was consistently prompt, clear, and courteous at all stages of the submission and publication process. The editorial team demonstrated a high level of organization and responsiveness, ensuring that all queries were addressed efficiently and that the process remained transparent and well-coordinated. The overall quality of the journal is reflected in its strong editorial standards, commitment to scientific excellence, and dedication to publishing clinically meaningful research. It has been a privilege to publish our work in this journal, and we would welcome the opportunity to contribute further in the future.'' Best wishes from, Dr. Efstratios Trogkanis, Cardiologist.
Dear Reader: We have published several articles in the Auctores Publishing, LLC, journal, Clinical Medical Reviews and Reports in recent years (CMRR). This is an ‘open access’ journal and the following are our observations. From the initial invitation to submit an article, to the final edits of galley proofs, we have found CMRR personnel to be professional, responsive, rapid and thorough. This entire process begins with Catherine Mitchell, Editorial Coordinator. She is simply outstanding, and, I believe, unparalleled in her capacity. I cannot imagine a more responsive and dedicated Editorial Coordinator. As I read the dates and timing of her correspondence with us, it seems that she never sleeps. I hope Auctores Publishing, LLC, appreciates her efforts as much as these authors do. Thank you to Auctores Publishing, LLC, to the Editorial Staff/Board, and to Catherine Mitchell from a grateful author(s).
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
